I-Zoledronic acid: isenzo samachiza kunye neempawu ezifanayo

Kuyaziwa ukuba i-bisphosphonates inepropati yokukhusela ukuphuhliswa kweetasastasis yamathambo nokukhusela ukulahleka kweethambo zenyama. Enye yezilwanyana ezinobungakanani beli qela yi-zoledronic acid. Kukho ubungqina bokuba le nkunkuma inokuvinjelwa kwe-antigenogenesis, ukungena kwe-tumor, ukunamathela kweeseli zesisu kwiithambo zethambo, kunciphisa i-apoptosis, kunye ne-synergism kunye ne-chemotherapy.

Ukubunjwa kwebhotile 1

I-Zoledronic acid monohydrates - 4.26 mg, i-excipients - i-citrate ye-sodium, i-D-mannitol.

Pharmacology

Inhibitor ye-bone resorption. I-Zoledronic acid yile klasi entsha ye-bisphosphonates kwiklasi ephakamileyo. Inomthelela okhethiweyo kwisithambo samathambo. Iyancipha umsebenzi we-osteoclasts, ngaphandle kokuba nefuthe elibi ekubunjweni kunye nezinye iimpawu zethambo leethambo. Impembelelo ye-bisphosphonates kwithambo isekelwe ekuhambelaneni okuphezulu kumathambo esithambo samamineralized, kodwa indlela echanekileyo yee-molecule ezinika umsebenzi wokuvimbela i-osteoclasts ayizange ifundwe nanamhlanje. Kwakhona kunesiphumo esichasene ngqo, esinika amandla kwi-metastasis yamathambo.

Kwi-vitro, kuye kwafunyanwa ukuba i-zoledronic acid, ekwenzeni i-apoptosis kunye nokunciphisa ukusasazeka kweseli, inefuthe le-antitumor ngqo kwi-myeloma, kunye neeseli zomhlaza zesisu, ngelixa kunciphisa umngcipheko we-metastasis. Kwakhona i-zoledronic acid inepropati yokunciphisa uxinaniso lwe-calcium kwi-serum ene-hypercalcemia, ebangelwa yi-tumor.

Iimpawu zokusetyenziswa

• I-osteolytic foci kwiindawo ezininzi ze-myeloma.
• I-osteoblastic, i-osteolytic, ixutywe ngamathambo ama-metastases amakhulu.
• I-hypercalcemia, ebangelwa isakhiwo esibi.

Ukungqinelana

• Ukukhulelwa nokuncelisa.
• Ukungasebenzi.
• Abantwana kunye nabaselula (ukhuseleko lokusetyenziswa alusekwe).
• Ukunyuka kwamanzi kwi-bisphosphonates kunye ne-zoledronic acid.
• Ngokulumkisa: umsebenzi ongenakunqwenela umonakalo, i-asthma ye-bronchial, i- hepatic insufficiency.

Imiphumo emibi

I-anemia, i-thrombocytopenia, intloko yesisu, utywala, i-conjunctivitis, isifo sesisu, i-anorexia, ukuhlanza, isifo sohudo, intlungu yesifo, i-arthralgia, i-hypophosphatemia, i-hypocalcemia, i-fever, i-syndrome, i-asthenia, inzuzo yesisindo. Kwizigulane ezine-zoledronic acid, i-osteonecrosis yomhlathi idlalwa ngamanye amaxesha (ngokuqhelekileyo emva kokungenelela kwamazinyo okusebenza).

Indlela yesicelo

Ukuthintela kwaye uqhube imizuzu eyi-15, kodwa kungabi ngaphantsi. Kwiimitha zesistim ze- myeloma ezininzi , i-dose ye-4 mg kanye ngenyanga. Nge-hypercalcemia, ebangelwa i-tumor ebulalayo, idosi ingama 4 mg kanye.

Imiyalelo ekhethekileyo

Emva kokusetyenziswa kweziyobisi, kubalulekile ukulawula ukuxinwa kwe-magnesium, i-phosphorus, i-creinine kunye ne-calcium kwi -serum yegazi. Ukuba kunokwenzeka, iinkqubo zamazinyo kufuneka ziphetshwe.

Zoledronic acid. Analogues

Amalungiselelo "Actonel", "Aneldronat", "Aredia lyophilizate", "Bonviva", "Bonnronat", "Bonefos", "Klobir", "Xidifon", "Lindron", "Ostalon", "Ostealen", "Ostererepair" "I-Pamidronate", "Pomegara", "Risendros", "Strogos", "Tevanan", "Forosa", "Fosamax", "Fosfoteh", "Rizarteva."

Zoledronic acid. Ixabiso:

Ngokuqhelekileyo, iisayithi ezihambisa amayeza ngaphakathi kwemida yomthetho zibonisa iintengo zempahla yazo. Kodwa, ngokukrakra ngokwaneleyo, intengo ye-zoledronic acid idlalwa ngokubanzi. Kodwa ixabiso elilinganiselwayo li-ruble ezili-14 ngebhotile. Kuthengiswa kwii-pharmacy kuphela kwimigomo.

Ulwazi oluchazwe ngentla lujoliswe ekufundiseni abasebenzi bezonyango. Le ngqungquthela kwi-zoledronic acid ayifaki indawo yokubonisana nogqirha ofanelekileyo, kwaye ayinakuqinisekisa ukuba ifuthe elifanelekileyo liyiyo.