UNjingalwazi Skulachev: wamehlo. Wamehlo "Vizomitin" (ilahla Skulachev) ncomo, ixabiso, isikhokelo

Ixesha akemi ngxi, yaye zonke iintlobo zobomi bemvelo on Earth kuxhomekeke kutshintsho ukwaluphala. Amafama iinkqubo ukuguga ukukhangela imbonakalo ukunganeliseki eziphilayo wakhe kunye nabanye, ukwenzeka sesindululo ngexesha ukuphefumla okukhawulezayo, dyspnea, ethobe ukuma kunye nentshukumo imiqathango. Ngaphezu koko, umbono kuguga.

Kukho uluvo, leyo, ngokuzenzekelayo, eqheleke kakhulu ukuba inkqubo ukuguga ayikho into ukuyeka, kwaye isantya kwakungenzeki kwaphela. UNjingalwazi Skulachev, wamehlo zona isiphumo mmangaliso ngokwenene, ihambelana omnye umbono.

Kakade ke, ukuguga - yinkqubo yendalo, kodwa ngenxa yesizathu esithile ayikwazi ayilibali phantsi? Ukuguga ayikho ngaphandle kwesizathu. Xa isangqa izazinzulu ababandakanyeka kwinkqubo nokushwabana umzimba womntu, kukho uluvo ngamandla ukuba umxokelelwane yethu DNA zibhalwe inkqubo ekhethekileyo elinoxanduva ukwaluphala emzimbeni. Emva kokuba iminyaka ethile, kukho kusebenze le nkqubo, nto leyo ekugqibeleni kukhokelela le meko - ukufa.

Yintoni ingozi amehlo abalupheleyo yi

Waphula umthetho iinkqubo imbono olubonakalayo yenye imiqondiso yokwaluphala. Hayi, Kambe, u nga langutana njhani abantu kwimeko elikhulu yempilo, oko kwanele ukuba inkcaso esebenzayo kunye yinxalenye zonke iintlobo zezifo yokwaluphala, kodwa ukuba umntu ngesiquphe alahlekelwe umbono, okanye ziya kugxagxiseka kakhulu, nkqu "iqhawe" elo baya yokukhubazeka.

uninzi lwezifo iliso zikhula ngokuhamba kwexesha ngokucothayo kakhulu. Nge ubudala, le ndlala lacrimal asebenza ngaphantsi, yaye oku kuquka ukwehla imveliso kunye nomgangatho iinyembezi. Iba lubonakale emva kokuba kweminyaka engama-40 ubudala, kodwa oko kwenzeke emva-30.

Njengokuba, yintoni le nto? Kungokwemvelo ukuba ukhulile uba ukubhitya zokhuselo iliso plyonochku ngokwandileyo kwenzeka microtrauma kwenwebu kunye umonakalo, izifo ukudumba, eyestrain ngokukhawuleza. Xa olunye microchanges ezinjalo isiseko kuphuhliso izifo ukusongela ezifana cataract, ukwanda koxinzelelo intraocular kunye nophuhliso ukunyanga iglaucoma agalelwa, ukuze baqale utshintsho sisiba mandundu le retina nemithambo optic yelahleko okuqhubekayo umbono. Kodwa musa ukoyika ukuba ezi zifo Inokwenzeka, nabo bonke a jiffy. uphuhliso lwabo iyacotha kwaye ngokuthe ngcembe.

Oku wamtyhala into yokuba lo njingalwazi wagqiba ukwenza wamehlo Skulachev. Uhlaziya ukuba kuthi ga ngoku kubo ezihle kakhulu. A elikhulu kakhulu, ukuba mkhulu, inani lezigulane lwamehlo ukufumana ithuba kwakhona jonga ecacileyo-amehlo kwi ihlabathi ngaphandle utyando. Makubulelwe ukuba kusungulwe nguNjingalwazi Skulachev iliso ngamathontsi, ixabiso leyo ngaphezu wedemokhrasi.

Antioxidants ezifana ayo

E Moscow State University. University ukususela ngo-2005, uye waqalisa iprojekthi yophando kuphuhliso kwamachiza eyenzelwe ukuba ukulibazisa ukusebenza kwenkqubo wehlise ukwaluphala. Phantsi kwenkokhelo V. P. Skulacheva, Academician of the Russian Academy of Sciences, isazinzulu ezinto ngubani iminyaka engaphezu kwamashumi amane wenza uphando kwiinkqubo eziqhubeka kwindawo mitochondria, kokusungulwa uhlobo olutsha lwe izithako ezisebenzayo - antioxidants uhlobo ayo.

