Buserelin yokothula - inkcazo kunye nesicelo neempawu

Ukukhethwa isiyobisi hormone kufuneka isekelwe kuphononongo ngenyameko iimpawu kunye nokuchongwa kakuhle ubungozi yeziphumo ebezingalindelekanga.

Ukulungiselela "Buserelin Depot" ithelekiseka nabanye ngempumelelo yalo phezulu kwaye linokuba phantsi iimpawu ezibi. Yena lilungu arhente anticancer hormone.

Isenzo amayeza ye ichiza

Intshukumo ibandakanya buserelin antigonadotropnym, anti-androgenic, anti-estrogen, iziphumo anti-ithumba. Drug kweziyobisi "Buserelin Depot" yi ukhuphiswano Zinxibe ukuya receptors leeseli secreting gonadotropin-ukukhupha factor (ukuba ngaba isakhiwo nomhlehlo Icipande ingqondo yebhinqa).

Inxaxheba kwinqanaba lokuqala igalelo ichiza waphawula ukwanda ezidlulayo kweli yoxinaniso ka LH kunye FSH (hormone gonadotropic), ezabiwe yebhinqa, nto leyo ekhokelela ukuba nokwanda umxholo Gomonov angasese. Emva 14 - kweentsuku 21 uvimba kuthetha umsebenzi gonadotropic ngu feedbacks ezimbi, nto leyo ekhokelela ekubeni unciphiso ebalulekileyo LH kunye FSH, kwaye, ngenxa yoko, kunye nokwehla ekuvelisweni hormone ngesondo. Ngenxa yoko, amadoda testosterone yoxinaniso unciphisa, ifikelela kwinqanaba apho lusekiwe emva orchiectomy (xa kuthenwa zonyango). Abafazi iziyobisi isiphumo "Buserelin Depot" uvikivwa ukuya kwinqanaba estradioda ezikhoyo kwixesha posklimaktericheskom.

Ukusetyenziswa ichiza "Buserelin Depot"

Oku isetyenziswa kunyango lomhlaza yesinye, kwezinye iimeko, esetyenziswa kthen imveliso testosterone amatyhalarha. Kwakhona esetyenziswa ukunyanga umhlaza webele (izifo enama-oxhomekeke, nto leyo luphawulwa engemveliso ekumgangatho ophakamileyo estrogen okanye ivela kwi endometriosis). Ezinye izifo, waphatha "buserelina weziSetyenziswa": fibroids zesibeleko, hyperplasia endometrial, eqhuba inkqubo-IVF ekunyangeni ukungachumi.

Izimo kunye nezincomo ezizodwa

Hypersensitivity, orchiectomy, ukukhulelwa, zisanyisa. Amanyathelo ezithatha ichiza kwi ngezifo ye womchamo kwinqanaba Ukudlulela vertebral, lwegazi, isifo seswekile, kunye noxinzelelo. Buserelin yokothula kunye nokukhulelwa - amagama ezingahambelaniyo.

imiphumela emibi

Isiguli ezikhala oluthile kwicala e-nervous system central ngohlobo yintloko, uvalo, sokulibala, kunesifo, sinciphise ingqondo, isiyezi, kukungazinzi ngokweemvakalelo, kwaye maxa wambi kukudakumba. Kokuba waziva ukuduma okanye uxinzelelo lweliso lakho, umbono norhatyazo okanye ukuva. It kuhlala "komzimba." Kwiveki yokuqala yonyango kwabasetyhini baphawula psevdomenstruatsiya, ngoko wabeka ukoma lobufazi, kunokwenzeka demineralization ithambo, yehle yobuntu. Xa abantu, esi sifo ukuba mandundu kwi yokuqala 2 - iiveki ezi-3, okanye zibonakale gynecomastia, kunciphise amandla. Eyiyo enye Inokwenzeka: ukudla, ukuphazamiseka dyspeptic. Buserelin yokothula notywala awahambisani. Xa izigulane lwegazi nande uxinzelelo, izinga intliziyo. Ukususela ziyabagulisa kwenzeka: ukurhawuzelela, irhashalala, bronchospasm, ukothuka anaphylactic. Ukutshintsha izalathisi laboratory: dyslipidemia, hyperglycemia, ukwanda transaminases kunye yibilirubin, thrombocytopenia kunye leukopenia.

Imithetho-siseko ye ichiza

ulawulo Intramuscular: ezilawulwa nangoko emva ukulungiselela ukumiswa.

- xa prostate ithumba kwiiveki 4 4.2 mg.

- Endometriosis - yaziswa kwiinyanga 4.

- kunye myoma iinyanga wesizalo -3.

- nenzalo - 4.2 mg.

ulawulo Intranasal:

- ngokuba unyango lwezifo ababhinqileyo ezichazwe ngentla - elawulwa ngaphakathi komgodi ngeempumlo 900 mg / ngosuku (idosi enye, ka-3 ngosuku), ukususela nge-1 - iintsuku ezi-2 ukuba sexesheni.

- nenzalo 600 mg / imini, 1 ithamo em- ngeempumlo izihlandlo ezine ngosuku. Ukuba ichazwe ngamandla kuvalwe iindlela nkqubo zokuzala, ithamo liye lancitshiswa amaxesha-2.

Amanye amanqaku:

- Unyango umhlaza prostate lwenziwa ubomi;

- amachiza anti-androgen elawulwa iiveki ezi-2. kwaye iiveki ezi-2. unyango kunye buserelin, kuthintela iingxaki ezinokuthi zenzeke ngexesha kwiiveki zokuqala zonyango;

- kwixesha lokuqala unyango kwabasetyhini zingavela cyst ovarian;

- kufuneka ukuthintela ukukhulelwa kunye ukukhulelwa ukufumana amayeza ukunyanga buserelin, kodwa kwiinyanga ezi-2 zokuqala kuyimfuneko ukusebenzisa iindlela ezingezo-hormone yothintelo;

- nomphumela omuhle kunyango ngamachiza le endometriosis intsumpa ngokunciphisa nezihlandlo likakade.

Intsebenziswano kunye namanye amachiza

Buserelin kunciphisa ifuthe amachiza hypoglycemic. Inokubangela hyperstimulation ovarian, ukuba isetyenziswe kunye iziyobisi eziquka iihomoni ngesondo.