"Zanidip": imiyalelo yokusetyenziswa, ukuphononongwa kwezigulane kunye noogqirha, ezifanayo. "Zanidip-Recordati": imiyalelo, ukuphononongwa, ukufana

Ngokwezibalo, malunga nama-26% abantu abadala kwihlabathi bahlala bexinzelelo lwegazi. Ngokuqhelekileyo, esi sifo sichaphazelekayo kunye nemfuza yokuzalwa yomntu. Nangona kunjalo, kukho ezinye izizathu zokuvela kwayo. Ezi ziquka ukukhuluphala, ukutshaya, ukusetyenziswa kakubi kwetafile zetyuwa, ukungaphumeleli kwamandla kunye namavithamini emzimbeni, ukusetyenziswa kakubi kotywala, iimeko ezixinzelelekileyo, umsebenzi ophantsi kunye nabanye.

Kufuneka kwakhona kuqatshelwe ukuba uphuhliso lwexinzelelo oluxhomekeke ngqo kuxhomekeke kwiminyaka yobudala bomntu. Umdala, umngcipheko weimeko ezinjalo zesifo. Xa uneminyaka engama-40, esi sifo sisoloko sisisiphumo sezilonda ze-vascular sclerosis.

Ulwazi jikelele

Ngokudla kaninzi, oogqirha bafaka izigulane zabo zifunyaniswa " njengengozi ephezulu yengozi." Yintoni na? Kuyisifo esingapheliyo kunye nesimo somfutho wegazi ophezulu. Uphawu oluphambili lweklinikhi yinyuka eqhubekayo kunye nexesha elide kwingcinezelo yegazi.

Utshintsho kwesi sifo luyahluka. Nangona kunjalo, okokuqala, bakhathalela iinqanawa kunye nentliziyo.

Ukuphucula imeko yesigulane, oogqirha batusa ukuthabatha isichengisi esinjengeZanidip. Iingxelo zezigulane malunga nokusebenza kwezi zibisi, siya kuqwalasela kwizinto ezikule nqaku. Kwakhona kuyo kufumana ulwazi malunga nendlela yokuthabatha iyeza, enoba unemifanekiso kunye nemiphumo emibi.

Inkcazelo, ukubunjwa, ukuma kunye nokupakishwa

Isilwanyana "iZanidip", umyalelo wepakethi yekhadibhodi, ikhutshwe ngendlela yeepilisi zombala ophuzi, kunye nefom ejikelezayo kunye ne-biconcave engozini kwelinye icala. Bayi-film-coated kunye ne-yellow tint kwi-fracture.

Isithako esisebenzayo sale nkunkuma yi-lercanidipine hydrochloride. Kwakhona kubandakanywa izixhobo ezincedisayo, ezinikezwa ngendlela ye-povidone K30, i-lactose monohydrate, isitrodidium i-carboxymethyl isitashi, i-microcrystalline cellulose kunye ne-magnesium stearate.

Ngokubhekisele kwi-membrane yefayili yesilwanyana, iquka izinto ezifana ne-opadrai eluphuzi, i-talc, i-hypromellose, i-titanium dioxide, idayi yensimbi ye-yellow oxide kunye ne-macrogol 6000.

Unokuthenga iipilisi zeZanidip kwiiblisti, ezifakwe kwiibhokisi zephepha.

Iimpawu ze-Pharmacological zesibisi

Ngaba uyazi ukuba yintoni imithi yeZanidip? Imiyalelo yokusetyenziswa ibonisa ukuba i-blocker yeziteshi ze calcium ezicothayo. Isithako saso esisebenzayo ngumxube wezobuhlanga obuninzi be-stereoisomers. Kufuneka kwakhona kuqatshelwe ukuba ivela kwi-1,4-dihydropyridine.

Eli liyeza lithintela i-i-calcium ions ngaphakathi kweeseli zengqondo, iiselingi zedonga kunye nezihlunu.

