"Celecoxib": imiyalelo ukusetyenziswa, ncomo. analogue iziyobisi

Unyango izifo ezinxulumene ne umonakalo nenkqubo musculoskeletal, iimfuno bevela emarikeni lamachiza ukwenza amachiza amatsha kunye neziphumo ebezingalindelekanga ezimbalwa kunye ngempumelelo enkulu. Oososayensi bafumene kwaye bafaka isizukulwana esitsha non-steroidal amachiza-ukudumba ngokusekelwe celecoxib. La mayeza kunciphise ubungozi kwaye zivunwe ngcono ngumzimba.

Inkcazo "Celecoxib" iziyobisi

Ukusetyenziswa celecoxib inombala baluthuthu tyheli libhekisela coxibs iqela leyo ukubonisa inhibition uyakhetha wohlobo yesibini cyclooxygenase. Imithi ezisekelwe iikhompawundi ze langoku zabakhonzela endibuthethileyo iipropati anti-ukudumba kunye iintlungu. Ichiza original ngokusekelwe celecoxib kucingwa ziphuhliswe yinkampani American "Pfizer" iziyobisi "Celebrex". kwaba zahlolwa kuphandwa iimpawu pharmacodynamic yetyhefu emzimbeni womntu.

Ezinye imithi equlethe celecoxib iziyobisi esebenzayo nohlobo oluthile, kuquka "celecoxib" iziyobisi.

iifom balawule

iziyobisi Ifumaneka njengezingxobo gelatin nzima xa kukho umthamo esisebenza, 100 mg kunye mg 200. Ngokungafaniyo nabanye non-steroid arhente anti-ukudumba, akukho uhlobo idosi njengento amafutha, gel, izisombululo injectable okanye ukumiswa. Kwabanye abantu ngempazamo ngokuba ifomu ukukhululwa "Celecoxib" iziyobisi - tablets, nangona sithetha malunga njengezingxobo.

isakhiwo

Le esisebenza yi celecoxib kweziyobisi isixa 100 mg kunye mg 200. Ukubunjwa njengezingxobo ziquka amacandelo abancedisayo ezibonelela ukuzaliswa isithuba, le flowability kunye nozinzo umxube granulated. Ezi ziquka lactose, sodium lauryl sulfate, polyvinylpyrrolidone (K30), isodiyam croscarmellose, wemagniziyam stearate.

Iqhaganyishelwe kule ncwadi yesikhokelo "celecoxib" umyalelo kweziyobisi iquka ukwakhiwa kunye nenkangeleko uphawu kwiqokobhe gelatin capsule. Ngokutsho nkcazelo, kubonakala buthuntu, babe phantse emhlophe ngebala kunye ziphawulwe nangemiqondiso "100" okanye "200", ibekwe kwi band blue okanye omthubi, ngokulandelelana. Oku kukuvumela ukuba ukwahlula njengezingxobo kunye iidosi ezahlukeneyo. Ukwakhiwa inks qanda, bhlowu nazo zipeyintwe iinkcukacha ebonisa imibala ingozi eziphilayo.

amachiza afanayo

imveliso "Celecoxib" amayeza, analogue apho ikwaqulathe celecoxib into esebenzayo, unako ukubonisa isiphumo esifanayo kwezonyango kwi osteoarthritis ngamathambo abantu.

Ichiza original "Celebrex" yaye "Celecoxib" yayo generic, "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" zijongwa amayeza interchangeable. Nangona kunjalo, ixabiso kudidi lokuqala liya kuxabisa umyalelo yobukhulu ibiza kakhulu kuyaphi kunezixhobo zabo.

Xa Elungiselela "Celebrex" iqulethe celecoxib kwi umthamo 100 no-200 mg njenge medicament "celecoxib". amacandelo Auxiliary le philisi kunye nemvulophu yayo ingahluka zombini kumafa loqobo nelomyinge ukuba aluchaphazeli iipropati zabo. Ngokuphathelele uhlobo nokukhululwa generic "Celecoxib" analogue iziyobisi ziveliswa kuphela njengezingxobo gelatin nzima ukuze isetyenziswe ngaphakathi.

