"Sumatriptan": imiyalelo ukusetyenziswa, ncomo. Drug analogue "Sumatriptan"

Yintoni ukuthini iziyobisi "Sumatriptan"? Imiyalelo zokusetyenziswa ichiza, isenzo bayo amayeza, nokumila ubume kuya kwenziwa phambili umganyana. Kwakhona, kweli nqaku siza kukuxelela ngezinto i-ebonisa contra kunye neziphumo ebezingalindelekanga kweli chiza, oko iindlela zalo yesicelo umthamo, enoba wayenazo na analogue njalo njalo.

Ukubunjwa amayeza kunye Nokuhlanganiselwa yayo

Okwangoku, iipilisi kuphela enokufunyanwa ezikhemesti ngeempumlo ukutshiza "Sumatriptan". Imiyalelo yokusebenzisa esi sixhobo inika ingcaciso epheleleyo malunga nokuqulunqwa kwenqaku ichiza. Ubuyazi nayo iya kuba nako ngoku.

A macwecwe umboniso wawutyabeka ziqulathe le into esebenzayo ezifana sumatriptan succinate. Ngokuphathelele izinto abangabancedani, ezi ziquka ezi zilandelayo: calcium hydrogen phosphate dihydrate, microcrystalline kwincindi, giproloza (Klutsel okanye LF hydroxypropylcellulose), nemagnesium stearate, mannitol (okanye mannitol), isodiyam croscarmellose (okanye primelloza).

Lezithako ngeempumlo esebenzayo ukutshiza "Sumatriptan" Libuye sumatriptan. Njengoko yezigqeba ongumncedani, kodwa ingatshintshwa ngokungqinelana imilo yokhululo medicament. Kufuneka kuqatshelwe ukuba isitshizi esetyenziswa ukunyanga eziqhelekileyo ngaphantsi lee amacwecwe. Noko ke, kufuneka abasebenzisi zabo. Ngokuqhelekileyo, ezi ke kwizigulane bangakhululekanga ukuthatha iyeza ngomlomo.

Ezona mpawu amayeza ye ichiza

Ziziphi iimpawu ezi "Sumatriptan" tablets, nto leyo kwakhona sijonga ngakumbi?

Uthe alungiselelwe a protivomigrenoznoe ithetha. It is a agonist ethile uyakhetha of receptors-5-HT1-serotonin, leyo abekiwe egazini iimpahla ebuchotsheni. Kufuneka kuqatshelwe ukuba ichiza alunasiphumo kwi kwezinye iintlobo zeHPV zingonobangela receptors-5-ht-serotonin.

Emva ezithatha ichiza yenza vasoconstriction yelo umandlalo carotid yodidi oluphezulu. Ngoko ke, lo medicament "sumatriptan" (tablets) obonelela intracranial igazi kwizihlunu extracranial. Kufuneka kuqatshelwe ukuba vasodilatation meningeal, kunye ukudumba zabo kwaye oonobangela migraine ebantwini.

Asikwazi ukuba emva kokwamkelwa kwale sixhobo ayinasiphumo obonakalayo (negative) flow kwegazi lobuchopho. Tablets anqanda kuphela umsebenzi receptor Imisonto afferent (neziphelo zazo) le-luvo trigeminal, nto leyo ifumaneka kwi laseDura. Oku kwenzeka ngenxa ukwehla ukukhululwa neuropeptide oluvo.

Kufuneka kwakhona wathi ichiza "Sumatriptan" yaye "Sumatriptan Teva" ukubeka ecaleni ngokupheleleyo photophobia kunye isicaphucaphu, eziqhagamshelwe ngqo yokuhlaselwa migraine.

Ukusebenza ichiza

Indlela ngokukhawuleza kuza iingenelo emva kokuba ulwamkelo "Sumatriptan 'iziyobisi? Baqinisekiswa yale medicament ziqulathe ulwazi ichiza aqale ukwenza imizuzu kuphela emva kwe-30. Ngoko isigulane kufuneka athathe ne nedosi ye-100 mg. Ngokuzenzekelayo, 50-70% ezigulane eceleni ngokukhawuleza ukuhlaselwa migraine emva kokusetyenziswa 25-100 mg beziyobisi. Emini ngo 1/3 izigulane ndiphinde ndazisebenzisa, nto leyo ifuna ukusetyenziswa kuphindwa beziyobisi.