Umgaqo wokuthatha ixesha elide lokulwa ne-antihypertensive of the drug is ngenxa yempembelelo yokuphumla ngokuthe ngqo kwiiseli ezihamba kakuhle zeempahla.

Ngokomyalelo oqhotyoshelweyo, umphumo wokwelapha emva kokuba uthathe amayeza ufikelelwe emva kweeyure ezingama-5-7. Kule meko, ubude bezenzo zalo bugcinwa yonke imini.

Ngenxa yokukhethwa okuphezulu kwesicatshulwa kwiiseli ezihamba kakuhle zeenqanawa, akanayo impembelelo engenazo i-inotropic.

Ngoko yintoni i-drug Zanidip-Recordati? Umyalelo uthi uyisicatshulwa sokungathathi-hlangothi esingenanto ethile kwimpendulo yeapolipoproteins kunye neepoprothein kwi-serum yegazi, kwaye ayitshintshi iphrofayili yeoli kunye nabantu abanomfutho wegazi ophezulu.

I-Kinetics yokulungiselela

Uphi na iyeza Zanidip? Imiyalelo yokusetyenziswa iyasitshela ukuba emva kokuthabatha amacwecwe (10 okanye 20 mg), i-lercanidipine isondele ngokupheleleyo kwi-digestive tract. Emva kweeyure eziyi-1,5-3, uxinzelelo oluphezulu lweziyobisi kwi-plasma yegazi lufikelela kwixabiso le 3.3 ng / ml okanye 7.66 ng / ml, ngokulandelanayo.

Ukusasazwa kweziyobisi kumalungu kunye nezicubu zenzeka ngokukhawuleza. Ukuqhagamshelana neeplasma zeplasini zidlula i-98%. Xa uphinda uthabathe iipilisi, i-cumulation ayigcinwa.

Isilwayo senziwe ngokuxilongwa kwinqanaba lokuqala kwisibindi. Oku kungenxa yokuguqulwa kwezinto ze-CYP3A4. Kule meko, i-metabolites yamiselwa ukuba ayinayo imisebenzi yezolimo.

Iyeza "Zanidip" lihoxiswa, ukuphononongwa malunga neentetho ezincinci, ngamathumbu kunye nezintso. Kukho izigaba ezimbini ze-lercanidipine ngaphandle: yokuqala, ixesha eliyi-2 ukuya kweyure, kunye neyokugqibela-iiyure eziyi-8-10.

Engatshintshiyo, isilwanyana ayifumanekanga kwizilwanyana kunye nomchamo.

Kubantu abanokungafihleki kwe-hepatic ne-renal, i-plasma ye-protein ishicilelwe kakhulu. Kule nkalo, inxalenye yehhala yento esebenzayo yonyango inokunyuka kakhulu.

Izimpawu zokuthatha amayeza

Iyintoni injongo yeyeza Zanidip? Iingcamango zogqirha zithetha ukuba le mpilisi ibonakalisa ngokuphumelelayo kunye nexinzelelo olusisiseko sengqondo.

Ukungqinelana kokuthatha amacwecwe

Ngokwemiyalelo, isilwanyana "iZanidip" akufanele sithathwe phambi kwezi meko zilandelayo:

• Izifo ezinzulu zesibindi;
• Ukungaphumeleli kwintliziyo yesimo esingapheliyo (ngokukodwa kwisigaba sokuhlawula);
• Umsebenzi wezentengiselwano ezingasebenzi;
• Angina engaqinisekanga ;
• Izihlanganisi ezine-inhibitors ezinamandla ze-isoenzyme CYP3A4 (umzekelo, "ketoconazole", "Erythromycin", "Itraconazole"), kunye ne "Cyclosporin" kunye nejusi yamagilebhisi;
• Ngexesha lokukhulelwa;
• Ukuvalwa kweempahla ezivela kwi-ventricle yekhohlo yentliziyo;
• Ukunganyamezelani kwaLactose, ukungabikho kwe-lactase kunye nesifo se- galactose / glucose malabsorption ;
• Ngexesha lokuncelisa;
• Kutshanje kutshintshelwe i-myocardial infarction (ngexesha lenyanga enye);
• Kwixesha lokubeletha kwabasetyhini abangasebenzisi iindlela zokukhulelwa ngokwethenjelwa;
• Ebudaleni (ukusetyenziswa ngempumelelo kunye nokukhuseleko akumiswanga);
• Uhlobo lwe-hyperensitivity kwi-lercanidipine, kunye nezinye izidakamizwa ze-dihydropyridine okanye nayiphi na into yechiza.

