Izigulane "I-Cefotaxime": imiyalelo yokusetyenziswa, izibonakaliso, intengo. Uphononongo malunga neziyobisi

Akuyiyo imfihlo kunoma ubani ukuba i-anti-antibiotics ye-semisynthetic ine-wide range of action. Ezi zonyango zisetyenziselwa ukuphatha izifo ezahlukahlukeneyo ezivuthayo kunye nezifo ezithintekayo. Kodwa ngaphambi kokunyulwa kwaloo mayeza, ugqirha kufuneka ancome isigulane ukuba ahlolwe ngonyango. Le yindlela yodwa yokuqonda ukuba yiyiphi i-antibiotic eya kubonakala ngokuthe ngqo kwipilisi yesifo esithile.

Ukunyanga i-genitourinary system, kwakunye nephepha lokuphefumula, iilenki ze "Cefotaxime" zisetyenziswa ngokuthe tye. Izixhobo zalo mziza, ukuchasana kwawo, umlinganiselo kunye nendlela yokulawula, siya kuqwalasela ngezantsi.

Ukubunjwa, inkcazo, ifomu kunye nokupakishwa kweyeza

Ziziphi izithako eziqulethwe yi "Cefotaxime"? Izilwanyana ( umlinganiselo wezilwanyana walolu dakamizwa umiselwe ngabanye) zibandakanya i-substance esebenzayo, njenge-cefotaxime (i-sodium salt).

Ukulungiswa ngokwayo ngumgubo omhlophe okanye ophuzi, osetyenziselwa ukulungiselela isisombululo se- injection or injection injection.

Amachiza angathengwa kwiibhotile zeglasi, zifakwe kwiiphakheji zekhadibhodi.

Iipropmacological properties

Ngaba uyazi ukuba yintoni isiza "Cefotaxime"? Imiyalelo yokusetyenziswa (iisisiti kubantwana - uvavanyo aluyinto elula, kodwa kuthiwani ukuba kuyimfuneko?) Kuthiwa ukuba izidakamizwa ezincinci zimiselwe ngokulumkisa ngokukhethekileyo, kuba liyi-antibiotics ephakathi. Isisombululo saso sichazwa njenge-cephalosporins yesithathu.

Isetyenziswe ngokubambisana. Isebenza ngokuchasene nesityalo segram-positive, kunye ne-gram-negative microorganisms, ezibonisa ukuchasana okukhulu kwi-aminoglycosides, i-sulfonamides ne-penicillin.

Umgaqo wesenzo sokulwa ne-antimicrobial solu hlobo lusekelwe kwikhono lokunciphisa umsebenzi we-transpeptidase. Oku kubangelwe ukukhutshwa kwe peptidoglycan.

Iimpawu zeCinetic zeziyobisi

I-Cefotaxime ifake njani? I-Abstract (injections - le yindlela ephela yelisiza) ibonisa ukuba emva kokufakelwa kwe-injection ye-intramuscular ukuxininisa okuphezulu kwegazi kwimbali emva kwemizuzu engama-35. Phantse i-27-40% yento esebenzayo ibopha kwiiprotheni ze-plasma.

Impembelelo ye-bactericidal yesilwanyana ihlala kwiiyure ezili-12. Isilwanyana sitholakala kwi-gallbladder, i-myocardium, ithambo kunye nezicubu ezinotshontsho.

Umntu akanakunceda ukuthetha ukuba icandelo elisebenzayo lale chiza liyakwazi ukungena kwi-placenta kwaye ifunyenwe kwi-pleural, peritoneal, synovial, cerebrospinal kunye ne-pericardial fluids.

Phantse i-90% yesichengiselwano ixutywe emcinini.

Ngomjovo we-intramuscular, i-half-life of the drug is 60-90 imizuzu, kunye ne-injection ye-intravenous, iyure. Isithako esisebenzayo sinxulunyaniswa kunye ne-bile. Ukugqithiswa kwesilwanyana akugcinwa.

Iimpawu zokusetyenziswa

Kwiziphi izifo kufuneka ndisebenzise i-antibiotic "Cefotaxime"? Imiyalelo yokusetyenziswa (injections, ixabiso elibhaliweyo ngezantsi, kufuneka limiselwe kuphela ngugqirha) lithetha ukuba le nyilisi iboniswa phambi kwezifo ezithathelwanayo.

Kuqhelekileyo kusetyenziswa kwiimeko ezilandelayo zesifo sokuphefumula:

• Pneumonia;
• Pleurisy;
• Iimpazamo;
• Bronchitis.

