Ichiza "Doxorubicin": yesikhokelo, ncomo, iifoto, uhlobo ukukhululwa, umthamo, yokugcina. "Doxorubicin-Lance": imiyalelo yokusebenzisa

Umhlaza kuyingozi kakhulu ubomi babantu. It iqulathe iiseli okubulalayo olungalawulwayo ziyanda, ezinako ukungena kulo inyama engqongileyo kwaye iyakhula kwamanye amalungu.

Uphuhliso iziyobisi unyango lwezifo ezifana kungumsebenzi obaluleke kakhulu. Ngelishwa, kude kube ngoku akukho namnye kude kube sekupheleni kwaye nam andikhange isigqibo. Nangona kusekho iziyobisi ezinokucothisa ukwahlulwa kweeseli ithumba. Omnye wabo wabhekisela amayeza "Doxorubicin". Imiyalelo zokusetyenziswa kunye ifoto ichiza ziya kuhlawulwa kweli nqaku. Kuyo uya kufumana ulwazi malunga nokugcina uthe iindlela apho fomu iyafumaneka ukuba ukuthengisa, kwaye ngaphezulu.

Packaging, ukwakheka, imilo kunye nenkcazo

Ziziphi fom kuthengiswa "Doxorubicin"? Imiyalelo yokusebenzisa zibonisa iintlobo ilandelayo mveliso:

• Lyophilizate ukwenzela ukulungiselela isisombululo ukuba isitofu intravascular kunye intravesical. Yeyona ubunzima aneentunja ebomvu-tyheli iqulethe into esebenzayo ezifana doxorubicin hydrochloride. lwezithako olongezelelweyo usebenzisa mannitol. Amayeza kuthengiswa zeebhotile, abhijelwe kwibhokisi yekhadibhodi.
• Ingqondo ku tswala isisombululo ukuba isitofu intravascular kunye intravesical. Kuyinto ulwelo ebomvu neselubala leyo iqulathe doxorubicin hydrochloride kwaye ifumaneka iibhotile kunye iibhokisana.

Kwemithi beziyobisi

Yintoni na le amayeza njengoko "Doxorubicin"? Imiyalelo (ifom ukukhululwa beziyobisi saboniswa ngasentla) ukusetyenziswa ingxelo ukuba i anthracycline zintsholongwane anti-ithumba, leyo uyazimela nenkcubeko ngundo Streptomyces peucetius. Uyakwazi ukuba ekuphembeleleni iziphumo antimitotic kunye antiproliferative.

Unxulumano kunye DNA, i-medicament abangaphangeliyo RNA polymerase, DNA polymerase kunye topoisomerase uhlobo 2, kwaye kananjalo iyazingenela ukuveliswa radicals simahla kwaye enza phezu kodonga cell. Ngenxa yokuba eli futhe ukucola DNA phindana kunye eziphilayo nucleic yokuqaphela.

Akunakwenzeka ukuba uqaphele into yokuba sicinga indlela kuba nefuthe ngqo cytotoxic. Iiseli ukubonisa uvakalelo ngokukhethekileyo ichiza G2-lesigaba kunye S-isigaba sobomi babo.

iipropati kinetic

Yintoni kwikinetiki iparameters ezendeleyo iziyobisi "Doxorubicin"? Imiyalelo yokusebenzisa ithi emva inaliti efakwa, esi sixhobo ngalo lonke zisasazwe multiphase. Ngexesha Imizuzu yokuqala 5 le medicament wathimba izihlunu ngokukhawuleza, kwaye eyavela igazi kunciphisa ngokukhawuleza. Njengoko isigaba sesibini, kuliwa iimolekyuli iziyobisi kade ukusuka emzimbeni.

Lugxile iziyobisi esebenzayo esibindini, nezintso, udakada, imiphunga kunye myocardium. Kwakhona ingena ngumkhaya kwaye kwizondlo ubisi lwebele.

Impendulo kwiiproteni plasma kwenzeka ngo-75%. Yokucolwa kweziyobisi esibindini, ngaloo ndlela ukuzazi ithe esebenzayo ezifana doxorubicinol.

Ngexesha ukuncitshiswa radicals ezamahala kuyondelelaniswe transcriptase nga ibenefuthe kuphuhliso yetyhefu intliziyo.

