"Korvitol": analogue, ncomo, imiyalelo zokusetyenziswa. Yintoni indawo "Korvitol 50" yaye "100 Korvitol"?

Izifo sentliziyo zezona common kakhulu. Ukwenzela ukunciphisa ngokukhawuleza uxinzelelo, ukunciphisa izinga intliziyo, ukunciphisa imeko sifuba angina, migraine, iziyobisi ukuthatha "Korvitol". Analogs yamisa rhoqo ngenxa yezizathu ezithile. Eli chiza Izimo, ngoko ngaphambi kokuba uyisebenzise, bonana nogqirha wakho.

ifomu Ukukhululwa kunye nokwakhiwa ichiza

Ichiza fanele ukuya beta-blocker. Oveliswa ngohlobo amacwecwe ezimhlophe abe spigot setyhula, kunye nomngcipheko chamfer elinye macala. Ifumaneka iidosi ezimbini:

• "Korvitol 100". Iqulethe 100 mg eziqhumayo nto metoprolol tartrate.
• "Korvitol 50". Kuye sisincoko-50 mg isithako metoprolol tartrate esebenzayo.

izinto ezongezelelweyo zombini iintlobo yembambano efanayo phambi monohydrate lactose, nemagnesium stearate, povidone K30, isodiyam croscarmellose, lesilicon dioxide, talc colloidal.

Amacwecwe zipakishwe ngendlela namadyungudyungu zealuminum iziqwenga ezili-10. Le phakheji inokuba ukusuka namadyungudyungu-3 ukuya kwi-10. Kumayeza unikwa yesikhokelo.

Pharmacology kunye pharmacodynamics

"Korvitol" is a cardioselective beta-blocker, nto leyo ebonisa akukho msebenzi sympathomimetic kwaye akukho inwebu ozinzileyo izakhiwo. It anazo umfutho, antiarrhythmic, iipropati antianginal.

Abangaphangeliyo ngesixa esincinci β1-adrenergic receptors zentliziyo kwaye yehlise ukuyilwa catecholamines isebenze emkhosini ATP, kunciphisa intracellular calcium ion yangoku. Ngokungalunganga BATM, chrono-, syndrome kunye inotropic impembelelo.

TPR ekuqaleni kokusetyenziswa beta-blocker ukunyuka, yaye emva kweentsuku ezimbalwa basebenzisa iziyobisi babuyela kwinqanaba yokuqala, xa ukusetyenziswa ixesha elide lifinyele.

impahla umfutho zibangelwa ukuncipha kwimveliso ezesifuba Yindibanisela a inhibition renin le renin-angiotensin kunye neenkqubo luvo, baroreceptor nobuzaza ukubuyiselwa arch aortic ekugqibeleni ukunciphisa impembelelo yoluvo enovelwano kunye. Oku kunciphisa uxinzelelo igazi lokuphumla ngexesha umthwalo emzimbeni neuropsychic.

Isiphumo iqinile kuyafikelelwa kuzo kwimizuzu. Ngenxa yoko, uxinzelelo lwegazi iSystolic uvikivwa emva kwemizuzu elishumi elinesihlanu emva ezona yure ezimbini. Le nguqu afunyenwe buhlala iiyure ezintandathu. uxinzelelo lwegazi ukuzala litshintsha kancinci. Ukuqina kunokuzuzwa kuphela emva kweeveki eziliqela zonyango.

Antiangialnye umgangatho ichiza wagqiba ukuhla kwemfuno ioksijini engabalulekanga ngenxa ukuhla kwireyithi entliziyweni. Ukuncipha susceptibility lokuba innervation engabalulekanga enovelwano, inani kunye nobukhulu yokuhlaselwa angina. Kwandisa unyamezelo emzimbeni.

Iipropati Antiarrhythmic kubonakaliswa xa kususwa ibonwa arrhythmogenic ukunciphisa excitation kunye ethunjini sinus isingqisho, kunye inhibition of AV-Uhanjiso. Xa izenzo tachycardia supraventricular, ukwenzeka fibrillation atrial kunye ubhaqo of tachycardia sinus ezinxulumene nesifo sentliziyo kunye hyperthyroidism, iyeza kunciphisa izinga intliziyo. Maxa wambi ulibuyele sinus isingqisho. Kuwukhulula migraine kunye nokuthintela livela kwixesha elizayo.

