"Capecitabine": imiyalelo ukusetyenziswa, isasetyenziswa yokwenene, ifom ukukhululwa, umenzi. "Capecitabine-TL": mazwi

Capecitabine (. Latin Capecitabinum) - into leyo a carbamate ithe fluoropyrimidine. Lingcwaba lomfo iqela antimetabolites - iikhompawundi ezithile nako ukuze kuthintelwe ukukhula yamathumba amabi. Umdla nezinto ezinjalo intsukaphi 1960 g. Iziphumo zokuqala HIV afunyenwe izifundo iimpuku. Emva kwexesha elithile, kwafunyaniswa impumelelo yayo unyango lwezifo ezithile umhlaza ebantwini.

Namhlanje, amachiza amaninzi anticancer equlathe capecitabine kweziyobisi esebenzayo. Izimvo izigulane ezininzi ithi impumelelo isicelo izixhobo ezo kunyango anticancer.

Kwezonyango, kwakunye neempawu

Formula capecitabine - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. Iqela chemical Antimetabolites limelwe liqela izinto ezifanayo indalo ukuya kwimveliso yokutya emzimbeni (ukutya) babantu. Bayakwazi ukuzibandakanya reactions pathways, uze uzilungise isantya phantsi ezinye iinkqubo nemvelo. Ngenxa yoko kukho ukungasebenzi kakuhle iiseli ithumba zibalulekile kunye inhibition lokukhula kwabo xa usebenzisa amalungiselelo kweziyobisi capecitabine esekelwe. Izimvo zabantu sithetha ngayo ukunciphisa ubungakanani yamathumba. Le indlela yokusebenza kuthiwa osebenzayo.

Le propati ukuba ukusetyenziswa kweziyobisi antimetabolitnyh kubo kunyango anticancer. ukusebenza kwazo ukuzabalaza nxamnye yamathumba amabi, le iphecana zesisu kunye namadlala mammary. Kulo mzekelo, nemiphumo emihle unika zombini monotherapy kunye idityaniswe kunye nezinye izinto. Ukuza kuthi ga ngoku, ngenxa yokuba anti-metabolites wadala iimveliso ngaphezulu kwama-800, kodwa usaqhubeka ukukhangela amaqela ezintsha iikhompawundi.

indlela isenzo

Capecitabine yovulo livela kwi nezihlunu nethumba, emva koko iqalisa sizibhokoxe isiphumo yayo yityhefu kwi iiseli (indlela cytotoxic). Le into libandakanyeka nethe basabela njani kwaye ikhokelele ekubeni baphilileyo kunye iiseli nethumba eziguqulelwe kwi analogs cytotoxic. Ngenxa yoko kukho kukwaphula esivelisa into eyimfuneko ukuze DNA amagama kunye, ngenxa yoko, inkqubo hlula.

Ekubeni iiseli ayeke ukwandisa amanani abo. Kwenye mzekelo, kukho "endaweni" omnye enye into, apho njini iproteni uphazamiseke xa iziyobisi capecitabine compound esekelwe. Guide ikuchaza ngokweenkcukacha kule nkqubo.

Indlela yale nkqubo yenguqu kunciphisa ithuba umonakalo kwiiseli esempilweni. Capecitabine kuqwalasele kakhulu nethumba ngokwayo, kunokuba emzimbeni ezingqongileyo. Loo msebenzi akuyiyo ingozi umzimba xa umntu uphathwa ukuba ichiza esekelwe capecitabine kweziyobisi. Imiyalelo yokusebenzisa icebisa ukufumana imali ngeedosi echazwe ngokungqongqo ukuba kumiselwa gqirha khona.

Hlala kweziyobisi emzimbeni

Emva kokufumana capecitabine yi nokufunxwa yayo olukhawulezayo kwisiqwenga zesisu. Ukuba udla ngeli xesha, le nkqubo iya isantya. Ngoko ke, ngokusekelwe amachiza antimetabolite reception yenziwa emva kokungenisa. inguquko lwenzeka kwi kweziyobisi isibindi, umlinganiselo othile capecitabine kunye metabolites yayo Ububophe kwiiproteni (umz, albumin). Amanqanaba kwincopho serum zabubamba emva kweeyure 1.5 -3 emva kokuba isicelo iziyobisi. Oku kuthetha ukuba ichiza "Capecitabine" umyalelo. Analogs babe pharmacokinetics efanayo.