Half-ubomi doxorubicin kunye doxorubicinol efanayo kwaye imalunga 20-48 iiyure.

Malunga nama-40% ye-ithamo ichiza kokukhululwa kunye duct, kunye% 6-11 kuphela doxorubicin kunye nezakhi zayo, iintsuku ezi-5 afumaneka nomchamo.

Ubungqina obubonakalayo buxela

iziyobisi "Doxorubicin" banokuthi banyulwe koko izifo?

Imiyalelo zokusetyenziswa (umhlaza isinyi sisixhobo zisetyenziswa kakhulu) ithi: ukuba iyeza senza kakuhle xa:

• ndlala umhlaza ndlala, nee- kunye Ewing;
• ithumba Wilms ', umhlaza esiswini, uhlobo iseli encinane umhlaza wemiphunga;
• insulinoma, umhlaza webele, mesothelioma;
• umhlaza esophageal, carcinoid, neuroblastoma;
• nee- osteogenic, zamabanga hepatocellular carcinoma, lymphoma non-Hodgkin kaThixo ;
• Umhlaza nobubovu yesinye, umhlaza intloko entanyeni, thymoma amabi;
• umhlaza womlomo wesibeleko, ezinye iindidi yamathumba wamatyhalarha;
• wesizalo nee-, umhlaza endometrial, isifo Hodgkin kaThixo;
• rhabdomyosarcoma, leukemia oyingozi;
• leukemia lymphocytic ezingapheliyo, ezigula ezininzi.

Izimo

Yintoni imeko kwenkcazo isigulane ningabaleli kuye ichiza "Doxorubicin"? Imiyalelo yokusebenzisa, oncologists lokwenyani ukuba isixhobo ibonisa asiphumeleli kakhulu:

• zegazi ku doxorubicin okanye ezinye izinto kweziyobisi, kwakunye nabameli of anthracyclines kunye anthracenediones;
• unyango phambi, okanye amanye amalungu anthracenediones anthracycline ngeedosi ngokunciphisa, kwakunye nokusilela kwesibindi (esibi), iposi engabalulekanga, arrhythmias, izifo ezihlasela zosulele wentsholongwane egazini kunye nokungasebenzi intliziyo (yolawulo emthanjeni);
• yamathumba yingozi, zokuntshulisa eludongeni esinyini, izifo womchamo kunye Ngokuzimela (ngokuba intravesical).

Ngononophelo kakhulu, eli chiza kufuneka isetyenziselwe abantu abafumene ichemotherapy olunzulu, ngokunjalo izinto basengozini cardiotoxicity, waphula kwesibindi, ithambo ngumongo afunxwe iiseli umhlaza kunye nokutyeba.

Ukongeza, ingqalelo ngenyameko ichiza ezimiselweyo abantwana abantu abakhulileyo, kwaye njengenxalenye multi-iintlobo kunye nonyango antitumor multicomponent.

Drug "Doxorubicin": imiyalelo, idosi

Ngokutsho imiyalelo, ingqalelo ichiza nga ufakwe intraarterially, yegazi kunye intravesically. Kufuneka kuqatshelwe kanjalo ukuba esi sixhobo siza kusetyenziswa zibangele okanye zidityaniswe namanye amachiza cytostatic kwi iidosi ezahlukeneyo.

isisombululo iziyobisi zakhiwe "Doxorubicin" iza kusetyenziswa ngoko nangoko emva kokuba umenzi wayo.

ekwakhiweni inaliti efakwa

Xa umthamo abawacebisayo monotherapy "Doxorubicin" kumjikelo ngamnye yi-60-75 mg / macala onke. m kwiiveki ezintathu. Ngokuqhelekileyo, ichiza zifakwa kanye. Noko ke, le idosi lingaqhutywa nokuba kwizitofu ezininzi (in-mali ka-25-30 mg / macala onke. M ngosuku kwiintsuku zokuqala 3 zomjikelo).

Ukunciphisa isiphumo zinetyhefu ngendlela esetyenzisiweyo ulawulo ngeveki ka 10-20 mg / macala onke. amaxesha m ngeveki.

Xa kudityaniswe nezinye izinto anticancer medicament esebenzayo ibhalwa kumjikelo esithathwa xa isixa-mali ka-30-60 mg / macala onke. m kwiiveki-4.

izifundo ngokuphindaphindiweyo unyango kwenziwa kuphela emva kokuba lokuphelisa nya zonke iimpawu yetyhefu.

