Isizukulwana entsha NSAIDs: reviews, amaxabiso kuluhlu

A lot of iinguqu zophendlo lwezifo ukuba kwenzeka emzimbeni, kunye ziintlungu. Ukuphelisa ezo mpawu aphuhliswe NSAIDs okanye non-steroidal anti-ukudumba arhente. Bona anesthetized kakuhle, ukunciphisa nangokurhala, ukunciphisa ukudumba. Noko ke, amachiza amaninzi zineziphumo ebezingalindelekanga. Oku kunciphisa amathuba ukusetyenziswa kwawo ukuba ezinye izigulane. Pharmacology Modern liqulunqe isizukulwana entsha NSAIDs. iziyobisi ezifana kungenzeka kangako ukuba baxabane mnandi, kodwa kuhlala iziyobisi phumelela intlungu.

impembelelo kumgaqo

Oko kungenxa ifuthe NSAIDs emzimbeni? Benza phezu cyclooxygenase. Cox uye isoforms ezimbini. Ngamnye kubo uwugcinayo imisebenzi yayo. transcriptase enjalo (Cox) ebangela ngumbala kwemichiza ngenxa kwi CD ludlulele prostaglandins, thromboxanes kunye leukotrienes.

Cox-1 unoxanduva imveliso prostaglandins. Bakhusele esiswini imiphumela emibi kuba negalelo ekusebenzeni koLudwe zegazi, yaye iimpembelelo utshintsho flow kwegazi kwezintso.

Cox-2 ngokwesiqhelo engekho yaye umtshiso ethile enzyme kuhlelwe ngokusebenzisa cytotoxins, kwakunye nezinye mediators.

Isenzo esinjalo of NSAIDs njengoko inhibition of Cox-1, iphatha nobuninzi icala elingenzi nto-.

izinto ezintsha

Ngoko ke akukho mfihlakalo ukuba izicwangciso sizukulwana lokuqala NSAIDs nesiphumo esibi isifo esiswini. Ngoko ke, oosonzululwazi baye wabeka usukelo - ukunciphisa imiphumela ezingafunekiyo. Kwaye kwaqulunqwa uhlobo entsha ukukhululwa. Xa imixube ezinjalo isithako esebenzayo ilindele emvulophini ekhethekileyo. Le philisi yayenziwe ngezinto ezinjalo ukuba musa ukuluhlakaza kwindawo asidi esiswini. Baqala ke ukuba lungasebenzi kuphela xa udubuleke ethunjini. Kuyenzeka ukunciphisa isiphumo ukubacaphukisa kwi isifo esiswini. Noko ke, indlela yokwenzakala krakra iindonga iphecana zesisu nangoku igcinwe.

Oku kwabangela ekhemisi kuhlanganiswa yikhompawundi entsha ngokupheleleyo. amayeza Previous ukuba indlela bohluke kuzo amanyathelo. isizukulwana esitsha NSAIDs ephawuleka nempembelelo ukuvumbulula Cox-2, kwakunye inhibition kwemveliso prostaglandin. Oku kukuvumela ukufikelela zonke iziphumo eziyimfuneko - iintlungu, antipyretic, anti-ukudumba. Kulo mzekelo, isizukulwana entsha NSAIDs ukunciphisa impembelelo coagulation igazi, umsebenzi zegazi isifo esiswini.

ukusebenza Anti-ukudumba ngenxa permeability esezantsi yeendonga semithambo, kwakunye nokuhla nokudala ezahlukeneyo mediators arhabaxa. Ngenxa kule exposure inciphisiwe kwinwebu receptors iintlungu-luvo. Impembelelo amaziko thermoregulatory ethile ebuchotsheni, vumela isizukulwana entsha NSAIDs elibalaseleyo ukuthoba iqondo lobushushu lulonke.

Ubungqina obubonakalayo buxela

Eyaziwa imiphumela NSAIDs. Ifuthe iziyobisi ezifana ijolise ekuthinteleni okanye ukunciphisa inkqubo arhabaxa. La machiza ukunika isiphumo kakhulu antipyretic. iziphumo zabo phezu umzimba onokufaniswa ifuthe analgesics ezidakumbisayo. Ukongeza, ukuba zinika iintlungu, iziphumo anti-ukudumba. NSAIDs ifumana isikali ngokubanzi phantsi kweemeko eziqhelekileyo lwezonyango kunye kubomi bemihla ngemihla. Namhlanje yenye amachiza ezonyango ethandwa.

