Uhlalutyo anti-CCP in isifo samathambo: a izakhi norm

izibalo Medical abonisa ukwanda kwenani kunye nenkqubela kwezifo kwinkqubo weentshukumo. Iya isanda, izigulana abadala ukhalaze malunga yayinjengentuthumbo yentlungu yabo ezidibeneyo. Abantu abatsha kugula kwakhona angawaconganga, kwaye abantwana ubunzima kulo. isifo Joint kubalulekile ukuqaphela usaqala kakhulu ukuthintela ngakumbi progression kunye nezinye iingxaki. Iqhelekileyo phakathi ithambo isifo inkqubo isifo samathambo luphawulwa nasisihlo yonyango enzima ngaphantsi ezintsonkothileyo. Kwaye ngenxa yokuba bonke abantu abanesi sifo umntu azi malunga anti-CCP kulingwa kuzo izigulane isifo samathambo. Kuya kuba ngekhomyutha enikwe kweli nqaku.

Yintoni uvavanyo anti-CCP?

RA, okanye isifo samathambo - yinto ngezifo entsonkothileyo namalungu oluchaphazela zombini abantwana kunye nabantu abadala. Isifo luphawulwa ukudumba synovia, ukonakaliswa intlala joint, kunye deformation yayo. Imiphumo loo ezingaqhelekanga, zange labonwa usaqala kwaye khange iqaliswe unyango ngokukhawuleza kunokuba yingozi kakhulu. Deformation kunye nentshabalalo edityanelweyo kuqulatha ilahleko iyonke okanye olungaphelelanga umsebenzi motor, nto leyo ngenxa yokukhubazeka, kwiimeko ezininzi.

Kutheni imfuneko yokuba uhlalutyo anti-CCP in isifo samathambo? ukusebenza uNorma kubaluleke kakhulu.

Yintoni na ukuba?

Inyathelo elibalulekileyo kukuba ukufumanisa isifo samathambo ngendlela ngexesha, nto leyo eya amisele unyango olusebenzayo kunye eyiyo yomguli, leyo ukuyeka inkqubo yokukrala kwaye ubuyisele umsebenzi ngokubambisana. Ukulungiselela le njongo iindlela ezibini eziya kubavumela ukuba ukujonga lwee- antibodies tsitrullinovomu peptide elibujikele (anti-CCP), kunye factor samathambo (RF).

Ukuxilonga ukungaqheleki kwibakala lokuqala, oogqirha bacetyiswa ukuba basebenzise uhlalutyo anti-CCP, ngokuba le ndlela izikhombisi zichanile yaye ivumela ukufumanisa isifo nokuba kweqonga. Uvavanyo ye RF kakhulu ezithile, kunye nokuchaneka iziphumo kuxhomekeke kakhulu ngexesha kuphuhliso ngezifo.

isifo samathambo ibanjiwe kakuhle kwixesha yokuqala usebenzisa anti-CCP uvavanyo. Kwakhona, enkosi igazi yokubona izilwa-buhlungu kunye namagosa amakishayo ukuba ajikeleze apho, ngethuba ukuqhubela phambili kwesifo ngaye. Olu vavanyo silinganisa inani ozalanayo tsitrullinovogo izilwa peptide elibujikele kwi egazini. Le peptide - njengesakhi esibalulekileyo emzimbeni. Citrulline wenziwe ngexesha indlela usebenzisa anginina zengqo- ukuba eyahlukileyo acid acid.

Yiloo nto anti-CCP arthritis. UNorma baya kunikwa ngezantsi.

Isilumkiso! Ndimele nditsho ukuthi citrulline akazibandakanyi ngakwicala leeprothini yokuqaphela kwaye iboniswa ixesha elithile emzimbeni.

