Imiyalelo yokusebenzisa "tiapridal". Analogs nokubuyekeza

"Tiapridal" - amayeza antipsychotic akhiwe tiapride. Ichiza lisetyenziswe njenge sine, iintlungu kunye thile. Isiseko amanyathelo antipsychotic - evalela i receptors dopamine, nto leyo echaphazela kakhulu nokusebenza CNS. Kweli nqaku ukuchaza ngokweenkcukacha malunga ichiza.

Ubume eliquka ichiza

Iyeza ifumaneka ngeendlela ezimbini, cwecwe zingathengwa kwaye isisombululo:

• Enye ngumbongo ampoule omnye iquka 100 yecandelo engundoqo kunye nezinto abancedisayo. Njengoko izithako abancedisayo ezisetyenziswa ukwakheka povidone, nemagnesium stearate, mannitol. Ukubunjwa kwakhona neyongezelelwe i zolwelo dioxide colloidal, lesilicon kunye microcrystalline kwincindi.
• Ngaphandle kokuba icandelo iphambili isisombululo liquka sodium chloride namanzi ngenaliti.

Kwi bhokisi enye eziqulathwe iipilisi 20 (namadyungudyungu 2 tablets-10) okanye ezineengqayi 12 (2 namadyungudyungu of ezineengqayi 6). Imiyalelo yokusebenzisa "Tiapridal" ngokohlobo isisombululo ukuba isitofu ikuvumela ilawulwa yegazi kunye intramuscularly. Olu hlobo ichiza efanelekileyo kuphela ukuba unyango izigulane abadala.

Pharmacodynamics "tiapridal"

Le medicament iye neuroleptic, iintlungu kunye nesenzo anxiolytic. Njengoko yesikhokelo, "Tiapridal" emane iibhloko ukusebenza D ₂ receptors of dopamine engundoqo. Ngaloo ndlela D ₁ receptors lungenasiphumo. Ichiza ubani ayeke ukuba ukhwekhwe, xa isetyenziswa abadala kwenza ukucinga.

Pharmacokinetics "tiapridal"

ulawulo Intramuscular beziyobisi (200 mg) zenqanaba yayo ubuninzi emzimbeni ibanjiwe emva kwemizuzu engama-30, usebenzisa iipilisi kwi idosi enye - imizuzu engama-60. Le bioavailability beziyobisi xa kusetyenziswa ngoko nangoko phambi izidlo nge-75% landile ukuya 95%. Ngenxa yokuba iziyobisi kwandisa ukusetyenziswa kunye inqanaba yayo ubuninzi kwi ephilayo (40%).

Absorption emzimbeni elicothayo kubantu abalupheleyo. "Tiapridal" imiyalelo ukusetyenziswa ubhekisela arhente iwela imiqobo placental negazi-nobuchopho. Yinto eyaziwayo ukuba ngexesha unyango ichiza ekhoyo nokwakheka ubisi lwebele. Kwabasetyhini, ukususwa kwenxenye ichiza ngokukhawuleza ngaphezu koko amadoda (iiyure ezingaphezu 2.9), umahluko kukuba iiyure 0.7. Nethe esibonakala njengophakathi. Kwindawo engundoqo ye ichiza (70%) liyasuswa umzimba nezintso ingatshintshanga.

Iimpawu "Tiapridal" ukulungiselela

Ukuphumeza uthomalaliso ngamachiza "Tiapridal" ukufunda ngolu hlobo lulandelayo:

• zeDyskinesia (tardive, kulogo);
• syndrome Gilles de la Tourette;
• chorea;
• izifo zokuziphatha (ndlongondlongo karhulumente, ukuphazamiseka et al.), nto leyo flow enkulu butywala ezingapheliyo kunye nezigulane abadala;
• obubonakala ziqhwalelisa indlela yokuziphatha, ezifana nemeko ndlongondlongo nokuyaluzela;
• ubuhlungu ubhalo olunzulu (ifom ezingapheliyo).

Izimo, kulinganiselwe ukwamkela "Tiapridal" iziyobisi

Sinqanda ukufakwa "Tiapridal" imiyalelo zokusetyenziswa abantwana abo ubudala ngaphantsi iminyaka emithandathu. Xa therapy ezingabantwana ukuba iipilisi kuphela kwenziwa. Ichiza kufuneka baphathwe abafazi abakhulelweyo kunye nezigulane usancancisa. Iyeza alisetyenziswa kwimeko hypersensitivity amacandelo yayo, kunye nezinye iindlela ezinjalo. Izimo ziquka ezinjalo ithi:

• hepatic kunye ukusilela kwezintso, eye bawayo kakhulu;
• prolaktinzavisimogo ekuxilongweni nangezilonda, rhanelwa phambi kwalo;
• crisis unesifo;
• isifo pheochromocytoma, kukho urhano ikhona.