Igalelo elihle elaziwa kwi ezi zinto zilandelayo:

1. Izifo yenkqubo musculoskeletal. Maxa komsipha ezahlukeneyo, nemivumbo, iinkcukacha iyeza samathambo nje ezinye endaweni yazo. NSAIDs ezisetyenziswa osteochondrosis, arthropathy ukudumba, samathambo. Eli chiza lineziphumo anti-ukudumba e zokufota, akwazi herniated.
2. ubuhlungu obukhulu. Amalungiselelo esetyenziswa ngempumelelo yokulunywa biliary, izifo izifo. Abasusa le yintloko, nkqu uqaqanjelwa, kidney ubuhlungu. NSAIDs asetyenziswa izigulane kwixesha postoperative ngempumelelo.
3. lobushushu eliphezulu. ukusebenza Antipyretic uvumela ukusetyenziswa kweziyobisi kuzo izifo Ukungafani zombini abadala kunye nabantwana. La machiza kakuhle maxa nomkhuhlane.
4. Thrombus Ukwakheka. NSAIDs iziyobisi antiplatelet. Oku kwenza ukuba isicelo ischemia. Basimisela njengenyathelo lokuthintela ekuhlaselweni sentliziyo kunye stroke.

ngezigaba

Malunga 25 neminyaka eyadlulayo, kwathiwa yenzelwe 8 kuphela amaqela NSAIDs. Namhlanje, elo nani liye lanyuka ukuya kwi-15 Noko ke, eli nani ngqo wabizwa oogqirha alithathwanga. Evela kwimarike, ngokukhawuleza iphumelele ukuthandwa NSAIDs. Amalungiselelo bagxothwa analgesics opioid. Ngenxa yokuba, ngokungafaniyo elidlulileyo, akazange ukubangela ukudandatheka sokuphefumla.

Ulwahlulo lwe NSAIDs ibandakanya ukwahlulwa ibe ngamaqela amabini:

1. amachiza abadala (sizukulwana kuqala). Olu didi lubandakanya iziyobisi aziwayo, "Tsitramon", "aspirin", "ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. NSAIDs ezintsha (sizukulwana yesibini). Kule minyaka 15-20 edlulileyo, Pharmacology eye yakhula nemveliso kakhulu, ezifana "Movalis", "Nimesil", "UDenise", "Celebrex" "Arcoxia."

Noko ke, le ulwahlulohlulo kuphela NSAIDs. Amachiza isizukulwana esitsha zahlulwe avela non-acid kunye asidi. Ekuqaleni, cinga udidi yokugqibela:

1. Salicylates. Iqela liqulathe amachiza NSAID, "aspirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Abameli kolu didi neziyobisi "phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Esi sisizukulwana esitsha kakhulu ezintsha NSAIDs. Uluhlu amachiza: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam". Imithi eqolo, kodwa ifuthe lazo kwi umzimba ithatha ixesha elide kakhulu kunezinye NSAIDs.
4. ahlobene acid Phenylacetic. Loo iqela NSAIDs iquka lithetha "diclofenac", "tolmetin," "Indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Imixube anthranilic acid. Eyona ummeli amayeza "Mefenaminat".
6. Iindlela of propionic acid. Olu didi iqulethe NSAIDs ezininzi ezintle. Uluhlu amachiza: "ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "tiaprofenic acid", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. ahlobene acid Isonicotinic. amayeza Main "Amizon".
8. amachiza pyrazolone. Kulo mqathango bobabo indlela ezaziwayo-kakuhle, "Analgin".

By non-acid yezabelo ziquka sulfonamides. Eli qela libandakanya iziyobisi, "Rofecoxib" "Celecoxib", "Nimesulide".

imiphumela emibi

isizukulwana esitsha NSAIDs ezidweliswe ngasentla, impembelelo ezahlukeneyo olusebenzayo emzimbeni. Noko ke, bona azichatshazelwa nokusebenza phecana zesisu. Ukwahlula la machiza lelinye lencopho yokudada: isizukulwana esitsha NSAIDs musani kunokuba yingozi kwi ijwabu intlala.

Noko ke, indlela enjalo ekwaziyo ingqondo inani yeziphumo ezingafunekiyo. Kufuneka bazi, ingakumbi xa ichiza kusetyenziswa ixesha elide.