Ngokusebenzisa isifundo emva kokusungulwa sokuqala sale hlobo amachiza, izazinzulu ziye zafumanisa ukuba antioxidants ayo wehlisa, kwaye kwezinye iimeko zijikwe iinkqubo kwezifo lwamehlo kwi izilwanyana nokuhlola. wenze umsebenzi omninzi kwi wayila kwamachiza amatsha ngokusekelwe antioxidants ayo sele kwiminyaka embalwa kamva, uNjingalwazi Skulachev wamehlo ebiqaliswe phantsi kwegama "Vizomitin".

Makhe sijonge enye Iimpawu zokuqala iliso ukuguga - kwekhono olunxulumene-ubudala ingaba lacrimal. Kwenzeka ntoni nge ubudala? Nge yobudala apho linciphileyo iimpawu kunye nemigangatho ye kulwelo lacrimal, yaye ngenxa yoko, uphuhliso onaso of "Amehlo owomileyo". Ubonakala imvakalelo lokuqala kabi emehlweni, yimvakalelo engenakubalwa enjengentlabathi okanye iqumrhu ezincinane amazwe, kunye, ngokuthe ngcembe ukuqhubeka kwesifo bangafumana nemiphumela emibi kakhulu.

Qaphela ukuba ukuhla ukusuka seengxangxasi ezikhoyo kusini kwimarike lamachiza ngamanani amakhulu. Enkulu kwaye isixa amachiza ezijoliswe kunyango ukwenza izinto kwangumqondiso ngexesha 'iliso owomileyo ", kodwa phantse bonke bephela (okanye ezininzi), i-analogu zokwenziwa of iinyembezi fluid kwabantu. Ububi wabo ukuba isigulane kufuneka ukusebenzisa la machiza avela izihlandlo ezili-10 ukuya 20-25 ngosuku, ukususela ukusetyenziswa nje amiselweyo ajoliswe isiqulatho iinyembezi fluid abaqhelekileyo kwi iliso.

iimvavanyo Laboratory and clinical

Ukuhla latest "Vizomitin" yahluke kuyaphi umgaqo amachiza afanayo operation ezisetyenziselwa ukunyanga iliso owomileyo. Bona kanye unobangela sifo, ukuphucula ukusebenza esinobubovu lacrimal nokumisa utshintsho zakhe sisiba mandundu. Ngaphezu koko, amathontsi zokutshiza nemiphumo efanayo njengoko amathontsi iinyembezi ngumntu cataract esekelwe.

Le meko - ayikho nje ingxelo yolwazi, kodwa eneneni lusekiwe mhaka. UNjingalwazi Skulachev wamehlo uphando ngamandla kwezilwanyana kunye neemvavanyo bezonyango beziyobisi landikhomba kumaziko ezininzi amehlo: kwi Zeliso yeSebe (Russian State University Medical) kwaye Research Institute of Diseases Eye Helmholtz.

Iziphumo ezifunyenwe kwezi zifundo kunye yolingo lwezonyango, iziphumo ikhuthaza kakhulu. UNjingalwazi Skulachev, amathontsi iliso, apho kuthengiswa phantsi kwegama "Vizomitin", uthi ukuba ngempumelelo kakhulu kunokuba amachiza afanayo ezisetyenziselwa ukunyanga ukuphelisa imiqondiso onaso 'yeso owomileyo ". Ngaphezu koko, kufuneka kuqatshelwe ukuba iziphumo ebezingalindelekanga ngexesha unyango nezi amathontsi kwizigulana mbaleko.

Ngokusekelwe kwiziphumo zezi zifundo, ichiza yabhaliswa kwi-Ofisi yoMphathiswa lezeMpilo noPhuhliso lwezeNtlalo ngoDisemba 2011 njengendlela keratoprotektornogo ebizwa ngokuba "Vizomitin", okanye wamehlo Skulachev. Apho ukuthenga amayeza namhlanje? Ekubeni lowe-2012, wabonakala ezikhemisti womnatha ngemiyinge eli lizwe.

