Immunoglobulin E nokubaluleka kwayo nokomzimba

Immunoglobulin E nokubaluleka kwayo komzimba - imiba edinga ukuqwalaselwa. Okwangoku, kukho iindidi ezininzi immunoglobulins (antibodies). Kukho iintlobo ezininzi antibodies nezahlukileyo yobume amanyathelo kunye indlela sifo anti-infective. Izilwa ukubangela imvula flocculation kwemveliso i onyibilikisiweyo ngokudluliselwa kwentsholongwane, agglomeration kunye agglutination awakwazi corpuscular (spirochetes, iintsholongwane, lenyama kunye neentsholongwane). Xa trypanosomes iseli inwebu vibrios kunye spirochetes esisigxina immunoglobulins izakhiwo ezithile kunye ngumphelelisi, ebangela zegazi adsorption. Ngokuqhelekileyo, le arhente ezisulelayo bazondelele kule inyama lymphoid. Le immunoglobulins kweeklasi G and M kunye ngumphelelisi unako hydrolyze spirochetes, trypanosomes, iintsholongwane kunye neentsholongwane.

Isiphumo omzimba kwi pathogen lunqunyanyisiwe xa ingena lentolongo, kwaye eveza iantigens kwiseli komhlaba. Immunoglobulins nga ukomeleza okanye buthathaka uxhathiso omzimba eziphilayo. Isilwa-unalo entsonkothileyo enoku excess iantigens, wenza isiphumo ekhuthazayo, kunye nezintsonkothileyo agqithisile antibodies ebangela nomkhwezeli. Amaninzi, ezi immunoglobulins ke unobangela iingxaki samathambo kunye negazi.

IgE ukuba kuhlelwe ubukhulu becala kwiiseli ze kwiinwebu nokuphefumla, gastro-wamathumbu phecana, kwakunye kwiindawo nkovu yengingqi. Okokuqala ngqa, njengeklasi elahlukileyo immunoglobulin E ithe yaphawulwa ngo-1966, yaye ngowe-1968, i-WHO iye yamkelwa udidi ezimeleyo IgE of immunoglobulins.

olu didi lwe iiprotheni ezifumaneka ebantwini, obeku- kwaye ezinye izilwanyana elebhu. Uninzi E iimolekyuli immunoglobulin edityaniswe kwiiseli ulusu imasti kunye basophils. Ekubeni phantsi eziqhelekileyo boxinzelelo iimeko immunoglobulin E egazini serum ye nanograms ezimbalwa milliliter nganye, ingcamango esisiseko isakhiwo sale molecule zifumaneka kuphela ngokusekelwe isifundo iiproteni ezininzi myeloid. amanqanaba asezantsi kakhulu immunoglobulin E serum ngokucacileyo kuvela yokuba ikwazi 'umtsalane' ukuya kumphezulu iiseli kwaye ngokuqinileyo ukubophelela iiseli imasti kunye basophils.

Kukholelwa ukuba Іg E iklasi elikhulu immunoglobulins nezithi zikhuphe iiseli lwemasti kunye basophils inxaxheba negazi lakho. Inqanaba le iiprothini serum of izigulane kunye nokunyuka nokwaliwa kwaye ngokuqhelekileyo idlula 350-800 U / mg. Total IgE norm yayo abantwana abangaphantsi kweminyaka kwiinyanga ezili-12 ukuya ku-15 U / ml. IgE ludlala indima ebalulekileyo ngayo hypersensitivity ngokukhawuleza. Immunoglobulin E norm abadala aqala ku-0 ukuya kwi-120 U / ml.

Ngokutsho concepts mihla, umsebenzi ongundoqo immunoglobulin E kukukhusela inwebu yangaphakathi umzimba ngenxa ukusebenza yeemeko asekuhlaleni plasma yegazi kunye neeseli effector. Magciwane bayakwazi ukuba atyhudise kumgca buyakhusela ukuba zenza immunoglobulins of iklasi A. Emva koko amagciwane okanye iintsholongwane kumphezulu weeseli lwemasti ukubophelela iklasi immunoglobulin E ethile, ngenxa yokuba loo iiseli yentsebenziswano lwemasti bafumana uphawu ukukhulula abantu amine vasoactive nezinto chemotactic, nto leyo ebangela ethubeni ekungeneni of ajikeleza iklasi Ig i-G, zincedisa, eosinophils kunye neutrophils. into Eosinophilic chemotactic, nto leyo ekhululwa iiseli lwemasti, ikhuthaza ukuqokelela eosinophils nokutshatyalaliswa ziimpethu. Kukholelwa ukuba i-IgE adsorbed phezu sisidleleli, itsala macrophage wabulela Fc-receptor.