Ichiza "valparin": imiyalelo ukusetyenziswa, ukwakheka, ntonye, nokulingana. Izimvo kulungiselelwa

Kutheni kufuneka ukuba amayeza "valparin"? Imiyalelo ukusetyenziswa, ntonye kunye ezibonisa eli chiza zichazwe kweli nqaku.

Imilo kunye Ukubunjwa

Yintoni uhlobo ezendeleyo ichiza 'valparin'? Tablet - oko kule fomu beziyobisi umbuzo zingathengwa ekhemesti. Bathi babonise inyathelo elide, simise biconvex ngeenxa, kunye nombala yayisoma omhlophe.

Inxalenye ichiza 'valparin'? Guide ubonelela ukuba isixhobo iqulethe valproic acid kunye sodium valproate. Kwakhona kuquka excipients zilandelayo: glycerol, colloidal lesilicon dioxide, evdragit E-100, hydroxypropylmethylcellulose, polyethylene ethers 1500, ethylcellulose, isodiyam saccharin, lesilicon dioxide ukuphilisa, evdragit NOT-30D, titanium dioxide kunye talc.

Thenga iipilisi ingabonwa ngezithandelo ngamaqhekeza 10 cardboard bundle ngokulandelelanayo.

le mithi

Njani na ichiza 'valparin'? Imiyalelo yokusebenzisa (composition kuthetha iye ezichazwe ngasentla) ithi ukuba ichiza anticonvulsant. Iqulethe sodium valproate umxholo ukuthuthukisa Gaba ebuchotsheni, leyo eyenza igalelo ukwanda kwayo luvo postsynaptic.

Kufuneka kwakhona uqaphele ukuba icandelo ekuthethwa iphembelela uthutho ion potassium kwiseli neuronal. Le nkqubo ofihla uphuhliso kunye nokwanda excitation unesathuthwane e-luvo.

Kufuneka kwakhona wathi sodium valproate onesiphumo anticonvulsant kwiintlobo ezahlukeneyo ukuxhuzula.

Drug "valparin" angenayo i sine kunye neziphumo thile, yaye xi embindini umoya. Ukongeza, isithako yayo esebenzayo akanayo iziphumo ezibi izinga lentliziyo, ubushushu bomzimba yomguli, uxinzelelo lwegazi lakhe kunye nomsebenzi kwezintso.

Iimpawu kwikinetiki ye ichiza

Ziintoni iimpawu pharmacokinetic eli chiza 'valparin'? Guide lithi emva kokuthatha iipilisi ngaphakathi ukukhululwa ezilawulwa into esebenzayo iqala ngoko nangoko, yaye emva kweeyure 2-8, efikelela kwinqanaba plasma ubuninzi.

Bioavailability kuthetha ingqalelo 100%.

Isiphumo therapeutic beziyobisi ibonakala kuphela emva kokuba i-acid valproic ngegazi, lingana 45-100 mg / l. Iya kuthakazelelwa into yokuba izenzo zonyango imithi ze iindlela icandelo release ezingundoqo ezilawulwa ayisoloko ixhomekeke lamanani plasma.

Unxibelelwano ingqalelo neziyobisi kwiiproteni plasma nama-85-90%. It umzimba esibindini kwaye imveliso kunye nomchamo. Kulo-yokupasa yokuqala lokugaya uyabonakala.

Half-ubomi yomenzeli imalunga 9-20 iiyure. Xa abantwana, eli xesha lifinyele.

Ezibonisa yokwamkelwa

Phantsi kweemeko oko siyobisi ngempumelelo eziphatha 'valparin "? Imiyalelo yokusebenzisa, real ingxelo iingcali ezinamava ukuba uthe medicament iveliswa ngokukodwa ngenxa yonyango sokuwa nolahlo ngokubanzi, kubandakanywa ezi ndidi zilandelayo zokuhlaselwa:

• myoclonic;
• ungekho;
• atonic;
• wokuqinisa-clonic.