Iipilisi kunye isisombululo kunye esetyenziswa kunye "sultopride" kunye agonists dopamine receptor (ngaphandle ke unyango kwezigulane Parkinson kaThixo) agcinwa zidityaniswe kunye neentlobo ezithile neuroleptics, arhente anti-arrhythmic ngoweqela eziklasini kwaye III A.

Bazinyange "Tiapridal" umyalelo akavumeli ngaxeshanye ukusebenzisa "moxifloxacin", "sparfloxacin", "Difemanila", "Erythromycin", "bepridil," "mizolastine", "levodopa", "cisapride 'yaye efakwa" vincamine " .

Ukuba isigulane (ingakumbi abadala) aphathwe iziyobisi ukuze kukhokelela kuphuhliso hypokalemia, Uhanjiso ukonakala kwentliziyo, kululwa lekhefu QT, kukuvela bradycardia wavakalisa ubuntu, sebenzisa i "Tiapridal" kufuneka ngenyameko. Isilumkiso kufuneka kwiimeko ezinjalo:

• isifo Parkinson kaThixo;
• bekhubazekile QT lokuphumla zobude ubhalo;
• hypokalemia;
• ukusilela kwezintso ezingapheliyo;
• bradycardia;
• izifo apho ephazamisa yegazi (decompensation inqwanqwa);
• sokuwa.

Unyango with "Tiapridal"

ngokusetyenziswa "Tiapridal" manual icebisa ukuba usebenzisa i kuqala ngeedosi ezincinane, ngokuthe ngcembe zakhuliswa, ukuze ufumane isiphumo ubuninzi.

izifo zokuziphatha

Kuba gidi kuyimfuneko ukuba isicelo 200 mg beziyobisi imihla (ukuya kuma-300). Isiphumo emihle ifunyanwa kwiiveki ezintandathu nge-avareji. izigulane abadala alawulwa idosi esezantsi amayeza - 50 mg. A ithamo elinye ziphele kabini ngemini, kunye neendyebo zalo luvumelekile ngokuhambelana lethuba elifutshane elicaziweyo, isenzo lwenziwa ngokuthe ngcembe, kuthathelwa iingcebiso zeengcali akhawunti. Le idosi yemihla ngemihla mayingagqithi mg 300.

ndinentlungu engapheliyo obukhulu

Ithamo yemihla ngemihla ichiza ukunyanga iimeko ezinjalo ukusuka 200 ukuya 400 mg.

Chorea, Gilles de la Tourette syndrome

Xa uqala unyango lwe idosi umntwana yemihla ngemihla ikhethiwe kuthathelwa ingqalelo ubunzima bomzimba kunye malunga 3-6 mg / kg. Ukuba ufuna ukuba aqhube unyango omdala, kuqala wasebenzisa 25 mg beziyobisi ngosuku, kamva (emva kokunyuka kancinane umthamo) - 300-800 mg.

Kukuphazamiseka, uchuku

Ithamo ekucetyiswa yemihla ngemihla medicament uvela 100 ukuya 150 mg.

izifo zokuziphatha

Ithamo akukhuthazwa ukuba zisetyenziswe emini (200 ukuya 300 mg) kwimeko ithi delirious okanye predelirioznogo lisingisa 400-1200 mg. Ithamo liphezulu kunokwenzeka kufuneka kungagqithwa, ngu 1800 mg. Ukuqaliswa ichiza eveliswa kwi-avareji iiyure zonke ezintlanu. Ukuba unyango kuyimfuneko ukuba umntu osele ekhulile, yonke imihla 2-3 iinaliti phakathi apho waphawula lokuphumla iiyure ezi-6. Kuba unyango izigulane ezifana ekucetyiswa inani imihla mg 200 ukuya 300 medicament apha ngexesha bavunyelwe ukuba bangene ngaphantsi kwe 100 mg "tiapridal".

yokubonakalisa kakhulu eziluhlobo esingapheliyo intlungu

Amayeza ezisekelwe ilawulwa idosi yemihla ngemihla esilingana 200-400 mg beziyobisi.

iziphumo ezingalindelekanga xa uthatha "Tiapridal" iziyobisi

Xa ukuphatha manual "Tiapridal" umyalelo iziyobisi, uhlolo ukuqinisekisa amathuba reactions ethile egwenxa. Ukuhlukunyezwa zingenzeka kwi enzala, luvo, yonyango kunye neenkqubo sentliziyo. Ukongeza, kukho umngcipheko iingxaki izivamvo. Kuba nezinye iziphumo ezingalunganga ziquka aleji, obubonakala yesikhumba ephelekwa ukutyeba, hypotension intolerance.

