Beta-blocker: uluhlu iziyobisi, ezibonisa ukuba ukusetyenziswa

Iziyobisi kunye nemiphumela ephawulekayo zonyango ezisetyenziswa ziingcali. Zisetyenziswa ukuba unyango lwezifo kwentliziyo, ezo njalo kakhulu phakathi kwezinye ezimbi. Ezi zifo kusenokwenzeka ukuba ikhokelele ekufeni kwizigulane. Amayeza afunekayo ukuze ukunyanga ezi zifo, ngaba beta-blocker. Uluhlu udidi amachiza, equka amacandelo 4, kunye nokuhlelwa zabo thaca ngezantsi.

Ukuhlelwa beta-blocker

Ubume eekhemikhali eklasini yamachiza non-iyunifom kunye neziphumo zonyango bazimele. Kuninzi kakhulu kubalulekile ukwaba ngqo ukuya receptor ethile kunye ngobuhlobo kuye. Uphakamile ingakumbi ngenxa beta-1 receptors, iziphumo ebezingalindelekanga ezimbalwa iziyobisi. Kulo mba, uluhlu iziyobisi beta-blocker thaca njengoko esisiso.

Isizukulwana sokuqala kweemveliso:

• non-uyakhetha beta-receptor 1 kunye uhlobo 2, "Propranolol" yaye "Sotalol", "timolol" yaye "oxprenolol", "nadolol," "Penbutamol".

Isizukulwana yesibini:

• beta ukukhetha uhlobo receptor 1, "bisoprolol" yaye "Metoprolol", "acebutolol" yaye "Atenolol", "Esmolol."

besesithathu isizukulwana sikaEfrayim

• beta ukukhetha 1 blocker ngempahla ezongezelelweyo amayeza: "Nebivolol" yaye "Betaksalol", "talinolol" yaye "celiprolol".
• Nelektivnye beta-1 beta-2 blocker ezinezinye iimpawu amayeza: "Carvedilol" yaye "carteolol," "Labetalol" yaye "bucindolol".

Ezi beta-blocker (bona uluhlu lwe iziyobisi. Ngaphezu) ngamaxesha ahlukeneyo kwakukho iqela elikhulu iziyobisi ezithelekisekayo ezisetyenziswe kwaye ngoku kusetyenziswa izifo iimpahla kunye nentliziyo yegazi. Abaninzi babo, uninzi abameli izizukulwana yesibini neyesithathu, ezisetyenziswa namhlanje. Ngenxa yeziphumo zabo amayeza ukulawula ukulawula izinga lentliziyo kunye nokunyanzela isingqisho ethunjini ukuya ventricles, ukunciphisa amatyeli yokuhlaselwa angina of angina.

Key to yokuhlela

Amachiza zokuqala ngamalungu sizukulwana yokuqala, oko kukuthi, non-uyakhetha beta-blocker. Uluhlu lwe iziyobisi kunye amalungiselelo sele inikwe ngentla. La machiza ekwaziyo evalela i receptors kwe-1 kunye nohlobo-2, ukubonelela zombini iziphumo zonyango kunye icala, nto leyo kubonakaliswa bronchospasm. Ngenxa yokuba contraindicated kwizigulane kunye COPD, isifuba inyumoniya. Eyona nto ibalulekileyo amachiza sizukulwana sokuqala "Propranolol", "Sotalol", "timolol".

Phakathi abameli isizukulwana sesibini uluhlu lwamachiza beta-blocker, indlela amanyathelo apho lu dityanisiwe samabanga ethintela uhlobo nezamkeli kuqala. Bona lubonakala ngokuba sendiselane kwaphela uhlobo receptor 2, ngokuba kunqabile ukuba bronchospasm kubaguli nesifuma kunye COPD. Amalungiselelo ibalulekileyo sizukulwana 2 zibe "bisoprolol" yaye "Metoprolol", "Atenolol".

Isizukulwana wesithathu beta-blocker

Abameli besesithathu isizukulwana - ke blocker beta yakutshanje. Uluhlu iziyobisi iquka "Nebivolol", "carvedilol", "Labetalol", "bucindolol", "celiprolol" kunye nabanye abantu (bona. Ngaphezu). Eyona ibaluleke kakhulu ukusuka kwindawo kwezonyango umbono zezi zilandelayo: "Nebivolol" yaye "Carvedilol". Imvelaphi advantageously ivalekile beta-1 receptors kudaleke ukukhululwa NO. Oku kubangelwa ukwandiswa imithambo yegazi nokucutha umngcipheko umonakalo atherosclerotic.