Kwakhona, eli chiza omiselwe sokuwa buso, yaye ngokukodwa, e-:

• ukuxhuzula ngokubanzi zamabanga;
• kuhlanganiswa okanye nokuxutha izinto ezilula.

Ukongeza, amacwecwe ubunjwa zisetyenziswa xa syndromes ezithile (Lennox-Gastaut syndrome, West).

Siphelisa ukusetyenziswa iipilisi

Kuye naziphi Izimo iziyobisi "valparin"? Ngokutsho imiyalelo evela sixhobo, kukho izithintelo ezininzi nokusetyenziswa:

• ngexesha lokukhulelwa;
• ukuphazamiseka kakhulu kwi injeke;
• thrombocytopenia;
• hepatitis etsolo okanye engapheliyo;
• porphyria;
• amatyala esebenzayo hepatitis (Genesis iziyobisi);
• lwebele;
• ubudala zabantwana ukuya kutsho kwiminyaka emithathu;
• hypersensitivity ukuba ichiza, kuquka valproic acid.

"Valparin" Anticonvulsant: imiyalelo yokusebenzisa

Le umthamo ichiza unyule ngamnye, ngokuxhomekeke ubunzima bomzimba kunye nobudala isigulane.

Ngokuqhelekileyo, kuba yokuqala abadala iidosi 600 mg beziyobisi ngosuku. Kule alandelayo eli nani linyuke nge-200 mg (zonke iintsuku ezintathu ukuze kufikelelwe isiphumo ezinqwenelekayo).

Ubuninzi ukwamkelwa kuthetha phantsi ingqalelo yi amaxesha 1-2 ngosuku. Ubuninzi umthamo elicetyiswayo yi 1-2 g beziyobisi ngosuku.

Tablets "valparin", imiyalelo zokusetyenziswa eyayiqwalaselwe kweli phepha kufuneka uginye xa lilonke, usele imali encinane amanzi ashushu.

Xa abantu abadala irejimeni wemithi esi sixhobo uyafana nomthamo kwirejimeni kubaguli abadala, kodwa ezikhethiweyo qho ngamnye.

Iintsana ezinobunzima 20 kg zedosi wokuqala medicament yi 400mg ngosuku. Kuyimfuneko ukwandisa isixa ngokuthe ngcembe ukuze kufikelelwe isiphumo olifunayo (malunga 20-30 mg / kg ngosuku, ngo-1-2 ngeedosi).

Umntwana ukukhathaza ukuya kwi-20 kg abanike amayeza anticonvulsant kuyathintelwa.

Iintshukumo ngu-lomsebenzi

Zintoni iziphumo ebezingalindelekanga unobangela "valparin" icwecwe? Imiyalelo yokusebenzisa lazisa ukuba ukuthathwa eli chiza xa abantu abagulayo ukuze ukwehlelwa ziziphumo ezingafunekiyo:

• ziyabagulisa: Stevens-Johnson syndrome, irhashalala, erythema multiforme, pruritus, ulusu, photosensitivity.
• inkqubo yokucola: isicaphucaphu, hepatitis, ukugabha, ukuqhina, urhudo, pancreatitis.
• inkqubo Reproductive: amenorrhea zasesekondari, sexesheni rhoqo.
• CNS: isiqaqa, iingcangcazela, Ataxia, abazi kakuhle.
• inkqubo hemopoietic: anaemia, zegazi udibaniso inhibition, thrombocytopenia, leukopenia, neutropenia, yehle lwefibrinogen.
• Okunye: ukutyeba, ilahleko iinwele, creatinine serum, hyperammonemia.

anticonvulsant libanda

Ziziphi iimpawu kwenzeka xa uthatha ngeedosi eziphezulu beziyobisi 'valparin'? Imiyalelo yokusebenzisa (tablets zingathengwa kuyo nayiphi na ekhemesti kwi kagqirha) uthi ukuba mhla libanda ngabom okanye ngempazamo beziyobisi phantsi kwathathelwa ingxelo enqabile. Njengoko umthetho, ekugxojweni wemithi ichiza kunegalelo ukubonakala isicaphucaphu, isiyezi, ukugabha, urhudo, ukudandatheka yokuphefumla, isiqaqa, kunye hyporeflexia.

