"Theofedrine": umyalelo. Iibhilethi "Theofedrine": ukuhlaziywa, intengo

Ndingayisebenzisa njani i-Teofedrin? Imiyalelo yokusetyenziswa kwesi sixhobo ichazwe ngokucacileyo kwinqaku elinikeziweyo. Kwakhona kubonisa ukuba le mveliso ixabiseke kangakanani, yintoni ekujoliswe kuyo, yintoni imiphumo emibi, izifaniso kunye nokuchasene kwayo, yintoni ebandakanywe ekubunjweni, njl.

Ukubunjwa, uhlobo lokuvelisa, ukupakisha

Uhlobo luni lwe-Teofedrine lwenziwa ngaluphi uhlobo? Uqeqesho lonyango luthi lukhutshwa kuphela kwiifomethe. Unemibala emhlophe okanye i-beige, kunye nesimo seplati-cylindrical. Ithebhulethi nganye ine-chamfer and inclusions.

Ziziphi izinto ezenza iyeza "Theoferrin" ziquka? Ukubunjwa kwesi sidakamizwa kulandelayo:

• Izinto ezisebenzayo: i-paracetamol, i-theophylline, i-cytisine, i-phenobarbital, ephedrine hydrochloride, i-caffeine kunye ne-belladonna.
• Izinto ezongeziweyo: i- stearic acid, isitashi sezambane, i-povidone kunye ne-calarum stearate.

Ngaloo ndlela, unokupheliswa ngokukhuselekileyo ukuba isilwanyana "Theoferrin H" sisilwanyana esidibeneyo.

Iibhilethi zithengiswa kwizikwere zokujikeleza, ezifakwa kwiipakethi zekhadibhodi.

I-Pharmacological action

Isiyobisi seTofedrin, ixabiso elibhaliweyo ngezantsi, liyilungiselelo elihlangeneyo. Inomphumo we-antispasmodic kunye ne-bronchodilator. Ezi zakhiwo zinikezelwa kudibaniselwano lwe-methylxanthine (i-caffeine ne-theophylline) kunye ne-m-cholinolytic atropine kunye ne-sympathomimetic ephedrin, eziyizona zinto eziphambili ze-belladonna.

Ngokuphathelele i-phenobarbital, iyakususa i-excite system.

Iipropati zeyeza

Zonke izidakamizwa ze-bronchodilator, kubandakanywa nesilwanyana "Theoferrin", zifana nomgaqo wabo wokusebenza. Oku kuthetha ukwandisa ukuhlengahlengiswa kwebronchi, kunciphisa uxinzelelo kumjikelezo omncinci wokujikeleza kwegazi, kwaye kunciphisa iinqwelo zemipuphu, iinqanawa ze-coronary, zivuselela iziko lokuphefumula, zinefuthe lezithintelo (ngokukhawuleza zivakaliswe), zandisa ukuphuma kwegazi, amandla kunye nentliziyo.

Omnye akanakunceda ukusho ukuba ngenxa yobuninzi bezinto ezifana neparacetamol ekubunjweni kweziyobisi, kunomphumo we-analgesic kunye ne-antipyretic.

Pharmacokinetics

Ingaba isilwanyana "i -oeoephedrine" siyifumene kakuhle? Umyalelo uthi emva kokuthabatha iipilisi ngaphakathi, i-substance yabo esebenzayo iyamkelwa ngokukhawuleza kwindlela yokutya.

Uxinzelelo oluphezulu lweziyobisi egazini lwenziwa emva kwemizuzu engama-60. Iimetabolites ezifakwe kwi-paracetamol zithengiswa ngeeyure eziyi-1-4 (kunye nomchamo). Isiqingatha-nobomi besilwanyana esingatshintshiyo esivela kwiplasma singama-3 iiyure. Ukuba iintsholongwane kunye nesibindi ziyahluleka, kwaye xa kwenzeka ukudlula ngaphezulu, esi sibonakaliso sinokunyuka.

