Uphando lubonisa: "Tylenol" kususa intlungu nje kuphela, kodwa phezu iimvakalelo

Abaphandi e Ohio State University wafumanisa ukuba eli candelo engundoqo ntlungu ezininzi acetaminophen (paracetamol) ezingaphezulu ngaphambili isiphumo icala engaziwayo omnye. Phakathi kwezinye izinto, le nto "ibulala" nesimo sengqondo esihle.

experiment Inkqubela

82 nxaxheba bophononongo baye bohlulwa babe ngamaqela amabini. Abameli omnye kubo idosi yemihla ngemihla ka-1000 mg paracetamol, elinye libe placebo. Ichiza bangene igazi emva kweyure malunga. Kwaye loo nto ithetha ukuba ixesha lesibini ibakala nokuhlola. Ngoku, ivolontiya ngalinye kwakufuneka ukubona iifoto ezibangela iimvakalelo ezahlukeneyo (ukusuka ezimnandi kakhulu kunezinye negative), yaye emva koko ukuchaza iimvakalelo zabo. Kwathi kanti, zokuphelisa iintlungu eqhelekileyo buthuntu imbono nangokweemvakalelo-nxaxheba kwelo qela lokuqala. Ngokubanzi, balibikela iimvakalelo ngaphantsi eqaqambileyo xa kuthelekiswa nxaxheba wathabatha placebo. Abo kuni abaye ngokusondeleyo kulandela uphando, wazi ukuba kungqinelwano asikwazi kulinganiswa causation. Nakuba kunjalo, ukuba ngaba uye wakuqonda ezinye ukuhlola okwenziwa kule ndawo, ngoko ke ufumana yonke umfanekiso.

Eyona nto in okuphelisa ezininzi intlungu

I-paracetamol amaqela enkulu ntlungu ezithengiswa ngaphandle kagqirha. Umzekelo, ichiza "Tylenol" lisetyenziswa eUnited States iminyaka engamashumi asixhenxe. Zonke iziphumo ebezingalindelekanga ukwimo esebenzayo ixesha elide efunda. Uphononongo ngoku ikwazile ukongeza enye into kuludwe umxhelo. Ukuba uyakholwa Association of amayeza yabathengi, ngokusekelwe kwi-paracetamol wavelisa iziyobisi ezahlukeneyo ezingaphezu kwama-600. Oku kwenza izibalo lokuhlela wathi licandelo elinye iikhemikali ixhaphakileyo eziqulethwe amacwecwe.

Ulwazi Izigulane

Abavelisi buyisela ulwazi malunga diphu "Tylenol", "kazz" okanye "ibuprofen". Ezi iziphawuli - "ntlungu" yaye "ukulahla iimvakalelo" - inyaniso ngokulinganayo. Kuphela ngenkankulu umboleki ufuna ukuthenga impahla, nto leyo ibandakanya ingxelo ezothusayo. Olu lwazi kufuneka kusala ngaphandle ingqalelo abantu self-medicate. A intloko kancinane - nangoko kuziwa ipilisi osindisayo yohlangulo. Kakade ke, kukho amaxesha xa engenako ukumelana intlungu, kodwa kukho abanye xa kwakunzima lula ukuyenza ngaphandle ichiza. Ekubeni kwacaca ukuba ulawulo intlungu 'ingozi "usenokuba neziphumo ezibi kakhulu kunokuba thina ngaphambili ekwakucingwa, umntu ngamnye kufuneka bahlangane umba yokuthatha nzulu intlungu.

izifundo zangaphambili

izifundo Ngaphambili ejoliswe ngokuphonononga amathuba acetaminophen, ngokusichazela ezithile umdla. Izazinzulu ziye ukuba le nto asichaphazeli nje emzimbeni kodwa ubuhlungu. Kwaye oku kuthetha ukuba ingasetyenziswa njengenye component unyango yokuntsonkotha ukuphazamiseka engqondweni. Nangona kunjalo, ulwazi olutsha ebonisa licuthe lwaseNtshona Koloni ziba iimvakalelo ezakhayo, kufuneka ukulumkisa oogqirha kunye nezigulane. Ukusetyenziswa "Tylenol" kunye nezinye nucleoside iintlungu kuveliswa ngokusekelwe paracetamol, kungakhokelela ekubeni nemiphumela emibi kakhulu.

