I-Streptomycin yezilwanyana: imiyalelo yokusetyenziswa, inkcazo nokuhlaziywa

Kunani na kwaye kuboniswe ntoni na isilwanyana semfuyo njenge "Streptomycin"? Imiyalelo yokusetyenziswa, ixabiso kunye nenjongo yalo myeza iya kuxutyushwa ngezantsi.

Ifomu, inkcazo yemveliso yezilwanyana

Isilwanyana "iStreptomycin sulphate" (isilwanyana semfuyo) yityuwa yesiseko sezinto eziphilayo, eveliswa ngumkhuhlane omncinci.

Xa kuthengiswa le mveliso kuza kwifom ye powdroscopic powder okanye ubunzima obumhlophe bombala omhlophe, ukunambitheka okukrakra, ngaphandle kwento epholileyo kunye ne-solvle kalula kumanzi, i-novocaine ne-saline.

"I-Streptomycin" yezilwanyana zonyango isetyenziswe rhoqo njengoko kuyimfuneko. Kufuneka kwakhona kuqatshelwe ukuba luzinzile kwisixokelelwano esibuthakathaka, kodwa siphula kakuhle kwizixazululo ze-alkali (ngokufudumala) kunye ne-acids ezinamandla.

I-Pharmacology yemveliso yeyeza

Isilwanyana "iStripomycin" sisebenza njani kwizilwanyana? Imiyalelo yokusetyenziswa kweengxelo ukuba le arhente inezixhobo ze-bactericidal kunye ne-bacteriostatic ezinxamnye ne-gram-negative ne-gram-positive bathogenic bacteria.

Ukuphumelela kwe-antibiotics kwilezi ziyobisi ngenxa yokukwazi ukuvimbela iprotheni ekuqaleni kwiiseli ezincinci kumgangatho weerbosomes. Kufuneka kuphawulwe ukuba le nkunkuma ayinayo ingxaki kwizifo ezibangelwa yiClostridia kunye nezinye i-anaerobic microorganis, i-fungi, i-plasmodia, i-virus kunye ne-rickettsia. Ukongezelela, ezinye ii-microorganisms zibonisa ukuchasana okuphezulu kwi-streptomycin, kwaye ekuzaliseni ibhakteria ukuchasana nokulwa ne-antibiotic kwenzeka ezinsukwini ezimbalwa. Ngexesha elifanayo, iintlobo ezininzi ezingamelana nazo ziphuhliswa ekupheleni kwenyanga yesibini yonyango. Ukukhusela oku kunye nokuphelisa isifo, kufuneka usebenzise umlinganiselo omkhulu weziyobisi, kunye nokudibanisa namanye ama-agent antimicrobial.

Iimpawu ze-Pharmacokinetic zonyango

Ngaba isilwanyana "iStreomyomycin" sithatha izilwanyana? Imiyalelo yokusetyenziswa ithi xa ilawulwa ngomlomo ayinakunyuswa kwaye isuswe ngokupheleleyo emathunjini.

Ngeenjini zangomzimba, i-active active yeli gama ixakeka kwigazi, kwaye ifunyenwe kwiindawo ezixhasayo kunye ne-peritoneal, i-bile, i-vitreous humor, umchamo kunye namehlo.

Kwiinkqubo ezivuthayo ezivuthayo kwisigxina se-pleural, ukuxilongwa kwe-antibiotiki kunokufikelela kuma-50% epheleleyo legazi.

Ngokuphuhliswa kwe-meningitis streptomycin uyakwazi ukungena emgodini womgogodla kwisixa se-10-50%.

Le arhente idlula ngokulula kwi-placenta. Ngomsebenzi wesibindi oqhelekileyo, i-streptomycin iqokelela kwimigangatho ephezulu kwietululini ze-hepatic. Ngomsebenzi ophazamisayo wale nxalenye, ungena kwi-bile ngemali encinci, kwaye kunye ne-cholecystitis umxholo wayo kwi-gall bladder i malunga ne-85% yezinga legazi.

Ukuxinwa kwe-streptomycin kwimizimba eyahlukahlukeneyo kunye nezitho zigcinwa ngeeyure eziyi-8-13. Le nkunkuma isuswa ngokukhawuleza emzimbeni ngomchamo.

Iimpawu zokumisela iyeza

Ziziphi izifo eziphathwe yilo mbuzo? Yintoni umyalelo wokusetyenziswa kweziyobisi uthi ngale nto? "I-Streptomycin sulfate" icelwe:

• Nge-leptospirosis, tularemia, pneumonia;
• Isifo esiphezulu seengulube kunye ne-erysipelas, i-catarrha fever (engalungile);
• Izifo ezithatha i-Diplococcal, i-mastitis, i-endometritis;
• I-endocarditis, i-meningitis, i-postpartum kunye ne-sepsis enxeba;
• I-Actinomycosis yeenkomo kunye ne-campylobacteriosis, kunye nezinye izifo, i-agent engabangela ukuba i-streptomycin ibe nefuthe kakhulu.

Izibhengezo zokusetyenziswa

Ngaliphi na ixesha akufanele unikwe umyalelo wezilwanyana "Streptomycin" kwizilwanyana? Imiyalelo yokusetyenziswa, iqhotyoshelwe kumachiza, zibonisa oku kulandelwayo okulandelayo:

• Ukuphakama okukhulu kwezilwanyana ukuya kuma-antibiotic aminoglycoside;
• Ubuninzi bokungaphumeleli kwe-cardiovascular and renal.