Ezi ziphumo bezingalindelekanga eziziintloko ziquka:

• nesiyezi;
• ukozela;
• intloko ebuhlungu;
• nokudinwa;
• iyangongoza intliziyo;
• kongeza uxinzelelo;
• a ukuphelelwa encinane ngumphefumlo;
• ukhohlokhohlo owomileyo;
• esiswini;
• iiprothini umchamo;
• enzyme zesibindi siphakamileyo;
• irhashalala (indawo);
• ukugcinwa fluid;
• komzimba.

Kulo mzekelo, umonakalo isifo esiswini akukho iqatshelwe wokwamkelwa NSAIDs ezintsha. Amachiza ungabi sisizekabani exacerbation izilonda ukopha.

Izindululo zokusetyenziswa

Amachiza best anti-ukudumba kufuneka phenylacetic acid, salicylates, pirazolidony, oxicams, alkanones, iziyobisi of propionic acid kunye sulfonamide.

Ukusuka ubuhlungu bamalunga kakhulu ngempumelelo nokuphelisa iziyobisi "Indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Le NSAID ngopfu osteochondrosis. Amayeza ngasentla ngaphandle ukulungiselela "ketoprofen" zabakhonzela endibuthethileyo isiphumo anti-ukudumba. lithetha "piroxicam" beyela kolu didi.

analgesics abaphumelelayo "Ketorolac" iziyobisi "Ketoprofen", "Indomethacin" "Diclofenac".

Inkokeli phakathi kwesizukulwana wakutshanje kuphando lwe NSAIDs yaba ichiza "Movalis". Esi sixhobo kuvunyelwa ukuba asebenzise ixesha elide. iziyobisi Anti-ukudumba ziqalisa analogs iziyobisi "Movasin", "Mirloks", "bu-", "Artrozan", "Melox", "Melbek", "Mesipol" yaye "Amelotex".

Drug "Movalis"

Eli chiza ifumaneka njengoko amacwecwe, suppositories kunye nesisombululo efakwa lolawulo intramuscular. Agent ibhekisa avela enolovoy acid. Ebonakala iintlungu iziyobisi egqwesileyo kunye neempawu antipyretic. Kuye kwafunyaniswa ukuba iinkqubo phantse kuzo zonke ukudumba iyeza ozisa nefuthe kuyingenelo.

Iimpawu zokusetyenziswa neziyobisi osteoarthritis, ankylosing spondylitis, isifo samathambo.

Nangona kunjalo, qaphela ukuba kukho Izimo kwi-arhente kufumana:

• hypersensitivity nakweliphi na iyeza;
• isifo ezilinyaziweyo kwinqanaba oyingozi;
• lomonakalo sezintso yayinzima;
• isilonda ukopha;
• ukusilela hepatic yayinzima;
• ukukhulelwa, isikhuselo-lweehagu;
• ukusilela senhliziyo esibi.

Musa ukuthatha abantwana ichiza ukuya kwiminyaka eli-12.

izigulane abadala abafunyenwe osteoarthritis, kucetyiswa imihla 7.5 mg. Ukuba kuyimfuneko, eli idosi ukuze kukhule 2 amaxesha.

Xa isifo samathambo kunye ankylosing spondylitis norm imihla 15 mg.

okukhulu kufuneka bathathe amachiza kwizigulana abo ezithandwa ukuvela yeziphumo ebezingalindelekanga. Abantu abaye babonisa insufficiency kwezintso kwaye abakhoyo wehemodialysis, kufuneka uthathe akukho mg ngaphezulu kwe 7.5 emini.

Iindleko ichiza "Movalis" emacwecweni 7.5 mg, № 20 ngu 502 engange.

uluvo kwabathengi malunga iyeza

Izimvo zabantu abaninzi zixhomekeke intlungu kakhulu, ubonise ukuba ichiza "Movalis" - isixhobo kakhulu ukusetyenziswa ixesha elide. Kokuba zivunwe kakuhle zizigulane. Ukongeza, ubukho balo elide emzimbeni kwenza ukuba idosi enye ye amayeza. Into ebaluleke kakhulu, njengoko uninzi kubathengi, kukuba ukukhusela intlala, kuba chiza akukho nefuthe elibi kubo. Kubalulekile kakhulu ukuba izigulane abaye basebenzisa indlela e osteochondrosis, arthrosis.