Ukulawulwa kakuhle kweyeza

Iyeza "Zanidip-Recordati" ngokucetyiswa kunconywa kubantu abanokukhubazeka kwesibindi (ukulinganisela okucokisekileyo kunye nobumnene), kunye nesifo esingapheliyo senhliziyo yesifo se-sinus, ukungaphumeleli kwe-ventricular kunye ne-IHD, kunye nokufumana i-Digoxin, i-beta-blockers ngokufanayo.

Iibhilethi "Zanidip": imiyalelo yokusetyenziswa

Ngenxa yenani elikhulu lemiphumo emibi, isicatshulwa esikulo mbuzo sifanele sichazwe ngumsebenzi onolwazi. Njengomthetho, eli liyeza linconywa ukuba lithathe inani le-10 mg kanye ngosuku.

Iibhulile kufuneka zithathwe ekuseni, ¼ ihora ngaphambi kokudla kwasekuseni.

Ngokuxhomekeke kwimpembelelo yokwelapha, umlinganiselo wesilwanyana esibuzwayo unokuphindwa kabini, oko kukuthi, ukuya kuma-20 mg. Ukwandisa amayeza okusetyenziswa kweziyobisi kufuneka kwenzeke ngokuthe ngcembe. Ukuba kuyimfuneko, ukwanda kwenani leyeza kuqhutywa emva kweveki ezimbini emva kokuqaliswa kweyeza.

Ndingayithatha njani i-Zanidip-Recordati? Iibhulile azihloliswanga. Zigxile ngokupheleleyo kwaye zithathwa ngesixa esaneleyo samanzi.

Kubantu abadala, ukulungiswa kwenzalo akudingeki. Kodwa xa bethabatha amachiza kwimeko yabo, kubeka iliso rhoqo.

Ekubeni kweso sesibindi okanye ukungaphumeleli kwintsipho yoxinzelelo olulinganisiweyo okanye obunzima, ukulungiswa kwemilinganiselo akufuneki. Kwiintsuku ezimbalwa zokuqala isilwanyana simiselwe kwisixa se-10 mg, kwaye ngokulumkisa ukwandisa umthamo ukuya kwi-20 mg ngosuku.

Ukuba isiphumo esichaphazelekayo sichazwa ngamandla, ngoko i-dosage ibonisiwe iyancitshiswa.

Iziganeko ezimbi

Ngaba kunokubangela ukungathandeki okungafunekiyo kweZanidip-Recordati? Iingxelo ezivela kubathengi zixela ukuba, xa bethatha le mayeza, bahlala benemiphumo emibi. Ziziphi, esiza kuziqwalasela kwangoku:

• Amasosha omzimba: i-hypersensitivity.
• I-cardiovascular system: i-tachycardia, i-angina, i-palpitations, ukuphazamiseka, ukukhupha ulusu kwesikhumba ebusweni, intlungu esesifubeni, ibonakaliswe ukunciphisa uxinzelelo lwegazi, i-myocardial infarction.
• Inkqubo yokukhathazeka: ukulala, ukuphathwa kwentloko, isisu.
• Igalelo lokutya: ukuhlanza, ukunyanzelisa, ukunyuka kwesantya, ukunyuka okuguquguqukayo kwenzululwazi yesibindi, isifo sohudo kunye nentlungu yesisu.
• Isikhumba: ukugqithisa.
• Imisculoskeletal system: myalgia.
• I-urinary system: polyuria.
• Abanye: i-edema yedatha, i-asthenia, i-gingival hyperplasia, ukhathala okwandayo.