Kukho non-steroidal anti-ukudumba agents, cyclooxygenase esebenzayo ngokulinganayo kuhlobo lwesibini kodwa umahluko nje ekwakhiweni kweli candelo esebenzayo, lo pharmacokinetic kunye neempawu pharmacodynamic. Ezi ziquka sulfonamide compound nimesulide isimo idosi yemihla ngemihla mg 200 abaphatha ngempumelelo iimpawu osteoarthritis kunye isifo samathambo. Imixube esekelwe ukusebenza kwayo anti-ukudumba kwaye iintlungu ngokuthi ziyibuyisela umva le cyclooxygenase yesibini ukusa kumkhamo engaphantsi - yohlobo yokuqala, kuchaphazela iindidi njengabalamli iintlungu kunye nokudumba.

Njengoko nimesulide, celecoxib emele udidi sulfonamide kwezinto, kwaye kananjalo ukuba idosi yemihla ngemihla mg 200 ishenxisa iimpawu osteoarthritis. Akunamsebenzi zinqanda uhlobo cyclooxygenase kuqala kunye nezenzo kwi inani elincinane njengabalamli iintlungu kunye nokudumba.

An coxibs unyango ulawulo ngomlomo iindlela injectable of NSAIDs. Enye yezinto ezilungileyo eziphambili "Celecoxib" imveliso - ixabiso. Iinaliti (ampoules ukuba isitofu) nabanye abasebenzi abanga-steroidal amachiza-ukudumba zibiza imali eninzi kakhulu, kodwa ke loo ukusebenza inaliti mkhulu lee umphumo ukusuka ukusetyenziswa kweziyobisi kwiintlobo okuqinileyo.

indlela isenzo

Drug "Celecoxib" - ichiza emele isizukulwana esitsha arhente nonsteroidal anti-ukudumba, anti-ukudumba, iintlungu, umsebenzi antipyretic. indlela yayo yokusebenza enxulumene ne uvimba ukuyilwa prostaglandins ukudumba ngokunciphisa umsebenzi Cox-2.

reactions ukudumba ukuqala uqhelwaniso uhlobo yesibini cyclooxygenase, bona ibalekisa ukuqokelela prostaglandin amagama kunye nezinto eziphuhlisa komtshiso oko. State iphuhlisa ukufukuka kunye neentlungu.

Cyclooxygenase Uhlobo lokuqala alichaphazeli ukulungiselela enyangayo ithamo "celecoxib". Imiyalelo yokusebenzisa ichaza inertia beziyobisi ngokubhekiselele kwesi enzyme ezinxulumene nemisebenzi yayo of nokomzimba ibakho kwiiseli ze phecana kunye zegazi nezakhiwo zesisu.

Kwakhona, kwi imiyalelo enikwe data kwi ifuthe iziyobisi nezintso. Phantsi yintshukumo celecoxib lingaphantsi kwe iboniswe Umchamo Ukwakhiwa prostaglandin E2 kunye F1-6-nee-prostaglandin, kodwa ayitshintshi ulwabiwo B2 11-dehydro-thromboxane, nto leyo ibonisa ukuba iyeza isiphumo uyakhetha.

Ukusetyenziswa ichiza "Celecoxib" akuthethi kukhokelela ekuncipheni kwireyithi ukuhluza kwi kidney glomeruli abadala kwaye izigulane insufficiency kwezintso.

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Ngokutsho iimpawu pharmacodynamic yokulungiselela "celecoxib" sicelo kuya kuba olusebenzayo unyango samathambo kunye psoriatic samathambo, nangokurhala ezingapheliyo kunye neentlungu yomqolo kunye sacroiliac amalungu kunye osteoarthritis.

Ngenxa kwiipropati yayo iintlungu esetyenziselwa kubuhlungu xa intlungu musculoskeletal emva kokuba unyango ngotyando, seTrojan, nto leyo sikhatshwa sexesheni kabuhlungu. Isiphumo anti-yokukrala ichiza ijolise ekunciphiseni outgrowths kunye polyp kwi ikholoni kunye ezinqeni kwi lokufunyaniswa "polyposis adenomatous".