Uninzi osisiqu esiswini saso umchamo, ephantsi - kunye endleni. Ngaphezu koko, amagqabi kuphela capecitabine umzimba singaguqukanga (3%), kodwa nezakhi zayo. Ezinye zazo umzimba ukuba iikhompawundi ngaphantsi esebenzayo. Le yokuhlala kunye nokuguqulwa capecitabine emzimbeni azichatshazelwa isini, ubudala, uhlanga.

Xa beqeqeshwe?

Capecitabine ibe imixube ezahlukeneyo elawulwa ukuba izigulane kunye nomhlaza webele, kuquka isigaba kuwenza. Kulo mzekelo, izinto ezisetyenziswa kwi-sikhokelo kuphela, okanye idityaniswe unyango kunye Izimo okanye ukunqongophala ukusebenza nechemotherapy. Amaninzi, capecitabine kudityaniswe docetaxel.

Kwakhona emiselweyo ukuba izigulane umhlaza colon, kuvuleke iminxunya, isisu, injeke, umhlaza colorectal, kokubini ukusasazeka asekuhlaleni kweqonga, kwaye ngexesha Ukudlulela. Xa unyango lomhlaza colon kwakhona wabelwa "capecitabine". Imiyalelo yokusebenzisa ukulandela ngenyameko idosi ekucetyiswa ze ithobele icebiso gqirha khona.

Intsebenziswano kunye namanye amachiza

Ukuba chemotherapy yaba kuphumelele, liyincutshe Oncology angamisela unyango zombini, nto leyo eza kusetyenziswa "capecitabine". Imiyalelo zokusetyenziswa inika uluhlu lwezixhobo, apho kunokwenzeka ukuba mix ngempumelelo.

Umzekelo, with "docetaxel" - iziyobisi cytotoxic zodidi lwentshukumo ukuba imvelaphi yemifuno. Oku uyakwazi ukuqhubeka ixesha elide ukuba iiseli kungomlinganiselo eziphakamileyo. Noko ke, indibanisela enjalo arhente ukuba contraindicated kubantu kunye nenani zegazi kunye neutrophils 100,000 / ul-1500 / l, ngokulandelelana. Kwakhona "Docetaxel" alisebenzi izigulane elandileyo izinga yibilirubin. Kulo mzekelo, imiphumo kunokwenzeka ezingemnandi. Ukuba 'Docetaxel "ngenxa yezizathu" ukuwa "le irejimeni yonyango, qhubeka unyango" capecitabine ", kodwa amathamo nokuphungulwa.

Xa kuthe unyango hypersensitivity reactions "capecitabine" yaye "docetaxel" yokumisa kunye nokuvala iimpawu yabangela. kufakelelwa Scheme zidityanisiwe iphuhlisa yezandla abanezakhono somdlavuza. Esi sikimu siyahlengahlengiswa xa kuthe neziphumo ezinetyhefu.

"Capecitabine" elingatyunjwanga ngaxeshanye "Sorivudinom" - i-arhente antiviral. Le yindibaniselwano kunokwandisa ubuthi kwichiza yokuqala. Ukusetyenziswa idibene iziyobisi antiepileptic "phenytoin" kwandisa lwee- kubemi plasma yegazi. Kwakhona ukopha kunokwenzeka disorder ekusebenziseni anticoagulants coumarin kunye neendlela, apho icandelo engundoqo - capecitabine. Imiyalelo yokusebenzisa zilumkisa ngemiphumo kunokwenzeka, ngoko kufuneka kuqala wazi nayo ngokwakho.

Ngubani na contraindicated?

Isizathu ukuba contraindicated okanye kuphela ichiza kungaba:

• uvakalelo oluphezulu (hypersensitivity reaction).
• Ubukho insufficiency kakhulu kwezintso okanye hepatic.
• zikumanqanaba ahlukeneyo lokukhulelwa (ichiza luchaphazela iziqhamo), ngaphandle kweemeko apho ubomi sikanina iincwadi kuqala;
• Ukondla ukondla usana.