Kakade ke, njengayo nayiphi na ichiza elitsha ineempahla esebenzayo eyaziwa ngaphambili "Vizomitin" sakhululwa kuphela ngokumiselwa. Ingaba ndithenga ngaphandle wamehlo Skulachev? Apho ukuthenga kubo, ukuba akunjalo iresiphi? Musa asebenzise amaqhinga, qhagamshelana nogqirha wamehlo wakho khona. Ikhefu Amayeza akukho mfuneko yakusithumela iintsilelo - it becala limisela injongo yayo ekujoliswe, mvisiswano leyo, kwelinye icala, kuthetha nempembelelo entle kwisicelo.

A ukufunyanwa ekhethekileyo ngokwenene uNjingalwazi Skulachev. Wamehlo, leyo ncomo ukudibana okulungileyo kuphela ziye zaba nempembelelo ngokungummangaliso. Kuba ukuphunyezwa zabo izifundo zonyango kufuneka ibe opticians kungekuphela eRashiya kodwa ehlabathini lonke. Eli chiza isihloko iinkomfa ezahlukeneyo kunye zocweyo ukuzisa ulwazi yonke zamehlo.

Makhe ihlale ngakumbi ukulungiselela "Vizomitin". Imiyalelo zokusetyenziswa unako ukunika ulwazi oluninzi umdla.

Inkcazelo yokulungiselela

Le ndlela yeyona kakhulu engafihliyo, mhlawumbi ulwelo olunombala opalescent noko okanye kancinci. into esebenzayo Plastohinonildetsiltrifenilfosfoniya na bromide, nto-1 ml yokulungiselela iqulethe 0,155 micrograms. Njengoko excipients kusetyenziswa benzalkonium chloride, hypromellose, sodium chloride kunye nabanye. Eli chiza eka arhente pharmacotherapeutic iqela keratoprotektornyh, kwakunye iqela Antioxidants.

Idatha kwi pharmacodynamics

Plastohinonildetsiltrifenilfosfoniya bromide ephindeneyo yemvelaphi plastoquinone kona kusebenzayo oko kuthiwa linker chain ezinxulumene triphenylphosphine intsalela. Njengokuba Dr Skulachev uthe wamehlo (ixabiso kubo ngenxa cheapness wayesisalamane Yindibanisela le compound ayikho phezulu) kwi nanomolar zoqhaphelo ekwaziyo sibonise umsebenzi omkhulu kakhulu antioxidant ukususela phezulu oluvuselela kwiinkqubo slezoobrazovaniya ukwandisa uzinzo ebonakalayo akhiwa umboniso ukukrazuka kwaye kuba nefuthe iinkqubo epitealizatsii.

data pharmacokinetic

Ukuza kuthi ga ngoku, kufuneka kuthiwa ukuba inani lezifundo pharmacokinetic engazanga lwenziwe ebantwini. Ngokubhekiselele izifundo izilwanyana pre-lwezonyango, ukusasazwa zamathontsana into esebenzayo eziphilayo kwaphawuleka ukuba iintsuku ezi-2 emva kokuba nolawulo ngomlomo okanye parenteral. Ubukho bromide plastohinonildetsiltrifenilfosfoniya ibhaliswe kwi ezixinene aphezulu izihlunu kwezintso kunye zesibindi izihlunu, intliziyo emva iyure-1 emva nolawulo. Wawuqhutywa ukuba ubutyebi ngokukhawuleza kakhulu phantsi wokuqhekeka kobudlelwane phakathi usebenzisa enzyme kwaba ekwaziyo iibhondi covalent kunye neeproteni.

Iimpawu kunye Izimo

Ashiye Skulachev "Vizomitin" oqeshwe onaso 'yeso owomileyo ", utshintsho ezinxulumene-ubudala ingaba lacrimal, ikhompyutha syndrome. Ngokusekelwe yokuba uphando lwezenzululwazi olujongene nemiphumela beziyobisi nangoku okoko, kucetyiswa ukuba cataract, glaucoma kunye nonyango ezimbaxa kwisuntswana nasiphi na isifo zamehlo.

Njengoko Skulachev Vladimir wabonisa, amathontsi amehlo abo contraindicated xa kwimeko hypersensitivity ukuba ichiza, ngokunjalo nabantwana abangaphantsi kweminyaka engama-18.