Indlela ukuthatha

Thatha amayeza "Celecoxib" imiyalelo ukusetyenziswa ngaphakathi ikhuthaza ukuba yokungena kunye nasekusebenziseni ukutya. Le njengezingxobo musa ukuvula kwaye luthi, wabaginya yonke ngokusela namanzi amaninzi.

Imali ubuninzi celecoxib, apho kungathathelwa ngosuku 0.4 g Le ukulungiselela lisetyenziswa in excess kuphela kwiimeko ezinqabileyo.

iingxaki sentliziyo kunokubangela ngeedosi eziphezulu kunye nonyango elide kunye ichiza "Celecoxib". Guide iqulathe ulwazi iidosi ezincinane ukwenzela unyango kwangumqondiso ukufunda nganye. Ibonelela iingcebiso ukusetyenziswa elifutshane.

Ukuphelisa iimpawu ezinxulumene osteoarthritis, kunye ankylosing spondylitis, yonke imihla ukuthatha amaxesha enye okanye ezimbini 200 mg beziyobisi.

Ukuze ukuphelisa iimpawu isifo samathambo usebenzisa idosi yemihla ngemihla ye-200 okanye 400 mg, nto leyo ithathwa njengento kabini.

Iintlungu kunye seTrojan lokuqala sinyangwa ngosuku lokuqala idosi eliphezulu 400 mg, kunye yokwamkela ngakumbi 200 mg kunokwenzeka, ngosuku usebenzisa 200 mg amaxesha 2 ngosuku.

Abadala, kunye nezigulane isidanga wobulali isibindi ayoneli okanye ngobulali ukumodareyitha insufficiency kwezintso, akukho recalculation of ithamo lwenziwa.

ubunzima Low (ngaphantsi kwama-50 kg), ubungqongqo umyinge sisibindi - iindidi data ye abanyangwa amathamo eliphantsi amayeza emiselweyo.

Ngokuqhelekileyo, ngokuba unyango iinkqubo ukudumba kwamalungu kusetyenziswa iinkqubo unyango ngokusekelwe ukusetyenziswa kweziyobisi eliqela iintlobo ezahlukeneyo balawule. Dibanisa "celecoxib" Isingxobo, amafutha, okanye gel-udidi ukufudumala "Apizatrona" okanye "finalgon. ukusetyenziswa mlonyeni ebangela isiphumo yethutyana, ngoko zisetyenziswa kunye iziyobisi yokwamkela endlwini.

Oku othintela ukusetyenziswa

Ayizizo zonke izigulane izifo amalungu, ungenza uthathe iziyobisi "Celecoxib". Imiyalelo zokusetyenziswa iqulathe uluhlu kwezifo kunye neemeko apho isixhobo onganenzakalisayo ngaphezu okulungileyo. Ezi ziquka:

• izigxala, isifuba, imeko ezikumila kunje yintshukumo aspirin kwakunye namanye amachiza nonsteroidal anti-ukudumba;
• operation ehlobene ne kwemithambo esa yokumilisela ;
• exacerbation of isilonda Peptic;
• esiswini kunye nokopha emathunjini;
• ukudumba isifo emathunjini;
• Ukungaphumeleli intliziyo;
• izifo kobuchopho kwemisipha intliziyo;
• ukulahleka ezincinane peripheral kunye neempahla palsy kunye kakuhle ukuhamba kwegazi yobuchopho;
• imilo nedostatochnosttyazheloy hepatic;
• ukusilela kwezintso yayinzima;
• nabantwana;
• uncancisa lo mntwana;
• ngaphantsi kweminyaka elishumi elinesibhozo;
• hypersensitivity ku excipients;
• anda susceptibility kwicandelo sulfonamide kulo.