Kwakhona ukufumana Umda capecitabine kubantu abanesifo sentliziyo (isifo), xa imo eyandileyo lwee- yibilirubin egazini, isifo zesibindi kuwenza ukuxhatshazwa imisebenzi yayo engundoqo. akukho amalungiselelo ekucetyiswa ukuba abantwana kunye nabantu abadala. Oku kungqina ichiza "Capecitabine" umyalelo. Baqinisekiswa ukuthetha ngezinto ezahlukahlukeneyo iziphumo ebezingalindelekanga kunye neziphumo yityhefu kwi unyango. Ngoko ke, unyango capecitabine kwenzeka phantsi kweliso elibukhali lika a somdlavuza lwengcali.

Ingaba kukho naziphi na iziphumo ebezingalindelekanga?

Emva ezithatha ichiza inokuba intloko ebuhlungu, imo ukudinwa, silale, buthathaka. Ugwayi Inokwenzeka, okanye vice versa - ukozela. Kwiimeko ezinqabileyo - ukulahlekelwa ulungelelaniso kunye nokulungelelana, ukudideka.

ziziphumo ebezingalindelekanga kwi nemithambo yegazi i-anaemia (anemia). Ukuze isiXhosa inokubangela angina, ischemia engabalulekanga, ukufa kwamalungu omzimba, ukusilela intliziyo kunye nabanye. Ukuba inkqubo amalungu nokuphefumla inxaxheba, kusenokubakho ukuphelelwa umoya, umqala obuhlungu, ukhohlokhohlo. kunqabile kakhulu - Embolism yemiphunga, aqaqambayo zemiphunga.

Xa isetyenziswa kuhlanganiselo kuphela okanye idityaniswe unyango kunokwenzeka iziphumo ezingalunganga kwi kwinkqubo musculoskeletal. Oku kuzibonakalisa iintlungu imilenze kunye esinqeni, vuka izihlunu hypertonus (myalgia), iintlungu ngokudibeneyo (arthralgia).

Le isikhumba nayo iya kuchaphazeleka. Kungabangela dermatitis, erythema, kome kakhulu ulusu, ukuba bomvu, esibuhlungu, antsi, bechuba, ukurhawuzelela, nombala ukwanda, umonakalo kuchaphazela iinzipho. Kwiimeko ezinqabe kukho iintanda ulusu, hypersensitivity ukuba yelanga imitha, bechuba kunye nokwanda ubu amacwecwe nail.

Phakathi kwezinye iziganeko ezibi Inokwenzeka iinkqubo ezosulelayo ngenxa ukuthoba zokuzikhusela zomzimba. Emva Unyango ngamachiza ibangela ukuhla zegazi kunye iiseli ezimhlophe zegazi. kubonakaliswa ichaza medicament "Capecitabine" umyalelo manual. Analogue ukunika neziphumo ezifanayo.

ichiza

"Capecitabine" ezifanele ukusetyenziswa ngaphakathi kuphela. Kudla kokuhlanjwa phantsi ngamanzi emva kangangesiqingatha seyure emva kwesidlo, kodwa kamva. Le idosi yemihla ngemihla umiselwa somdlavuza khona, kuxhomekeke kubungakanani yamathumba, uphuhliso yeqonga, kwaye ummandla umphezulu emzimbeni wonke. Kunqweneleka ukuba ingcali sele kwafuneka izakhono ukusebenza kweli chiza. Eyona njalo emiselweyo kabini-ngemihla - kusasa nangokuhlwa. Kulo mzekelo, ikhondo yonke sihlala iiveki ezimbini, ze emva koko - nekhefu iintsuku ezisixhenxe, kulandele unyango phinda.

Izigulana insufficiency kwezintso, ngokwemithamo ngemihla lifinyele. Ngokunciphisa inani leukocytes (leucopenia) kunye neutrophils (neutropenia) egazini bayaqhuba ezithatha ichiza. Ngoko lithethelela ukuba indlela "Capecitabine" umyalelo manual. Ntonye okanye analogue yayisalawulwa inyathelo gqirha khona.

ubuthi

Kukho degrees ezininzi, ngokoko apho ekuphuhliseni iziphumo yityhefu beziyobisi "capecitabine" (Imiyalelo Sebenzisa). Izimvo abantu abaninzi bathi le yinkqubo ngamnye.