Ukongeza, ichiza sidima Usisindisile ngeentlungu ezahlukeneyo - bamazinyo, intloko ebuhlungu. Nika ingqalelo eyodwa izigulane kwi uluhlu umxhelo yeziphumo ebezingalindelekanga. Ngoxa afumane unyango NSAID nangona ezilumkisayo umenzi, nzima imiphumo ebuhlungu.

Drug "Celecoxib"

Isenzo esi sixhobo zijoliswe ekunciphiseni imeko yomguli kunye osteochondrosis kunye arthrosis. Ichiza ngokupheleleyo ephelisa intlungu, ngempumelelo nokuphelisa inkqubo arhabaxa. iziphumo ezibi ometyiso ziye zachongwa.

Iimpawu zibonisa ukuba ukusetyenziswa enikwe kule ncwadana zezi:

• samathambo psoriatic ;
• ukudleka;
• isifo samathambo;
• ankylosing spondylitis.

Le kuqulunqo lineqela Izimo. Ukongeza, ichiza ayenzelwanga kubantwana abangaphantsi kweminyaka eli-18. isilumkiso Kufuneka waphawula ukuba abantu babe nokusilela intliziyo kwafunyaniswa njengendlela yokwandisa susceptibility ekugcineni fluid.

Iindleko ichiza kuyahlukana nedlela package, kummandla ka-500-800 engange.

umbono kwabathengi

reviews kakhulu ziphikisana ngalo eli yeza. Ezinye izigulane ngenxa yale ndawo elalinokuphumelela ubuhlungu bamalunga. Ezinye izigulane zithi ukuba ichiza zange kunceda. Ngoko ke, le ndlela akusoloko olusebenzayo.

Ukongeza, asimele sibe uthathe iziyobisi ngokwabo. Kwamanye amazwe aseYurophu eli yeza akuvumelekanga kuba kunesiphumo cardiotoxicity, leyo Kwanele ukuba intliziyo ngokungalunganga.

Drug "Nimesulide"

Eli yeza nje kuphela ukusebenza anti-ukudumba kunye antipain. Iindlela uye iipropati antioxidant anqanda izinto iziyobisi kutshabalalisa uYesti intlala kunye collagen.

Isicelo sicombululo sazo:

• samathambo;
• samathambo;
• ukudleka;
• myalgia;
• arthralgia;
• bursitis;
• umkhuhlane;
• syndromes ubuhlungu ezahlukeneyo.

Kulo mzekelo, isiphumo iintlungu beziyobisi inikeza ngokukhawuleza kakhulu. Ngokuqhelekileyo, isigulana uziva isiqabu kwimizuzu engama-20 emva kokuba yokufakwa. Yiloo nto le sixhobo lusebenza kakhulu ukuba iintlungu paroxysmal ahlekise.

Phantse ngamaxesha onke, ichiza laye ukunyamezeleka kakuhle zizigulane. Kodwa ngamanye amaxesha, usenokuba neziphumo ebezingalindelekanga ezifana nesiyezi, ukozela, intloko ebuhlungu, isicaphucaphu, heartburn, hematuria, oliguria, urticaria.

Esi sixhobo akavumelekanga ukuba ukufumana abasetyhini abakhulelweyo kunye nabantwana ukuya kwiminyaka eli-12. inkathalelo eyodwa kufuneka athathe i "Nimesulide" abantu iziyobisi abubonileyo lwegazi, umsebenzi kidney kakuhle, umbono okanye intliziyo.

iziyobisi Price kwi-avareji engange 76,9.

Yintoni na abathengi?

Izimvo ukulungiselela phantse eyakhayo ngaso. Ekubeni ichiza ngokupheleleyo nokuphelisa intlungu yaye kunciphisa nangecesina, imilo ezinkulu komtshiso oko.

Izigulane ezininzi ingxelo ukuba iimpawu isiqabu kwenzeka ngokukhawuleza ngokwaneleyo, kunye nobude amanyathelo kwalo malunga ezisibhozo iiyure.

isixhobo Excellent kususa ngokugqibeleleyo izinyo, kubuhlungu, iintlungu samathambo. Ichiza linokunceda nobunzima okubangelwa nemithambo senzela.

Drug "Ksefokam"

Eli chiza ibandakanyiwe oxicams qela. Eli qela NSAID ahluke landa isiqingatha-ubomi, nto leyo kokudibana iziyobisi ixesha elide. It kakhulu zanciphisa kangaphi lokufumana medicament. Ngenxa yoko, ingozi yeziphumo ebezingalindelekanga lifinyele.