Ukuxinwa kwe-theophylline egazini kufinyelelwe malunga nama-2.5 iiyure emva kokuthatha amacwecwe. Ubomi bemizuzu engama-11.

Ukuxhamla kwe-atropine kunye neeplasma zeplasini zifikelela kuma-18%. Phantse i-50% yale nkunkuma idityaniswa kunye nomchamo.

Ngokubhekiselele kwi-ephedrin, iphinde ixutywe kakuhle kwindlela yokutya, idala kwaye igcine izinga eliyimfuneko yokwelapha leziyobisi egazini. I-metabolize le nto kwisibindi, kwaye ixutywe kunye nomchamo.

Iimpawu zokusetyenziswa

Ziziphi iiplatethi ezinokumiselwa? I-Teofedrine? Ngokuqhelekileyo zisetyenziswe njengesilwanyana esincedayo kwizifo zesifo sokuphefumula, ezihamba kunye ne-bronchospasm. Kwakhona, iyeza lisiwe:

• I-asthma yeBronchial;
• I-bronchitis engapheliyo (isithintelo);
• Emphysema yemiphunga.

Ukungqinelana kokusetyenziswa

Njengomthetho, i-bronchodilators, kuquka i-drug "Theoferrin", ayimiselwe ukuba izigulane zi:

• Angina pectoris;
• Ukungaphumeleli kwintliziyo yesimo esingapheliyo;
• Ukuchithwa kwe-coronary circulation;
• I-glaucoma yokuvalwa kwe-Angle;
• Ukuphazamiseka kwengqumbo yentliziyo;
• Hyperplasia yeprostate;
• Hyperthyroidism;
• Ukuxhamla kunye nezinye iimeko ezixhalabisayo;
• Uxinzelelo lwengqondo
• Ukukhulelwa;
• Ubuntwaneni (kuphela kwiminyaka eyi-18 kuphela);
• Ngethuba lokutya;
• Ukunyanzeliswa kwesigulane kumalungu angena kwisibisi.

Kufuneka kwakhona kuqatshelwe ukuba le nyilisi isetyenziswe ngokulumkileyo kwi-diabetes mellitus, i-renal ne-hepatic insufficiency, ingxaki yokucoca, kunye nokulutha komxhomekeke kweziyobisi.

Imithi yeTheophedrine: imiyalelo yokusetyenziswa

I-arhente ecatshangelwayo ithathwa ngomlomo. Ukuyeka ukuhlaselwa kwe-asthma ye-bronchial, isetyenziswe njengomncedisi. Isicatshulwa sithathwa kanye ngeepilisi ezimbini ngosuku. Ukuba kuyimfuneko, i-arhente inokumiselwa amaxesha amathathu ngosuku. Umlinganiselo ophezulu wemihla ngemihla iipilisi ezi-3.

Ukuze iprophylaxis, amayeza athathwe ngomlomo ngesigqithiso okanye i-tablet yonke emva kokutya (kanye ngosuku).

Ukuphepha ukuphazamiseka kobusuku bokulala, ukuthatha imithi eyenziwa kusasa okanye ngemini.

Ubungakanani bonyango olulolo hlobo luxhomekeka kwimeko, kunye neziganeko zesifo kunye nomphumo.

Iziganeko ezimbi

Impendulo engalunganga emva kokuthatha isilwanyana kumbuzo ivela ngokukhawuleza. Nangona kunjalo, kwezinye iimeko, isigulane sinokufumana ezi zinto zilandelayo:

• Ukuphazamiseka kwentliziyo kunye ne-tachycardia.
• Injabulo yengqondo, intloko, ukuthuthumela, ukulala, ukuphazamiseka kokulala.
• Isisindo, ukunciphisa ukutya, ukuhlanza, ukutshaya.
• Umlomo owomileyo, ukugcinwa kwamanzi, ukunyuka kwesithukuthezi, ukuphendula ngokuthe tye.

Ukugqithisa

Xa kuthathwa amacwecwe amacwecwe (ngezinga eliphezulu), zingabangela iziphumo ezilandelayo zesifo sobutyhefu: intlungu yesisu, isicupunu, ukuhlutha kwesisu, ukuhlanza, ukuphazamiseka okubonakalayo, ukungazinzi.

