"Valacyclovir": imiyalelo ukusetyenziswa, ncomo. Analogs "valaciclovir"

amagciwane ulinde umntu zonke inyathelo yobomi yayo ekhawulezileyo. Nabanye babo, amajoni omzimba lomntu esempilweni uyakwazi ukulawula ngokwabo. Kwaye ukujongana umntu kufuna antivirals ezizodwa. kushishino Modern iye uphuhliso kunye nokuveliswa kwamayeza - kwishishini loxubo - sele siphuhlisiwe kwaye sele ukulungele ukuba iziguli zayo abanikezeli beenkozo zononophelo lwempilo uluhlu lwe loo mayeza. Omnye wabo sisiyobisi "Valacyclovir."

Umgaqo ekusebenzeni medicament

Iziyobisi "valaciclovir" engundoqo esebenzayo - hydrochloride valaciclovir (556 mg ipilisi nganye). valacyclovir Pure - 500 mg. Eli candelo abangaphangeliyo ukuba Yindibanisela iintsholongwane DNA ebangela herpes abangaphangeliyo iinkqubo phindana (retards okanye abangaphangeliyo inkqubo kabini iimolekyuli DNA ngokupheleleyo).

Emva kokuba medicament engena emzimbeni, oko uqalisa acyclovir kunye L-valine. Emva koko, ngenxa phosphorylation of triphosphate acyclovir kwakhiwa leyo, enyanisweni, abangaphangeliyo herpes virus DNA yokuqaphela, ngaba ningabaniki (DNA) kabini. Mhlawumbi oku kubangelwa kukuba acyclovir ezifakwe isakhiwo DNA wentsholongwane. Sinokuthi "Valacyclovir" uyamkhetha kakhulu ngokuphathelele ancedisana bachatshazelwa yintsholongwane.

Sphere yemfundiso "valaciclovir"

Ngokubanzi, "Valacyclovir" umyalelo kusetyenziso olulawulwayo (iingcali zempilo - ukumisela ukufumana) abantu abaphethwe zizifo ezosulelayo ye inwebu yangaphakathi kunye ulusu, wamqumbisa yintsholongwane Herpeszoster. Makhe Siyayamkela ichiza ngeenjongo zokuthintela. Kwakhona, iingcali angatyumba "Valacyclovir" kuthintelo losulelo cytomegalovirus, nto leyo ngethuba lokuqhubeka thuba postoperative malunga abohlukeneyo. intando iziyobisi olusebenzayo tile prolechivanii.

Izimo kunye kulinganiselwe ukufumana

"Valacyclovir" into contraindicated kubantu kunye uvakalelo oluphezulu yecandelo engundoqo esebenzayo kweli chiza. isicelo iziyobisi engamkelekanga ngexesha abohlukeneyo in nokufakelwa zezintso kunye umongo wethambo. Kwakhona ukumisela "Valaciclovir" izigulane ezine-HIV (ukuba umgangatho lymphocyte CD ₄ idlule umgca 100 mg / L). Kukho Izimo ngokufumana amayeza abantwana abafikisayo abangaphantsi kweminyaka engama-18. Ngaphandle kulo mzekelo nibe ngabantwana abathe baba nokufakelwa amalungu omzimba. izigulane ezinjalo zivumelekile ukuba kunyanga "valaciclovir" kunye neminyaka eli-12 ubudala.

Ngokuphathelele kwimiqathango, ekubeni "Valacyclovir" - amayeza kakhulu ndlongo, kukho imiqathango ukusetyenziswa zawo abafazi abakhulelweyo kunye noomama zokonga. Naluphi na uphando olulodwa elabhoratri esi sifundo kuthwalelwa phandle.

Ukuba umfazi uceba ukukhulelwa kunye nomntwana, yaye umzimba kulele yintsholongwane herpes aleleyo, kufuneka ukwazi ugqirha. Kuba olungekazalwa usana exacerbation losulelo herpes kunokuba yingozi. Ngexesha lokuzalwa kukho amathuba osulelo lwe umntwana nonina. Ilungelo lokuba babe kwimeko ukukhulelwa ezicwangcisiweyo bangenele uviwo lokuqala ubukho xa umzimba kuhlobo lwesibini herpes. Kwakhona, ugqirha unokuchaza ezinye iinkangelo rhoqo kwi ngokuchonga intsholongwane herpes kunokwenzeka.