Libanda, "tiapridal"

Ukuba usebenzisa ithamo ngokugqithiseleyo libanda, kunokwenzeka kunye neempawu zayo ziquka ukuphazamiseka osezingqondweni, eyona kakhulu apho - isiqaqa, syndrome neuroleptic (yingozi, iifom oyingozi). Ukuze kulungiswe le meko le ephilayo lwenziwa unyango olusekelwe kwi-arhente anticholinergic. Emva kokuba kupheliswe eyimfuneko ichiza ukwenza unyango kwangumqondiso kunye plasmapheresis.

oyi

Phambi kokusebenzisa iyeza "Tiapridal" umyalelo manual lithethelela ukuba ulungise hypokalemia. Ngexesha unyango kubalulekile ukuba iliso rhoqo balance electrolyte, aqhube i electrocardiogram, iliso utshintsho umfanekiso lwezonyango.

Ukuba kuyimfuneko ukusebenzisa iziyobisi anticholinergic kukhokelela ekufumaneni neuroleptics syndrome extrapyramidal aphuhliswe endaweni dopamine receptor agonist.

Ngexesha unyango kufuneka bashiye imisebenzi ziyingozi kube usongo, ayikhuthazwa tu ukwenza umsebenzi ofuna yinkathalelo ebalulekileyo kunye nempendulo ngokukhawuleza.

Intsebenziswano kunye nezinye izinto

Ezinye amalungiselelo ile ngokuthatha amayeza "Tiapridal" umyalelo, impendulo enxulumene ne ngenene ingenzeka yokusabela olungafunekiyo. Ayikhuthazwa ngexesha unyango isicelo "Clonidine", antihistamines, anxiolytics, barbiturates kunye opioids, njengoko "tiapridal" isiphumo iya kuba qatha kakhulu. Ngenxa ukungavumelani kufuneka kuthathwe "levodopa" kunye notywala. Amayeza zinokudityaniswa kunye nokusetyenziswa neurotrophic iziyobisi, analgesics, lakhula, neuroleptics. zisengozini enkulu yokuba hypotension intolerance, kukho ukusetyenziswa ngaxeshanye iziyobisi umfutho with "Tiapridalom".

Iindleko analogue iziyobisi, ukubuyekeza ichiza "Tiapridal"

Ukuba unyango kuyimfuneko "Tiapridal" ithetha inkcazelo umyalelo ke uyazi yintoni isiyobisi. Ixabiso iziyobisi kubaluleke kakhulu ekukhetheni umntu medicament ukuba unyango. Isisombululo kule ezineengqayi zingathengwa malunga 995 engange, kunye tablets - kuba 1,400 engange.

Phakathi analogue beziyobisi - "Eglonil", "Betamax". Kwezi ababambeleyo ukuze ukhethe "Sulpiride" okanye "Prosulpin". Kukho nenye analogu beziyobisi - "tiaprid", yena ingqalelo kakhulu zifikeleleke, oko kakhulu ukhetho edumileyo, imveliso iziyobisi yasekhaya elijongene inkampani "Organic". Njengenxalenye "tiaprid" uyisondeze into efanayo esebenzayo, nto leyo eyinxalenye amayeza "Tiapridal". Ukusetyenziswa analogs Guide lithethelela ukuba ukhethe, xa ayikwazi ingasetyenziswa kunye namanye amachiza soqobo ngaxeshanye ibanga iziphumo ebezingalindelekanga kwaye ayinikeli nomphumo oyifunayo. Ukuze ichiza waphumelela, ithathele ingqalelo ezininzi iingongoma xa ekhethiweyo.

Ngexesha unyango, kubalulekile ukuba ulandele iingcebiso yonke kagqirha kunye nezindululo, equlethe imiyalelo zokusetyenziswa. "Tiapridal", njengoko kuboniswa ingxelo, kwiimeko ezininzi, isetyenziselwa ukuphelisa imiqathango kunye uchulumanco luvo kunye nokuziphatha ndlongo, ukugula ngengqondo utywala. Ngokuqhelekileyo, izigulane kunye noogqirha bonelisekile osisiphumo unyango. Ngokusisiseko, sokuvuselela akufuneki ngenxa yokuba waye- yifuna liphuhlisa emva ekuphunyezweni ikhosi yokuqala. Ukuphonononga zibonisa ukuba amayeza izigulane "Tiapridal" ukusebenzisa lula.