Kufuneka kwakhona kuqatshelwe ukuba le nkunkuma ayikwazi ukudibaniswa namanye amanxusa ase-aminoglycoside (kuquka ne "Neomycin," i-Kanamycin, "i-Monomycin," i-Gentamycin ") ngenxa yokunyuka okunokwenzeka kwiphumo le-nephrotoxic.

Imiyalelo yesilwanyana "Streptomycin Sulfate" (ukusetyenziswa kwezilwanyana)

Ngaphambi kokusebenzisa i-ejenti kumbuzo, ichithwa kwi- saline yomzimba, amanzi angenawo okanye isisombululo se-novocaine esingu-0.25-0.5%. Umlinganiselo olandelayo uhambelana: 0.25 g we-streptomycin kunye no-1 ml we-solvent. Ngendlela, isisombululo se-glucose njengokugqibela asivumelekile.

Iindlela ezininzi ezingakumbi ziba nzima kakhulu. Isisombululo esisisigxina singagcinwa kwiqondo lokushisa kwiveki nganye (kungcono ukuyigcina kwisigumbi sefriji).

Ndingayisebenzisa njani iStraptomycin kwizilwanyana? Umyalelo wokusetyenziswa uthi isisombululo esenziwe ngokufanelekileyo sinokulawulwa nge-intramuscularly, kunye ne-topically, ngaphandle, ngomlomo, nge-intramuscularly, intraperitoneally, intratracheally, intrauterine kunye ne-intracavitary.

Iijoyi ze-intramuscular zezilwanyana zenziwa ngokujulile kwi-muscle. Olu unyango lwenziwa iintsuku ezingama-4-7. Amachiza alawulwa kabini ngosuku kwiiyure ezili-12 kwezi zilandelayo:

• Inkomo encinci - 10 mg / kg kubantu abadala kunye ne-20 mg / kg yezilwanyana eziselula;
• Amahhashi - 5 mg / kg izilwanyana ezindala kunye ne-10 mg / kg encinane;
• Imfuyo enkulu - 5 mg / kg kubantu abadala kunye ne-10 mg / kg yabaselula;
• Izinja, ihagu - 10 mg / kg kubantu abadala kunye ne-20 mg / kg kwizilwanyana eziselula;
• Inkukhu - 30 mg / kg abantu abadala kunye 40 mg / kg yabaselula.

Nge-leptospirosis, isilwanyana "Streptomycin" silawulwa iintsuku ezingama-4 ukuya kwi-25 mg / kg. Kwiimeko ezinzima kakhulu, le mali iyanda.

Kufuneka kwakhona kuqatshelwe ukuba, ukuba kuyimfuneko, eli liyeza lidibene ne "Polymyxin", "i-Penicillin" kunye namayeza e-sulphonamide. Ukuhlanganiswa kwezidakamizwa kubangela ukulungelelaniswa kwezenzo, kwaye kuthintela ukuvela kwamagciwane okuxhatshaza kwi-streptomycin.

Iziganeko ezimbi

Ngoku uyazi ukuba yintoni isilwanyana "Streptomycin Sulfate". Imiyalelo yokusetyenziswa kwezilwanyana nayo ichazwe ngasentla.

Ngamajingi eengxathuba, ukukhula ngokukhawuleza kwezilwanyana kungabonakalisa kwiinkomo , okuyiyo ingozi kwimpilo nobomi bezilwanyana. Ukuvela kweengxaki ezinjalo zihambelana neempawu zomzimba wakhe kwaye azixhomekeke kumyinge we-antibiotic esetyenziswayo.

Kwakhona, iingxaki ezahlukeneyo zingahlakulela emva kokulawulwa kokuqala kweziyobisi, ezidla ngokubangela ukunyanzeliswa kwezilwanyana ngexesha loqeqesho oluphindaphindiweyo.

Xa ukuphathwa kwesi sidakamizwa kwimfuyo kunokuthi kubonwe ukusabela okuyingozi, isifo sohudo, i-tachycardia, i-dermatitis, isisithulu kunye nokulungelelanisa ukulungelelaniswa kwesindululo.

Iindleko kunye neempendulo

Iindleko zesilwanyana esibuzwayo (ibhodlela eli-1 g) li malunga neeruble eziyi-18.

Ezinye iingcali azicebisi ukuxuba "iStreomyomycin Sulfate" kunye ne "Penicillin" kwisirinji enye. Nangona kunjalo, abanye abagqirha bezilwanyana basebenzise ngempumelelo le nhlanganisela kunyango lwemfuyo.

Abantu abadibene nezilwanyana zezilwanyana ixesha elide baxela ukuba unxibelelwano olunjalo lubangele ukuba bavelise i-dermatitis.

Ngokutsho kweengcali, ukuxelwa kwezilwanyana ezazilawulwa "iStreomyomycin" kuvunyelwe kuphela iveki emva kokusetyenziswa kokugqibela kwesi sidakamizwa. Imfuyo yezilwanyana ibulewe ngaphambi kokuba umhla wokugqibela ungasetyenziselwa ukuveliswa komgubo.

Ngokuphathelele ubisi, ngenjongo yokutya ingasetyenziswa kuphela emva kweentsuku ezimbini emva kokulawulwa kokugqibela kweziyobisi.