Ukuze ukuphelisa ezinjalo iimeko isigulane emiselweyo lavage esiswini kunye namalahle ziyasebenza. Ukuba kuyimfuneko, unyango isigulane lwenziwa ngokohlobo unyango kwangumqondiso kunye olugqitha esikhumbeni.

Intsebenziswano kunye namanye amachiza

Nokuba bengena intsebenziswano kunye namanye amachiza amayeza "valparin"? Imiyalelo yokusebenzisa yazisa isigulane ukuba valproate sodium ukuze ikhulise isiphumo antipsychotics, lakhula kunye neziyobisi antiepileptic.

Ngokungafaniyo nezinye anticonvulsants , abaqondanga isiyobisi ikhuthaza hepatic enzyme yoqheliso, yaye ngoko ke ayithethi ukunciphisa ukusebenza zokucwangcisa ngomlomo.

Xa reception engumzekelo "warfarin" kesodiyam valproate zasinciphisa ipesenti ziyabophelela kwiiproteni plasma kuqala.

I engekho mthethweni esebenzayo kugqalwa uyakwazi ukutshintsha plasma lamanani lamotrigine, kunye phenytoin. Xa kudityaniswe yezabelo of anticoagulant acid acetylsalicylic nefuthe antiplatelet kunyuswa.

Nge ukusetyenziswa ngaxeshanye "valparin 'ukusuka ethanol kunye nezinye iziyobisi zisidimaze CNS ivaliwe (umz, Mao inhibitors lo lakhula tricyclic, iziyobisi antipsychotic) ukuze eyomeleziweyo CNS kukudakumba.

Utywala kunye namanye amachiza hepatotoxic kwandisa umngcipheko nomonakalo wesibindi.

ekuqulunqeni kujongwa kwandisa isiqingatha-ubomi 'lamotrigine "kwaye ithintela yokucolwa yayo kwaye ofihla enzyme hepatic. Ngokuphathelele oku isiqingatha ubomi ichiza ukuze kwandiswe ukuya kutsho kwiiyure ezingama-70 kwizigulane abadala yaye ukuya ku-45 - abantwana.

"Valparin" uyakwazi ukwehlisa kugqitywe "zidovudine" nge-40%. Ngaphezu koko, isiqingatha-ubomi balo akatshintshi.

Mao Inhibitors lakhula, tricyclic kunye neziyobisi antipsychotic (neuroleptics), kwakunye namanye amachiza ukuba axhuzule umqobo osezantsi, kakhulu ukunciphisa ifuthe medicament ingqalelo.

Ibele nokukhulelwa

Ngokutsho kweengcali, ukusetyenziswa "valparin" iziyobisi ngexesha sokukhulelwa kunokwenzeka kuphela xa izibonelelo ekujoliswe kuzo oomama elizayo udlula kakhulu umngcipheko ezingayingozi usana.

Xa ekufumaneni ichiza ngethuba lokukhulelwa, qiniseka ukuba aqhube esweni ezizodwa siswini yosana olungekazalwa.

Ukusetyenziswa ichiza ngexesha zisanyisa ayikhuthazwa.

ulwazi oluthile

Phambi kokuba uqale unyango lwe-mali, qiniseka ukuba udibane nogqirha wakho.

Xa inkqubo yokufumana amayeza anticonvulsant kufuna esweni rhoqo yibilirubin egazini, amylases neeplatelets, kwakunye transaminases zesibindi (rhoqo emva kweenyanga ezi-3).

