"Dopamine" - yintoni leyo? "Dopamine": umyalelo, isicelo, ixabiso

Ichiza "Dopamine" Kubonakala ngathi ngumgubo crystalline of umbala omhlophe kunye livumba kunzima perceptible of zehydrochloric acid. Le fom ngayo ngohlobo hydrochloride. "Dopamine" - into enyibilikayo emanzini kunye notywala. It banazo alkalis, ii-arhente ezahlukeneyo oxidizing kunye neetyuwa zentsimbi. Iimpawu kunye Izimo ukuba ukusetyenziswa kweziyobisi "Dopamine", ukufundiswa ukusetyenziswa kwayo babekwa kwiimpapasho zethu.

Kuthethwa ekhutshwe njenge sisombululo ukumnika mxube.

iimpawu kwemithi

"Dopamine" - into, a neurotransmitter. Kwiipropati pathways ye dopamine yinto siphu- adrenaline kunye noradrenaline. Ichiza luchaphazela receptors esihambelanayo, nokuba kungomlinganiselo eziphezulu kwandisa umsebenzi α- kunye β-adrenoceptors. "Dopamine" umsebenzi ijolise:

• isixhasi ukumelana iperipheral vascular;
• ukwanda koxinzelelo lwegazi iSystolic;
• ukukhuthazwa izinga intliziyo;
• ukwanda output intliziyo;
• utshintsho minor kwi izinga intliziyo;
• mpilo ebalulekileyo.

"Dopamine" Kwakhona uphucula igazi ukugeleza iimpahla ingqondo, intliziyo, izintso kunye namathumbu. Ukwandisa ireyithi product glomerular kesodiyam zinomgutyulo yi kwizintso.

"Dopamine" - ichiza ngokukhawuleza-esebenza. Emva kwemizuzu 5-10 emva i / umsebenzi v ukumnika iphela. Kwisiqingatha ubomi - malunga ezimbini imizuzu. Isiqingatha sempahla esinxibelelana iproteni kwi plasma yegazi. Ichiza udlula inkqubo yokucolwa ngokukhawuleza nezi ntso, nomhlehlo wesibindi kunye negazi iplasma ngenxa kwimpembelelo Mao kunye catechol-O-methyltransferase ukuya imo metabolites luyeke ukusebenza uze ke ngenkuthalo eveliswe kwizintso. Ikota ukusetyenziswa iidosi is kuguquka norepinephrine kwi ihlume luvo adrenergic. Ngenxa ekupheliseni esebenzayo asinto zemali beziyobisi emzimbeni womntu, nokuba emva kwexesha elide ulwamkelo.

"Dopamine": application

Ubungqina obubonakalayo buxela ukuba ukwamkelwa:

• iintlobo ezahlukeneyo abanjwe, ezifana ebuhlungu, cardiogenic, postoperative, zomzimba, endotoxin.
• olujikeleza Acute kunye nokungaphumeleli intliziyo.
• imveliso eliphantsi inhliziyo.

"Dopamine" kunye ukothuka cardiogenic abaneemfuno ezizodwa, oko yandisa umsebenzi engabalulekanga contractile.

Ichiza iphethwe yegazi. 125 okanye 400 ml iipesenti ezintlanu isisombululo sodium chloride okanye isisombululo glucose ezifunekayo kwi-25 okanye 200 mg ngokulandelelanayo. Ngenxa yoko, 1 ml yesisombululo wafumana 200 okanye 500 kweziyobisi .mu.g. Ukuba sigulane asikwazi abasayi kwenziwa imiqulu ezinkulu ulwelo ingenziwa isisombululo kanzulu xaxa ukuze 1 ml 800 micrograms waba "dopamine". Ukuze wenze oku, thatha 200 mg nganye ml 250 isisombululo. Izinga intshayelelo ifikelela ug / kg 1-4 ngomzuzu ukuya ubunzima bomzimba avareji ye-70 kg (2 11 amathontsi ye 0.05% isisombululo okanye ukusuka ngamathontsi 1.5 ukuya kwisi-6 ka-0.08% solution). Umthamo therapeutic - 5 ukuya ku-9 mg / kg min 1. Izikali "Dopamine" 10-15 .mu.g / kg ngomzuzu iluncedo xa vasodilation kunye hypotension. Izinga Ulawulo angandiswa ukuya ku-18 .mu.g / kg ngomzuzu. Nokuhlanganiswa lwenzeka ngaphandle kokuphazanyiswa yaye iquka ixesha ukusuka kwiintsuku 2-3 iiyure ukuya 1-4 okanye ngaphezulu. Ithamo ngosuku elingagqithanga 800 mg. Kunye nokuqaliswa kwe "Dopamine" ibanjwa esweni ECG. Nokuzimisela ithamo kunye nezinga nolawulo ngokwe uxinzelelo esimbaxa, izinga intliziyo, imveliso kwentliziyo, izinga lentliziyo kunye diuresis. Ukuba asivelanga hypotension, nokwehla nomchamo imveliso, ithamo kufuneka incitshiswe.

Izimo

Ichiza contraindicated xa kuthe kwakho iingxaki ezifana:

• arrhythmia;
• pheochromocytoma;
• hypertrophy prostatic;
• ukuvalwa glaucoma.

imiphumela emibi

Ukuqaliswa osisiqu ngeedosi ezinkulu, inqanaba eliphezulu "Dopamine" kunokubangela iziphumo ezingalindelekanga, kuquka:

• lafa;
• tachycardia;
• vasospasm;
• arrhythmia;
• ephula isingqisho sokuphefumla;
• anginal kunye intloko ebuhlungu;
• lengqondo yokususa ;
• nezinye inyathelo Adrenomimeticalkie.

Ekubeni ekupheliseni "Dopamine" iyasebenza, ezi mpawu zingasentla shwaka ukuba ukwehlisa isikali okanye ukuphelisa ulawulo beziyobisi. Ukuba isingqisho yophukile, kuyimfuneko ukusebenzisa iziyobisi antiarrhythmic, kuquka "Verapamil", "lidocaine" kunye nabanye. isisombululo Extravasation "Dopamine" kunokukhokelela necrosis le inyama ongama adipose kunye nesikhumba.

oyi

"Dopamine" ngethuba lokukhulelwa ezifakwe kuphela xa unyango kokwaneleyo unina, kunye nesiphumo therapeutic ingaphezulu kwe umngcipheko olungekazalwa.

isisombululo Fresh kufuneka texture ngaphaya kwaye abanazo nombala zangaphandle.

unyango ngaxeshanye kunye namanye amachiza

Ichiza kufuneka ithathelwe ngokunxuseneyo kunye glycosides ezesifuba womchamo (umz, furosemide kunye nezinye). zomzimba ngenxa ifuna ukuqaliswa "Dopamine" kunye liphela negazi, iplasma okanye plasma ethutyana.

Musa ukuthatha "Dopamine" ngexesha elinye "cyclopropane", Mao inhibitors kunye njengearhente zomzimba kunye halo ( "Halothane" kunye nabanye).

kuqulunqo mix ngodaka azamkelekanga kunye izisombululo obrak nezinye iziyobisi.

"Dopamine" - iyeza esetyenziswa kuphela kagqirha. ixabiso layo kuxhomekeka idosi inani ampoules kwi phakheji, ukusuka 80 ukuya engange 300 pack ngamnye (5-10 ampoules).