"Zaldiar": imiyalelo ukusetyenziswa. Ukuphononongwa, ixabiso, lencazelo

Iintlungu yenye iziganeko ezingemnandi ebomini bomntu. Uninzi amachiza ezikhoyo bayakwazi ukususa iintlungu ngobunzulu buthathaka okanye eliphakathi. analgesics opioid, ezibandakanya lithetha "Zaldiar" esichazwe kweli nqaku, usiza balahle intlungu zabangela zizifo ezinzulu.

Ngaphandle kwento yokuba ichiza nje ezidakumbisayo, ukukhululwa kwakhe kuphela ezikhemisti ngokumiselwa (ifom 148). Oku kungenxa yokuba amacandelo athile ifakiwe kumafa yayo, ukuze ibandakanye iingcali izinto ezinamandla. Amaxabiso amayeza e kweli qela alinakuphelelwa ingqalelo kufumaneka ekubeni kubekho inani elikhulu labathengi, nto leyo nayo eziyimiqobo eqinisekileyo ukuba iziyobisi kwande. Kodwa siza sithethe kancinane emva koko, kodwa ekuqalekeni siya ukuqonda inxalenye emacwecweni, iimpawu eziphambili izithako zayo esebenzayo kakhulu ngakumbi.

Ukwakhiwa "Zaldiar" Amacwecwe

Yintoni na inkalo "Zaldiar 'iziyobisi? Ukwakhiwa - yiloo nto idlala indima enkulu impumelelo lwaso nasiphi na isiyobisi. Ukongeza paracetamol ezaziwayo esisetyenziswa ngokubanzi ekhoyo emacwecweni kwi mali ka-325 mg, "Zaldiar" iqulathe into eyaziwa ngokuba tramadol hydrochloride (37.5 mg). Ukuba abathengi baqhelene ne-paracetamol phantse ukususela ebuntwaneni, ukuba tramadol yaziwa ngaphantsi kakuhle ngezangqa ngokubanzi. Ukongezelela, maxa wambi igqalwa ichiza, xa enyanisweni akunjalo. Njengabo bonke analgesics opioid imvelaphi zokwenziwa, tramadol uyakwazi ukwenza kumacala amabini, oko ingasetyenziswa ukuphelisa intlungu kwelona nqanaba eliphezulu, kunye neziphakathi. Iinkcukacha ezingaphezulu malunga noku ziya kuxutyushwa kwicandelo kwiipropati imithi.

Ukongeza iikhompawundi esebenzayo, ukulungiselela "Zaldiar" ibandakanya isethi amacandelo abancedisayo: kwincindi, istatshi, nemagnesium stearate, idayi, kunye nabanye abaninzi.

Inkcazelo yokulungiselela, ifomu release

medicament Iveliswe ngohlobo amacwecwe, ama-camera ndizayo iqokobhe. Imilo tablet lume, ngeenxa zonke, biconvex, kugalelwe kwicala elinye othi "T5", yaye kwelinye - logo lomenzi "Gryunental". Esingxotyeni umbala - yellow ukukhanya. Ekuveleni amacwecwe elibonakala ngokucacile maleko ezimbini: i nomphandle wocango yellow - ezimhlophe okanye phantse emhlophe.

"Zaldiar" Amacwecwe bahlala namadyungudyungu zizele-10, nto leyo babekwa iibhokisi iziqwenga 1, 2, 3 okanye 5 kunye nemiyalelo yokusebenzisa.

Pharmacokinetics kunye pharmacodynamics of "Zaldiar" iziyobisi

Amalungiselelo ibandakanya nje ezimbini izinto ezisebenzayo ukusebenza iintlungu. Kungenxa yoko le nto ipilisi "Zaldiar" imiyalelo zokusetyenziswa libhekisela ekulungiseleleni ahlangeneyo. Umphumo ntlungu kulo mzekelo inabela kumacala eziliqela. Ngaloo ukuphelisa intlungu nokuba obukhulu.

Pharmacodynamics paracetamol ke ukhupha ulwenziwo cyclooxygenase ziintlungu kunye lobushushu amaziko zobuchopho. Kulo mzekelo, iyeza aluchaphazeli izicwili peripheral, oko kukuthi umsebenzi wabo prostaglandinsinteticheskie. Ukongeza, paracetamol aluchaphazeli amanzi kunye electrolyte nokugqwesa umzimba.

izenzo Tramadol on amaziko iintlungu ngandlel ngokwahlukileyo: lwesiyobisi metabolites yayo uyakwazi ukwenza receptors ekuthiwa-m-opioid. Kwakhona iyazingenela receptors non-opioid yi inwebu hyperpolarization kwi leesynapse ze umnqonqo kunye luvo lialio. Nangona ukufana sisenzo tramadol kunye into, isiphumo sayo amaxesha 6000 ngaphantsi, ezifana icaffeine.

