MMF (mycophenolate mofetil): inkcazelo, analogs

Mycophenolate mofetil (inn Mycophenolic acid) iqukiwe iqela immunosuppressants. Makhe sihlolisise ngokweenkcukacha amatyala apho kuyimfuneko ukusebenzisa ichiza, yintoni na le Izimo ukuba ukusetyenziswa kwayo kunye neziphumo ebezingalindelekanga.

Ukongeza, sifumanisa ukuba kukho ndlela ezifanayo mihla Pharmacology.

isishwankathelo

mycophenolate mofetil ifumaneka ngohlobo njengezingxobo gelatin nzima zeempondo zeendlovu idibene nomgubo emhlophe ngaphakathi.

Thenga iziyobisi ezikhemisti kuphela xa unayo iphepha likagqirha elivela kugqirha.

ezikhabhathini uneminyaka emibini ithetha. Kugcine oko kufuneka kube kwiqondo ukuya degrees 25.

Ukuze sibe nokuqonda olubonakalayo ngendlela esixubusha ibukeka drug (mycophenolate mofetil), photo bakhonza ngasentla umzekelo ngokomzekeliso.

ichiza

Enye philisi kuthetha iqulethe 250 mg umchiza (mycophenolate mofetil). Ukongeza, amacandelo akhoyo ngokwemfundo kwanancedisayo, ezifana sodium croscarmellose, microcrystalline kwincindi, povidone nezinki stearate.

Pharmacokinetics

Emva kokuba ichiza ukufunxeka ngokupheleleyo kwaye olupheleleyo ukutya presystemic. Kulo mzekelo, uyazikhomba into esebenzayo plasma emsebenzini ngenxa yeenguqu yayo ekhawulezileyo ibe metabolites esebenzayo.

Lithetha idubule kunye nomchamo kunye ngendle.

Ubungqina obubonakalayo buxela

Kwezinye iimeko, sebenzisa na mycophenolate mofetil? Imiyalelo yokusebenzisa ngokukhawuleza uphendule lo mbuzo.

Oogqirha athi ezithatha ichiza ngenxa prophylaxis ahlekise yotyando ukubandlululwa izigulane emva kidney abohlukeneyo, isibindi okanye intliziyo.

Izimo

Akukho iimeko ezininzi apho ukusetyenziswa ichiza kuyathintelwa "Mycophenolate mofetil". Ezi ziquka phambi hypersensitivity lomguli ukuya into ephambili osebenzayo okanye namanye amacandelo arhente, kwakunye ngethuba lokukhulelwa zisanyisa.

Ukusebenza kunye nokhuseleko ichiza unyango abantwana abangakhange ichongiwe, ngoko musa ukusebenzisa oko wezifo.

imiphumela emibi

Mycophenolate mofetil ukwazi ukuba bamqumbise ezinye iziphumo ebezingalindelekanga. ukusetyenziswa kwayo ile cyclosporine kunye corticosteroids zinokubangela urhudo, ukugabha, leukopenia kunye nokudumba. Kwezinye iimeko, kwakukho uphuhliso lymphoma kunye nezinye ezinezigulo, ingakumbi ulusu.

Ukongeza, zonke izigulane yotyando basemngciphekweni zizifo ezosulelayo, apho nomsindo kwamagciwane ichele. Avamise kakhulu phakathi kubo herpes, candidiasis kunye cytomegalovirus.

Ezinye ukusabela zimaxongo azibonakalisa ngohlobo tile, usulelo womchamo, rhinopharyngitis, nokushisa, umsebenzi isibindi okungaqhelekanga, esophagitis, ukopha zesisu, usulelo lwe iphecana eliphezulu wokuphefumla, ukukhohlela, intloko ebuhlungu, gastroenteritis, ukudinwa, sinusitis, candidiasis ngomlomo , i-pancreatitis, pancytopenia, neutropenia, njalo-njalo.

Kukho usongo kakhulu kwaye kwezinye iimeko nesenzeko ingozi ezifana nesifo sephepha, endocarditis ziibhakteriya, usulelo Nedlac mycobacterial.

Umthamo kunye noLawulo

Indlela yokusebenzisa ichiza "Mycophenolate mofetil"? Imiyalelo incamathele kuyo, inika ulwazi olulandelayo.

Kuthintelo kidney ukulahlwa. Ithamo lokuqala arhente eziza kuqaliswa kuloo emzimbeni kwisithuba seeyure ezingama-72 emva kokuba abohlukeneyo kuqhutywa. Kamva, umguli kuya kufuneka ukuba uthathe 1 g kabini indlela ngemini.

Ngaloo mycophenolate mofetil into esuke xa zidityaniswe kunye corticosteroids kunye cyclosporin.

