Makroprolaktin - yintoni na? Uhlalutyo makroprolaktin: nanjengokwesimo kwaye ukutenxa

Prolactin (lyuteotropnym) ekuthiwa hormone yi iiseli yebhinqa sobuKristu. Le nto iye eziliqela ngeendlela, kwifomu apho ukuba ebantwini. Enye indlela loo makroprolaktin hormone luteotrophic. Yintoni na, yintoni na imisebenzi yayo kunye neepropati, ezichazwe ngezantsi.

concepts prolactin

Hormone iqulathe iiprothini kwaye kwaqwalaselwa kweziyobisi peptide prolaktinpodobnyh. impahla yakhe isekelwe inxaxheba kwiinkqubo yokuzala, kwaye amalungu ukuba iithagethi yezenzo - amadlala mammary.

Le ezenza ukuba prolactin ziye afumaneka kwezinye iindawo zomzimba, kodwa awukacaci indlela abasabela ngayo nefuthe kwezinto hormone. receptors Ukudideka lufumaneka amalungu alandelayo:

• spleen;
• ekukhanyeni;
• thymus;
• intliziyo;
• pancreas;
• sezintso;
• wesibeleko kunye amaqanda;
• esikhumbeni.

Hormone ikhona egazini labantu ngeendlela ezintathu: i-85% izinto unalo uhlobo monomer,-10% - ifomu dimer ne-5% kuphela kukuba ngohlobo makroprolaktina.

Imisebenzi ye prolactin

I 'umsebenzi' eziyintloko hormone kukwandisa nokugcina inqanaba obaneleyo ukubunjwa yobisi ngethuba lokuncancisa. Xa ukukhulelwa, inqanaba eyaneleyo prolactin agcine ngesondo hormone estrogen. Emva kokuba umntwana ezelwe isixa estrogen kunciphisa kakhulu.

Ngeli xesha imveliso prolactin egcinwa yi kwingono ukukhuthazwa mechanoreceptors. nosana ibele yabo esebenzayo kubangela ukukhululwa yioxytocin, ekwazi ukutsala ubisi. Okt prolactin ivuselele imveliso yobisi kunye nokwanda yayo esifubeni, kodwa inkqubo yokwabiwa ubisi lidibana yioxytocin.

Isenzo prolactin ngethuba lokukhulelwa unako ngokwenkangeleko ukubonwa kuzalwa. High lamanani hormone kubeka istampu kwi usana. Kwiintsuku ezimbalwa emva kokuzalwa esifubeni sana, kakhulu, inokuba obhobhozayo njengamasi engadingi ukuba ungenelelo ezongezelelweyo kunye ngokuzimeleyo kuvavanywa ngethuba kwiiveki zokuqala yobomi.

Ezinye iimpawu hormone luteotrophic:

• inhibition of ovulation;
• ukwandiswa kwexesha ubukho luteum corpus;
• ukuthintela ukukhulelwa;
• isiphumo iintlungu amancinci;
• inxaxheba lokusekwa lunezinto;
• ukuqinisekisa unyamezelwano omzimba nombungu;
• inxaxheba ekuqinisekiseni uyolo.

Indlela kophuhliso izifo

Xa amadoda esempilweni umfazi non-okhulelweyo ngubani na iingxaki zempilo, prolactin elinganeno yi dopamine kweziyobisi esebenzayo. Oku kuhlelwe kule ngxenye. Kuyo nayiphi na imiqathango pathologic kantu ubudlelwane phakathi ngxenye kunye posa, okubangela adenohypophysis iiseli nokulungelelanisa hormone luteotrophic nokunyuswa kwezinga yayo serum.

Makroprolaktin - yintoni na?

Olu hlobo prolactin leyo enobunzima eliphezulu eziphilayo. Ikhona emzimbeni ngezixa ezincinane. Le peculiarity ifomu - lonxibelelwano immunoglobulin kweziyobisi hormonally esebenzayo.

Prolactin kunye makroprolaktin kwi imali ngaphezu norm kufuneka abe khona kuphela abasetyhini abakhulelweyo kunye phindeke. Onke amanye amatyala zithathwa zophendlo lwezifo.

Makroprolaktinu ukuba ubunzima ephakamileyo eziphilayo, bakholisa ukuba yande emzimbeni. Abanye benza output ihomoni luteotrophic ngenxa amazinga ngokukhawuleza ubunzima ezinto ephantsi.