Ukufunxeka paracetamol kunye tramadol kwi wokugaya kwenzeka ngokukhawuleza ngokwaneleyo. Ukufunxeka ngokupheleleyo paracetamol ngokukhawuleza kakhulu tramadol. Cleavage lwedatha izithako ezisebenzayo kwenzeka ubukhulu becala esibindini. Bona eyenziwa ikakhulu kwindlela wokuchama (30% ingaguqukanga, ubuncinane 60% njengoko metabolites).

Ubungqina obubonakalayo buxela

Le medicament "Zaldiar" imiyalelo zokusetyenziswa icebisa ukuba kwimeko ephakathi ngobunzulu womelele iintlungu of imvelaphi ezahlukeneyo (isifo, ukwenzakala, nangokurhala, njalo njalo. D.) of. Ngaphezu koko, kufanelekile ukusebenzisa le ukulungiselela iinkqubo zonyango phambi (diagnostic nezinyangayo) ezinokuba ukuvise intlungu. Thenga ichiza "Zaldiar" ngaphandle kagqirha, njengoko kuchaziwe apha ngasentla, oko akwenzeki. Kungenxa yoko le nto ukusetyenziswa kwayo ifumaneka kuphela kwiimeko apho afuneka khona ngokwenene.

Izimo

Ngokuphathelele ukusetyenziswa Zaldiar "imiyalelo iipilisi 'ukuba ukusetyenziswa libhekisela Izimo ukuthini nakwenzeka kokufumana kweziyobisi, kwakunye oogxa bakhe izithako ezisebenzayo. I contraindication lokuqala yaye okubaluleke igqalwa isici zamacandelo alo, kubandakanya okunye. Enye contraindication ubudala lomguli ukuya kwiminyaka eli-14. Ukongeza, kukho uluhlu olude olubanzi kwezifo kunye neemeko apho ezithatha ichiza akwenzeki ngenxa umngcipheko iingxaki ezahlukeneyo.

Ngenxa yoko, nathi ingqalelo iimeko apho amacwecwe ezo contraindicated "Zaldiar" (analogs ze izinto ezisebenzayo kwaye akufunekanga ukuba isetyenziswe kwiimeko ezidweliswe ngezantsi):

• sokuwa ukuba zingalawulwa lokuthathwa iziyobisi ezithile;
• izifo kakhulu izintso wesibindi, xa hepatic ingakumbi ukusilela kwezintso;
• wombuso emva ukurhoxiswa iziyobisi, okanye ekuthiwa-yokuyeka syndrome;
• utywala okanye ukunxila okanye iziyobisi (kubandakanywa iziyobisi, depressants luvo central, hypnotics, analgesics kunye nezinye iziyobisi).

Ithi apha ngasentla kulindeleke ukuba athobele. uluhlu Here'sa iimeko phantsi kwayo "Zaldiar" ukusetyenziswa kweziyobisi kufuna esweni ngenyameko lomgadi isigulane:

• yothuse, evela ukwenzakala okanye kwezinye iimeko;
• bekhubazekile craniocerebral sandla nelula;
• ukwanda koxinzelelo intracranial (hypertension);
• sokuwa, ukungenisa ezilawulwa amayeza;
• kuphazamisane umsebenzi nokuphefumla;
• ukudideka okanye ukusilela nokungacaci osezingqondweni lemvelaphi ezahlukeneyo;
• izifo viral kwesibindi (hepatitis);
• izifo nesiqephu biliary;
• Alcoholism abanesifo sesibindi okanye hayi;
• ukuxhomekeka kumachiza ezidakumbisayo;
• hyperbilirubinemia (ebubonisayo);
• intlungu epigastric of imvelaphi ezingaziwayo.

Ukongeza, ichiza "Zaldiar" umyalelo ncwadi incoma bethabathe isilumkiso kubantu abadala ngaphezu kweminyaka 75, kwakunye nabo, ukongeza ichiza, psychotropic ezimiselweyo kunye nezinye arhente iintlungu kunye ekuthiwa-inyathelo engundoqo (kubandakanywa Ukubulawa lendawo ).

