"Glyurenorm": imiyalelo yokusetyenziswa, ukuphononongwa, ukufana nokufana

Isifo sikashukela esingekho-insulini okanye isifo sikashukela sohlobo lwesibini sibizwa ngokuba sisifo sesifo. Ibonakala nge-hyperglycemia engapheliyo, ephuma ngenxa yokuphazamiseka ekusebenzisaneni kwe-insulin kunye neeseli zamathambo.

Iimpawu zesifo esinjalo zomile kwaye zomele emlonyeni, zixhamle umchamo, ubuthakathaka obunamahlunu, ukuhlutha kwesikhumba, ukuphilisa amanxeba kunye nokukhuluphala. Ukunyangwa kohlobo lwe-2 lweswekile , isilwanyana "Gljurenorm" sisetyenziswe. Imiyalelo yokusetyenziswa, iiferensi, iipropati kunye nefom yezilwanyana zinikezelwa ngezantsi.

Ukubunjwa kweziyobisi, inkcazo, ukupakisha, ifomu

Ngowuphi uhlobo abavelisa iGlenororm? Imiyalelo yokusetyenziswa ikwazisa ukuba le mveliso ikhiqizwa ngendlela yamacwecwe amhlophe kunye aguguleyo obunzima, ngokubeka ingozi kunye nemigqomo, kunye nokubhala "57C" kunye ne logo yenkampani.

Icandelo eliphambili leziyobisi ekuthethwa ngayo yi-glycidone. Ikwabandakanya isitashi sommbiwa omisiwe, i-lactose monohydrate, isitashi esine-soluble kunye ne- magnesium stearate (izixhobo ezongezelelweyo).

Xa kuthengiswa kwesilwanyana "Gljurenorm" (amacwecwe) kuza kwi-blisters yeziqwenga ezili-10, ezipakishwe kwiipakethi zekhadibhodi.

I-Pharmacological action

Iyintoni na isilwanyana "Gljurenorm"? Imiyalelo yokusetyenziswa kweengxelo ukuba eli li-arhenglycemic agent, i-derivative sulfonylureas (isizukulwana sesibini). Kujoliswe ekulawuleni komlomo kuphela.

Isilwanyana esibuzwayo sinemiphumo eyongezelelekileyo yepascreatic ne-pancreatic. Ivuselela ukukhutshwa kwe-insulin kwaye inokubangela indlela ye-glucose-mediated of formation yayo.

Iingcaphephe kwizilwanyana zebhoratri zibonise ukuba izidakamizwa "iGlyurenorm", umyalelo walo oqulethwe kwibhokisi yekhadibhodi, unako ukunciphisa ukuxhatshazwa kwe-insulin kwi-adipose tissue kunye nesibindi sesigulane. Oku kubangelwa ukuvuselelwa kwendlela yokwenza umyalezo emva kokufumana i-insulin, kunye nokunyuka kwama-receptors kuwo.

Impembelelo ye-Hypoglycemic emva kokuthatha le nkunkuma ikhula emva kwemizuzu engama-65-95. Ngokubhekiselele kwisiphumo esiphezulu sonyango, kufike malunga neeyure eziyi-2-3 kwaye ihlala malunga neeyure eziyi-8-10.

Iimpawu zekinetic

Imiyalelo yokusetyenziswa kwe "Gljurenorma" ithi ukusetyenziswa kwesilinganiso esisodwa sale mayeza (15-30 mg) kukhuthaza ukunyuswa kwayo ngokukhawuleza nangokugqibeleleyo kumgudu wokutya (malunga ne-80-95%). Ingqungquthela yokuxinwa kwayo ifikelelwe emva kweeyure ezingama-2.

Into esebenzayo yeziyobisi inxulumene kakhulu neeplasma zamaprotheni.

Akukho datha kwinqanaba elinokwenzeka le-glycidone okanye ezivela kwi-placenta okanye i-BBB. Akukho nalukho ulwazi malunga nokungena kwe-glycidone kubisi lwebele.

Kuphi i-metabolism ye-drug "Gljurenorm"? Umyalelo wokusetyenziswa uqinisekisa ukuba i-ejenti ephantsi kwengqwalasela isetyenziswe kwisibindi ngokudemethylation kunye ne-hydroxylation.

Uninzi lweziphumo ezivela kwi-glycidone zidityaniswe emathunjini. Isiqingatha-nobomi beli liyeza li-1-2 iiyure.

