"Nimesulide" iipilisi. Imiyalelo yokusebenzisa, nabalingani real

Jeezy - luhlobo beenzame lomzimba olusa ukutsala ingqalelo yomntu, ucele uncedo. Ngoko ke embi ukuba into "ebukumkanini Danish", kwaye izibonelelo umzimba akwanelanga ukulungisa le ngxaki, kufuneka inkxaso evela ngaphandle.

Consumer amayeza lemarike Russian Federation thaca amakhulu amayeza ukunceda abantu ukumelana iintlungu. Onke amayeza ukwakheka ezahlukeneyo, ububanzi kunye indlela nempembelelo. Enye kakhulu ngempumelelo ke amachiza ukusuka iqela non-steroidal amachiza-ukudumba. Phakathi kwawo ke ukunqunyanyiswa kunye tablets "Nimesulide".

Isakhiwo kunye Nokuhlanganiselwa

macwecwe Round abe imilo lenticular. Xa umbala inokuba kuba luthuthu yellow okanye nje omthubi. Icandelo engundoqo esebenzayo - into Nimesulide in tablet nganye - 100 mg. Ukusuka inani ingabizwa neselulosi ezongezelelweyo microcrystalline, starch (umbona), isodiyam wesitatshi glycolate, colloidal lesilicon dioxide.

Ukongeza, ichiza okunikelwa abathengi ngohlobo emigutyeni kukunqunyanyiswa "Nimesulide." Ubume iyafana naleyo amacwecwe, 100 sachet mg ngalinye candelo engundoqo esebenzayo.

pharmacodynamics

Nimesulide emane abangaphangeliyo cyclooxygenase-2, cyclooxygenase-1, isiphumo sayo kangangoko encinane kakhulu. Kulo mba, lo inhibition of prostaglandins kuyondelelaniswe waphawula Bamqumbisa basabela arhabaxa. Nangona kunjalo, indlela ukuyilwa prostaglandin-uhlobo lolawulo nimesulide abonakalisa ukusebenza kunzima perceptible, nto leyo obubonakala wammela encinci kwinkqubo yokwetyisa.

Ukongeza, isenzo ngempumelelo nimesulide ebonakaliswa inhibition le ukuyilwa radicals simahla. Nangona kunjalo, iinkqubo hemostasis kunye phagocytosis ayihambelani ubunzima imiphumo yale nto. Indlela of medicament isiphumo anti-ukudumba bafakela ithatha indawo enkulu kunye nobuchule ukucinezela ukukhululwa myeloperoxidase (in izifo ezininzi ukudumba kunokubangela umonakalo izihlunu, yenye yeempawu lichaneke diagnostic kubonisa ingozi yokuba sisifo sentliziyo okanye istroke).

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

kwenkululeko Wide ezaneleyo ichiza "Nimesulide". Yintoni eyenza eli chiza? Ngenxa yokuba chiza phezu isiphumo entsonkothileyo yabantu - antioxidant, iintlungu, antipyretic kunye anti - ke wabelwa kunye nenani izifo arhabaxa. iziyobisi olusebenzayo phambi osteoarthritis (isifo esinganyangekiyo ndibanisela kwindawo yokuqala wamginya intlala articular), tendinitis (ukudumba umsipha esiqwini ukuphela), bursitis (ukudumba iingxowa yangaphakathi, benamandla kwamalunga).

Iziphumo ezincumisayo ubonisa "nimesulide" kwi ukunyanga isifo samathambo, izifo samathambo extra-articular. ekulweni ngokuphumelelayo nezifo ezosulelayo ukuba zihamba ziinkqubo arhabaxa. Lidla "Nimesulide" icwecwe ezisetyenziswa izifo nococeko, unyango ukwenzakala imvelaphi ezahlukeneyo. Izigulane zithi nokuphelisa olusebenzayo intlungu ngexesha kwimo postoperative.

Izimo "nimesulide"

Ekubeni medicament libhekisela kwiqela yokuhlangana Square National mihla, iye kwakuhlaziya uluhlu olubanzi lwe Izimo. "Nimesulide" (ukususela oko kunceda iyeza - sele ekuxoxwe ngazo ngaphambili) ukuba athathe abantu hypersensitivity nakweliphi kumafa yayo. Akukho chiza elawulwa kwabo izigulane kunye nembali kuvela reactions hepatotoxic kunye reactions hypersensitivity njengoko nokuthimliswa, bronchospasm, urticaria (aspirin okanye abanye abameli NSAIDs qela).