Ukwenzela ukuphepha umngcipheko engafanelekanga kwisigulana, ugqirha kufuneka phambi kokuba emisela ichiza ukwenza uphenyo kuyimfuneko, apho uyakwazi ukubona sifo ekhankanywe ngasentla.

Indlela ukuthatha ichiza "Zaldiar": mazwi

Drug "Zaldiar" yamkelwe kuphela phantsi kweliso zonyango. Le idosi indlela reception zeengcali igqiba, ngokusekelwe kwi imeko yomguli, izinga ubukhali iintlungu. Ngokutsho izindululo oogqirha, kufuneka uthathe iipilisi yonke ngaphandle ityumza yaye ngaphandle ukuhlafuna. Ubungakanani bamanzi wahlamba phantsi ngamayeza, kufuneka kwanele ukuqinisekisa ukuba ungene esiswini ngaphandle kokuphazanyiswa.

Ithamo okokuqala abadala (-14 iminyaka) ukuba amacwecwe 1-2, kuxhomekeke iingcebiso zeengcali. Usuku ayikhuthazwa tu into yokuba ukusebenzisa ngaphezulu kwe-8 tablets "Zaldiar". Phakathi ubuchule ekufuneka ilandelwe ngexesha lekhefu iiyure ezi-6. Ukuba esinye reception ngenxa yesizathu esithile entweni, akukho mfuneko yokusebenzisa ngokwemithamo iziyobisi langoku zangaphambili.

Izigulane abadala (kweminyaka engama-75), ungasebenzisa idosi eliqhelekileyo ichiza, kodwa into ekufaneleke ukuba siyicinge kukuba kususwe amacandelo ichiza kunye metabolites abantu abanjalo kuye kwacotha ngaphezu kwezinye amaqela ubudala. Kule nkalo, kucetyiswa ukuba ukwandisa lokuphumla phakathi namatheko amacwecwe iiyure 10-12.

Wezintso kwaye zesibindi ukusilela nayo ifuna i imo hlengiso ulwamkelo kunye wekhadi "Zaldiar" iziyobisi. Kufuneka kuqatshelwe ukuba phantse bungaveli emzimbeni ngexesha ihaemodialysis tramadol amacwecwe esisebenza. Ngako oko, izigulane kakuhle umsebenzi sezintso kufuneka makangenzi kuphindwa amayeza ithamo emva kwale nkqubo, ekubeni kusenokuba kwenze libanda. Ezo ngcebiso ingabhekiswa izigulane kakhulu umsebenzi othile hepatic. Kulo mzekelo, ingozi yeengxaki aziphumi tramadol kunye paracetamol ukusuka. Ingozi iingxaki kwandisa ngokubonakalayo abantu esibindini unenzondelelo utshintsho ngenxa nokwenzaliswa ziziphumo zotywala.

Ukusebenzisana beziyobisi kunye namanye amachiza

Ukulungiselela "amanqaku Zaldiar 'kuzo ziza kuchazwa koku, unako ukusebenzisana ngamachiza amaninzi. Akusoloko indibanisela onjalo kunempembelelo entle emzimbeni wakhe. Yiyo loo nto iingcali bacebisa ukuba abantu abenza ezi pilisi, ingxelo ezithatha ichiza xa ababelwe kwezinye iziyobisi.

Kubalulekile ukukhumbula ukuba amachiza ngokudibeneyo lolwamkelo esikolweni "Zaldiar", ixabiso apho uya kubhengezwa, kunye namanye amachiza opioid kuquka ubungozi kukuyeka ukhuphiswano izinto ezisebenzayo ngokunxulumene receptor intlungu. Ukuba kuyimfuneko, eli Hour isiyobisi nezinye iziyobisi kunye iipropati ezifanayo kufuneka zipheliswe.

Amayeza gqiba umsebenzi we-CNS, ezibandakanya okudambisa kunye namayeza belele ukwandisa iziphumo ebezingalindelekanga uphawu "Zaldiar" iipilisi. Kunjalo iimveliso utywala-based.

A Inani iziyobisi, iphambili yona uqhelwaniso microsomal igcwala, kwakunye noxinezeleko tricyclic, barbiturates kunye ethanol, ukunciphisa impembelelo amacwecwe components esebenzayo "Zaldiar" kwi embindini intlungu, apho isiphumo zabo iintlungu lifinyele. Uyancipha nexesha amanyathelo iziyobisi.