Pharmacokinetics

iziyobisi "Sumatriptan" sebenzi elingakanani? Impendulo yalo mbuzo ikwafunyanwa kwi imiyalelo ukusetyenziswa kwemali. Emva kokufumana ichiza ngaphakathi, yena phantse nangoko wendele lokugaya. Emva kwemizuzu malunga 45 uyondelelwano lwee- ichiza serum igazi ifikelela malunga ne-70%.

Ngenxa ukufakwa engaphelelanga futhi umzimba lokuqala-pass, lo bioavailability ngokupheleleyo kwesi isiyobisi xa kubhalwa nge-avareji-14%. Ngokubhekisele ukuzenza iiproteni plasma yegazi, oko liphantsi kakhulu (malunga 15-21%). Ixesha isiqingatha-ubomi malunga iiyure-2. Ukulungiselela yayifumana becala ngenxa nezintso.

Absorbability beziyobisi kwiimeko ezithile clinical

Ngokutsho ubugcisa, uhlaselo migraine musa kakhulu kuchaphazela absorbability yomenzeli sumatriptan esebenzayo (ngenxa yokufakwa okanye ulawulo intranasal).

Ukuba isigulane kuphazanyiswa umsebenzi kwesibindi, ngoko emva kokusebenzisa amayeza ukuze babe izinga lwe isithako esisebenzayo kwi plasma. Oku kwenzeka ngenxa yokunciphisa ubucukubhede lokuqala-empumelelo.

Ubungqina obubonakalayo buxela ukuba ukusebenzisa amayeza

Kwezinye iimeko, prescribers "Sumatriptan"? Imiyalelo zokusetyenziswa ichiza uthi kufuneka zithathwe kuphela izenzo migraine (ngaphandle aura okanye wayo).

Izimo nokusetyenziswa

Ukuba kukho izinxaxhi Akuvunyelwe ukuthatha amayeza "Sumatriptan" analogs kweli chiza ngayo ngokungqongqo? Ndifuna ukugxininisa ukuba noku imiyalelo kukho isixa esikhulu solwazi. Kungenxa yoko le nto ngaphambi kokuba uthathe ichiza kunye nayo, qiniseka ukuba ufunda.

Ngoko ke zintoni contra-kubonakala lubonise ichiza? Cinga kuluhlu olusekenene ngoku:

• ukwanda Uvakalelo isigulane iziqalelo kuqulunqo;
• izigulane abadala (iminyaka engaphezu kwengama-65);
• basilar, okanye oftalmoplegicheskaya migraine ifomu hemiplegic;
• yokwamkela ngaxeshanye a medicament kunye imithi eziqulathe ergotamine kunye nezakhi zayo ezahlukeneyo, kwakunye Mao inhibitors (akuvumelekanga sisamkela kuthetha ngaphambi kweentsuku ezili-14 emva kokuba ukurhoxiswa uthe ARVs);
• isifo sentliziyo, orhanelwa oko;
• kolutsha kunye nobudala babantwana (eyi-18);
• angina, kuquka Prinzmetal angina ;
• ukukhulelwa kunye ibele;
• iposi engabalulekanga, kuquka aphuma embalini;
• lwegazi (uhlobo eyenzeke);
• lwegazi (uhlobo elawulwayo);
• occlusive kwemithambo peripheral;
• sokuwa, kubandakanywa naziphi na iimeko zophendlo lwezifo ezinxulumene zisembundwini sokuwa eliphantsi;
• ukusilela kwezintso okanye hepatic;
• ukufa icala okanye isimo otshintsho yokumpompoza kwegazi yobuchopho, kuquka imbali kwemali.