Xa isicelo ngeedosi eziphezulu kwezonyango, ngokungafaniyo nonselective beta-blocker, asinto ibe nafuthe kangako ngokukhawuleza kwi amalungu eziqulathe β2-adrenergic receptors, kunye ekudleni ukutya. Xa kusetyenziswa ngeedosi ezinkulu (100 mg ngosuku) kunempembelelo ukuvimbela kwi zombini iintlobo zeHPV zingonobangela β-adrenoceptor.

Metoprolol 95% ifunxwe ukusuka esiswini kunye amathumbu. I-plasma xi liphezulu waphawula emva kweeyure 1-2. Ngenxa nethe esebenzayo xa kuqala ukuthatha bioavailability isiyobisi-50%. Phezu ukusetyenziswa elandelayo ichiza, oko kwandisa kwi-70%. Ukutya ukutya lonke ixesha kwandisa bioavailability ka-20-40%.

"Korvitol 'inxibelelene ubonelelo igazi nge-10%, vd - 5,5 l / kg. Udlula BBB kunye umqobo plantsentarny. Kwazona ngobisi lwebele ngeedosi ezincinane.

Phantse yonke ichiza umzimba esibindini. metabolites ezimbini eziyintloko bathathu luphawulwa beta-adrenoceptor ekuvimbeni impahla. Nethe beziyobisi uthabatha inxalenye isoenzyme ye cytochrome P450 (CYP 2D6). Kukhuthaza ithatha malunga 3.5 iiyure. Ichiza esiswini saso umchamo, no-5% iya ingatshintshanga.

isifo sezintso anqanda yokucolwa of metoprolol. Kuphula bioavailability in kwesibindi. Le into esebenzayo ongakhululwanga ivela emzimbeni ngexesha olugqitha esikhumbeni.

Ubungqina obubonakalayo buxela ukuba iziyobisi ukusetyenziswa

"Korvitol" kufuneka zisetyenziswe kuphela kagqirha lwegazi. Oku kusetyenziswa monotherapy okanye zidityaniswe kunye nezinye izinto umfutho. Lo ebonisa ukuba ukusetyenziswa yi tachycardia, isifo sentliziyo, iposi engabalulekanga. Amaxesha amaninzi sebenzisa "Korvitol 100", analogue ukunqanda kwamalungu omzimba kunye neengxaki isingqi intliziyo, uthintelo migraine.

Izimo

"Korvitol 50", kwaye ichiza xa kukho umthamo 100 mg ingenakuthatyathwa uthuke cardiogenic. Contraindication ikhonza AV-block II kunye degree III kunye block sinoatrial. Musa ukuthatha amachiza syndrome kokugula sinus bradycardia. Ban kukho ukusilela peripheral yegazi kunye nokungaphumeleli intliziyo. Tablets musa ukusela angina, iposi etsolo engabalulekanga kunye umfutho hypotension.

Awukwazi ukudibanisa amayeza "Korvitol 50" (ngokufanayo, ukuba kukho imfuneko, kuya kukunceda ukhethe ugqirha ukuphatha) kunye nokusetyenziswa monoamine oxidase inhibitors nezitofu efakwa "Verapamil".

Ichiza akayibonisanga ngexesha lwebele-ibele, abantu abangaphantsi kweminyaka elishumi elinesibhozo ubudala, kunye nabantu abane hypersensitivity ukuba metoprolol, izinto ezongezelelweyo njengenxalenye indlela.

Kunye ezizodwa isilumkiso ithathe amayeza seswekile, isifuba inyumoniya, emphysema, lactic metabolic, iphika obstructive ezingapheliyo imilo. Kuphela phantsi kweliso lwezonyango kufuneka adle abantu amayeza kunye nesifo semithambo peripheral, kwezintso okanye insufficiency hepatic. Balumke ekusebenziseni iipilisi 'Korvitol "kufuneka izigulane myasthenia gravis, AV-kuvalwe iindlela I isidanga, kwakunye pheochromocytoma, ukudandatheka kunye hyperthyroidism. Ngenyameko ndichaza oku ukhwekhwe kunye nezigulane abadala.