Abantu asebekhulile kunye nezigulane eziphakathi, iimpawu zekinetic ze "Glyurenorm" ziyafana.

Ngokweengcali, i-metabolism yeli cilisi ayitshintshe kwizigulane ezinobungozi obushushu. Kufuneka kwakhona kuqatshelwe ukuba kwizigulane ezinomsebenzi wokuguqulwa komzimba, isiza asizihlanganisi.

Iinkcazo

Ngaphansi kweyiphi imeko i-drug "Gljurenorm" iphumelele kakhulu? Imiyalelo yokusetyenziswa, ukuphononongwa kubonisa ukuba uphawu lokusetyenziswa kwalo luhlobo lwesifo sikashukela kubantu asebekhulile nabangaphakathi-ubudala (kunye nokungasebenzi kweyeza lokutya).

Ukuthintela ukuthatha amayeza

Ziziphi iimeko eziphikisanayo zokumisela iipilisi ze-Glenororm? Imiyalelo yokusetyenziswa ibonisa ukungqinelana oku kulandelayo kwilisi:

• I-Porphyria ephakathi kakhulu;
• Isifo sikashukela sohlobo lokuqala;
• Ukuhluleka kwe-Hepatic yezinga eliphezulu;
• I-acidosis yesifo sikashukela, i-precoma, i-ketoacidosis kunye ne-coma;
• Ikhefu emva kokuthengiswa kwe-pancreatic gland;
• Izifo ezinqabileyo ezinobuncwane ezifana ne-galactosemia, ukunyamezela kwe-lactose, ukungabikho kwe-lactase kunye ne-glucose-galactose malabsorption;
• Izimo ezintle zesigulane (umzekelo, imisebenzi yokugonywa kakhulu, izifo ezithathelwanayo);
• Ixesha lokukhulelwa;
• Ubuncinci obudala (ngenxa yenkcukacha enganeleyo kwokhuseleko kunye nokusebenza kwamachiza kweli qela leminyaka);
• Ixesha lokuncelisa;
• Hypersensitive to sulfonamides.

Ukunyanga iziyobisi

Ngokulumkisa, amayeza ayalelwe:

• I-Febrile syndrome;
• Ukungabi ne-glucose-6-phosphate dehydrogenase;
• Izifo ze-thyroid gland (kunye nokuphulwa komsebenzi wayo);
• Utywala.

Imithi yokwelapha "Gljurenorm": imiyalelo yokusetyenziswa

Iiblulethi "Gljurenorm" zonyula okanye zonyulwa kuphela ngaphakathi. Ekufunyeneni kwabo kuyimfuneko ukugcina zonke iingcebiso zogqirha malunga nokulingana kweyeza kunye nokugcinwa kokutya. Akuvumelekile ukuba siyeke ukuthatha imithi ngaphandle kokubonisana nengcali ngaphambili.

Inqanaba lokuqala le-ejenti ekubhekiselwe kuyo iiphilisi eziyi-0.5 (i-15 mg) kwisidlo sasekuseni sokuqala. Amayeza kufuneka athathwe ekuqaleni kwesidlo. Emva kokutya, akufanele udibe ukutya.

Ukuba ukusetyenziswa kwamacwecwe e-1/2 akubangeli ukuphucula, emva kokubonisana nogqirha, i-dosage yanda ngokunyuka. Ngomthamo wemihla ngemihla ye "Gljurenorma" ayikho iipilisi ezingaphezu kwe-2, inokuthathwa kanye, ngexesha lesidlo sasekuseni.

Ukuba ugqirha uye wamisela iqondo eliphezulu leziyobisi, ngoko kubekho umphumo ongcono kakhulu omele ukwahlula ube ngama-2 okanye ama-3.

Ukwandisa umthamo weepilisi ezingaphezu kwe-4 ngosuku aluqhelekanga ukunyusa kwabo ukusebenza. Ngoko ke, akukhuthazwa ukuba athathe iyeza elithi "Gljurenorm" ngenani elichaziweyo.

Kubantu abanomsebenzi wokuguqulwa komonakalo, ukulungiswa kwemilinganiselo akudingeki.

Ukuthatha iziyobisi ezingaphezu kwe-75 mg kwizigulane ezinomsebenzi onobungozi obunobunzima kufuna ukubeka esweni rhoqo ngugqirha.

