Nalidixic acid: Isicelo in Medicine

Yinto eyaziwayo ukuba iintsholongwane zezona kwamagciwane osetyenziswe kwezifo ukudumba kunye nezifo. Kukukhupha umzimba kubo, esebenzisa antibiotics ezahlukeneyo. Kukho amaqela ezininzi iziyobisi, isenzo sakhe sibhekiswe nxamnye bacterium. Enye ngale ndlela ke nalidixic acid. Yeyona isithako esebenzayo zamachiza ezininzi antibacterial. Omnye umzekelo - ipilisi "nevigramon". Eli chiza eka quinolones, iqela amayeza - antiinfectives. Phambi kokuba uqale unyango, kufuneka kudlule iimvavanyo ukuba ukuchonga pathogen aze avavanye ubuntununtunu kwayo medicament.

Nalidixic acid - ntoni na?

Ngokuqinisekileyo wonke uqhelene ngamalungiselelo eziqulathe nalidixic acid. Le nto sele iminyaka amayeza njengento arhente anti-ngeentsholongwane kunye anti-olwaye lwamfimfitha. Nalidixic acid, njengoko kuchaziwe apha ngasentla, libhekisela kwiqela quinolones. imithombo Medical ukuziqonda ezi izinto kwiziyobisi antibacterial. Nalidixic acid kuyinto imithi eyenziweyo ukuba idaliwe elebhu. Kuyinto ngumgubo umbala otyheli, nto leyo azinyamalali emanzini. Eyona ukusetyenziswa acid - iyeza. Ulilungu kwezinye antibiotics.

Action nalidixic acid

Ukuze ukwazi phantsi kweziphi iimeko kusebenza nalidixic acid, kuyimfuneko ukuba bafunde indlela yesenzo yayo. Iziphumo ezingundoqo ichiza - ke ingcinezelo sokwanda iintsholongwane kunye yenkxwaleko yabo. uyakwazi amanyathelo ukuphelisa DNA kudibaniso amagciwane polymerization. iziyobisi acid nalidixic benza emane kwi Igram (-) iintsholongwane. Ukuba zisebenza ukulwa iintsholongwane ze sodidi Proteus, Escherichia coli. Ngoko ke, abathintela izifo ukudumba, ezo eyabangelwa yile ntsholongwane.

Isenzo ichiza ixhomekeke eyavela emzimbeni. Ngeedosi ezincinane, asinto ibe nafuthe bacteriostatic, oko kukuthi, oko abangaphangeliyo DNA ukuphindaphindeka. Ezinkulu lamanani ichiza kuchaphazela phezu njini protein RNA. Ngoko ke, sebenzisa ixesha elide okanye ulawulo iipilisi ngeedosi enkulu leyo amanyathelo bactericidal. Kufuneka kukhunjulwe ukuba Igram (+) iintsholongwane kunye anaerobes ke ongenandaba nalidixic acid. Ngoko ke, ngaphambi kokunika oko, kufuneka enze uvavanyo bacteriological kwezinto eziphilayo (umchamo, igazi) kwaye bachithe antibiotikogrammy.

Iimpawu zibonisa ukuba ukusetyenziswa kwe nalidixic acid

Kukho iindidi zezifo ukudumba apho nalidixic acid isicelo. Imiyalelo ezisebhokisini kunye imveliso, ukuba ukuchaneka ngongoma leyo wathunyelwa into esebenzayo osulelo. Nakuba kunjalo, kufuneka sikhumbule ukuba ezi zifo azisoloko zibangelwa Igram (-) izihluma. Ngoko ke, xa kwawo of ichiza kufuneka kufakwe kunye kwelinye ichiza ngeentsuku ezi-3. Acute ukudumba sezintso - emininzi ephambili kwezifo elabelwe apho nalidixic acid. Ukusetyenziswa iimveliso eziqulathe le nto, kuqhelekile kuphela kwi-, kodwa nakwezinye iinkalo amayeza. Yayibubungqina eziphambili - is:

1. Ngokuzimela. Ukudumba esinyini amaninzi zibangelwa yi-Escherichia coli ne Proteus, kunjalo prescribers quinolone ukuba ukusebenza phezulu nxamnye ezi Cya.
2. Pyelonephritis. Ukudumba tubules kidney aphendule kakhulu kakuhle kunyango kunye nalidixic acid iziyobisi, ingakumbi kwisigaba oyingozi.
3. Uxilongo lwe zizifo womchamo. Kulo mzekelo, iziyobisi ezimiselwe ukuba zazo yomchamo kunye nemisebenzi.
4. media Acute otitis.
5. Cholecystitis.
6. Kwiintetho ezikralayo, isifo ezinkulu nezincinane emathunjini (enterocolitis).
7. Urethritis kunye prostatitis.

Kwakhona, nalidixic acid unako kubhalwa kunye nezinye izifo ezibangelwa gram (-) iintsholongwane.

Ziziphi amachiza eziqulathe nalidixic acid?

Kukho iimveliso ezininzi equlethe nalidixic acid. kubo bonke intshukumo enye kwaye zibonisa ukuba ukusetyenziswa. Kwezinye iimeko, idosi ezahlukeneyo ukwimo engundoqo esebenzayo. amagama ahlukeneyo kunye amaxabiso ala machiza ixhomekeke ilizwe ngawo kunye nenkampani evelisa amayeza. Ummeli idumileyo i "nevigramon" iziyobisi. Eli chiza nucleoside ezininzi. Phakathi la machiza, "Negro", "Nalid", "Tsistidin", "Vintomilon", "Urogram" kunye nabanye. Onke la machiza sibe nefuthe ofanayo emzimbeni.

Nalidixic acid: imiyalelo yokusebenzisa le medicament

Amalungiselelo eziqulathe nalidixic acid, ukuba kuthathwa kukho umthamo 500 mg amaxesha 3-4 ngosuku. Kwiimeko ezininzi, esi sixa lwe isithako esisebenzayo laliwaphethe tablet elinye okanye capsule. Xa inflammations kakhulu ingathatha 1000 mg kane ngemini. Ebantwaneni, idosi kufuneka kubalwe (60 mg / kg ubunzima bomzimba).

Izimo side effects

Kanye antimicrobials ezininzi, nalidixic iasidi contraindicated kwi kwabafazi ezintathu zokuqala zokukhulelwa kunye lokuncancisa. Kwakhona, la machiza ayikwazi ingasetyenziswa abantwana ukuya kwiminyaka emi-2. Phakathi kwezinye Izimo bodwa kwezintso kunye insufficiency hepatic.

iziphumo ezibi ziquka umsebenzi zesisu ○ (flatulence, isicaphucaphu, ukugabha), isiyezi, kunye negazi. Amanyathelo kufuneka kusetyenziswe abantu acid nalidixic bathwaxwa ezimbi luvo (Parkinson kaThixo, sokuwa, stroke).