Iimpawu zokugqithisa

Ziziphi iziphumo eziza kulandelwa xa uthatha amayeza angaphezulu kwamayeza eZanidip? Umyalelo ubonisa ezi zilandelayo zibonakaliso zokudlula ngaphezulu: i-myocardial infarction, i-reflex tachycardia, i-pipeline vasodilation kunye nokuncipha okuphawulwe kwimixinzelelo yegazi, ukwanda kwithuba kunye nobukhulu bokuhlaselwa kwe-angina.

Ukuphelisa iimeko ezinjalo, unyango olusetyenziswayo.

Ukusebenzisana kwezidakamizwa

Ngaba kunokwenzeka ukudibanisa iyeza "Zanidip" kunye nezinye iziyobisi? Imiyalelo yokusetyenziswa ibonisa ukuba le nkunkuma ayinqatshelwe ukudibaniswa kunye ne-inhibitors ye-CYP3A4 (i-isoenzymes ye-cytochrome P450 yesibindi), njenge-Itraconazole, i-Ketoconazole ne-Erythromycin. Oku kubangelwa kukuba zonke izidakamizwa ezidwelisweyo zandisa ukuxinwa kwe-lercanidipine egazini, kwaye zikhokelela ekubeni nomthelela ochasayo.

Ukwamkelwa kwesigxina ngexesha elifanayo kunye ne "Cyclosporine" kuyaphikisana, njengoko oku kungakhokelela ekunyuseni kwimiba yezi zombini kwigazi lomguli.

I-Lercanidipine ayivumelekanga ukuba isetshenziswe ngejusi yamagilebhisi. Le nhlanganisela inokukhokelela ekubanjweni kwefuthe lokulwa ne-antihypertensive and inhibition of lercanidipine metabolism.

Ukunyamekela kufuneka kuthathwe ngokulawulwa kwangaphandle kweZanidip kunye neyeza ezifana ne-Astemizol, i-Terfenadine kunye ne-Quinidine, kwakunye neziyobisi ezithintekayo kwiiklasi lesithathu (umzekelo, i-Amiodarone).

Ukudibaniswa kwezilwanyana ezibhekiselweyo kunye nezidakamizwa ze-anticonbulsant ("Phenytoin," "i-Carbamazepine") kunye ne "Rifamycin" inokubangela ukuhla kwezinga le-lercanidipine egazini, okuphumela ekunciphiseni kwefuthe le-lercanidipine.

Xa idiza idibene ne "Digoxin", kuyimfuneko ukubeka iliso rhoqo imiqondiso yobunxila.

Amayeza athile kunye ne "Midazolam" ekukhuleni angakhokelela ekunyuseni kwe-lercanidipine kunye nokwehla kwinqanaba lokubanjwa kwalo.

Iingcali zithi "i-Metoprolol" inako ukunciphisa ukufumaneka kwe-lercanidipine ngama-50%. Nangona kunjalo, ukuhlaziywa kwe-Metoprolol ngokwayo kungatshintshi. Esi siphumo siphumelele ekunciphiseni kwegazi legazi elibangelwa yi-beta-blockers.

Isilwanyana "Cimetidine" kwisilinganisi se 800 mg ngosuku asikho kwiinguqu ezibalulekileyo ekuxininiseni kwe-lercanidipine egazini. Kodwa xa kuthatyathwa, kunonyamekela unyango olukhethekileyo, kuba ngokunyuka kwamanani, ukuhlaziywa kwe-lercanidipine kunokunyuka, kwaye ngenxa yoko, umonakalo walo okhuselekileyo unyuke.

Xa udibanisa iZanidip kunye neSimvastatin, isilwanyana sokuqala kufuneka sithathwe ekuseni, kwaye sesibini ngokuhlwa.

Isilwanyana "I-Fluoxetine" ayinaso impembelelo kwiikinetics ze-lercanidipine.

Ukwamkela ngokufanayo "iZanidip" kunye ne "Warfarin" akuchaphazeli i-pharmacokinetics yolu hlobo.