Kukho izidanga ezininzi yetyhefu:

• 1 degree. Kukho ezimbalwa iziphumo ebezingalindelekanga.
• 2 isidanga. Ibe ngcono kakhulu (ukuya ku- 4 ngosuku) kulandele ngokwamathambo ukudumba, ukuba bomvu, umsebenzi disorder, esibukhali ukunyuka yibilirubin. Kweli nqanaba, ulwamkelo ziphazamise capecitabine de iimpawu ubuthi isigaba 1.
• 3 isidanga. Urhudo ophilisayo ukuya amaxesha 9 ngosuku. Oku kwenzeka malabsorption (sprue). Xa oku kwaqondakala isikhumba onamandla, exwebula, ukuba bomvu, namadyungudyungu kunye nezilonda. Kukho iintlungu elibukhali kwi eziphelweni, yehle yokusebenza. Yibilirubin linyuke amaxesha 3. Kweli nqanaba unyango luyekisiwe, nokubonakaliswa yetyhefu of 1 baqhubeke nokufumana iindlela kwi idosi asezantsi.
• 4 isidanga. isisu rhoqo - ukuya amaxesha-10 ngosuku. Esitulweni igazi. Kukho imfuneko yokuba kuqaliswe iziyobisi, ngokudlulisela iphecana zesisu. Ukuba iimpawu esi sidanga zonyango kufuneka lizakumiswa kwaye zange kuqaliswe.

Ngawaphi amanyathelo ekufuneka siyigcine ukhuseleko?

Ikhosi ye unyango kufuneka kwenzeke phantsi kweliso zonyango abasenyongweni. Yingcali kufuneka ngexesha ukubona izinto eziyityhefu -. Nokuba isicaphucaphu, urhudo, njl Phezu efumanise ezi mpawu, unyango yoxhaso. Ukuba kuyimfuneko, ukuphelisa iimpawu, ukunciphisa idosi yemihla ngemihla, yenza ikhefu. Unyango kufuneka kuqhube, ukuba iimpawu yetyhefu musani isongela ebomini.

Kuba abantu abane coronary nesifo sentliziyo zokucupha specialist kufuneka ngokucokisekileyo ngakumbi. Kulo mzekelo, udinga ixesha lokutyhila nefuthe elibi kwinkqubo sentliziyo kwangethuba ukuze kwenziwe amalungiselelo angawo.

Iingcali ayiyeke ukusetyenziswa kweziyobisi ngendlela ezingabantwana. Ukusebenza lokusetyenziswa yayo iye ayasekwa abantwana. Ukuba unyango ufakwa umfazi yokuzala, kufuneka acetyiswa ifuthe capecitabine ekukhuleni kosana olungekazalwa. Ngexesha unyango, kufuneka usebenzise zokucwangcisa ethembekileyo.

Amalungiselelo kunye analogue

Kukho iimveliso ezininzi ngokusekelwe capecitabine. Kwimarike Russian kukho 7 Igama zorhwebo ichiza, enziwe kwakhona ziinkampani ezininzi zasekhaya kunye angaphandle. Umzekelo:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Kuseloko lasekwayo zonke ezi zinto omnye kwaye eyona nto efanayo esebenzayo - capecitabine, kuba umyalelo yabo iya kuba efanayo. Ngokuqhelekileyo libonisa itafile ukubala idosi elinikiweyo ubunzima bomzimba kunye unyango ulungiso yesekethe xa umqondiso kumanqanaba angafaniyo yetyhefu.

Kubalulekile ukuqonda ukuba into yokuqala ekufuneka zifundwe, xa wamiselwa, umzekelo, "Capecitabine TL" - imfundiso. Ulwazi olunikezelweyo ezingafanelekanga izixhobo self-administration! Zonke izibalo ezinxulumene idosi kunye nonyango irejimeni, uvelisa ugqirha - somdlavuza ngobuchule ezaneleyo kulo mbandela. Self-ulawulo arhente anticancer ebangela umonakalo noqhekeko umzimba.

Makhe sihlolisise ezinye iziyobisi.