Ngexesha lokukhulelwa "Korvitol" ipilisi ukumisela kuphela kukuswela engxamisekileyo, xa kukho bradycardia ezingekazalwa, hypotension, hypoglycemia. Kulo mzekelo, inkqubo impiliso kufuneka uthathe indawo phantsi kweliso n'wina gqirha. Kwixesha elizayo, akhokele kweliso nokusingelwa usana ngexesha leeyure 48-72 emva kokubeleka.

ifuthe Metoprolol ngeentsuku komntwana yokuqala yobomi ayaziwa, ngoko abagada ukusebenzisa ichiza, kucetyiswa ukuba uyeke ukuluncancisa.

"Korvitol": ukusetyenziswa amathamo ecetyiswayo

Ikhosi zonyango isigulane ngasinye umiselwa gqirha, kwaye kuxhomekeke kule khosi yesi sifo. oyingcaphephe Kuphela kufuneka anyulwe ulwamkelo kunye umthamo ichiza "Korvitol". Imiyalelo yokusebenzisa (analogs kweziyobisi kbavelisi Russian abiza kakhulu) ichaza kuphela iirejimeni ezindala e izifo ezithile.

Ngenxa yoko, lwegazi kunye angina ukusetyenziswa kweziyobisi ngaphakathi 100 mg kanye yonke imihla okanye 50 mg kabini ngemini. Ukuba kuyimfuneko, isixa ichiza lanyuka ukuya kwi-100 mg, kuhluthwa kabini yonke imihla. Le idosi iphezulu kunokwenzeka imihla 200 mg.

nokuphazamiseka yeZiko wentliziyo, ukumqumbisa ukuvela tachycardia, ulwamkelo lokuqala ibhalwa isixa ka 50-100 mg ngosuku. Esi sixa-hlulwa ibe izihlandlo ezibini. Njengoko kufuneka idosi yemihla ngemihla landile ukuya 200 mg.

Ukuthintela migraine iziyobisi ezimiselwe yi-100 mg kanye ngemini, okanye ml 50 kusasa nangokuhlwa. Xa isiphumo enyangayo ifunyanwa, ithamo kufuneka incitshiswe. Le nkqubo kufuneka yenziwe kancinci phantsi kweliso zonyango abasenyongweni.

abantu abadala kunye nesifo sezintso idosi ihaemodialysis ngemihla hayi lifinyele. Xa sisibindi xa yonke imihla mabaphakelwe ichiza lifinyele, ugxininisa imeko yesigulane.

Kuzo zonke iimeko ngasentla, "Korvidol 'lisetyenziswa ngomlomo, emva kwesidlo wabahlamba phantsi intwana yamanzi. Iipilisi kufuneka makaginywe ngaphandle ukuhlafuna. Ukuba ichiza basela yonke imihla, ukuthatha ize kusasa. Xa kusetyenziswa kabini icwecwe ethathwe kusasa nangokuhlwa.

libanda

Medicine "Korvitol" xa kwimeko libanda, ngoko nangoko bayayeka ukuthatha. Iimpawu kakubi indlela ezivelileyo sinus bradycardia, isicaphucaphu, isiyezi, sinciphise uxinzelelo lwegazi, reflex gag, cyanosis, arrhythmia, bronchospasm, niphele, arrythmia ventricular.

Acute libanda degree yokuxhoba "Korvitol" (analogue eRashiya ungathenga ngayo nayiphi ekhemesti evela engange-30 nangaphezulu) abonisa ukuba abanjwe cardiogenic, angabikho zingqondweni, AV-yaye kuvalwe, ilahleko lokuqonda, cardialgia. Ngokuqhelekileyo, Iimpawu zokuqala ukusetyenziswa ngokugqithisileyo iziyobisi kuvela emva kwemizuzu engama-20 - Iiyure ezi-2 emva kokuba yolawulo.

Into yokuqala isigulane wahlanjwa esiswini kunye emiselweyo neziyobisi adsorbent. Ukuba bekukho ukuhla elibukhali kwi uxinzelelo lwegazi, umntu obekwe kwi Trendelenburg sikhundla. Xa uxinzelelo kusithwa kwinqanaba kakhulu kwaye kukho ukusilela kwentliziyo, bradycardia, ngoko elawulwa yegazi emva kwesithuba imizuzu 2-5 beta adrenostimulyatorov. Le nkqubo yenziwa phambi kokuba iziphumo ezidibanisayo. izitofu efakwa zingenziwa kwi umthamo we 0.5-2 mg "Atropine sulfate."