Xa kunesiphumo esingaphelelanga sonyango kunye ne "Glyurenorm" isiguli sinokunikezelwa kwakhona "iMetformin".

Iimeko zokugqithisa

Ukunyuswa kwamaxabiso okuphakanyiswa kwe-sulfonylurea ezivame ukukhokelela kwi-hypoglycemia. Ukongezelela, ukugqithisa kwesi sidakamizwa kunokubangela iziphumo ezilandelayo: ukunyuka kwesithukuthezi, i-tachycardia, ukunyanzeliswa, ukulamba, ukunyanyelwa ikhanda, ukubetheka, ukugubha, ukuxhalala, ukuxhalabisa, ukukhathazeka, ukuphazamiseka, ukuphazamiseka.

Ukuba unemiqondiso ye-hypoglycemia, kufuneka uthathe i-glucose okanye ukutya okunotye kwi-carbohydrates.

Iziphumo eziPhakathi

Ngoku uyazi oko kuchazwe kweso sonyango njenge "Gljurenorm". Imiyalelo yokusebenzisa le mayeza iye yahlaziywa ngasentla.

Ngokutsho kweengxelo zezigulane, malunga nemvelaphi yokuthatha le ngcebiso ingavela:

• Thrombocytopenia, stenocardia, agranulocytosis;
• I-Pherehesia, i-hypoglycemia, isiyezi;
• I-Leukopenia, intloko yesifo, i-extrasystole, ukulala;
• Ukuphazamiseka kweendawo zokuhlala, umvakalelo wokukhathala, i-hypotension;
• Ukungafezeki komzimba, umlomo owomileyo, isifo seStevens-Johnson;
• Ukunciphisa ukutya, ukuphendulela iifoto, ukususa isantya, ukugquma;
• Urticaria, ukuhlanza, intlungu kwisifuba, i-cholestasis;
• Ukubambisa, ukubetheka kwesikhumba, uhudo, ukuphazamiseka esiswini.

Ukusebenzisana kwezidakamizwa

Ngokusetyenziswa kwe-glycidone kunye ne "Allopurinol", kunye ne-ACE inhibitors, iziyobisi ezenziwe ngama-antifungal, i-analgesics, i-coumarin derivatives, ii-NSAID kunye nabanye, ukunyuka kwe-hypoglycemic ye-yangaphambili kunokwandiswa.

"I-Rifampicin", i-barbiturates, kunye ne "Phenytoin" inciphisa umphumo we-hypoglycemic "Glyurenorma".

Iingcebiso ezizodwa

Amagunya e-Hypoglycemic for administration of oral should not substitute for therapeutic diet.

Abantu abanesifo sikashukela kufuneka balandele ngokungqongqo zonke iingcebiso zegqirha.

Xa iimpawu ze-hypoglycemia zivela, kufuneka uthathe ngokukhawuleza ukutya okuqukethe iswekile.

Ukunyamezeleka kwengqondo kunokunyusa umonakalo we-hypoglycemic yeliyobisi.

Ngenxa yokuba ukunyuka kwe-glycidone ngokusebenzisa izintso akubalulekanga, isicatshulwa esicatshungulwayo singakunikwa ngokukhuselekileyo kwizigulane ezinobungozi bezintlu, kunye ne- nephropathy ye-diabetes.

Kwiimvavanyo zeclini, kwafunyanwa ukuba ukusetyenziswa kwesilwanyana esibuzwayo kwiinyanga ezingama-30 akuzange kubangele ukwanda kwisisindo somzimba wesigulane. Ukongezelela, iimeko zokulahlekelwa komzimba we-1-2 kg zaphawulwa.

Iingxoxo kunye nokuhlaziywa

Iziganeko zesilwanyana "Gljurenorm" ziquka ezi ndlela zilandelayo: Gliklada, Amiks, Glianov, Glairi, Glibetic.

Ukuphonononga malunga nesilwanyana esikulo mbuzo kungafumaneka ngokuhlukileyo. Ngokweengxelo zabathengi, le nkunkuma ifumaneka kakhulu kwaye iyatholakala kuwo wonke umntu. Nangona kunjalo, ku funeka kuqatshelwe ukuba izigulane ezininzi zixhalabile kakhulu ngohlu lweempendulo ezimbi zale mpendulo. Nangona oogqirha bathi baqheleke kakhulu kwaye kuphela phantsi kweemeko ezithile.