Inkcazelo ngamalungiselelo

• "Capecitabine - TL" lenza OOO inkampani Russian "Technology amayeza." Ingxenye ebalulekile - capecitabine. Imiyalelo zokusetyenziswa, ifom ukukhululwa umdla abaninzi. Cinga iinkcukacha. Le tablet, umboniso-camera. Umxholo wenkqu esebenzayo - mg 150 okanye 500. amacandelo Auxiliary: kwincindi, lactose, isodiyam croscarmellose, hypromellose, wemagniziyam stearate. Omnye iphakheji inokuba iipilisi 60 okanye 120, kuxhomekeke umthamo ichiza "Capecitabine - TL". Imiyalelo kufuneka siqulathe inkcazelo eneenkcukacha malunga nokusetyenziswa kwemali.
• "Capecitabine" - imveliso yasekhaya kunye isithako efanayo esebenzayo. incazelo yakhe ifana yindlela ezidweliswe ngasentla. uhlobo Ukukhutshwa ichiza "Capecitabine" - tablets. Imiyalelo yokusebenzisa nazo apha kwiphakheji.
• "Kabetsin" - arhente anticancer ngokwenziwa Russian ( "Inkampani" Deco "). Product ifomu - amacwecwe bhanya isale mg 150 okanye 500 of into esebenzayo. izithako eziziisekondari: microcrystalline kwincindi, crospovidone, starch, wemagniziyam stearate. Shiya ezikhemesti kuphela kagqirha.
• "Kapetsitover" - yimveliso yenkampani Russian OJSC "Veropharm". Le arhente anticancer ekhoyo emacwecweni mg 150 okanye 500 ka 60 - amaqhosha 120. Ngaphandle capecitabine, kumalungiselelo iquka lactose, kwincindi, isodiyam croscarmellose, isodiyam stearate, kunye hypromellose.
• "Kapametin FS" - eziveliswa inkampani Russian "Nativ" - nokuthatha inxaxheba kwinkqubo sokungenisa endaweni iziyobisi. "Kapametin FS" ukukhupha umthamo 150 - 500 mg arhente esebenzayo - capecitabine. Imiyalelo yokusebenzisa (kwakhona umvelisi Cwangcisa kuyo) uza kukuxelela ukuba zingaphi iipilisi pack nganye - 60 okanye 120.
• "Tutabin" - imveliso amazwe ngokusekelwe capecitabine. Ikhupha inkampani Argentina Laboratorio VARIFARMA SA, nto leyo nayo arhente rejista. "Tutabin" evela ngokohlobo amacwecwe kunye isiqulatho isithako esisebenzayo of mg 500. Packaging - ikhadibhodi ibhokisi kunye imiyalelo enikwe.
• "Xeloda" - i-arhente antitumor. Iveliswe eSwitzerland yi "yi F. Hoffman La Roche" kwaye iinkampani zayo ofisi omele kwamanye amazwe - Mexico nase-United States. Kwimarike Russian kukho 5 iziyobisi kunye negama lorhwebo. ifomu Product - iipilisi (150 - 500 mg) kwi iziqwenga 60 okanye 120. uqiniseke enye.

reviews

Ukuphonononga umsebenzi ngokusekelwe ezahlukeneyo zamachiza capecitabine. Inkoliso yabo HIV, kodwa kukwakho ncomo negative. Noko ke, oku akuthethi abonakalise ezi mali njengoko kwelungileyo nembi, ngenxa yokuba kufuneka ithathele ingqalelo ngamnye umzimba lomntu ngamnye. Nisamkela efanayo yabantu ezahlukeneyo ungaze isiphumo esifanayo. Enye into ebaluleke kakhulu kukuba apho umzimba enqamlezeneyo neoplasm kwaye beluqhubekeka ixesha elingakanani na.

Abantu abathatha ichiza, uthi isiphumo eyityhefu emva kweentsuku eziliqela wokwamkelwa olomeleleyo. Noko ke, abaninzi ingxelo ukuphucuka okubonakalayo imeko yabo kunye yokungenela kuxolelwe. Yimeko Kubalulekile ukuba ichiza zizakusebenza kakuhle kangangoko kunokwenzeka ukuba umntu oyedwa, i somdlavuza Consulting nokubambelela ngokungqongqo imiyalelo yakhe ngokuphathelele unyango.