Ukuba yifuna lingapheleli, basebenzise iziyobisi ezifana "Dopamine," "Norepinephrine", "Norepinephrine" okanye "dobutamine". Ngamanye amaxesha ilawulwa 1-10 mg of "Glucagon" okanye ukuseta intracardiac pacemaker transvenous. Xa kuthe bronchospasm lesitofu a adrenostimulyatorov emthanjeni beta. Ukuba uxhuzula, ngoko ngokucotha wenze ngenaliti emthanjeni "Diazepam". Ihaemodialysis kulo mzekelo akusebenzi.

imiphumela emibi

ukulungiselela ukwamkelwa Constant "Korvitol" (iipilisi) kungabangela inxalenye Central luvo intloko ebuhlungu System, buthathaka kwezihlunu, ukudinwa ngokugqithiseleyo, ukuba nesiyezi, ukuba inhibition yokusabela kwengqondo kunye nokomzimba, paresthesia izandla neenyawo. Ebonakalisiwe ukudakumba, ukuxhalaba kunye noloyiko, ingqalelo aphazamiseka. ukozela bakhathazekile, amaphupha ezimbi, sokulibala, ukudideka, ilahleko memory lwexesha elifutshane. Asthenic syndrome kungenzeka.

"Korvitol" kunye analogs yayo kunokubangela ukungaboni, kome kakhulu kwindawo efakwe kwamehlo, ukuncitshiswa imveliso iinyembezi fluid. Kwiimeko ezinqabe kakhulu, kukho conjunctivitis, nokuthimliswa. Kukho ingxolo ezindlebeni.

Ichiza kunokubangela ukungasebenzi le nkqubo sentliziyo njengohlobo sinus bradycardia, izinga intliziyo eliphezulu, zokucutha ngesiquphe, hypotension, intolerance umlinganiswa. Kwiimeko ezinqabileyo, ukuhla contractility engabalulekanga, zisiba sisifo sentliziyo, arrhythmia, vasoconstriction. patency iqhosha ukuphazamiseka. kuvela kardialgiya.

Kunye nokusetyenziswa rhoqo iziyobisi waphawula kwekhono ye phecana emathunjini, nto leyo ezabonakala ngokohlobo isicaphucaphu, ukugabha reflex, iintlungu esiswini, urhudo, umlomo owomileyo. Ezinye izigulane waphawula utshintsho ezithandwayo, ukwanda umsebenzi obalulekileyo enqanda zesibindi. Kwiimeko ezinqabe kakhulu, ebonakalisa hyperbilirubinemia.

Ngenxa unyango zaye bephawula ukusabela dermatological. Le ukhwekhwe kunye okubi yayo, bomvu, angawokubhuda. ukubila ngokugqithisileyo, kwakubhalwa, alopecia uhlobo ingathityazwa kunye photodermatosis.

ziphumo bezingalindelekanga yokuphefumla nazo ngokohlobo dyspnea kunye ingxinano la mabinzana ngeempumlo. Ezinye izigulane ndinesifo nokubamba-bamba umphefumlo.

Ngamanye amaxesha kwakukho hypoglycemia kunye nemeko hypothyroid. izigulane zabagula thrombocytopenia, leukopenia, kunye agranulocytosis. Kukho aleji ngokohlobo sokudlathuka kweenwele, ezindlwini kunye njengamaqhakuva. Kwabonwa iqolo (kwamalungu), ukutyeba, ilahleko yobuntu, amandla.

oyi

Xa ukusetyenziswa kweziyobisi ethwele ulawulo ekhethekileyo izinga kwentliziyo, uxinzelelo lwegazi kunye iswekile amanqanaba, ingakumbi xa izigulane kunye seswekile sinwenwa. Kwimeko yokugqibela, ithamo uyonyulwa ngokuhambelana kwepatheni sifo.

Kufuneka bafundise isigulane indlela yokubala izinga lentliziyo kunye nemfuneko ukuyalela icebiso ugqirha xa izinga intliziyo ngaphantsi kwama-50 u. / Min.

Ukuba emisiweyo eliphezulu-dose (200 mg ngosuku), kunciphise cardioselective. Xa izigulane unyango ukusilela intliziyo lwenziwa ngexesha imbuyekezo.