Umngcipheko senhliziyo

Okubalulekileyo, ukusetyenziswa kweziyobisi iintlungu (umz, aspirin kwakunye ibuprofen) ezinxulumene ne risk ukusilela ngentliziyo congestive. Abantu abenza ithinasi igazi, ngoko nangoko khawuleza bathi, "Kutheni, ngokuba aspirin sisiseko yamayeza ukuthintela egazi igazi?" Noko ke, abantu abaninzi ukulibala ukuba kulo mzekelo, isigulana ifumana kwi cwecwe imali amancinane esisebenza, incommensurable kunye oko kudla kuthathwe kuphele iintlungu. ngeedosi kwemfuneko yonke imihla kukhokelela ingxaki iziphumo, kunye nabantu ebuhlungu endaweni yokulungisa intliziyo yakho. Singasathethi ukuba aspirin bunokusenza udonga isisu, ngoko ekuvelisweni iziyobisi, ithinasi igazi, eyona nto esebenzayo yenziwe edityaniswe nezinto wemagniziyam iqokobhe.

Uphengululo eyiyo yolingo lwezonyango

Izazinzulu ziye zaphononongwa 754 ulingo lwezonyango, apho kwafunyanwa unxulumano olucacileyo phakathi ukuthathwa analgesics kunye nengozi yokufa sisifo sentliziyo abantu. Ngokutsho ababhali kwakhona, ukusetyenziswa ixesha elide iziyobisi, ngenxa eziqulathe acetaminophen, ebangela amawaka isifo sentliziyo ehlabathini lonke. Ntlungu ubangele zokuma ngequbuliso. Idatha zaqokelelwa kwithuba elisusela kumhla woku-1999 - 2003, iziphumo zophando epapashwe kwi-Lancet. Kwakhona kwisaveyi kuphawuliwe notorious iziyobisi "Vioxx" ogama umenzi sele uqalile promotion elikhulu-isikali ngeendlela amayeza ngenxa emarikeni kwenkulungwane yama-20 emva kwexesha.

iziphumo zesaveyi

A meta-analysis of iimvavanyo lunomkhethe kunye nezifundo lokuqwalasela lubonise ukuba coxibs (NSAIDs) zinxulunyaniswa nokwanda ubungozi sisifo sentliziyo kunye nezigulo ezinxulumene nomsebenzi phecana eliphezulu zesisu. Izazinzulu zithi ukusetyenziswa ixesha elide amathamo aphezulu amayeza eentlungu iqulethe ingozi enokwenzeka kwimpilo yabantu. Ngenxa yesi sizathu, xa "Vioxx" iziyobisi kuye lwayekiswa eUnited States.

Ukuphelisa neemvakalelo ezingakhiyo

Cinga ngefuthe amayeza intlungu ukunciphisa imbono iimeko ezimbi. Njengoko unokuthelekelela, eyona nto esebenzayo ukuze sabelane iimvakalelo zibe okulungileyo nokubi. It ungakwazi imbono jikelele ngokweemvakalelo, kwaye, kunye ne "ubulala 'ezimbi kunye nesimo sengqondo esihle. Oku kuthetha ukuba umphumo iintlungu kwi uluhlu olubanzi iimvakalelo kunye nokuziphatha. Umzekelo, kunciphise uvakalelo usabakhokela abantu ukuba babe ngaphantsi ezinkulu, badla bazive sengqondo nzima kwaye kufikwa kumntu ngamnye.