Makroprolaktin, izinga eza kuxoxwa ngezantsi, kukho umsebenzi ophantsi zebhayoloji, yaye ngenxa yoko, utshintsho ezincinane zalathisi umzimba wakhe ukuze baphendule. Lo mfanekiso kwezonyango ibuthathaka, okanye sikhatshwa ukuphazamiseka ukuba sexesheni, nto leyo luphawu ethile ngezifo.

Abameli iinkunzi nako ukufaka yile hormone. Unoxanduva kwimveliso amadlozi, umsebenzi wabo kunye Yindibanisela testosterone. amanani Madoda makroprolaktina liba kakhulu kwabasetyhini.

Uvavanyo lwamanqanaba zesifundo hormone, kwakunye neempawu zawo ubunjani kunye neenkcukacha zamanani elabelwe kwimeko iinjongo diagnostic ukungachumi kuyoluka.

Gipermakroprolaktinemiya

Ukuba makroprolaktin bayavuswa, ngoko lizwe kuthiwa gipermakroprolaktinemiey. Le ngezifo ayikho into ukunisa kuphuhliso yamathumba amabi webele kwamathambo xa kuthelekiswa kurhulumente yokwandisa ubungakanani prolactin obuqhelekileyo.

Kufuneka kukhunjulwe ukuba ukunyuka elibukhali hormone kwi non-ibele uthi ukunyhashwa kumsebenzi kwenkqubo hypothalamic-yebhinqa. Ubukho ebalulekileyo iimali makroprolaktina ukuze ibonakale njengoba seTrojan, maxa wambi ibe ngunobangela ukungachumi.

prolaktinoma

Igama elithi "prolaktinoma" libhekisela yamathumba nabungozi le yebhinqa, nto leyo inkalo yemveliso hormone luteotrophic. Adenomas angenzeka zombini abasetyhini kunye namadoda. Umyalezo weimeyile ukuvela prolactinoma ayide icace. Kukho izimvo le ukuthambekela ilifa, kwakunye nenyaniso yokuba yamathumba kwenzeka ngaxeshanye kunye ngezifo zeminye imibutho kwinkqubo yonyango.

iintlobo ezimbini yamathumba zihlelwa ubungakanani kunye nendawo:

• intrasellyarnye lukwazi le turcica sella , yaye ububanzi of ngaphantsi kwe-10 mm;
• ekstrasellyarnye yandisa ngaphaya turcica sella, yaye ububanzi lingaphezulu kwe-10 mm.

Ukongeza syndromes eziphambili kunye kubonakaliswa; wagaleleka kuyo iingcali ukuba uxilongo kunye prolactin makroprolaktin, kukho iqela neminye imiqondiso kwezonyango izifo:

• ukuvala zasendle olubonakalayo;
• ukwehla okukhulu acuity olubonakalayo;
• uqhekeko emehlweni;
• ukungakwazi ukusebenzisa umbono peripheral;
• intloko ebuhlungu;
• ukudana;
• ixhala yaye akhawuleze ukucaphuka;
• kwiimeko ezinzima, yimfama iyonke.

Ngaphandle noxilongo zaselebhu, ukubeka uxilongo elichanekileyo, ukusetyenziswa CT kunye MRI yobuchopho, iimvavanyo Ingqondo (kwamadlala) kunye densitometry (uqikelelo kwamathambo esetyenziselwa umahluko).

uxilongo Iimpawu

Uhlalutyo on makroprolaktin - ntoni na? Le yokusabela indlela immunohemilyuminestsentnoy diagnostic, nto leyo emiselweyo zonke izigulane amanqanaba eziphakamileyo of prolactin emzimbeni.

Uhlalutyo yenye yeendlela ezintsha. Xa Obamba iimolekyuli hormone "podselyayut" amasuntswana ezibengezelayo leyo, ngokuzibophelela kwi prolactin ikhanyisa izabelo baboniswa kweultraviolet kwimitha. Inqanaba chweba ulinganiswa luminometer - ezizodwa izixhobo eziphathwayo.

Iimpawu ubuninzi makroprolaktina uzimisele ukusebenzisa polyethylene ethers. Baqhuba isimemezelo of nezakhiwo omzimba. Ukuba emva kokuba inkqubo i-serum uzimisele ngaphantsi kwe-40% yamanqaku ewonke kwinqanaba hormone luteotrophic, oku bubungqina bokuba kukho inani ebalulekileyo makroprolaktina eziphathekayo uphando.

