Mikoflukan: imiyalelo yokusetyenziswa

Ifom yenqanaba

Isilwanyana "iMkoflukan", umyalelo onikwe apha ngezantsi, unokuveliswa ngendlela yamacwecwe aneengcamango ezahlukileyo zezinto ezisetyenziswayo okanye ngendlela yesisombululo sokunyusa. Iipilisi zimhlophe ngombala, zijikeleze ngokuma, kunye neengqimba ezincinane.

Kwiipilisi ezine-50 mg yesithako esisebenzayo, ukudandatheka "F" kwicala elinye kunye "50" kwenye. Ifom efakwe, "Mycoflucan" 150 mg yezinto ezisetyenziswayo - "F150" kunye nomgca wokudibanisa, ngokulandelanayo.

Isisombululo seziyobisi singenakubalabala, sibala, kungekho nxalenye.

Izithako: amaphilisi

Inkunkuma esebenzayo: i-fluconazole - 50/150 mg (kwitafile e-1).

Abamkeli:

- silicon dioxide ,

- lactose,

- Povidone,

- magnesium stearate,

- Croscarmellose,

- talcum powder,

- microcrystalline cellulose

Solution

Isithako esisebenzayo: i-fluconazole - 2/200 mg (kwi-1 ml kunye ne-bhotile ye-1 ngokulandelanayo).

Abamkeli:

- amanzi omjovo,

I-chloride ye sodium.

Isenzo se-Pharmacological yesilwanyana "Mikoflukan"

Umyalelo uthi le nkunkuma ifanelekile kwi-agents e-antitifungal evela kwi-triazole derivatives. I-Fluconazole inhibits ulwaphulo lwe-ergosterol ngolu hlobo lulandelayo: luqhekeza ukulungeleka kwodonga lweseli. Isiza sisebenza ngokuchasene noMicsporum, Candida, Trichophyton, Cryptococcus neoformans.

Isici sesenzo se-pharmacological yesilwanyana kukuba yinto efanayo ngexesha elifanayo lokukhetha inhibitor ye-cytochrome P450 kwi-fungi, kodwa ngelo xesha asibonisi nxaxheba malunga nale nkqubo ye-enzyme kumntu.

Pharmacokinetics yeziyobisi

Isilwayo siphumelele ngokupheleleyo emva kokulawula kwayo, kwaye ukusetyenziswa kokutya kunye nokuthotyelwa kwesilwanyana akuchaphazeli ukutyunjwa kwayo nayiphi na indlela. Ukufumaneka kwezidakamizwa ngu-90%. Isilwanyana sisasazwa kuzo zonke izitho kunye nezicubu zomzimba. Ingxube ye-plasma iyalingana nokugxininisa kwezi ziko kunye nezicubu ezilandelayo: umlenze odibeneyo, ubisi lwebele, umlenze, ukufihla isisu, umthambo kunye ne-perinatal fluid, kwaye kwi- cerebrospinal fluid ukufumaneka kwayo kungabikho kwi-50 ukuya kwi-90%.

Ukongezelela, kwezinye izitho kunye nezicubu ukuxinwa kweziyobisi kunokugqithisa ukudityaniswa kwiplasma. Phakathi kwabo, i-epidermis, i-dermis, i-stratum corneum, i-sweat fluid. Ubomi bemizuzu engama-30.

Izimpawu zokusetyenziswa kweziyobisi "Mikoflukan"

Umyalelo uthi le nkunkuma iye yandisa umsebenzi ngokuchasene nezilwanyana ezinxulumene nezifo ezithintela ukusuleleka kwi-fungal:

• Candidiasis,

• Cryptococcosis,

• I-Candidiasis yeembrane ezinamaqabunga,

• Candidiasis wesisu,

• Ukuthintela ukusuleleka kwezifo,

• Isikhumba sam Mycosis,

• Onychomycosis,

• Pityriasis lichen,

• Paracoccidioidosis,

• Coccidiomycosis,

• Ipistolplasmosis,

• Sporotrichosis.

Imiphumo emibi yeliza "Mikoflukan"

Iimpendulo zeqela lokuvavanya emva kwechungechunge lwezifundo zonyango, kubandakanywa uphando lwe-placebo kunye nezinye iindlela zokuphanda, lubonise ukuba isilwanyana sinokuthi sibe neendlela ezilandelayo:

- malunga nephepha lomathumbu:

• Intlungu yesisu,

• Isihlunu,

• Flatulence,

• Uhudo;

- kwiiNC:

• Utywala,

• Intloko;

- ngenxa yokuphendula

• Ukuphendula kwe-Anaphylactic yomzimba,

• Ukugqithisa isikhumba.

Ukungqinelana kwisiza "Mikoflukan"

Umyalelo weli chiza uthi kukho ezimbalwa ukuchasana nokulawula kwayo, phakathi kwazo:

• Unyaka ukuya ku-1 unyaka,

• Ukukhulelwa,

• Ukuvakalelwa kwiimpawu ze-triazole kunye ne-fluconazole.

Ukusebenzisana kwezidakamizwa

Ixesha leprothrombin landa kunye nokusetyenziswa kwesilungiselelo se-antiticoagulant nge-coumarin.

Iziphumo ze-sulfonylureas, ii-oglycemic oral agents zikhulisa kakhulu ubuncwane babo xa zidibene ne-fluconazole.

Isiqingatha-ubomi se-fluconazole sinciphisa xa siboniswe kwi-rifampicin.