Zavunyelwa creatinine

Xa yesilungu, igama elithi "ukucoca", nto leyo imele i Isalathisi oluninzi ngesantya lokuhlanjululwa ulwelo ezithile eziphilayo. Ukuba sisebenzisa esi sikhokelo iye banzi kakhulu ukuqonda kwethu pharmacokinetics kunye pharmacodynamics zezi kunye nezinye izinto.

Ngoko ke, umzekelo, kugqitywe creatinine ugqibe ngokusebenzisa iimvavanyo diagnostic Reberga-Toreeva. Kubalulekile ukuphawula ukuba Kule meko kungenzeka ukuba ukumisela isantya ukuhluza nomongo endogenously kuhlanganiswa ize inikezele ngaphandle (amayeza kunye nezinye iindlela). Uqikelelo lwenziwa yi yokubala ucoco ngobunzulu (glomeruli) plasma release izinga evela into ethile. Le akhawunti kubanjwa ngexesha ezinzileyo (ikakhulu - ngosuku).

Ethetha creatinine, kufuneka sinikele ingqalelo yokuba ukusisusa ivela emzimbeni kubangelwe ikakhulu umsebenzi ukuhluza ye nezintso. Ngokusekelwe kule, ezifana creatinine rate sokucoceka bekuya kuba ebalulekileyo kuvavanyo sezintso glomerular product ukusebenza. Kufuneka kuqatshelwe ukuba eli nani luphawulwa kungekuphela nje amandla ukusebenza kwenkqubo filter, kodwa ezinye ukuphazamiseka amalungu oluntu kunye neenkqubo. Kulungiswe kwehlisa, ukucoca creatinine kwaye inokuba kubonisa kwegazi ngokwaneleyo ukuya kwizintso (yegazi, yaye elibukhali etsolo kunye nophuhliso - thromboembolism).

Isantya sokwehla lomsebenzi sezintso kwenzeka emva kweminyaka engamashumi amane. Ukunciphisa izinga product glomerular ka-1% ngonyaka ngamnye. Emva kweminyaka engamashumi amathandathu, inqanaba lomsebenzi yehliswe kancane ngokukhawuleza (ezi nguqu ezidibene ngokuyintloko kunye nokuguga yento ephilayo). Nakuba kunjalo, kufanele kuqatshelwe ukuba naziphi na iziphiwo ukuguquka akwenziwanga yathi ngenxa yokuba abadala kuyehla zonke iinkqubo pathways, kuquka Yindibanisela creatinine iqala.

Xa ulungiselela isampuli Rehberg kuyimfuneko ngaphandle ukusebenzisa iziyobisi ezithile ezinokuthi kuchaphazela ekuhambeni zophononongo (iziyobisi "cortisol" "Furosemide", "Corticotropin", "Methylprednisolone," "Thyroxine" kunye nabanye).

Ukuze ufake isampuli umchamo isampulu olwenziwa, kwakunye uvavanyo lwegazi kwi-avareji kwinqanaba plasma creatinine.

Phakathi izinto ezibonisa ngenjongo yokufunda: ngezifo yonyango, uvavanyo lomsebenzi kwezintso ezisebenzayo, ngokunjalo nohlolo nefuthe eyahlukahlukeneyo.

Kuxhomekeka kwinqanaba lokuncitshiswa e imvume ukuchaza ezi okanye okunye ukwaphulwa.

• 30 ml / min / m2 kunye 1.7 - ukuhla umsebenzi sezintso eyenze;
• 30-15 ml / min / m2 1.7 - ubukho ukusilela kwezintso (okanye babuyekezwe isidanga subcompensated);
• <15 ml / min / m2 1.7 - ukusilela kwezintso decompensation isigaba.

Kubalulekile ukuqonda ukuba amandla ukusebenza kwenkqubo ukuhluza imisela kugqitywe kwezintso of creatinine, izinga elo ngexesha sample Reberga ibonisa izintso eziqhelekileyo.

Noko ke, ezinye izifo musa kusenokukhokelela kwiinguqu ze isalathisi (umz, pyelonephritis ezinganyangekiyo).

inqanaba creatinine egazini kuxhomekeke umsebenzi kuyondelelaniswe zayo zemveli kunye ekujikelezeni kwayo zinomgutyulo womchamo. Kubalulekile ukuqonda ukuba eli nani kuxhomekeke nje kuphela umsebenzi kwenkqubo yokuhluza, kodwa isantya nomthamo reabsorption kwezinto kukwenziwa umchamo ephambili.

Ngoko ke, okwangoku Reberga isampuli (nokumisela kugqitywe creatinine) ngokwaneleyo ukufumana ukusetyenziswa kabanzi njengonyango diagnostic. Ubuhlobo ngqo phakathi kugqitywe kunye kidney umsebenzi inika inkqubo eliphezulu ukubaluleka diagnostic.