Kuyo nayiphi na imeko, phambi kokuqeshwa beziyobisi kolu didi lwezigulane umsebenzi ngezempilo ukuba uthelekise isiphumo okulindelekileyo unyango mingcipheko kamama impilo yosana elizayo okanye sele ezelwe. Kukho ulwazi acyclovir ume ngaphandle ubisi lwebele kungomlinganiselo ukuba amaxesha amaninzi ngaphezulu eyavela kwi plasma (ukususela kumaxesha 0.6 ukuya 4.1).

ziphumo bezingalindelekanga kunokwenzeka

Kwi yokulungiselela "Valacyclovir" imiyalelo ukusetyenziswa njengendlela amabango medicament ezinokubangela uluhlu olude lwe iziganeko ezibi. Ekubeni ichiza sele udlule zonke ulingo lonyango kunye nezifundo lokuqwalasela (iqela kwezigulane herpes zoster, herpes omnye nguye; kodwa ephelekwa immunodeficiency), ngoku afumaneka phantse kuzo zonke kunokwenzeka iziphumo ebezingalindelekanga.

Human git unako ukuphendula ngokusetyenziswa ukukhathazeka medicament kwi epigastrium. Ngaba ukuphuhlisa iimeko ezifana ukudla, isicaphucaphu, ukugabha, urhudo, hepatitis, enzyme zesibindi ophakamileyo.

Ngomhla inxalenye yenkqubo luvo inokuba yokusabela "Valacyclovir" (testimonials nomonde - proof) ngokohlobo isiyezi kunye yintloko, ukudakumba, nemibono, ukwazi kakuhle (kakhulu ezinqabileyo). Ukuba izigulane kufuneka ukungaqheleki kumsebenzi kwezintso okanye ezinye izinto predisposing - mhlawumbi ekuqaleni isiqaqa. Ukususela kumaxesha ngamaxesha unako ukuviwa abasabela ngayo yegazi njengoko tachycardia (ukwanda izinga lentliziyo), okanye uxinzelelo oluphezulu lwegazi.

Lidla kukho kukwalisa yendalo: ukurhawuzelela, irhashalala, urticaria, anaphylaxis, angioedema kunye angioedema. Phakathi kwezinye izenzakalo negative ngokufumana medicament "Valaciclovir" (analogs lenze ncakasana impendulo enye okanye efanayo kakhulu) ukuze aphuhlise dyspnea, photosensitivity, emzimbeni (emzimbeni), thrombocytopenia (sehle amanani zegazi, nto leyo kunye nobunzima ukuba bayeke ukopha, kunye ukopha oluphuculweyo). Kwakhona, oogqirha bathi malunga imbonakaliso kunokwenzeka of nasopharyngitis, igazi aplastic, vasculitis.

A indlela ngokufumana nasekukhupheni imo

"Valaciclovir" (tablets) athathwa ngomlomo kungekho ukutya. mode reception kunye idosi iyahluka ngokuxhomekeke sifo nobukhali imeko yesigulane.

Amaninzi, le amayeza ezimiselweyo unyango legciwane herpes. Kule meko idosi yemihla ngemihla 1000 mg (tablets 2). Kuyanconywa ukuba amathamo amabini, elinye icwecwe kusasa nangokuhlwa. unyango Drug ekungabonini ukusuka kwiintsuku ezi-5 ukuya kwali-10 (ikhondo kakhulu kwesi sifo). Kule mo, kwaye ithamo elinye ichiza sithathwa njengenyathelo lothintelo.