Drug "Ksefokam" ezo ukukwazi liphezulu ukuhambisa intlungu. imiphumela yayo iintlungu kwi obubonakala amandla zifana icaffeine. Nakuba kunjalo, ngokungafaniyo le yokugqibela, esi sixhobo ayikhobokisi kwaye aluchaphazeli inkqubo luvo.

Ngexesha uvavanyo, wawuqhutywa ukuba ichiza nokuphelisa intlungu iiyure ezili-12.

Iindleko beziyobisi azipilisi (8 mg) № ukupakisha 10 ngu 205 engange.

Drug "Rofecoxib"

Eli chiza iintlungu anti-ukudumba, antipyretic nesiphumo anti-edematous. Abelwa indlela ephumelelayo ngenxa izifo zilandelayo:

• periarthritis ezingapheliyo;
• isifo samathambo;
• tendonitis;
• bursitis;
• yokulimala imicu kwemisipha, izihlunu.

Ngexesha elifanayo, iimpawu ezibuhlungu ezibangelwa yi-neuralgia, i-osteochondrosis kunye ne-pulpitis zichithwe ngempumelelo yi-"Rofecoxib". I-remedy igqithise ngokupheleleyo i-lumbago, isifo sezinyo, i-radicular syndrome.

Isilwanyana asikwazi ukuthathwa izigulane ezine-asthma zesifo se-bronchial, emva kokuhlaselwa kwentliziyo, ukubetha. Ungayisebenzisi abantu abanomdlavuza, ugxininiso lwegazi kunye ne-atherosclerosis. Isibisi asivunyelwe abantwana abangaphantsi kwe-12. Ukongezelela, ngaphambi kokusetyenziswa, kucetyiswa ukuba uhlolisise ngokuthe ngileyo imiphumo emihle.

Isiza "Parecoxib"

Esi sixhobo esihle kakhulu, sivumela ukunciphisa ukusabela okuvuthayo kunye negalelo ekunciphiseni ubukhulu beentlungu zamkeli. Isilwanyana siyimfuno yezigulane ezathi zenziwa utyando.

Iphelisa i-syndromes ezibuhlungu ezinokulinganisela kunye ezinamandla. Imiselwe emva kwe-endoprosthetics ye-hip kunye namadolo, ama-hysterectomy, i- coronary artery bypass grafting, isetyenziswe kwindlela yamazinyo.

Isisombululo seziyobisi sisodwa. Kuxhomekeka kwiimeko zeklinikhi kunye nezibonakaliso. Abantwana abaneminyaka engaphantsi kweminyaka eyi-18 abachazwa ngamachiza.

Isiza "Arkoksia"

Isiza linegama elinye - "Etorikoksib." It has a high-inflammatory, properties analgesic. Isiza lisiza ukunqanda intlungu.

Izigulane ezinezifo ze-musculoskelet system kunye noncedo lwale mpendulo zilahla ukuqina komso. Baye baphucula ukuhamba kwamalungu, kunciphisa ubunzima bokuvuvukala, kwaye kulungelelanisa kakuhle impawu zesifo seentlungu. Emva kokuthatha impembelelo yokwelapha kuza kumashumi amabini anesine imizuzu. Into esebenzayo yeziyobisi ifakwe ngokupheleleyo ngegazi. Isilwayo asifumaneki kakhulu. Esi sibonakaliso singama-100%.

Umthamo weziyobisi unokumiselwa kuphela ngugqirha. Njengomthetho, uhluka ukusuka kwi-60 mg ukuya kwi-120 mg yonke imihla.

Isilwayo asijolise ukuba sisetyenziswe ngabasetyhini abakhulelweyo nabantwana abangaphantsi kweminyaka eyi-16 ubudala.

Isiphelo

I-pharmacology yanamhlanje ayimi. Iinkqubo ezintsha ze-NSAID zisebenzayo. Uluhlu lwezidakamizwa ezitsha ngokutsha, olunikeziwe ngasentla, lukuvumela ukuba ukhethe umlungeleliso olungcono kunoma yiphina i-pathology. Nangona kunjalo, kufuneka kukhunjulwe ukuba la mayeza ayinako ukuphilisa eso sifo. Zineempembelelo ezichasayo kunye nefuthe.