Njengoko kukhankanyiwe ngasentla, ichiza "Sumatriptan" kufuneka zisetyenziswe ngexesha lokukhulelwa. Kodwa ukuba ubungozi obunokubakho umbungu ngaphantsi isibonelelo ukuya unina, solo emiselweyo amabhinqa zikarhulumente nabongi noomama. Kodwa, ukwenza oku liyincutshe onamava kuphela (ichiza sithathwa ngqo phantsi kweliso lalo). Hi ndlela leyi, ayikhuthazwa tu into yokuba usana ibele lakho phakathi kosuku emva kokufumana amacwecwe utshilo.

Drug "Sumatriptan": imiyalelo yokusebenzisa

Eli chiza sithathwa ngomlomo, kungakhathaliseki ukuba ukutya ukutya. Esithathwa kule meko kufuneka kulingana nama-50 mg (xa kukho imfuneko - 100 mg).

Ukuba ugqiba ekubeni usebenzise medicament ngeempumlo "Sumatriptan" (ukutshiza), umthamo yayo ngu-20 mg ethatheni nganye. ulawulo-phindo lwe ichiza livunyelwe ngaphambi kwe emva 2 hr.

Esithathwa eliphezulu yemihla ngemihla yolawulo yomlomo mg 300. Xa usebenzisa ekuqulunqeni intranasal, nto ilingana amathamo ezimbini mg-20.

iimpawu imithi

Ngoku uyazi indlela yokoyisa a migraine. "Sumatriptan" (tablets zokutshiza) alwa kakuhle umsebenzi. Nakuba kunjalo, kufanele kuqatshelwe ukuba medicament ayenzelwanga ukuba prophylaxis of uthe kutenxa kokumiselweyo.

Ukusetyenziswa ichiza kunokwenzeka kuphela kwimeko apho uphethwe bakhohlwa. Ngaphambi kokuqeshwa ichiza "Sumatriptan" izigulane Nedlac kwaye kwafunyaniswa ukuba ngaphambili kunye migraine, ugqirha kufuneka uqinisekise ukuba alawule ezinye iimeko luvo eyingozi. Kufuneka kwakhona ikhunjulwa into yokuba izigulane unesifo emva kokwamkelwa kwezi tablets ndandinixelele ukuphuhlisa ukuphazamiseka cerebrovascular.

Ubukho ezingaqhelekanga kwinkqubo yokujikeleza (kumadoda amakhulu ngaphezu kweminyaka engama-40 kunye namabhinqa postmenopausal) ufuna zoviwo lokulungiselela nezoviwo ukuze ngaphandle ukungaqheleki iimpahla sentliziyo kunye negazi.

Okwangoku kukho ulwazi malunga isahlakalo kwephulwa kuququzelelo, ubuthathaka kunye hyperreflexia emva ezithatha ichiza, "Sumatriptan" kunye namanye amachiza ukusuka kwiqela uyakhetha inhibitors.

Ngaphambi nasebudeni unyango kunye ichiza thaca kufuna ukutya ukutya rhoqo, kwakunye ngqo ukutya engqongqo. Ngenxa yoko, isigulane kufuneka kuphelisa kudliwe zenu ukudla eziqulethe tyramine kweziyobisi (itshokolethi, zesitrasi, ikoko, iseleri, amandongomane, itshizi, iimbotyi, kunye iitumato). Ukongeza, kuyimfuneko ukuba bashiye zokusela iziselo ezinxilisayo, kuquka iiwayini ezibomvu, abengezelayo neyomileyo, champagne, ibhiya.

Ukuzilolonga nokulondoloza yokuphila esempilweni ngokubanzi (ukuhamba, ukuqubha, Ukuskiya), kwakunye ubukho nasiphi uyithandayo negalelo ukuvela neemvakalelo ezintle, nto leyo ithintela uphuhliso isigulana abantu yokuhlaselwa migraine.

Imiyalelo malunga nokusetyenziswa spray ngeempumlo

Igama orhwebo isitshizi kunye sumatriptan into esebenzayo iyalila "Imigran". Eli chiza la macandelo alandelayo:

• kuqinisa iminwe;
• alunywe;
• blue iqhosha.