Ukuba luchaphazela amalungu samathambo umzimba ivavanywa utshintsho ezininzi. Ngelo xesha linye isakhiwo chain protein acid acid, echaphazela zilindelekileyo zokusombulula ukusebenza ngokufanelekileyo intlala joint, wakha citrulline. Peptide equlathe citrulline, ibonwa yi amajoni omzimba ngolwasemzini kwaye ukhupha izilwa ukuphelisa le ngozi.

Ziziphi iingenelo wenza uhlahlelo anti-CCP in isifo samathambo? UNorma kufuneka makwazeke kuni nonke.

iingenelo anti-CCP

Anti-CCP uvavanyo inceda ukumisela iintlobo ezahlukeneyo kuphela isifo, kuquka samathambo, kodwa akukho ndlela efanelekileyo zokufumanis ezinye izifo. Le ndlela yoviwo serum igazi yenye yezona fastidious kunye ngqo ngexesha elinye, kuba sibona nje kuphela sifo kusekwangoko yakhe, kodwa ke ibakala sifo nangesimilo yayo. Uvavanyo iboniswe ngenxa uxilongo amalungu samathambo kunye RA ekuqaleni yophuhliso lwayo. Uphononongo ivumela ukwenza inkqubo unyango ephelele kakhulu, nto leyo ejolise ndahlukane ukususwa iintlungu kunye nokudumba, nokulahlwa ekhawulezayo kwezifo ezifana nesifo samathambo.

CCPA zinezibonelelo ezininzi phezu RF: Amathuba aphezulu efumanise anti-CCP antibodies iinyanga eziliqela ngaphambili uphuhliso articular nonspecific syndrome okanye isifo samathambo ngendlela entsonkothileyo kakhulu samathambo; ukumisela ukuba sikwinqanaba lokuqala RA ngowama-70%; ukuba ukujonga uhlobo sifo; imisele RA e linyathelo okuqhubekayo-79% yamatyala; Okukodwa nokuchaneka lokuvandlakanya nge-98%.

Kwaye konke oku hlalutyo bangabhaqa anti-CCP arthritis. Yintoni na, esiye sakuphonononga.

indlela CCPA kungenziwa ngokuba eliphezulu-ngqo, ngokunxulumene apho oogqirha bakhe banamathuba amaninzi ukuba anikwe izigulane abo zonke iimpawu samathambo. Ngokutsho iziphumo uvavanyo kumiselwa uhlobo samathambo, kwakunye ukuqikelela egcine, nto leyo evumela ukuba unikeze unyango kwisigulane echanekileyo.

Iimpawu ze inqubo

Yintoni inkqubo kwamalungiselelo uhlalutyo? Emva ulawulo ukuba uhlahlelo nomonde olwa-CCP, kufuneka ligcine inani lwemithetho. akakwazi ukudla phambi kovavanyo (iiyure 8). Naluphi na ulwelo, kuquka iti, ijusi nekofu, ayikwazi ingasetyenziswa kwisithuba seeyure ezingama-24. Lo mgaqo ukwasebenza ukuba ukutshaya kuba lo utshayayo kuya kufuneka ukunikezela imidiza iiyure ezi-2 ide Baya kucalula anti-CCP arthritis. Ingcaciso iya kuba yechaneke ngaphezulu. Uphawu uvavanyo nje nga umnxeba abambe ungatyanga.

Uvavanyo: algorithm

Uvavanyo lwenziwa uthatha igazi emthanjeni. Emva koko, ke licatshulwa yintloya, nto leyo kamva kusetyenziswa ukuhluza ukuba anti-CCP. Omelele ngakumbi spetstsentrifuge serum. Kuxhomekeka ukungxamiseka analysis and laboratory yengqesho, iziphumo ziya kufumaneka ingadlulanga iveki okanye kanye inani ngemini.

Okubalulekileyo! kungenziwa emkhenkceni serum kanye kuphela, ngoko ke iziphumo sele iza kuba ayichananga xa kwakhona lomkhenkce.