Kwakhona, isixhobo sisebenza xa:

• I-meningitis ye-bacterium;
• Endocarditis;
• Iingxaki zengqesho;
• Septicemia;
• Izifo zethambo kunye namathambo;
• Isifo seLyme;
• Izifo zephepha lomchamo, umqala, intloko, impumlo, iintso;
• Izifo zamalungu kunye namathambo;
• Izifo zesisu;
• Izifo ezenzeke ngokuchasene nemvelaphi ye-immunodeficiency.

Kufuneka kwakhona kuqaphele ukuba ii-injection ze "Cefotaxime" zivame ukumiselwa ngenjongo yokuthintela izifo eziye zaphuhliswa emva kokungenelela kokuphaphaza (kubandakanywa ukungasebenzi, ukuxhatshazwa kwemithi, kwintlobo yesisu, njl njl).

Ukungqinelana nokusetyenziswa kweziyobisi

Malunga nendlela yokuhlaziya ijoyi ye "Cefotaxime", siya kukuxelela emva kancinci. Kufuneka kuqatshelwe ukuba le mpendulo ayinaso uluhlu olude kakhulu lweengqinisiso. Ngokwemiyalelo, le nyanga ayimiselweyo xa:

• Ukuhlamba;
• Ukukhulelwa;
• I-hypersensitivity yomntu ngamnye kwisithako esisebenzayo;
• Enterocolitis (kubandakanywa kwimbali).

Ngaba ndingayifaka isisombululo seCefotaxime? Izibetho kubantwana (impendulo malunga nokusebenza kwezilwanyana ziya kuboniswa ekupheleni kwinqaku) ivumelekile ukuba yenziwe kuphela emva kokuba isiguli sifinyelele kwiminyaka engama-2.5 engama-(kwisingeniso / / m).

Unonophelo olukhethekileyo, unyango luyalelwe iintsana ezisandul 'ukuzalwa ngexesha lokuncelisa (ekubeni isicatshulwa sidityaniswe kwixabiso elincinci nobisi lonina), kunye nokusuleleka kwesifo esingasigxina kunye neNNC (kubandakanywa kwimbali).

Kwi-pathology ye-system ye-renal kunye ne-hepatic, isigulane sidinga ukufumana uviwo olongezelelweyo lwezokwelapha ukuze kufumane isigqibo malunga nokungabikho kokuchasene nokunyanga kwamayeza.

Isiza "Cefotaxime": imiyalelo yokusetyenziswa (iinjenge)

Ungayilungisa njani i powder ngokuchanekileyo? Ukuze uphendule lo mbuzo, makhe sibuyele kwimigaqo eqhotyoshelweyo. Ichaza iindlela ezicacileyo zokulungiselela izisombululo zeseyile.

Ngoko, ukwenzela ukungeniswa kwe-injection (injection) yesilwanyana 1 g ye powder idibanise 4 ml yamanzi ukwenzela inkunkuma (engenamntu). Imithi ekulungeleyo ilawulwa ngokukhawuleza imizuzu engama-4-7.

Ukunyuka kwe-intravenous, 1-2 g ye powder ihlanjululwe 50 okanye 100 ml ye-solvent. Njengoko isetyenziswe kwisisombululo se-0.9% se-sodium chloride okanye isisombululo se-5% se- glucose (dextrose). Ubungakanani bejojo engama-55-65 imizuzu.

Ukulawulwa kwe-intramuscular of the drug, 1 g ye powder iyachithwa 4 ml ye-solvent. Njengoko isetyenziselwa amanzi kumjoza okanye isisombululo se-1% se-lidocaine.

Ngaloo ndlela, isicatshulwa esikulo mbuzo sinokulawulwa nge-intravenously drip okanye jet, kunye ne-intramuscularly.

Amachiza ngokuqhelekileyo anikwe izigulane zabantu abadala, kunye nabantwana abaselula abaneminyaka engaphezu kwe-12 ubudala kunye nesisindo somzimba esingaphezu kwama-50 kg. Xa kufuneka ngokukhawuleza, kusetyenziswa ukuphatha abantwana abancinci.

Isisombululo semveliso yeyeza

Ngoku uyazi ukuba ungenza ntoni ngee-Cefotaxime injections. Kodwa yintoni umlinganiselo wabo? Kuxhomekeke kwiimpawu kunye nobukhulu besifo.

Ukufumana izifo zesifo se-urrogen, kunye nezifo ezingenakunzima, ichiza lilawulwa nge-intravenously okanye nge-intramuscularly 1 g nganye iiyure ezingama-9 ukuya ku-12.

Ukufumana izifo ezixhasayo - 1-2 g nganye iiyure ezili-12.

Nge-gonorrhea enobucayi, imithi imiselwe nge-intramuscularly kwi-dosage ye-1 g (kanye).