Izimo ukuba ukusetyenziswa medicament kukuba izilonda ilunga-ezilinyaziweyo kwinkqubo yokwetyisa, utyekelo ukuphuhlisa ukopha nawuphi na imvelaphi (t. E. nguqu ekusebenzeni igazi ekunqandeni).

Medicine "Nimesulide" umyalelo othintela izigulane kakuhle kwezintso, hepatic, insufficiency intliziyo. Izigulane with "aspirin" isifuba, utywala kunye nokuxhomekeka neziyobisi kunye musani uthathe iziyobisi.

Musa ukumisela amayeza kwezo meko, ukuba isigulane inyuswe lobushushu emzimbeni okanye ezinye iimpawu ezifana nomkhuhlane zikhona. Ukongeza, oku akwamkelekanga ukuba "Nimesulide" abantwana, abakhulelweyo kunye nabafazi phindeke.

reactions icala kunokwenzeka 'nimesulide "

Ukusetyenziswa koMgaqo-medicament kunokubangela eziliqela ziziphumo ebezingalindelekanga ezivela amalungu kunye neenkqubo umzimba ezahlukeneyo.

Ukusabela ziqhelekileyo nâzo kwingcombolo inkqubo yokwetyisa, kwaye sikubonise isicaphucaphu, ukugabha, urhudo, flatulence, kunye nophuhliso gastritis. Ngaphantsi akholisa ukubakho ukopha zesisu, izilonda de perforation. Maxa wambi uyakwazi ukuva ukuqunjelwa, stomatitis, iintlungu esiswini.

Ngaba kunokubangela "nimesulide" kwicala isenzo yinkqubo hepatobiliary, kaninzi ebonakalaliswe kumanqanaba zesibindi transcriptase, ubuncinane - kuphuhliso kwesibindi (kubandakanywa fulminant ..), Cholestatic senyongo.

Kwi indlela nemithambo yegazi na ongathi, ukuba kukho lenyukile uxinzelelo lwegazi, izigulane kunqabile ukhathazeka malunga iyangongoza ngentliziyo, legazi, ukuhlisa, uxinzelelo lwegazi iyaxhuma.

inkqubo wokuchama zinako ukuphendula yimbonakalo nokudumba (hayi rhoqo), kunqabile - wokuchama ukugcinwa, hematuria, dysuria. kunqabile kakhulu elo nxeba ukusilela kwezintso, nephritis Embi, oliguria.

abasabela kangangoko CNS amaninzi kuboniswa nesiyezi, umkhuhlane, asthenia. na ngaphantsi badla weva malunga yintloko, uphuhliso somnolence (ukufana thile ukulala), Reye kaThixo syndrome (Encephalopathy), emzimbeni (umzimba lobushushu nciphisa ngaphantsi kwenqanaba efunelwa ukugcina ukutya eziqhelekileyo). Maxa wambi uyakwazi ukuva ngayo ezinjalo "Nimesulide", njengoko uvalo, ixhala, amabi.

Ngokumalunga inkqubo emithanjeni kunye nenkqubo hematopoietic, "Nimesulide" (Instruction, abahambisa ncomo ukuqinisekisa olu lwazi) obungakwazi ukubangela anaemia, eosinophilia, kodwa ngaphantsi okuba ukuphuhlisa thrombocytopenia purpura pantsitopenicheskaya.

Ayifane yenzeke, kodwa unako ukuva malunga ukuphazamiseka pathways (hyperkalemia), amajoni omzimba (hypersensitivity, anaphylaxis), amalungu yombono (yombono ifiphale, clouding Ngowamasimi), izifo, mediastinum (ukuhlaselwa dyspnea, bronchospasm, isifuba). Kwakukho ngayo ulusu kunye inyama ongama (ukubila, ukurhawuzelela, dermatitis, urticaria, erythema, kunqabile kakhulu - ityhefu epidermal necrolysis, Stevens-Johnson syndrome).

umthamo kunye circuit isicelo mode

tablets izigulane abadala "nimesulide" zicetyiswa ukuba omnye ngexesha (100 mg) kabini yonke imihla. Kukhethwa ukuba enze njalo emva kwesidlo uze usele amanzi unyango. Ukuba ngumgubo kukunqunyanyiswa, ngoko imixholo sachet umntu exutywe 100 ml yamanzi. Abafikisayo ngaphezu kweminyaka eyi-12 ubudala akukho mfuneko ukutshintsha ithamo, kwaye abantwana eli chiza ukuze Andamkeli akuvumelekanga. Kwimeko unyango izigulane abakhulileyo a hlengiso idosi akukho eyenziwa.