Nokusebenzisa kakuhle ichiza "Celecoxib" kufuneka babe ngabantu abanezifo ye phecana zesisu ezinxulumene Peptic isilonda ukopha ngaphambili, usulelo iintsholongwane kwiinwebu sodidi Helicobacter pylori.

ukugcinwa kwamanzi emzimbeni kwaye izicwili ezithambileyo nokudumba, ukuphazamiseka kwesibindi zasesekondari izifo yeqonga, intliziyo kunye semithambo, emzimbeni, apho ukwanda kwinqanaba cholesterol kwi plasma yegazi waphawula lipid ukutya, isifo seswekile, iswekile, izifo somatic in kakhulu kwaye unobangela eliphezulu ukusetyenziswa kakuhle ichiza "celecoxib" phantsi kweliso gqirha.

imiphumela emibi

Nangona impumelelo ezintsha ekudalweni isizukulwana esitsha coxibs, ezi izinto kunye neziyobisi esekelwe phezu kwazo olungenayo yeziphumo ebezingalindelekanga.

Okuhamba i "Celecoxib" imiyalelo iziyobisi ukusetyenziswa, angqina nomonde kunye neengcali - le mithombo eziqulathe ulwazi malunga neziphumo kunokwenzeka ezibi ezinokuthi zenzeke kule amalungu abalulekileyo.

Impembelelo kunokwenzeka elibi kwinkqubo yokwetyisa luphawulwa NSAID-gastropathy, iintlungu esiswini, ubucaphucaphu, ukugabha, heartburn, ukunciphisa imfuneko ekudleni kunye norhudo. ukusetyenziswa zexesha elide amathamo aphezulu kunokubangela zizilonda kunye nokopha kwi inwebu kwiinwebu esiswini namathumbu, ukopha iintsini, ukusebenza ngokugqithiseleyo kwesibindi transferase.

izifo luvo kubonakaliswa uchulumanco, intloko ebuhlungu, isiyezi, somnolence efuna, ithi depressive.

Impembelelo kwinkqubo yegazi ngenxa uxinzelelo naqhama kwemithambo, kunye tachycardia.

Ukulungiselela "celecoxib" yehlise ukuxhathisa kwizifo ezosulelayo kwenkqubo nokuphefumla, leyo ungaboniswa kuphuhliso sinusitis, nokuthimliswa, pharyngitis, intlungu empumlweni nasemqaleni, khohlo, dyspnea, bronchospasm.

Impembelelo ichiza ziimvakalelo ebangela ukwehla ngokweembono eziviwayo kunye ukubonakala ukuduma.

Kwinkqubo wokuchama kuchaphazela iziyobisi "Celecoxib" ukuze ufumane ukusilela kwezintso kunye nophuhliso nokudumba syndrome.

Ngokumalunga igazi-ukwakha amalungu, ichiza kunokubangela ngokubonakala agranulocytosis, ianemia, leucopenia, thrombocytopenia.

irhashalala zingenzeka kunye ukubonakala pruritus komzimba, urticaria, photosensitivity, angioedema yobuso kummandla, kwiziphelo, esini.

iimpawu reception

Drug "Celecoxib" abaphumeleli ehambisana kunye nengozi eyonyukileyo iziphumo ezibi yegazi ezikhokelela thrombosis, iposi ye engabalulekanga emangalisayo umsipha kunye stroke. Ingakumbi ingozi uyanda ngexesha ulawulo ezingapheliyo amayeza zizigulane kuye kukho izifo sentliziyo.

Ukunciphisa ubungozi iingxaki ezinjalo izigulane ezithatha ichiza "Celecoxib" ukumisela pamo liphantsi kuninzi ixesha elifutshane unyango. Isigulana kufuneka uxoxe nogqirha wakho imiqondiso kunokwenzeka wezifo kwaye ufumane ingcebiso basabela njani xa zithe zenzeka.

sebenzisa indibaniselwano acetylsalicylic acid ngeedosi ezincinane ku "celecoxib" iziyobisi Ukunciphisa iimpawu sentliziyo. Izimvo kumagqirha zibonisa isiphumo antiplatelet aspirin lokuhlambulula igazi xa uthatha coxibs, ecingisisiweyo ezinjalo iipropati anti-thrombotic. Ngokuqhelekileyo, indibanisela enjalo iboniswe izigulane abadala kunye ukuphazamiseka kwenkqubo musculoskeletal kunye nemithambo yegazi, zinetyhefu zesisu uyandiswa xa non-uyakhetha ezingezo-steroidal amachiza-ukudumba. Kodwa ke ukusetyenziswa celecoxib kweziyobisi kunye namanye NSAIDs ayikhuthazwa.