Kufuneka kuqatshelwe ukuba iqhosha blue luvuliwe ngokukhawuleza kakhulu kwaye kube kanye kuphela. Kule uxhulumaniso uyacetyiswa ukuba cofa kuyo uze kwincam ungeneyo sicatshulwa ngeempumlo. Kungenjalo, idiphu ngokupheleleyo kuya kubakho ndabulaleka.

Ukusebenzisa isitshizi ngeempumlo, isigulane kufuneka athathe indawo obutofotofo, elele phantsi, emi okanye ukuhlala. Hi ndlela leyi, emva kucetyiswa nakumarhanana isigulane ukuba icocwe kunye namalaphu okusula cotton.

Ukususa iphekhi blister kunye nokususa ichiza ukusetyenziswa ngeempumlo, ichiza kufuneka lingeniswe ethatheni mnye. Ezinye sicatshulwa ngeempumlo, kufuneka wacofa ngomnwe ukuya ekudibaneni ngeempumlo. Kulo mzekelo, isigulane kufuneka ukuphefumla ngomlomo.

Faka incam kulo kuqulunqo ngeempumlo ethatheni kufuneka 1 sentimitha. Intloko isigulane kufuneka ugcine ngqo, kungekhona ukuze ulahle umva umva. Emva koko, isigulane kufuneka uvale umlomo wakhe benza Ukuphefumla ezithuleyo ezicothayo ngokusebenzisa impumlo, kunye umgudu ngaxeshanye ukuze nqakraza kwiqhosha blue kunye ubhontsi wakho. Kulo mzekelo, umntu ngathi iqhosha ixinene kakhulu. Kodwa akunjalo. Ngexesha Inaliti beziyobisi waya kwisisu ngeempumlo ze isigulane kufuneka uve isandi nqakraza ityhafile. Oku kuthetha ukuba iqhosha iye yasebenza ngempumelelo.

Emva kwale nkqubo, isigulane kufuneka ukuba ukuvula umlomo wakhe Phefumla kancinane ngalo. Head kufuneka siqhubeke ukugcina ngqo. Okulandelayo, isigulane kufuneka uphefumle cwaka nge lweHo- ngeempumlo, nangenxa koko uwukhuphe - ngomlomo (imizuzwana 10-20). Kucetyiswa ke ukuba ukuphefumla nzulu kakhulu.

Xa inkqubo igqityiwe isitofu beziyobisi, umntu azive ubukho ukufuma impumlo, kunye njengento engafanelekanga. Ezi njengokungathi azikho yingozi empilweni ngok kakhulu badlule ngokuzenzekelayo. Emva kokuba isicelo olunye kwisixhobo nga ishenxiswe.

Oyi xa usebenzisa

Drug "Sumatriptan Teva", izimvo zazo HIV ukuba kakhulu, kufuneka zithathwe ngononophelo kakhulu abaqhubi bezithuthi, kwakunye nabo bathatha inxaxheba kwimisebenzi eziyingozi ezifuna amazinga ukwanda yokusabela kunye nengqalelo.

imiphumela emibi

Kungabangela iziphumo ebezingalindelekanga amayeza "Sumatriptan"? Amalungiselelo okulolu hlobo igalelo kuphuhliso iqela elikhulu iziganeko ezimbi. Makhe siqwalasele ngokweenkcukacha ngaphezulu:

• kwegazi yabantu. Ngomhla inxalenye inkqubo isigulana wegazi ukuze waqaphela, iposi engabalulekanga, uxinzelelo lwegazi okwethutyana ophezulu (idla kungekudala emva kokungenisa), tachycardia, bradycardia, tachycardia, kwaye kwezinye iimeko, arrhythmia, ziba kwemithambo yenhliziyo, utshintsho ECG idlule syndrome Raynaud kaThixo.
• luvo kunye izitho. Emva ezithatha ichiza umntu namava ukudinwa, isiyezi, yokuswela amandla, ukozela. Kwezinye iimeko, ichiza ebangela diplopia, ukuxhuzula, ukwenzeka yokudanyaza iyabhabha phambi kwamehlo akhe, nystagmus, sinciphise acuity ezibonwayo, scotoma kunye noluphakathi ilahleko otshintsho umbono.
• Lokugaya. Ukususela kokudla kwi isigulane kubonwa uyagabha, dysphagia, isicaphucaphu, nikhulela (minor) umsebenzi enqanda zesibindi, ubuhlungu esiswini kunye nokudumba kobuchopho.
• Umzimba. Emva ezithatha ichiza, ezinye izigulane ingxelo ukubonakala pruritus, irhashalala, urticaria kunye erythema. Kwakhona, kukho anaphylaxis, yimvakalelo ubushushu, ukuntlontlozela kunye neentlungu entloko, ubunzima, uxinzelelo, ukuhlisa, kunye myalgia. ulawulo Intranasal beziyobisi nga kwenzeka ngohlobo reactions zengingqi kwemiphunga ukuphazamiseka zezomzuzwana okanye nokushisa emqaleni kunye lweHo- ngeempumlo kunye samarhanana ukopha.