Kuthintelo ukulahlwa intliziyo. Ithamo lokuqala kufuneka kuthathwe zingadlulanga iintsuku ezi-5 emva kotyando olwenziwa. Kamva isixa eyimfuneko imveliso 1.5 g kabini ngemini

libanda

Idatha kwi libanda, iziyobisi, "mycophenolate mofetil," ayikho.

Oku kuthetha ukuba akunakubakho baphethe ukusuka umzimba olugqitha esikhumbeni. Iziyobisi yekeyeke asidi duct (cholestyramine) ukuze kube lula kususwa IFC ephilayo, ukwandisa zinomgutyulo yayo.

Iimpawu ze isicelo

Xa efumanise neutropenia isigulane kufuneka incitshiswe zethamo ngokusondeleyo esweni imo yempilo yomguli okanye ziphazamise unyango mycophenolate mofetil.

Phambi severe ukusilela ezingapheliyo kwezintso kufuneka ngokusondeleyo esweni imeko yempilo kwaye ayidluli yindlela ithamo eliphezulu, kulo mzekelo okumane 2 g ngosuku.

izigulane abadala (iminyaka 65) ekucetyiswa ukuba ukusetyenziswa kwe-1 g beziyobisi, amaxesha 2 ngemini.

Ulwazi malunga nokusebenza arhente kwi unyango kwezigulane ukusilela kwezintso owayefumene esinye okanye intliziyo isibindi, engekhoyo. Kwakhona, akukho ulwazi malunga nendlela ichiza olusebenzayo izigulane kunye nezilonda zesibindi owayefumene abohlukeneyo intliziyo senziwa.

amanyathelo okhuseleko

Kuyo nayiphi na imeko ayikwazi ukuvula philisi kulungiselelwa. Ukuba musa ukudibanisa ngqo kunye umgubo: oko inhalation, zidibene nesikhumba okanye ngenwebu yangaphakathi. Ukuba, ke, kwathi, kwangoko kufuneka ahlambe kummandla ochaphazelekayo ngesepha namanzi.

analogue izimali

Ingaba kukho amayeza buyisela imveliso "Mycophenolate mofetil"? Analogs, Kakade ke, akukho nto. Baye balalisa efanayo (International Nonproprietary Igama), okanye ikhowudi ATC. Iya kuba kuphela spectrum ezahlukeneyo ephezulwana msebenzi kunye nemali neendleko.

Eyona idumileyo ke iziyobisi zilandelayo:

• "Baksmun". Isetyenziswa ile cyclosporine kunye corticosteroids kuthintelo ukulahlwa kwentliziyo, isibindi okanye izintso emva abohlukeneyo.
• "Zenapax." Isetyenziswa ukuthintela ligatya ukufakelwa kwezintso nodibaniso cyclosporine GCS.
• "Imusporin". Isetyenziselwe uthintelo kunye nonyango amalungu zilinywe kwaye lomongo wethambo ngokunjalo isifo samathambo, uveitis zemveli, isifo Behcet kaThixo, systemic lupus zomzimba, kunye nezinye izifo.
• "Imufet". Kwakunye ichiza ephambili, arhente elawulwa xa zidityaniswe kunye corticosteroids kunye cyclosporin okhusela ligatya a sezintso zilinywe okanye isibindi.
• "Layfmun". Isixhobo has a spectrum ezibanzi amanyathelo. Ingasetyenziswa ukuvimbela kunye nonyango yokulahlwa amalungu zilinywe yi umzimba ithambo ezinomongo, kwakunye samathambo, nephrotic syndrome, iintlobo obunentshukumo systemic lupus zomzimba, isifo Behcet kaThixo, uveitis zemveli kunye nezinye izifo.
• "Mifenaks". Ubungqina obubonakalayo buxela ukuba ukusebenza ngendlela efanayo naleyo iindlela eziphambili.
• "Mifortik". Yenzelwe ukuba ukuthintela ukwaliwa kidney zilinywe.
• "Mofilet". Iimpawu kunye nokusetyenziswa ziyafana kunye mycophenolate mofetil.
• "Panimun". Asetyenziswe abohlukeneyo kwemiphunga, intliziyo, izintso, lomongo wethambo, injeke, ngokunjalo nezifo ezithile.
• "CellCept." It linokukwenziwa xa esinye zezintso.
• "Sertikan". Oku kuboniswa ngenxa yotyando kwezintso okanye izigulane intliziyo nokulolonga okanye ephantsi umngcipheko ngumzimba.
• "Tsikloral". Isetyenziswa kunye nezinye iziyobisi nokufakelwa amalungu omzimba.
• "Ekvoral". Oku lisetyenziswa abohlukeneyo amalungu parenchymal, kwakunye nokuthintela ukulahlwa emva abohlukeneyo.

Nangona isibakala sokuba bonke ibenodidi efanayo amanyathelo, phambi kokutshintsha amachiza iphambili kuye nawuphi na, kufuneka kuqala thethane, uze udibane nogqirha wakho.