Ukusetyenziswa ukukhulelwa kunye ngexesha lokuncancisa

Ukuza kuthi ga ngoku,-lunomkhethe ngokupheleleyo, iimfama, izifundo ezilawulwa beziyobisi abafazi abakhulelweyo, kwakunye ababethinjwe ngaphandle koomama abalupheleyo. Ngenxa yale meko, ayikhuthazwa tu ukusebenzisa iziyobisi ngexesha yokumitha. Ukuba kukho imfuneko ukungabikho ukuqeshwa kwixesha zisanyisa, lwebele-zokuxheshisela kufuneka kupheliswa.

Indlela yokwenza isicelo kunye idosi

Ichiza kufuneka wabethelela 1-2 ngamathontsi kungena kulo sac conjunctival of iliso yomguli kathathu ngemini. Kuxhomekeka ebukhulwini iimpawu kunye ubungqongqo lokuqhubeka kwekhosi konwaywa esi sifo ngabanye abekwe nokunyanga zamehlo.

side effects kanye libanda

Ngokutsho uphando, ngokunjalo uvavanyo lwezonyango kunye kwilebhu ichiza, iziphumo ebezingalindelekanga ziye zachongwa, kodwa kube sisibonakaliso negazi lakho. libanda ngedatha isicelo ngokwemixholo kwichiza ekhoyo.

okwenziwa Drug

Idatha ye imithi kunye namanye amachiza kufuneka amaqela. Ukuba kukho imfuneko yokuba isicelo ngaxeshanye "Vizomitina" kunye nezinye amathontsi iliso, iliso instillation umsantsa phakathi kufuneka babe imizuzu emi-5.

oyi

Ngokwenene na kwiimvavanyo zeklinikhi iziphumo iziyobisi zifunyenwe, ukuba "Vizomitin" okwaziyo ebangela ukuphazamiseka yokuhlala elifutshane elide, kulandele ukuncitshiswa yayo. Ukuba emva ulawulo ichiza waphawula ukuphazamiseka ezibonwayo, kufuneka uyeke kwisithuthi okanye iindlela zolawulo, kwakunye nokusetyenziswa izinto ezifuna ingqalelo, kude recovery ngokupheleleyo acuity olubonakalayo.

release Form

Wamehlo kunye isiqulatho isithako esebenzayo 0,155 ug / ml ziveliswa zeebhotile ezizodwa polyethylene 5 ml umthamo kunye anokuthintela - iidropha uze ujije cap. Ichiza iyekelela kuphela ngokumiselwa. Gcina i drop iliso eyimfuneko lobushushu ukusuka ku-2 ukuya kwi-8 ⁰ C.

Apho ukuthenga ichiza

Thenga amathontsi "Vizomitin" namhlanje ogama ixabiso ayikho enkulu, ukuba asidlulisele iziphumo ezilindelekileyo, kusenokwenzeka phantse kuzo zonke ekhemisti Russia. Iindleko avareji kwi amathontsi Russian Federation imalunga 500 engange. Ifuthe ichiza nje eyenziwe ngabantu. Inani elikhulu labantu bakwazi ukucima kunye nombono kwacaca oku kuthetha. Njengoko kubonisiwe nguNjingalwazi Skulachev, amathontsi iliso, ixabiso efumanekayo ukuba wonke umntu uya kuba nempembelelo olusebenzayo unyango ngabo abaphethwe zizifo amehlo.

Akukho mathandabuzo ukuba emva kwexesha elithile, kwiiyunivesithi ezenza uphando bapase isifundo ngokupheleleyo wamehlo "Vizomitin" uze linokuba eliphezulu apho kuya kubakho amathuba amatsha ukulungiselela ukusetyenziswa antioxidants ayo kuphela kulo mkhuba bezonyango belo zamehlo, kodwa nakwezinye amasebe amayeza.

Izimvo kulungiselelwa

baqinisekiswa ezininzi abantu abaye basebenzisa wamehlo "Vizomitin" ngokusekelwe isenzo sabo. Izigulane Sinovuyo lokuba ukulungiselelwa ayifuni instillation rhoqo, kunye nokusetyenziswa ixesha elide, yaye wenza ntoni nezihlandlo ukusetyenziswa kwayo kungancitshiswa kube kanye ngemini. Ngokutsho kubathengi, iingxaki amehlo ngokwenene kuconjululwa. Angabikho neentloni, ngaphantsi udiniwe, ukudumba kwenzeka. Naziphi na iziphumo ebezingalindelekanga, izigulane zaye akekho.