Ngokutsho kweengcali, valproic acid okwazi ziyibuyisela zegazi udibaniso. Oku kwandisa kakhulu umngcipheko eyandileyo ixesha coagulation igazi ukopha. Kuyimfuneko ukuba bakuthathele ingqalelo into yokuba iingxaki athe anxulunyaniswa ukopha kwixesha postoperative, abantu abafumana sodium valproate.

Ukuba unyango lwexesha elide eli chiza xa izigulane ukuphuhlisa ukopha ezizenzekelayo hematoma kwakhiwa. Kulo mzekelo, iipilisi kufuneka imiswe ngoko nangoko.

Njengoko kukhankanyiwe ngasentla, isodiyam valproate, ichiza kubangela pancreatitis, kwaye ikhuthaza ukuphazamiseka umsebenzi kwesibindi (ngokuqhelekileyo kwiinyanga ezi-6 zokuqala zonyango). Kulo mba, ekuqaleni unyango kuyimfuneko ukuba iliso ubume somdlavuza pancreatic, kwakunye esweni rhoqo iimvavanyo umsebenzi wesibindi, kwaye izinga prothrombin.

Ukuphazamiseka wesibindi ukusilela hepatic kwizigulane abafumana sodium valproate ibonakala abantwana sokuwa xa izifo pathways kwaye sisiba mandundu, ukukhubazeka engqondweni kwaye organic isicwili sobuchopho ngezifo.

Xa kokwakhelwa iimpawu ezifana silale, buthathaka iphawulwe, ukudumba, nokugabha, nenyongo, kufuneka ngoko nangoko ukuphelisa ukusetyenziswa le medicament.

Xa unyango 'valparin "isigulane kufuneka silumke kakhulu xa besebenza ngoomatshini yingozi. Oku kungenxa yokuba i-medicament esebenzayo ikwazi yokunciphisa ingqalelo.

Imigaqo nemiqathango yokugcina

iipilisi Anticonvulsant "valparin" kwabiwa ezikhemisti kuphela kagqirha kagqirha. Kufuneka zigcinwe zikhuselekile kubantwana ze akhuselwe ukusuka ukufuma kubushushu ongekho ngaphezu kwama-30 degrees.

Ithuba lokugcinwa beziyobisi ethathelwa ingqalelo yi kweminyaka emithathu (ukususela kumhla wokwenziwa).

Medicament "valparin": analogue, izithetha-ntonye

Ichiza kuthethwa kutshintshwa? Okufanayo analogue kule sixhobo, zininzi. Ezi zibandakanya ezi amayeza zilandelayo: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Njengoko kunjalo kunye "valparin", ezi mali kufuneka kwenziwe kuphela odolo zoogqirha, kwi iidosi kucetyiswa ngokungqongqo.

Uluvo kwabathengi kunye neengcali

Yintoni oogqirha bathi ngale amayeza, ezifana 'valparin'? iingcali Guest zibonisa ukuba ichiza esebenzayo nefanelekileyo, ingakumbi sokuwa ngokubanzi kunye noluphakathi.

Ke ukuba abathengi, uninzi lwabo bayavumelana ngokoluvo gqirha. Izigulane bathi lo ukwamkelwa kuthetha lula uphuhliso olukhawulezayo wayaneka abathintela excitation (unesathuthwane) ngokuthi iiseli zemithambo-luvo. Nakuba kunjalo, kufanele kuqatshelwe ukuba ukusetyenziswa kweli chiza rhoqo ibanga iziphumo ebezingalindelekanga. Ngokutsho ingxelo yabathengi, abasabela ezibi kakhulu ngokuqhelekileyo ziyenzeka zezi: nokwaliwa eluswini, isicaphucaphu, igazi, kunye ukutyeba. Ukuba ngaba wehlelwa zezi mpawu kufuneka ngoko nangoko qhagamshelana nogqirha.