Tile "Valacyclovir" yemiyalezo icebisa ukuba ukuthatha ngendlela eyahlukileyo. Apha ne nedosi ye-1000 mg - umsebenzi. Yamkela Mode - kathathu ngemini (okt tablets 6 ngosuku, izihlandlo ezithathu ngamaqhekeza 2 ...). Ikhosi lonyango ngokuqhelekileyo ithatha iintsuku ezisi-7. I msinyane emva kokuqala kweempawu zesi sifo isigulana afune uncedo lonyango, umphumo oluvumelanayo kuphunyezwa ngokukhawuleza.

Kuba izigulana ezingaqhelekanga kumsebenzi kwezintso kufuna uhlengahlengiso balawule.

Ezinye iimpawu isicelo "valaciclovir"

Kuba abantu ukusilela kwezintso kwi sicelo beziyobisi kwandisa amathuba nengxaki yemithambo-luvo okanye kakhulu lwe sifo. Izigulane abakhulileyo kufuneka ngethuba unyango nokunyusa inani lokuthathwa kweqela fluid. Simele siqiniseke ukuba abantu ogula sisifo sesibindi.

Ukuba iyeza uqeshwa ngemvumelwano unyango lwezifo ezifana, ezifana herpes obuni, "Valacyclovir" akayi kuba nako ukuthintela usulelo lwe iqabane. Ngoko ke, ebudeni unyango kufuneka basenokuziphepha iintlobano zesini.

Ukuba isiguli ukufakelwa kwezintso okanye lomongo wethambo, iye yabonisa umfanekiso onyango lwe-HIV, kukho imo immunodeficiency eqatha, ukusetyenziswa "valaciclovir" kunokubangela imiphumo vuhlayiseki, abulawe. Mhlawumbi uphuhliso purpura thrombocytopenic: utshintsho zophendlo lwezifo kwi kumacandelo enye okanye ngaphezulu hemostasis, ezivakaliswe hemorrhages capillary melkopyatnistyh eluswini, phantsi kwesikhumba okanye ngenwebu yangaphakathi. Kukho kwakhona yindlela uremic syndrome (ukumisa umsebenzi kwezintso, umchamo ayeke inkqubo). Zombini ezi meko (purpura kunye uremia) kunye Amathuba aphezulu kunokukhokelela ekufeni.

Musa kuqesha "Valacyclovir" abantwana abangaphantsi kweminyaka eli-18 ubudala, njengoko kungekho amava onyango kunye nezigulane ezinjalo.

Ukuba ngexa unyango isigulane iphuhlisa ukuxhuzula, ukuphazamiseka, ukuba nemibono, ingqondo, ukudideka - evela ekusetyenzisweni ichiza kufuneka lwayekiswa yaye adibane yincutshe.

Intsebenziswano kunye namanye amachiza

Nayiphi ngokwezonyango kakhulu obubonakala intsebenziswano "valaciclovir" kunye nezinye ichiza wamiswa. Nangona kunjalo, lo kuqulunqo ingxenye main esebenzayo i imveliso nge kwizintso yi secretion tubular. Ngoko ke, naziphi na iziyobisi ukuya kukhuthaza indlela efanayo, ubanjisiwe ngaxeshanye, uya nzima inkqubo nokwandisa kwi plasma yoxinaniso of valacyclovir. Okokuqala bonke abasebenzi kwicandelo lononophelo lwempilo kufuneka sinikele ingqalelo leziyobisi cimetidine kunye ezifana ezithintela indlela secretion tubular.

Uyondelelwano lwee- acyclovir kwi plasma kuyenyuka, ngelixa lokufumana "valaciclovir" yaye "Mycophenolate". Parallel abafumana Pharmaceuticals, nzima okanye kokuphazamisa inkqubo kidney ( "Tacrolimus", "Cyclosporin" kunye m. P.), eza kuphucula umthwalo kule amalungu.

amachiza afanayo

Uluhlu iziyobisi antiviral namhlanje ubanzi ngokwaneleyo. Nhlanhla ikhowudi ATC inqanaba 4 iziyobisi lukhulu, kodwa medicament ekufutshane "Valacyclovir" "Valtrex", "Vayora", "Valogard", "Valtsikon", "Valavir", "Valvira", "Vatsireks". Olu luhlu ayikho kakhulu ngokupheleleyo, kunokwenzeka ukuba uqhubeke.