Ithamo iyonke ichiza kufuneka ibe ngaphezulu kwe 550 mg / macala onke. m.

ulawulo intra-emithanjeni i-arhente

Njani na naliti intra-esimbaxa "Doxorubicin 'iziyobisi? Khokela ithi ukunika sidetone abantu hepatocellular carcinoma medicament esebenzayo ukuba kwenziwa ngabo kwemithambo eqhelekileyo hepatic xa kukho umthamo 35-150 mg / macala onke. m. Ngelo amathuba xesha phakathi imijikelo kufuneka alingane ukususela kwiiveki ezi-3 ukuya kwiinyanga ezi-3.

Ukuqaliswa ichiza kwi lwesinye

Njengoko esinyini zenyuse iziyobisi "Doxorubicin-Teva"? Imiyalelo yokusebenzisa ingxelo yokuba eli esithathwa kuthetha ukuba ulawulo intravesical kufuneka 35-50 mg kufakelo ngalunye.

Iinkqubo zonyango kufuneka wenziwe emva kwesithuba seentsuku 7-28, kuxhomekeke injongo (ukuthintelwa okanye unyango).

Abasuka sisombululo zeziyobisi kufuneka 1 mg / 1 isisombululo ml amanzi okanye ngokwasemzimbeni.

Instillation lwenziwa zingekapheli iiyure ezi-2. Ekupheleni isigulane kufuneka bayikhuphe isinye.

imiphumela emibi

Ukulungiselela "Doxorubicin", apho umyalelo ochazwe ngasentla kunokubangela abasabela ecaleni kulandelayo:

• ukugabha, iintlungu esiswini, isicaphucaphu, ukudumba, stomatitis, urhudo, esophagitis, ngomlomo isifo hyperpigmentation, ukudla, ukwanda yibilirubin yoxinaniso egazini, ukopha zesisu, ukwanda transaminases hepatic;
• ulapha-oxhomekeke ingathityazwa leukopenia, thrombocytopenia, ianemia, leukopenia, neutropenia;
• sinus tachycardia, ibhloko atrioventricular, uhlobo tachyarrhythmia ukusilela congestive intliziyo, bradycardia, thrombophlebitis, bundle block lakhe isebe, abanala makhwiniba kwi ECG, arrythmia ventricular, Embolism yemiphunga, phlebitis, iingxaki thromboembolic;
• amenorrhea, oligospermia, hyperuricemia, amabala wokuchama ebomvu, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• neurotoxicity peripheral, ukuxhuzula, isiqaqa;
• nokudumba, alopecia ingathityazwa, photosensitivity, isikhumba hyperpigmentation, irhashalala, ukurhawuzelela, iintlungu eziqatha, irhashalala, erythema, sangaphandle efumileyo;
• dermatitis, irhashalala, bronchospasm, isikhumba ukuthotywa, anaphylaxis;
• phlebitis Local, nangokurhala iphawulwe, fleboskleroz, thrombophlebitis, iintlungu wengingqi, izicwili necrosis;
• polyuria, nocturia, dysuria, necrosis lwesinye inwebu, hematuria, ukungakhululeki, ukuchama ibuhlungu;
• striation erythematous kuyo inaliti;
• ukudinwa, umkhuhlane, ifiva, kuthibaza, uphuhliso lymphocytic okanye leukemia myelocytic (yondele), hyperuricemia, amaza, nephropathy;
• isilonda 12 duodenal / esiswini, sclerosis biliary.

iimpawu libanda

Ziintoni iimpawu libanda, zenzeka xa usebenzisa inani elikhulu "Doxorubicin 'iziyobisi? Imiyalelo Sebenzisa ithi ukuba libanda yemali kungakhokelela iimpawu inetyhefu kakhulu eyaboniswa inkqubo yokucola ukutya, ngokunjalo myelosuppression kakhulu. Ukongeza, amathamo aphezulu ichiza kunokuba kakhulu lula ukuba isifo sentliziyo oyingozi.