Kuba abantu abaphethwe insufficiency hepatic, ukucoca creatine ku ezahlukene 30-80 ml / min., Idosi olungachanekanga. Ukuba Isalathisi uvikivwa (ml 30 / min okanye ngaphantsi.) - esalelweyo ukufumana medicament.

Ezi ngcebiso ezingundoqo ulwamkelo ichiza "Nimesulide". Idosi ichanekile ukhethe olusebenzayo kancinane, nangenxa xesha lifutshane kangangoko, nto leyo eya Kucutha umngcipheko neziphumo ezibi. ikhondo Ubuninzi unyango kunye nokusetyenziswa "Nimesulide" aliyi kuba ngaphezulu kweentsuku 15.

oyidlayo kakhulu: Iimpawu, Treatment

Ukuthatha ipilisi "Nimesulide", kuyimfuneko ukubambelela ngokwemithamo acetyiswayo imiyalelo okanye ekhethiweyo yi igqirha khona. Self-zolawulo medicament kunye (okanye) ukusetyenziswa kwayo ulwimi kunokuphumela libanda. Eyona njalo wabona ezi mpawu zilandelayo: isicaphucaphu, ukugabha, ukopha, iphecana zesisu, ukozela, silale, lwegazi (uxinzelelo lwegazi), inhibition komsebenzi yokuphefumla, ukusilela oyingozi kwezintso.

Unyango xa libanda kwangumqondiso, ukuba isimilo axhasayo. nimesulide ikhubalo engekhoyo okwangoku. Ukuba ekubeni overdosing okanye ukuthatha idosi eliphezulu medicament ongenakuwelwa iiyure ezingaphezu kwama-4, isigulana isibhedlele lavage esiswini yokwamkela ekucetyiswa izifunxi (umz, carbon luvuliwe kwi-mali ka 60-100 mg ukuba umntu omdala) yaye ezinye iintlobo iziyobisi osmotic isisu.

Ngeli xesha lonke unyango kufuneka sibekwe esweni ngononophelo iingcali zonyango ukusebenza kwesibindi kunye nezintso. Ulwazi malunga namathuba ukususwa nimesulide ukusuka umzimba ihaemodialysis ayifumaneki. Ngenxa iqondo eliphezulu yokubopha iziyobisi kwiiproteni diuresis ngebhaxa asiphumeleli.

imiyalelo Special

"Nimesulide" ukuze abe amayeza ezikhemesti ezingayi, kunjalo, kufuneka zithathwe ngononophelo. Kuphephe isicelo engumzekelo i medicament kunye nabanye abasebenzi abanga-steroidal arhente anti-ukudumba, analgesics umlindi. Ngophuhliso iimpawu izigulane, nomonakalo wesibindi uphawu (isicaphucaphu, ukugabha, ukudla, umchamo) okanye ukunyusa umgangatho transaminases hepatic yesicelo "nimesulide" kufuneka kushiywa. Ukuba kukho nefiva okanye iimpawu ezifana nomkhuhlane, unyango kufuneka kupheliswa ngoko nangoko.

Uqaphele ukuba izigulane zakhe kufuneka ukuba ngaxeshanye kunye "Nimesulide" amayeza ukuthatha ukuba kwandisa umngcipheko izilonda emathunjini kwegazi. Amanyathelo ezimiselweyo kweziyobisi abantu abaphethwe ukudumba okwenziwa sisilonda sikabhobhosi okanye isifo Crohn kaThixo, izilonda ukuba imbali kwizigulane abalupheleyo.

Abantu abafuna ukuthatha "Nimesulide" kunye aspirin ngeedosi kwentliziyo kufuneka zabelwe unyango kunye gastroprotectives.

Ukusetyenziswa "Nimesulide" (okanye nayiphi na enye NSAID) kukuninzi kwaye kwithuba elide kukhokelela ekwandeni encinane umngcipheko iingozi thromboembolic (stroke, iposi engabalulekanga, njalo njalo. N.).

Izigulane ezahlukeneyo sentliziyo iingxaki "Nimesulide" inkqubo banokuthi banyulwe kuphela xa inzuzo ezilindelekileyo idlula umngcipheko yeziphumo ebezingalindelekanga.