Ukusetyenziswa idibene barbiturates kunye ichiza kunciphisa impumelelo paracetamol kunye notywala kunye nayo kunokubangela uphuhliso pancreatitis etsolo kule fomu. amachiza Nonsteroidal anti-ukudumba akukhuthazwa ukuba kubanjiswene emacwecweni "Zaldiar" ngenxa yentsebenziswano zabo nge-paracetamol. Isibakala sokuba oku becala kwandisa umngcipheko ukusilela kwezintso nezakhiwo sezintso necrosis papillary. Kwiimeko kakhulu, isigulane basenokuba umhlaza kwezintso okanye isinye.

Nokusebenzisa elide ichiza "Zaldiar" ukwandisa ukusebenza umzimba nokuba anticoagulants ezincinane Grand, oko kukhokelele ekwandeni kwengozi ukopha.

ukusabela ezingalunganga

Emacwecweni "Zaldiar" kukho iziphumo ebezingalindelekanga ezininzi ezichaphazela phantse onke amalungu kunye neenkqubo. Amaxesha amaninzi, izigulane kunye ngosuku lokuqala lokufumana imali ziqala ukuba ziphazamise nesiyezi, buso ilahleko inkumbulo, unditsho okanye Barr. Kwakhona phakathi abasabela ebuhlungu ephilayo ubuchule amalungiselelo okhankanywe iziganeko ezifana nobuthongo okanye sokulibala, isicaphucaphu, flatulence, esiswini, kunye nezinga intliziyo. Ukongeza kule miba ingentla apha, izigulane zinokuba zitenxo sexesheni, ukulibaziseka okanye ukungabi ukuchama, dyspnea, igazi aplastichnaya.

Imihla iyoluka unyango "Zaldiar" iziyobisi usenokuba ukuphuhlisa ukuxhomekeka iziyobisi okanye uyeka emva ukusilela ngokukhawuleza usuka ukuthatha iipilisi. Ukuze uphephe oku, kufuneka ukuba uthathe le iyeza elide ngaphezu imiyalelo akukhuthazwa ukuba zisetyenziswe, kunye nokupheliswa ichiza eziyimfuneko ukuze kufezekiswe ukunciphisa umthamo.

oyi

amalungiselelo ukwamkelwa okungalawulekilyo Long eziqulathe tramadol kunokubangela ukuxhomekeka iziyobisi, ochazwa uvalo, umsebenzi lengqondo ukucalulwa. Kulo mba, ixesha unyango "Zaldiar", ogama ixabiso liphezulu kakhulu, kuyimfuneko ukuba bagcine ngenyameko ixesha ekucetyiswa imicimbi yayo. Izigulane ubukhe ngaphambili wanayo uthandane, kufuneka uthathe amayeza phantsi kweliso zonyango.

Ukuqhuba izithuthi kunye nolawulo iindlela ezintsonkothileyo kwixesha unyango ngamachiza stop ngcono.

analogue Drug "Zaldiar": amaxabiso kunye nohlaziyo

Ngoko ke, ukusuka ngasentla, sinokugqiba ukuba ezibalulekileyo, sifanele kukhokela lolwamkelo esikolweni "Zaldiar" iziyobisi - imfundiso. macwecwe Price kuthelekiswa namanye amayeza strong akuthethi lingakhangeleka liphezulu kakhulu, kwaye malunga ne-800 engange pack nganye. Analogs babe ukulungiselela kancinane: ziyakwazi ukuchongeka umxholo macandelo mabini esebenzayo ngaphandle kokuba cwecwe "Forsodol", ixabiso ogama iphezulu kakhulu. Alithandabuzeki elokuba, amaxabiso amayeza ukusuka kwiqela analgesics opioid akakwazi angasezantsi, njengendlela "Zaldiar" yeyona ezingabizi kakhulu phakathi iimveliso efanayo.

Ngokutsho iingcali, eli chiza inceda ukumelana iintlungu, nokuba kwiimeko ezinzima kakhulu. Noko ke, zibonakalisa ukuba unyango ngamachiza elide okanye wengozi kunokubangela iziphumo ezingalindelekanga kunye navumelanayo. Izigulane abaye basebenzisa eli chiza nabo yaneliseka intsebenzo yakhe. Kodwa ke waphawula ukuba ukususwa kwaso kufuneka ibe ngokuthe ngcembe. Ekubeni ngaphezulu kwama-70% amatyala kufuneka impawu ekuthiwa ukurhoxiswa.