An ebubuvuvu loo ichiza "Doxorubicin" ayisekho. Xa libanda kuwa- chaphazela ilawulwa unyango nomqondiso. Kwakhona, ukuba esibhedlele yaye baphathwa kwiziyobisi antibacterial.

imithi

Ngaba kunokwenzeka ukudibanisa kunye namanye amachiza iziyobisi "Doxorubicin"? Imiyalelo yokusebenzisa kubonisa ukuba xa usebenzisa esi sixhobo zidityaniswe namanye amachiza cytotoxic ngokufuthi wabonakalisa letyhefu lwabo additive.

Xa ichiza zidityaniswe namanye amachiza cytotoxic, okuye cardiotoxicity (umzekelo, "ixa" okanye "Cyclophosphamide"), ufuna esweni ngenyameko intliziyo ngexesha lonke ikhondo unyango.

"Streptozocin" kwandisa isiqingatha-ubomi "Doxorubicin".

Uthomalaliso "Doxorubicin" isigulane ukuze ubonise iimpawu ahlekise ukopha Ngokuzimela emva unyango "cyclophosphamide", kwakunye ukuqinisa isenzeko kwesibindi zinetyhefu emva unyango "mercaptopurine."

Ukusetyenziswa "Paclitaxel" ngaphambi kokuba ukuqaliswa kanye "Doxorubicin 'ukuze bandiqumbise ukwanda egazini xi le yokugqibela.

Ziziphi amachiza abavumelekanga ukusebenzisa iziyobisi "Doxorubicin"? Imiyalelo zokusetyenziswa (izilwanyana akufuneki wabelwa) uchaza ukuba esi sixhobo kufuneka ukuxutywa kunye nezinye iziyobisi. Umzekelo, ukuba pharmaceutically ehambelana kunye "lweeHedfowuni", "Dexamethasone", isodiyam succinate, "hydrocortisone", "cephalothin", "aminophylline", "ixa" kunye namanye amachiza anticancer.

Xa kudityaniswe zokugonya live egazini phindana kunokwenzeka wentsholongwane egazini kunye reactions icala okwandisiweyo nciphisa omzimba kudibaniso emzimbeni wesigulane ukuphendula ngokusetyenziswa ngamachiza.

iingcebiso ezithile malunga nokusetyenziswa kweziyobisi

Oko umele ukwazi phambi kokusebenzisa i "Doxorubicin-Lance"? Imiyalelo zokusetyenziswa ibonisa ukuba ngexa unyango arhente antineoplastic kuyimfuneko ukuba enze esweni rhoqo umsebenzi kwesibindi, umfanekiso igazi peripheral, ECG kunye ultrasound zentliziyo.

iimeko yokuthengisa, indlela yokugcina kwithala ubomi

Apho ukuba ichiza "Doxorubicin-Lance"? Imiyalelo yokusebenzisa ingxelo ukuba esi sixhobo kufuneka igcinwe kwindawo eyomileyo nemnyama apho lobushushu awudluli degrees ezintlanu.

Le medicament iyekelela ezikhemisti ngokumiselwa kuphela. ukuphila kwishelufa kwiminyaka emibini.

Price kunye analogue

Iindleko ichiza kuqwalaselwa 120-150 engange e ml-5. Ukuba kuyimfuneko ukuba indawo ngokusebenzisa ezifana "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50"; "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" kunye nabanye.

Ukubuyekezwa yabathengi iyeza

Ngoku uyazi ukuba mawuzisebenzise njani ichiza "Doxorubicin". Imiyalelo yokusebenzisa kunye nokugcinwa iziyobisi uchazwe apha ngasentla.

Noko inani elikhulu reviews zabathengi ezinxulumene ngayo ezibi ezithe zenzeka ngexesha unyango kunye neziyobisi. Ukuze le miphumela ukubandakanyeka omzimba angaphakathi, yaye uhlale ixesha elide uziva ugula, ilahleko iinwele kunye nokusekwa izilonda kwiziza inaliti.

Kwi umyalezo ezintle zinqabile kakhulu. Kwaye oku ayimangalisi, ukususela ukusebenza anticancer neziyobisi kufuneka ukuba nazo zizivandlakanye liyincutshe onamava kuphela, ngokusekelwe kwinani elikhulu lezinto ezahlukeneyo: uhlobo monotherapy okanye unyango zombini, nomhlaza, imeko yesigulane, kunye nezinye iziphumo ixesha elide.