Kukholelwa ukuba beta-blocker - iziyobisi lwegazi kunye nesifo sentliziyo, ngoxa "Nebivolol" - ichiza generic oko kuhambisana kahle iinjongo zombini. Noko ke, ixabiso layo engaphezulwana nje kancinane kune ixabiso zabanye. Efanayo zokuhlola kodwa kancinane imali eninzi, kodwa i "Carvedilol". Luhlanganisa iimpawu beta-1 alpha-blocker ukuba inceda ukunciphisa frequency namandla izishunqulelo intliziyo, kwakunye ukwandisa kwimida iimpahla.

Ezi ziphumo zikuvumela ukuba ulawule ezingapheliyo sisifo sentliziyo kunye noxinzelelo lwegazi. Kwaye kwimeko ukusilela intliziyo, "Carvedilol" - ichiza abazikhethele, ngokuba kusenjalo nanamhlanje i antioxidant. Ngenxa yokuba isixhobo kuthintela ukuqhubela phambili umonakalo atherosclerotic.

Iqela kweziyobisi Iimpawu

Zonke izinto ezibonisa ukuba ukusetyenziswa beta-blocker zixhomekeke kwiimpawu ezithile zeqela iziyobisi ethile. Xa blocker non-uyakhetha ebonisa ayemxinwa, kanti bakhethe ezikhuselekileyo kwaye isicelo ngaphezulu ngokubanzi. Ngokubanzi, kubonakala eziqhelekileyo, nangona lunyiniwe ngenxa nakwenzeka ukusetyenziswa kweziyobisi kwezinye izigulane. Kuba iziyobisi ezingekho-uyakhetha zilandelayo zibonisa:

• iposi engabalulekanga kuwo onke amaxesha, angina, ukuphumla, angina eziguquguqukayo ;
• fibrillation Atrial normoforma kunye tahiforma;
• sinus tachyarrhythmia lokuqhuba kunye okanye ngaphandle kwakhe ventricles;
• senhliziyo (chronic);
• wegazi ;
• hyperthyroidism, hyperthyroidism, kunye okanye ngaphandle lunengxaki kuyo;
• pheochromocytoma evela lunengxaki unyango olusisiseko okanye izifo preoperatively;
• migraine;
• Sokuhlaziya kwemithambo aortic;
• iziyobisi okanye ukurhoxiswa alcohol syndrome.

Ngenxa ukhuseleko amaqela amaninzi ngakumbi isizukulwana yesibini neyesithathu, uluhlu lwamachiza beta-blocker iziyobisi,, ngokufuthi libonakala neerekhodi unyango kwentliziyo nezifo nemithambo. Ngokutsho nezihlandlo isicelo, ukuba phantse twatse kunye inhibitors ACE, zisetyenziselwa ukunyanga sisifo sentliziyo kunye noxinzelelo lwegazi kunye pathways syndrome kwaye ngaphandle kwayo. Kunye womchamo, la maqela mabini iziyobisi nako ukwandisa bempilo ukusilela ezingapheliyo inhliziyo.

Izimo

Beta-blocker, kwakunye nezinye iziyobisi, abanye Izimo. Kwaye ngenxa yokuba iziyobisi kwenza receptors, ukuba ikhuseleke kwe ACE inhibitor. Izimo Jikelele:

• isifuba, COPD;
• bradyarrhythmia, sinus lokugula syndrome;
• atrioventricular block degree II;
• hypotension lingaze;
• ekhulelwe, umntwana;
• Ukungaphumeleli intliziyo decompensated - ukusilela intliziyo II B-III.

Kwakhona uba uxabane contra njengempendulo ukwamkelwa blocker. Ukuba naliphi na nokwaliwa leziyobisi, ekutshintshweni kweziyobisi kwenye uyayisombulula le ngxaki.

Imiphumo nokusebenza kwamachiza

Xa iziyobisi angina ziyakwehlisa ngokubonakalayo nezihlandlo yokuhlaselwa angina namandla abo, ukunciphisa amathuba iziganeko zosulele coronary. Xa unyango CHF kunye beta-blocker kunye inhibitors ACE kunye womchamo ukunyuka ezimbini sokuphila. Amayeza ezisebenza tachyarrhythmias ekulawuleni okanye abacinezele ibetha ethunjini rhoqo kwi ventricle. Xa iyonke, imali ukunceda ukulawula naziphi na iimpawu zesifo sentliziyo.

Izigqibo malunga beta-blocker

"Carvedilol" yaye "Nebivolol" - yeyona ilungileyo beta-blocker. Uluhlu iziyobisi ukubonisa umsebenzi preferential ibeta-receptors, likwancedisa uluhlu amachiza eziphambili therapeutically ebalulekileyo. Ngokuba ebuninzini practice lwezonyango kufuneka zisetyenziswe nokuba isizukulwana wesithathu, oko kukuthi "Carvedilol" okanye "Nebivolol" okanye ikakhulu uyakhetha ukuba beta-1 iziyobisi receptor, "bisoprolol", "metoprolol". Nanamhlanje, isicelo sabo ikuvumela ukulawula lwegazi kunye ukunyanga isifo sentliziyo.