Myelosis Subleukemic - uhlobo elihle wegazi ezingapheliyo

myelosis Subleukemic yenye liqela wegazi olucothayo ezingapheliyo, apho unobangela sifo iba utshintsho zophendlo lwezifo iiseli siphu- myelocyte. Xeshanye nokwanda kakuhle leeseli hematopoietic kule nkqubo isifo izitshanguba fibro-sclerotic esebenzayo amathambo amathambo kunye ucinezelo ehamba ukuba umongo kunye notshintsho proliferative kwi udakada wesibindi. Kungenxa yoko le nto myelosis subleukemic wabhekisela ileukemia nje myeloproliferative.

Izizathu myelofibrosis kunye zabo sifo

Kwiimeko ezininzi, esi sifo kwenzeka kwizigulane yiminyaka engama-50 nangaphezulu, ngoko ke ixabiso ethile eqhotyoshelwe kahle yemfuza iiseli yenyukliya izinto stem ukhokho, ukuphazamiseka samathambo, izifo wentsholongwane egazini. zeendawana Morphological uba mieloza utshintshe zonke intsholongwane ezintathu hematopoiesis - granulocytic, megakaryocytic kunye erythroid. Kuxhomekeke yengxinano ezi ukuphazamiseka kwaye kuxhomekeke esi sifo nabanye abantu abane.

Kwiimeko ezininzi imali myelosis subleukemic kunokuba ingozi, kwaye kukho unxulumano ngqo phakathi yobudala ngomonde ngexesha ekuqaleni sifo nabanye abantu abane - kwencinane isigulana, nzima myelofibrosis kwenzeka. Kwi-terminal inqanaba esi sifo, nto leyo ukuphuhlisa emva 5-15, kunye neminyaka engama-20 emva kokuba efumanise impawu yokuqala, izigulane shaya ntlekele. Ke esi sifo kuthatha phezu iimpawu wegazi ludlule: inani elikhulu owaba- kuvela egazini peripheral. Iimpawu esiqulunqwe loo zesifo ifiva, iimpawu kunxilwe, siyagula kunye ukopha syndrome. Idla ukwanda udakada nesibindi. Kwezinye izigulane, mhlawumbi ngokukhawuleza ukuqhubeka kwesifo kunye ukubonakala yokuqala onaso ukopha kunye anemizatsiey yesigulane.

Lo mfanekiso clinical mieloza subleukemic

Kaninzi izigulane bakhathazeke ngayo ubuthathaka jikelele, ubunzima esiswini, nto leyo eyandisa ngentshukumo ngokukodwa emva nokutya (kungenxa ukunyuka okubonakalayo udakada kunye kwesibindi). Kukho izikhalazo intloko ebuhlungu, iintlungu emathanjeni kunye lomqolo. kunqabile kakhulu, kwi-terminal inqanaba lesi sifo, umguli lisenokuba ukuphazamiseka kakhulu nemizwa. Ugqirha kufuneka nakanjani ngaphandle aneziporo myelosis - imeko zophendlo lwezifo kwinkqubo ndixhalabele ukuba kwenzeka xa anemia ezithile megaloblastic. Le meko idla yenzeka kwegazi, olwenzeka xa izigulane inani elingonelanga vitamin B12 apha emzimbeni.

Ngaphezu koko, thrombosis akholisa ukubakho, nto leyo iba ityala ukunyuka kwenani zegazi egazini peripheral ngokubanzi, kwaye krovi.Poslednee ukuphazamiseka coagulation unokubangwa yi luhlaza morphological nokuba kakhulu inani elikhulu ziiplatelets. Maxa wambi, thrombocytosis kukhokelela kuphuhliso splenomegaly, kodwa udakada aqalile ukuba ndidilize zegazi nje kuphela kodwa ke iiseli ezibomvu, nto leyo ebangela uphuhliso kwegazi.

Le nkqubo yohlolo kunye nonyango iinketho izigulane

Uxilongo "myelosis subleukemic" kufuneka bangambathi ngenxa iimvavanyo zegazi lwezonyango, kwaye iziphumo okuhlatywa sternal okanye iliac trepanobiopsy. Utshintsho kwi test igazi kakhulu non-ethile kuphela nokuchongwa ukwanda okanye ukuncipha kwenani iiseli zegazi utshintshe iipesenti zazo ayikwazi unesifo "myelosis subleukemic".

Unyango kwesifo kwakhona kuxhomekeke kwimeko umongo kunye ekhoyo ukungaqheleki amathambo. Kwezinye iimeko, ngokwaneleyo kuyajongwa olutshintshayo kwisigulana, ngoxa myelofibrosis ngokukhawuleza phambili kufuneka ibe ukuqeshwa iziyobisi kusetyenziswe amachiza.

Kwi-terminal ibakala sifo kwezinye iimeko, kufuneka afumane unyango radiation, omkhulu ukuqeshwa ichemotherapy iprogram etsolo unyango leukemia myeloid, ekususweni udakada - kodwa kwimeko nganye unyango lwesifo isigulane kufuneka amisele udokotela abaqeqeshiweyo.