Kuba izigulana uxinzelelo lwegazi oluphezulu, iliso rhoqo kwale parameter xa befumana "Celecoxib" iziyobisi.

ingqalelo ekhethekileyo kufuneka inikwe esweni imeko eziphilayo nodibaniso anticoagulant (warfarin) kunye nezinto antiplatelet (acetylsalicylic acid, clopidogrel) usebenzisa inhibitors uyakhetha (citalopram, sertraline), ziyibuyisela inhibitors serotonin reuptake of CYP2C9 isozyme, iifom tablet glucocorticosteroids.

Ichiza "celecoxib" ikhuthaza imveliso yezinto prostaglandin, leyo mfumba ulwelo emzimbeni nokukhuthaza uphuhliso nokudumba. Qaphela ingakumbi unyango kwala machiza kufuneka babe ngabantu abaphethwe ukusilela intliziyo kwezihlunu kunye noxinzelelo oluphezulu lwegazi. kufuneka siyeke ukusebenzisa "Celecoxib" iziyobisi xa kukho iimpawu ukudumba izicwili.

Izigulane coxibs unyango iingxaki zezintso kufuneka ikhatshwe kweliso lomgadi Izalathi zazo eziphambili.

Xa emzimbeni ezithatha ichiza kunokwenzeka kuphela emva kokuba amanzi ikhosi emzimbeni.

Reception "celecoxib" iziyobisi antipyretic ngenxa inyathelo kukhokelela ingxaki i index edla umzi, njengoko ubushushu ophakamileyo ngexesha kuphuhliso iimeko esosulelayo.

Isenzo ichiza kunokubangela ukungaqheleki xa umsebenzi kwesibindi, ingakumbi kubantu pre-ezikhoyo ukuphazamiseka kwesibindi. zimpawu ezimandundu ezinxulumene hepatitis fulminant, isibindi nekrozomtkaney. Iimeko ezinjalo kwenzeka kwangoko, kodwa kwiintsuku kuphela emva kwe-30 emva kokuba isicelo ukulungiselela "celecoxib". Ngoko ufuna ukubeka esweni intsebenzo xa unyango kwesibindi esi sibonelelo, yaye kwimeko ukoyiswa enzima kufuneka ngokukhawuleza ukurhoxisa ukutyunjwa.

Nohlolo unyango 'Celecoxib "

amachiza Nonsteroidal anti-ukudumba ikhutshwa kuphela kagqirha. Iziphumo ukusetyenziswa "Celecoxib" ncomo lwemithi wesenzo ziyabethabethana. Enye iyeza kunceda ukumelana iinkqubo ukudumba kwamalunga, kuba abanye oko ninganqeni, ebangela eziliqela iziganeko ezibi.

Njengoko izigulane ezingaphezulu nokuvavanya ichiza "Celecoxib"? Ukuphonononga kubonisa inani iingxaki: iintlungu esiswini, zezintso, ukuphazamiseka exesheni. izigulane Loo gqirha uqhuba ukurhoxiswa medicament nesinika unyango.

Ngokusekelwe kwizimvo lezigulana imiphumela iziyobisi amalungu asha, kunokwenziwa isigqibo ukuba sisebenzayo ekulweni samathambo. Ukuphelisa iimpawu iintlungu, ukudumba izicwili kummandla ochaphazelekayo ezikumila esingapheliyo, izigulane ekwindla yaye izinga entwasahlobo unyango iziyobisi "Celecoxib". Oku kusetyenziswa kwiimbaleki xa umothuko namalungu.

Ingakumbi medicament wenza ngempumelelo xa zidityaniswe ne ukuzifudumeza amafutha kunye gel ukuba isicelo mlonyeni. Noko ke, ngokutsho iingcebiso eziqulathwe imiyalelo zokusetyenziswa elinikiweyo NSAID usebenzisa izifundo ezifutshane, ukuze xiphephana kwi nezi ntso, nomhlehlo wesibindi, intliziyo kunye isisu. Kungenjalo ukuba siphephe ukusilela kumsebenzi ezi imizimba.