Eli arhente linokudibaniswa ne-diuretics, i-beta-adrenoblockers kunye ne-ACE inhibitors.

Kufuneka kwakhona kuqaphele ukuba i-ethanol iphakamisa umphumo we-drugadipin.

Iingcebiso ezizodwa

Ukulungiswa kwe "Zanidip", ezifana nezo zidweliswe ngezantsi, kufuneka zinikezelwe ngokulumkileyo kubantu abanobuchopho obunobungozi kunye nesifo se-coronary disease, njengale meko kukho ingozi enkulu yokuhlaselwa rhoqo kwe-angina pectoris.

Ngaphambi kokuthabatha isiza kufuneka kuhlawuliswe ukusilela kwintliziyo yesimo esingapheliyo.

Ukunyamekela okuthethekileyo kufuneka kuthathelwe ekuqaleni kokunyanga, ngakumbi kwizigulane ezinomlinganiselo wokungafezeki kwesibindi.

Ngethuba lokunyanga, kuyinqweneleka ukwenza umsebenzi ngokunyanisekileyo ofuna ukunyuselwa okongeziweyo, kubandakanywa xa ushayela iimoto. Oku kubangelwa ukuba kwangoko ekuqaleni kweyeza kwaye xa i-doses igqithisiwe, kukho umngcipheko weentloko, ukulala nokusila.

Izimo zokugcina, ubomi belofu kunye nokuthengiswa kweziyobisi

Ndingawafumana phi iipilisi Zanidip-Recordati? Iziganeko zezilwanyana kunye neyeza zithengiswa nakwephi na ikhemisi. Nangona kunjalo, ungabathenga kuphela ngomyalelo.

Gcina eli liyeza lingenakufikeleleka kubantwana abancinci, apho ubushushu abugqithisi iidridi ezingama-30.

Ubomi beShefu yesilwanyana esikulo mbuzo yiminyaka emithathu. Emva kolu xesha, thabatha amayeza avunyelwe.

Ezifana neziyobisi

Ngaba uyazi ukuba yintoni inokuthi ithathe indawo yamatyebhethi "iZanidip"? Ingqungquthela yesi sixhobo kunzima ukufumana. Iingcali zibika ukuba ezo ziyobisi ngokuthi "Lercamen" kunye ne "Lercanidipine" zinempahla efanayo kunye nomgaqo wesenzo. Thatha la mayeza kuphela ngeengcebiso zonyango.

Isiza "Zanidip": ukuphononongwa kwezigulane kunye neengcali

Lo ngummeli onamandla kakhulu wokulwa ne-antihypertensive agent. Le ngcamango yabelwa oogqirha abaninzi. Phantse zonke izigulane ezithatha iiphilisi zeZanidip ziyavumelana nazo. Bathi ukuba emva kokuthatha amachiza abo imeko iphucula ngokucacileyo. Izibonakaliso zokubandezeleka kweengcinezelo ezibalulekileyo kunye nobunzima obukhawulezayo ngokukhawuleza.

Impendulo yodwa yileyeza kukuba ukufumana kwayo imvama kaninzi kubangele ukusabela kwangasese, ngokukodwa kwi-digestive tract kunye ne-cardiovascular system.

Kufuneka kwakhona kuqatshelwe ukuba abaninzi abantu bayakhalaza ukuba ixabiso leliyeza liphezulu kakhulu. Esi sidakamizwa kwisixa seepilisi ezingama-28 sinokuthengwa ngama-ruble angama-450-500. Kufuneka kuqatshelwe ukuba izifanisi zesicatshulwa esichazwe ngohlobo lwe "Lercamena" kunye ne "Lercanidipine" azincinci nhlobo. Zingathengwa ngexabiso elifanayo.

Iingcali zithi iindleko zesicatshulwa esiphathekayo "iZanidip" zihambelana ngokupheleleyo nomgangatho wayo. Oku kubonisa phantse lonke ixesha elide lokusebenzisa kwakhe.