Le medicament onesiphumo kwi iqondo umsebenzi zegazi. Le ngcaciso ibaluleke kakhulu izigulane abanengxaki ukopha diathesis. izibhaxu esikhumba ngokufuthi ngexesha ukusetyenziswa ixesha elide "nimesulide". Xa kuvela irhashalala, uba umonakalo appreciable ukuba inwebu yangaphakathi okanye naziphi na ezinye ukubonakaliswa elisisigxina ukunganyamezelani, unyango amayeza kufuneka kupheliswa.

Ukusetyenziswa "Nimesulide" abasetyhini abakhulelweyo zingabangela kuvalwa emithanjeni bile phambi kokuba luyimfuneko, ukunciphisa umthamo we fluid. ingozi eyonyukileyo ukopha intrauterine, buthathaka yabasebenzi, imbonakalo nokudumba. Ngenxa yezi zizathu, oomama abakhulelweyo ngexesha lokuqala kunye trimesters yesibini reception lokukhulelwa "Nimesulide" ayikhuthazwa.

Kufuneka ube impendulo umbuzo ukuba singathatha i "Nimesulide" ngaxeshanye kunye notywala, kuyacaca: indibanisela akwenziwanga kuvumelekile!

analogs

Phantsi analogs "nimesulide" libhekisela machiza abavela kumaqela NSAID equlathe njengoko koyintloko nto nimesulide esisebenzayo (ixabiso ngabo luya oscillate malunga noluhlu efanayo kodwa ngezantsi nje kancinane). Abasebenzi analogs zonyango kakhulu eyaziwa kwaye ngokuqhelekileyo emiselweyo ziquka iziyobisi "naiz" (gel, tablet, ukunqunyanyiswa), "Nimesil" (Ithatyathwe emigutyeni) "Niemiec" (tablets) ' "(gel, amacwecwe, amacwecwe ukunqunyanyiswa ngenxa owanyayo) nimulid .

Zonke analogs ilifa ukusebenza ngokwaneleyo yaye abelwe ukujongana uluhlu olubanzi zezifo, ukudumba benxibe umlinganiswa.

uhla amanani

Amaxabiso ngokwakhe "Nimesulide" kunye analogs ayo malunga enye, nangona ingqalelo iindleko iziyobisi ifikeleleke ngakumbi emininzi ebanzi kubathengi. Tablets "Nimesulide" (20 iiPC. Xa pack) liya kuxabisa engange 85-90 pack nganye. Inani elifanayo amacwecwe "Naiza" iya kuxabisa 110-140 engange, "Niemiec" (Kwakhona 20 iiPC.) - kule engange 115-134. Packaging "nimulid" iipilisi 30 ixabisa 180-220 engange. Umthamo Umxholo eyona nto ephambili esebenzayo (Nimesulide) kuzo zonke analogs efanayo - 100 mg.

Endaweni tablets "Nimesulide" (iindleko lisezantsi) zingafumaneka, umzekelo, i oluludaka "naiz" iindleko 200-300 engange ml-60 okanye "nimulid" - engange 75-105 kuba umlinganiselo omnye iziyobisi. Iyafumaneka ukuze uluhlu olubanzi kwabathengi iilozenji "nimulid": nezabelo-20 ngexabiso 130-155 engange pack nganye.

Mhlawumbi eyona ndlela ebiza yokukhululwa kwayo kweziyobisi kunye nimesulide njengecandelo eziphambili - ngumgubo 'Nimesil ". 30 iingxowa (package) buxabise abathengi imali engange ukusuka 560 ukuya 645.

Kuba isicelo mlonyeni abo babe- ephumelela nimesulide. Ngaloo ndlela, "naiz" iya kuxabisa 120-145 engange ukuba ityhubhu-20 g okanye engange 215-275 (50 g). Gel "nimulid" kancinci zitshiphu: 115-150 engange nganye ityhubhu umthamo '30

Elokuphetha Ndingathanda ukuthetha oku kulandelayo. Isigqibo sokusebenzisa "nimesulide", nayiphi analogu okanye naziphi na ezinye NSAIDs kufuneka athathwe yi-gqirha khona. umsebenzi wezempilo kuphela kuhlolwe ngokufanelekileyo ubungqongqo lwempilo izigulane zabo, ukuqwalasela zonke izifo ezinxulumene, khetha izinga iziyobisi ukukhetha nokuphuhlisa isicwangciso unyango ukwenzela ukunciphisa amathuba neziphumo ebezingalindelekanga kunye ukufumana iziphumo ezincumisayo.