Kwiintsholongwane ezinzima (umzekelo, nge-meningitis), isilwanyana sisetyenziselwa ngaphakathi, 2 g nganye iiyure eziyi-6-9. Umthamo ophezulu ngemini ngu-12 g. Ubude bonyango lubekwe ngabanye.

Ukuthintela ukuphuhliswa kwezifo ezithathelwanayo phambi kokuhlinzwa, isiguli ngexesha le-anesthesia yokuqala ejoyiweyo "i-Cefotaxime" kwisilinganisi se-1 g. Ukuba kuyimfuneko, i-injection iphinda iphindwe emva kweeyure ezingama-6 ukuya ku-12.

Kwinqanaba le-caesarean ngexesha lokusetyenziswa kwezibonda kwi-veinlical vein le nkunkuma ilawulwa nge-intravenously kwi-1 g. Ngaphezulu kwiiyure ezingama-6 ukuya kwe-12, i-injection eyongezelelweyo kwisilinganiso esifanayo.

Imiyalelo yabantwana

Ukuba kuyimfuneko, iisisiti ze "Cefotaxime" kwiintsana, kunye neentsana ezingaphantsi kweveki enye yobudala, zinikezwa nge-intravenously kwisixa esingama 50 mg nganye ngekg yeesisindo somzimba rhoqo kwiiyure eziyi-12. Kwiminyaka eyi-1-4 ukuya kweleveki, isilwanyana sinikezelwa kumyinge ofanayo, kodwa nganye iiyure ezingama-9.

Iintsana ezineminyaka engama-2.5 engama-50 kg weemithi zonyango ezingaphantsi kwama-50 kg zichazwe nge-intramuscularly okanye intravenously kwisixa semali engama-50-180 mg ngekhilomitha yesisindo somzimba (kwi-injini ye-4 okanye ye-6).

Kwizifo ezithintekayo ezibandakanyekayo, kubandakanya i-meningitis, ukulingana kwansuku zonke kwilisi kunyuselwa ku-100-200 mg ngekgiksi. Kule meko, iilenki zilawulwa nge-intramuscularly okanye intravenously kwisixa sama-4-6 amaxesha ngosuku. Iqondo eliphezulu leziyobisi ngosuku li-12 g.

Iziganeko ezimbi

Ngokuchasene nemvelaphi yokusetyenziswa kweziyobisi "I-Cefotaxime" kwizigulane zinokuthi zihlakulele iimpendulo zengingqi njenge:

• Ukukhathazeka ngejoyile yeesram;
• U-Phlebitis, ukuphuhlisa nge-infravenous infusion.

Ezi ziphumo ezinqwenelekayo ziyakuthi zibonwe:

• I-jaundice ye-Cholestatic, i-colitis e-pseudomembranous;
• I-hepatitis, isicupunu, i-hypoprothrombinemia;
• Ukwanda kwe-ALT, i-AST, i-hemolytic anemia;
• I-diarrhea syndrome, ukuncipha kwinani leeplatelet;
• Ukuvutha, i-neutropenia.

Kwiimeko ezinqabileyo, iimpendulo ezithintekayo ziyakwenzeka (inani elongeziweyo lama-eosinophil, i-edema ka-Quincke kunye ne-skin itching), kunye nephritis kunye ne-candidiasis.

Xa ubona ezinye iziphumo ezimbi, uncedo logqirha kunye nokurhoxiswa ngokuzimeleyo kweyeza kufuneka.

Ixabiso kunye neendlela ezifanayo ze-antibiotic

Iindleko zesilwanyana esibuzwayo zixhomekeke kumda we-intanethi kunye nommandla wokuthengisa. Ngokomyinge, iiboule-vials (iziqwenga ezi-5 nge-1 g) zingathengwa nge-ruble 160-170.

Ukuba kuyimfuneko, eli gama lingafakwa endaweni efana neClaforan, iCefabol neCefosin.

Nangona kunjalo, kufuneka kuphawulwe ngokukhawuleza ukuba la mayeza angasetyenziswa emva kokubonisana nodokotela.

Ukuphonononga malunga ne-agent antibiotics

Ngokwenziwa kwintsholongwane yabantwana, eli gama lisoloko lichazwe njenge-arhente ye-antimicrobial. Njengomthetho, kwenziwa kwimeko apho ezinye i-antibiotics zingenzi umphumo ontle wokuphazamiseka.

Izimvo zabathengi malunga neenjini ze "Cefotaxime" zithembekileyo. Iingxelo zezigulane ziqinisekisa ukuphumelela kwe-antimicrobial high. Nangona kunjalo, umntu unokufumana iimpendulo ezinjalo, ezithetha ngokuthe ngqo ngobuninzi beempendulo ezingalunganga emva kokuba unyango (ukubhubhisa, i-dysbiosis, colic nabanye).