Vasodilators.

iziyobisi Vasodilator - iziyobisi ukuba inyathelo myorelaxant phezu kodonga semithambo, nto leyo sayo olujikeleza oluya. Eli qela iziyobisi kakhulu isetyenziswa iqinile kunye iintlungu (kususa spasm) unyango.

Vasodilators lungahlulwa-hlulwa zibe beta-blocker, nitrate, ACE inhibitors kunye receptor.

Indlela yokusebenza ye B-blocker azezi kuvalwe receptors engabalulekanga imisipha intliziyo kwindlela catecholamines. Kananjalo kufuneka isiphumo sokuba kunciphisa inani zisaphila ngomzuzu, nto leyo ekuncipheni imveliso intliziyo. Kuvalwe iindlela receptors yoluvo kukhokelela ekuncipheni mpilo engabalulekanga kunye noxinzelelo lwegazi.

Beta-blocker zibe neziphumo antiarrhythmic, kwakunye zinqanda umsebenzi renin kwi plasma yegazi. Eli qela-arhente naye isiphumo cardioprotective, ngamanye amazwi, Kuyanceda ukubuyisela miokadiotsitov. Beta-blocker zahlulwe zibe non-uyakhetha kunye uyakhetha (umsebenzi analo sympathomimetic kwaye ngaphandle).

Eyona engundoqo abameli:

1. Propranolol kunye nadolol (ngaphandle umsebenzi analo sympathomimetic).
2. Pindolol kunye oxprenolol (kunye ubukho umsebenzi nofa).
3. Bisoprolol, Betoksolol, atenolol (uyakhetha).

Kukho inani lezifo apho obonisa ukusetyenziswa beta-blocker:

- isifo sentliziyo, sifuba angina;

- umfutho wegazi crisis;

- ukuhlukunyezwa rate (tachycardia);

- ukusilela intliziyo;

- MI wangaphambili;

- migraine.

Kukho kujonge izinto ezithile ekuqeshweni beta-blocker ngexesha lokukhulelwa, isifo seswekile kunye zisanyisa, kodwa oku akuthethi ukuba phantsi kwezi meko kuba contraindicated. Izimo Absolute ukuya khona kwezi mithi:

- ezingapheliyo pathology obstructive pulmonary;

- sisifo iperipheral vascular;

- block intliziyo 2-3 degrees.

ziziphumo ebezingalindelekanga kwi blocker baqeshwe:

- nokuphazamiseka yegazi ngohlobo ndindisholo okanye kweqondo ebandayo, spasm le bronchi enkulu.

- ukuhlukunyezwa hemogram (ukwanda kwinqanaba iswekile egazini, imbonakalo urea).

Vasodilators iqela nayitreyithi - enye yokuqala ezisetyenziselwa ukunyanga lwegazi, ischemia engabalulekanga, zibeyintlekele. indlela yazo yokusebenza kukunciphisa inani oksijini myocardium, oko kukhokelele ekwandiseni ngemithambo peripheral kwaye kunciphise lwemithambo ukubuya. La malungiselelo igalelo ekwandiseni ukuhamba kwegazi coronary ngenxa vasodilation, yaye ngoko, sizani ziba kwemithambo yenhliziyo.

inani Vasodilators nitroglycerin alinakusetyenziswa phambi legazi kwi ingqondo kunye ophakamileyo ingcinezelo intracranial, njengoko kulo meko, ukuba mandundu kuphela nobungozi besi sifo.

Vasodilators intloko zisetyenziswa ikakhulu xa uqaqanjelwa kunye spasm nemithambo. Kwiimeko ezinjalo, kungcono ukusebenzisa iqela beta-blocker, kuba nesiphumo esiphawulweyo kuniko myorelaxant phezu kodonga nemithambo

Iqela lokugqibela lwamachiza - neziyobisi vasodilators, ziphantsi iklasi ka-ACE inhibitor. Ezi izinto zisetyenziswa ubukhulu becala iposi engabalulekanga, lwegazi, kwekhono le ventricle lasekhohlo kwentliziyo. Izimo ukuya khona yabo ukukhulelwa, giperkaliyemiya, sezintso umfula stenosis.

Indlela yokusebenza kwala machiza nto ngokubonakala neziphumo neurohumoral (ukwanda umsebenzi inkqubo kallikrein-kinin, ukuphucula factor endothelium-iphumle), kunye neziphumo pathways (isenzo antioxidant, amanqanaba potassium olukhulu, uvakalelo izicwili yoluvo).

Imithi vasodilation isoloko isetyenziswa yezonyango mihla kwaye siqala ukusebenza therapeutic eyakhayo izifo imithambo yegazi entloko kunye nentliziyo, kwakunye nobukho yethishyu kobuchopho kwentliziyo kule nkqubo.