Ubungqina obubonakalayo buxela ukuba kuyokufunyaniswa isifo

Kukho eziliqela iimeko apho iingcali eyabelwe nezalathisi ezithile qualitative kwaye ubungakanani prolactin kunye neentlobo zayo. Uhlalutyo on makroprolaktin olwenziwa kwezi meko zilandelayo:

• Galactorrhea - secretion okungaqhelekanga zobisi okanye ngumthubi;
• phambi prolactin - nangezilonda adenohypophysis leyo nokulungelelanisa isixa ngokugqithiseleyo kweziyobisi hormone;
• ukulahleka ngesiquphe umbono;
• nenzalo;
• ukungabikho ndaba ngaphezu kweenyanga ezintandathu;
• wesizalo ivuza igazi umyalezo engaziwayo;
• ukufunda ngezifo le yebhinqa;
• ukunqongophala rhoqo ovulation;
• kwamathambo;
• lwebele;
• novavanyo lwesakhono unyango prolactin.

UNorma ukusebenza ngamaxesha ahlukeneyo

Inani prolactin ubonwe (iziphumo e mkIE / ml):

• Izinga eyindoda - 44,5-375;
• norm female - 59-619;
• postmenopause - 38-430;
• nabantwana - 205,5-4420.

iziphumo Ubhaqo Makroprolaktina zitolikwa ku embodiments ezinjalo:

• makroprolaktina imali ethe;
• makroprolaktin Musa abaziwayo;
• inani elikhulu intandabuzo makroprolaktina.

umphumela omuhle

Gipermakroprolaktinemiya ugqibe kwelobubi imvelaphi ezimbi zilandelayo:

• ngamathumba yobuchopho;
• iinkqubo Ithumba hypophysis;
• abanale (ukuhla of secretion hormone);
• syndrome yamaqanda polycystic;
• ukusilela kwezintso;
• isifo sesibindi;
• mgaqweni nobubovu adrenal, insufficiency adrenal ;
• zomzimba lupus;
• uhlobo isifo samathambo;
• zintswelo pyridoxine vitamin.

A isixa esikhulu phambi makroprolaktina kuthetha ukuba isigulana sibe ixesha elide ukuthatha amachiza amayeza.

Inqanaba yempembelelo hormone:

• antihistamines;
• antipsychotics;
• womchamo;
• antihypertensives;
• antipsychotics;
• izivimbela;
• lakhula;
• antiemetic kukuninzi kunye nokusetyenziswa ixesha elide.

amanani Ukuncipha

Kwamanye amazwe makroprolaktin, umlinganiselo kubafazi kuyahlukana nedlela xesha ebomini kunokuba ngaphantsi kwe lusebenze. Le Iziphumo uphawu kwezi meko zilandelayo:

• iqhosha yebhinqa, ezenzeka sizoku lwisana ukopha elikhulu ngexesha lokuzalwa komntwana;
• perenashivanie ukukhulelwa (iiveki ngaphezu 41-42);
• ukusetyenziswa ixesha elide kumachiza ukuba kuliwe unditsho, "calcitonin", iindlela hormone, "icaffeine", "rifampicin", "Nifedipine".

Ngubani utyumba isifundo nalapho ukuba anikezele

Uphando angathumela ezinye iingcali: ugqirha, womchamo okanye endocrinologist. irente Uhlalutyo kwiilebhu leekliniki ezizodwa zonyango kunye namaziko zocwangciso ntsapho. Kuba lokufunyaniswa igazi lwemithambo iyafuneka.

Iziphumo ukuba sibe siyasebenza, isigulane kufuneka ukulungiselela kuhlalutyo makroprolaktin:

1. iiyure ezili-12 phambi kokuba unikezelo ukwala ukutya.
2. Kwiintsuku ezimbalwa ngaphambi kokuba ulwamkelo ukusebenzisa iziyobisi ngokusekelwe estrogen kunye androgens. Yingcali, owasinikayo ulwalathiso, kufuneka azise isigulane ngayo.
3. Ukuze iiyure eziyi-24 ukuze ayeke ngokupheleleyo amayeza.
4. Iintsuku eziliqela phambi hlalutyo ukuze kuthintelwe naziphi umsebenzi ngokwasemzimbeni siphephe iimeko uxinezeleko.
5. Ngosuku lokuhanjiswa zohlalutyo kufuneka uyeke ukutshaya.

isiphelo

Enye ifom makroprolaktin hormone luteotrophic. Yintoni na, ziziphi iimpawu ekuhloleni umgangatho walo kunye nobungakanani - ulwazi oluyimfuneko ukuze isibini ngasinye ukuba ufuna ukuba abazali kwixesha elizayo, okanye kwinkqubo yocwangciso ukukhulelwa.