Utheni na ukuba uhlalutyo ACCP na isifo samathambo? Ntoni na, siya esele siyazi.

Malunga inkqubo yophando: i-serum ibekwe kwityhubhu uvavanyo kunye laser-ray. Le ndlela kuthiwa tsitofluometriey. Ngokunyanzela laser umqadi nangesimilo yayo esingamanzi kugwetywa ukungabikho okanye ubukho anti-CCP emzimbeni.

iindleko

Uhlalutyo ikhuselekile ngokupheleleyo kwaye yalula kumguli, kodwa kunokuba pricey. iindleko test kuhluka iwaka ukuya elinamanci asixhenxe amawaka engange, ngokuxhomekeke ukungxamiseka kunye laboratory amaxabiso, ukuqhuba uvavanyo. Olu hlahlelo ayithunyelwanga zonke izigulane, kufuneka ukuhlolisisa iimpawu yomguli kunye nezikhalazo.

Okulandelayo, cinga ukwenza njani ngaphandle zokucazulula yeziphumo zovavanyo anti-CCP arthritis.

yinto yamihla le

Ngokutsho iziphumo zovavanyo ugqirha uyazi malunga ubukho okanye ukungabikho RA, iqonga elisondeleyo esi sifo nobukhali yawo. Kufuneka kuqatshelwe ukuba olu vavanyo amayeza ngomnye kwabambalwa rate ogama ayahlukanga kubantu bobudala ezahlukeneyo.

Emva kokufumana igazi kunokugcinwa kuba ngaphezu kweveki kubushushu ngeedegree ukuya ku-8.

Emva koko hlalutya CCPA arthritis. -200 degrees - ke ubushushu neGauteng ngokupheleleyo isampulu yegazi, ngoko kunokugcinwa ngonaphakade xa kuyimfuneko.

Uhlalutyo kwiingxowa lamadoda, nabafazi, nabantwana babo bonke ubudala linokuchazwa 3-3.1 IU / ml kwaye kuphela kwiimeko ezithile enqabileyo oko kutshintshwa kancinane: ngo ubudala ekuqaleni umntwana ayakhekanga ngokupheleleyo inkqubo ithambo - 2,7-2,7 U / ml; CCPA RA abasetyhini abakhulelweyo - 3.8-4 U / ml; kubantu abadala angu ngokuthe ngcembe ukuya 2 U / ml.

Njani kumi uhlalutyo?

Thathela ingqalelo iziphumo zohlalutyo, ingcali unika unyango esimbaxa, ukusebenza oya kwakhona uvavanyo. Ukuchaneka unyango kufuneka kugwetywa ngokusekelwe ukunciphisa ubungakanani izilwa-serum kwegazi. Imela ubukho anti-CCP njengokuba isifo samathambo: 0-20 - salathisi negative; 20,0-39,9 - HIV, wavuma kubonakaliswa; 40-59,9 - HIV; iiyunithi ezingaphezulu kwama-60 - HIV, waveza ngamandla.

Okubalulekileyo! Kungakhathaliseki ukuba i-20 U / ml ithathwa uhlalutyo kuyinto eqhelekileyo ukuba, iingcali abaninzi bakholelwa ukuba RA bangagxothwa kuphela xa i parameters uhlalutyo CCPA Kute, oko kukuthi, kungekho antibodies kwi data egazini.

isiphelo

Kufuneka kukhunjulwe yonke isigulane ukuba uhlalutyo CCPA luyasebenza kwi-95%, kwaye ukuba iziphumo zovavanyo waba awunayo, kodwa zonke iimpawu isifo samathambo, kuya kufuneka ukuba kuqhuba iimvavanyo ezongezelelweyo ngokusebenzisa ezinye iindlela sifo, emiselwe ngugqirha khona.

Siye sahlolisisa uhlalutyo anti-CCP arthritis. Abafazi, amadoda kunye nabantwana amaxabiso eziqhelekileyo zahluke kancinane.