Imfuno abathengi ebanzi evela kuzo zonke analogue uba namhlanje "Valtrex". Le analog ngaphandle, exhob efanayo esebenzayo. Ukusebenza yokulungiselela kunye nezihlandlo iimpawu ezibi, reactions icala twatse "valaciclovir". Umahluko ikhona kuphela ixabiso, "Valtrex" zibiza kakhulu ngakumbi. Ngenxa yoko, izigulane ezininzi anomdla umbuzo "Valacyclovir" okanye "Valtrex" - kokona kulungileyo. Impendulo - omabini amachiza zisebenza ngokwaneleyo.

Ngokoluvo kwizigulane kunye lwempilo Iingcali zamayeza

izigulane ezininzi uphendule medicament ngendlela eyakhayo. Wabonisa iqondo eliphezulu ngobuchule "Valacyclovir" (reviews of abasebenzi bezempilo kunye nezigulane ngendlela efanayo) kwi unyango legciwane herpes. Ukudumba buye bungabonakali ngokukhawuleza kwaye ixesha ngokwaneleyo elide lungenzeki kwakhona. Lidla kunye iipilisi abantu basebenzise equlathe yamafutha iziyobisi valaciclovir (olunye uhlobo ukukhululwa iziyobisi). Kwiimeko ezinjalo, ukwanela unyango uyaphuculwa, iziphumo ezidibanisayo ifunyanwa ngexesha elifutshane. Noko ke, izigulane kufuneka ikhunjulwa into yokuba akukho okwangoku akukho amayeza unako ukuphelisa umzimba intsholongwane herpes, oko okwangoku kuphuhliswa. Kukho iziyobisi kuphela unyango nomqondiso.

Noko ke, ukususela kwiqela olwahlukileyo izigulane azikwazi ukuva ngokubonakala basabele ezibi. Amaninzi kuba kude kwisiqwenga zesisu: isicaphucaphu, ukugabha, ukuqunjelwa. abasebenzisi abaninzi anelisekile ixabiso elincinane ngokwentelekiso ipilisi okanye ngamafutha nganye "Valacyclovir." analogue zalo, njengoko umgaqo zibiza kakhulu ngakumbi,, kunye nokusebenza iimpendulo ezifanayo ezingalunganga nazo twatse.

Abasebenzi bezempilo nabo ukuqinisekisa ukusebenza kweli chiza antiviral ukuba unyango lwezifo ezininzi kunje.

"Valacyclovir" - inombolo iziyobisi 1?

"Valaciclovir" ukubeka yemiyalezo nokusebenzisa kakuhle kakhulu antiviral. Izifo imvelaphi wentsholongwane egazini kunokuba ngocoselelo kwaye umphelo zonakalise ubomi lomntu. Kodwa ilikhubalo, masithi yi usuleleko herpes okwangoku yasungulwa. Ewe, kwaye nasiphi na isifo bentsholongwane ukuze ubuyele emva kwexesha elithile. Esi sigqibo self-njongo kunye nokusebenzisa i "valaciclovir" ngaphandle thethwano kunye nogqirha igcwele neengxaki ezinzulu. Mncinane ukuba kungalindeleka - yinto nje ukungabikho iziphumo ezihle. Ukuba kukho iingxaki ezinkulu emzimbeni enxulumene nokusebenza kidney abohlukeneyo efanayo wezintso kwaye bone ngumongo self "valaciclovir" unako yaye kukhokelela ekufeni. Kunye neziphumo ebezingalindelekanga ezininzi.

Ukuba ichiza eza kuqeshwa ngugqirha khona, naye liphuhlise kwisiphaluka ukwamkela ekhethiweyo idosi nokusebenza "valaciclovir" kwi ukunyanga isifo liya kuba likhulu kwi ubuncinane amathuba iziganeko ezibi kunye nezigulo ekufumaneni medicament.