Kungandisa ubungqongqo reactions hypersensitivity (nembali okuphinde komzimba) kunye nokungabikho isiphumo ekuqalisweni kwe amathamo aqhelekileyo of "Epinephrine".

Kwisiqalo beziyobisi, kungaba kubi iimpawu yoluvo umfutho kwegazi.

Ukupheliswa unyango wenziwe ngcembe, ukunciphisa ithamo ukuya ezantsi iintsuku ezilishumi. Musa zenyuka ukusirhoxisa ichiza, njengoko inokubangela angina nokunyusa uxinzelelo lwegazi.

Xa izigulane ithamo angina lukhethiwe ukwenzela ukuba izinga intliziyo ilingana 55-60 u. / Min kwaye ayidluli 110 BPM ngexesha umsebenzi ngokwasemzimbeni. / Min.

Abantu lenses kufuneka ukwazi ukuba ngexesha unyango, beta-blocker ukuze ukunciphisa imveliso ulwelo iinyembezi.

Metoprolol kwezinye iimeko tifihla iimpawu hyperthyroidism. Izigulane thyrotoxicosis contraindicated ukurhoxiswa ngokukhawuleza beziyobisi, njengoko oku kuya mandundu kuphela sifo.

izigulane seswekile ayikwazi nangoko ukubona tachycardia wavusa hypoglycemia. "Korvitol" hayi ukwandisa insulin-eyabangelwa hypoglycemia okanye ukulibaziseka recovery glucose yegazi kumanqanaba yesiqhelo.

ngexesha uthatha amayeza abadala kufuneka basoko belwakhele umkhanya uxanduva umsebenzi yezintso, kwakunye izigulane insufficiency kwezintso.

Isilumkiso kufuneka uthathe amayeza umntu karhulumente edakumbisayo, njengoko iipilisi ukuze kuphuhle nobungozi besi sifo.

Ngethuba unyango kufuneka uyeke ukuqhuba kwaye uyeke imisebenzi enxulumene kwindlela ekwakugquba ngayo ingqalelo, efuna impendulo ekhawulezileyo.

Ngexesha unyango kufuneka sinxibe iimpahla ezivaliweyo, kuba ichiza kungadala photosensitivity.

Yintoni indawo 'Korvitol "?

Kwezinye iimeko, ichiza kunokubangela ezahlukahlukeneyo yeziphumo ebezingalindelekanga okanye nje musani kuza phezu isenzo, ngoko ugqirha lingatshintsha "Korvitol". Analogs babe iimpawu ezifanayo, ukunika isiphumo esifanayo zonyango kunye iqanjwa metoprolol tartrate. Bona zithandwa kakhulu kwaye ithengiswa phantse zonke ekhemisti kunye nexabiso abanye babo kunzima ukufikelela engange-50.

Ezi zilandelayo bayakwazi lokuthath'indawo "Korvitol" analogue ne zithako efanayo esebenzayo:

• "Betalok".
• "Egilok".
• "Metozok".
• "Metoprolol".
• "Serdol".
• "Vazokardin".
• "Lidalok".

neziphumo ezifanayo ube nemixube zilandelayo: "Aritel", "Estekor", "Bisomor", "Binelol" "Atenolol", "Kordinorm", "Betacam" "START_ITALICJ" "Nebilet", "Bisogamma" kunye nezinye iziyobisi.

Xa kutshintshwa iziyobisi omnye komnye, nibe nisazi ukuba analogu alusoloko lusebenza ngendlela eyiyo njengoko ichiza yakuqala, wadlula uthotho lweemvavanyo kunye uphando oluninzi.

Iindleko ichiza, izigxeko

Loo nto buyisela "Korvitol" nabalingani? Baqinisekiswa bathi kunzima ukufumana ichiza kunye ngexesha elifanayo samanyathelo, nangona luvelise eninzi iimveliso eziqulathe kanye izithako ezifanayo ezisebenzayo. Medicine kangangokuba ababambeleyo zibiza kakhulu, kodwa ke, njengokuba amava lubonise, ezi kunoogxa ezingasebenziseki kakuhle. Ukuphonononga abonisa ukuba "Korvitol" ngempumelelo kwandisa uxinzelelo lwegazi kwaye ithintela uphuhliso migraine.

macwecwe 50 ka 100 mg yeendleko 250-300 engange, okulinganayo izilinganiso-50 mg na umyalelo we-220 -250 engange.