Kufuneka kwakhona kuqaphele ukuba i-ephedrin, ethathwe kwimizi ephezulu, iqhubela phambili ekunyuseni kwi- glucose egazini. Isilinganiso se-Lethal (kunye nokulawulwa ngomlomo) kushiya 1 g.

Ngokubhekiselele kwi- paracetamol ukudlula, kwimeko apho isigulane sinokuphuhlisa i-hepatonecrosis, ukwandisa ixesha le-prothrombin, kunye nokwandisa umsebenzi we-transaminase yesibindi. Ezi ziphumo zenzeka emva kokuthatha ngaphezulu kwe-10-15 g yesisithi eso.

Njengoko unyango lwe-overdosage, ukugcoba isisu, ukuhlanza okufakelwayo kunye nokunyangwa kwamachiza kusetyenziswa.

Ukusebenzisana kwezidakamizwa

• I-Beta-adrenoblockers, i-carbamazepine, i- antiticoagulants engqalileyo, i- furosemide, i-cimetidine, i-antibiotics, i-verapamil, i-fluoroquinolones, i-MAO inhibitors, i-GCS kunye ne-contraceptive ye-hormonal iyakwazi ukwandisa i-theophylline kwigazi kwaye yandisa ingozi yokuphendula.
• Ukukhupha i-krasavki inciphisa umphumo we- anticholinesterase iziyobisi kunye ne-m-holinomimetikov.
• I-Paracetamol yandisa iipropati ze-anticoagulants. Impembelelo ye-hepatotoxic ye-paracetamol iyanda kunye nokusetyenziswa kwe-phenytoin, i-barbiturates, i-rifampicin, i-carbamazepine kunye ne-zidovudine.
• Ngokusetyenziswa okuhlangeneyo kwe-ephedrine kunye ne-MAO inhibitors, iintlungu ezinamandla ezixinzelelekileyo zenzeka. Kufuneka kwakhona kuqaphele ukuba i-ephedrine inciphisa iipropati ze-opioid analgesics kunye neminye imichiza ephazamisa inkqubo yesantya.
• Ngokusetyenziswa kwexesha elifanayo le-bronchodilator nge-beta-blockers engakhethiyo, umphumo wexesha elidlulayo liyabangela.

Iyeza leTheophoodrin: ezifanayo kunye neendleko

Ngokusetyenziswa okungenakwenzeka kwesi sidakamizwa esithi "iTeofedrin" oogqirha babonelela ezi zifana nale nkunkuma. Eyona ndlela isebenzayo kwaye ithandwayo ngamayeza alandelayo: iBronchophillin, T-Fedrin kunye ne-Trifedrine IC.

Amalungiselelo adwelisiweyo ayenayo eyona nto ayimfuneko, ngokubhekiselele kuyo ekufuneka isetyenziswe kuphela emva kokuba kuqeshwe ingcali.

Zingaphi iipilisi zeTeofedrin? Ixabiso lale mayeza aliphezulu kakhulu. Iindleko zayo ezilinganiselwa kuma-ruble aseRashiya angama-240. Kule meko, kufuneka kukhunjulwe ingqalelo ukuba kunzima ukuthenga eso sidakamizwa kwii-pharmacy. Kwenzeka ukuba kuncinci kuhanjiswe, kwaye yeso sihlandlo sithatha indawo endaweni ekhoyo.

Uphononongo malunga neziyobisi

Ininzi yezigulane ezake zathatha le nkunkuma zithi zisebenza kakuhle. Nangona kunjalo, abanye abantu bayakhalaza ukuba oogqirha babonelela izidakamizwa ezinamandla ngokungafuni.

Kufuneka kwakhona kuqatshelwe ukuba kukho imali enkulu yempendulo ukuba le nyilisi inokubangela ukuxhomekeka kwengqondo. Kulo mba, ukumkela kwakhe kufuneka kulawulwe ngokugqithiseleyo ngugqirha.