Intsebenziswano kunye namanye amachiza

Njani eminye imithi ngokusebenza kunye nefuthe "Sumatriptan 'iziyobisi? Imiyalelo, izimvo kwiingcaphephe ngalo mbandela eziqulathe ulwazi ilandelayo. Ukusetyenziswa ngaxeshanye ichiza kunye medicament "Ergotamine" kwaye ithetha ergotaminsoderzhaschimi nomonde kunokwenzeka vasospasm elide. Kulo mba, lo lokuphumla phakathi amathamo kula machiza kufuneka ibe ziiyure ezingama-24.

Ngokutsho uphando, kukho intsebenziswano phakathi ichiza "sumatriptan" kunye Mao inhibitor. Ngaloo isantya pathways lifinyele kuqala, kunye nokunyuka ingqalelo yayo.

Nokusebenzisa ngaxeshanye uthe amachiza-migraine, kwaye ephethwe uyakhetha serotonin reuptake inhibitors, isigulane lisenokuba ubuthathaka, hyperreflexia nokuphazanyiswa nolungelelaniso zeentshukumo.

Libanda, amachiza (iimpawu, unyango)

Kwenzeka ntoni ukuba anithanga ukuthobela idosi ekucetyiswa ngugqirha wakho? Xa ukusebenzisa ngokugqithisileyo yokulungiselela "sumatriptan" izigulane ukwandisa ngentla ngayo icala. Kulo mba, imeko yabo Kudinga ekhethekileyo iiyure ezili-10.

Ukuba kuyimfuneko, i-isigulane libanda, uncediswa ngokohlobo unyango nomqondiso.

Drug "Sumatriptan": analogue kunye nexabiso zeziyobisi

Zuza isixhobo nanini na ekhemesti. Kufuneka kuqatshelwe ukuba ixabiso "Sumatriptan" beziyobisi, xa kuthelekiswa nabanye, iphantsi kakhulu. Ngenxa yoko, amacwecwe kwama-50 umboniso kugalelwe kuwe kuya kufuneka uhlawule 170-200 kuphela engange Russian. Njengoko ngokuba ngeempumlo kuthetha ukuba ixabiso layo ngezinto efanayo.

nokuba noogxa babe ichiza "Sumatriptan"? "Amigrenin" - ichiza leyo kakhulu ngokuqhelekileyo ezifunyenwe ukuphelisa ukuhlaselwa migraine ukuba ngasentla kuthetha umfundi ongekhoyo esikolweni ekhemesti. Ngaphandle kwalo, analogue medicament "sumatriptan" kwimfuyo eqhubayo amachiza zilandelayo: "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-Teva", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "njalo-njalo.

Kwakhona, njengokuba ukuxinana efanayo ngeempumlo, ezinye iingcali Sicebisa usebenzise spray "Imigran".

iimeko Ukugcinwa ezikhabhathini

iziyobisi thaca kufuneka kugcinwe kuphela eyomileyo zikhuselwe ukusuka kwindawo elangeni. Lobushushu kwi gumbi kufuneka ungabi ngaphezu kweqondo lama-25. Ubomi lokugcinwa kwezinto zonyango ndawo iminyaka emi-3. Emva kweli xesha, ichiza kufuneka zisetyenziswe.