Protamine sulfate: Inkcazelo Umsebenzisi

Yintoni into neziyobisi protamine sulfate? imiyalelo ukusetyenziswa kwayo, kwakunye imilo kunye ubungqina mali iya zidweliswe ngezantsi.

Ubume, incazelo, uhlobo

Yintoni protamine sulfate? Le isisombululo uphumile njenge ulwelo bulubhelu okanye ezingenambala olungenazimfihlo elungiselelwe ulawulo efakwa. Amalungiselelo ezisekelwe kweli chiza igama elifanayo, kwaye ngakumbi iqulathe manzi inaliti.

Ekuthengisweni "Protamine sulfate" ikhutshwa kwi ezineengqayi ukuthi ibekwe kwi iseli lesishwankathelo ukusuka Polyvinyl chloride umboniso, ezo zipakishwe kwiibhokisi kwikhadibhodi. Kwakhona ezisebhokisini ibekwe imiyalelo ukusetyenziswa kunye qwenge ampoule.

isenzo Drug

Yintoni protamine sulfate? Guide ingxelo yokuba eli lweeHedfowuni ochasene (ezithile). 1 mg osisiqu ekwaziyo lwaze igazi yomguli ngayo malunga 80-115 IU of lweeHedfowuni.

ingxelo Action kuthetha emva isitofu efakwa iqala ngoko nangoko kwaye ithatha malunga neeyure ezimbini. Complexation beziyobisi ngenxa yobuninzi amaqela cationic yekeyeke kumaziko anionic lweeHedfowuni.

Ngokutsho imiyalelo protamine sulfate ebantwini complexed lweeHedfowuni-protamine, nto leyo waphula ukukhulula yokugqibela.

Xa libanda, oku kuthetha ukuba Isigulana kakhulu kunciphise igazi ekunqandeni, ekubeni ingqalelo ekuqulunqweni arhente esebenzayo liveza umsebenzi eliphezulu anticoagulant.

Pharmacokinetics kuthetha

Yintoni na iimpawu kwikinetiki le sulfate lweeHedfowuni protamine? Ngokutsho kweengcali, iye iimpawu pharmacokinetic beziyobisi azikhange zisafundwa. Ngoko ke, ukuba abayi zimelwe kule ncwadana.

Ubungqina obubonakalayo buxela ukuba isisombululo

Kwezinye iimeko, umguli efakwa isisombululo "Protamine sulfate" linokukwenziwa? Ukusetyenziswa kwale ndlela uboniswa:

• ngaphambi kokuba enziwe utyando abantu abathatha lweeHedfowuni ukulungiselela iinjongo zonyango;
• e hyperheparinemia;
• ngokuba nokopha ngenxa lweeHedfowuni libanda;
• emva kokuba umsebenzi imithambo yegazi nentliziyo namaphephandaba extracorporeal.

Imingcele ukuba isisombululo kuyo

Drug "sulfate Protamine" (a amayeza ukuyithenga kufuneka umisele ugqirha) ithe contraindicated kwezi meko zilandelayo:

• nge thrombocytopenia;
• uvakalelo oluphezulu ukuya iziqalelo ze ichiza;
• hypotension kakhulu;
• hyperheparinemia azalwa okanye idiopathic (kule meko ke imithi kuphumelele, kwaye kananjalo kwandisa ngokubalulekileyo ukopha);
• ulawulo insulin kunye nezinye iziyobisi equlethe sulfate protamine;
• kukwalisa imveliso yentlanzi, kuquka imbali;
• insufficiency adrenal.

Asinako ukuba amava yokusetyenziswa yezonyango esi sixhobo ebantwaneni anqongophele.

Ngethuba lokukhulelwa lokwaphusa "Protamine sulfate" zingasetyenziswa. Nangona kunjalo, oku kufuneka kwenziwe kuphela xa, ukuba isiphumo unyango iphezulu kakhulu kunaleyo kwenzeke ingozi olungekazalwa okanye umntwana.

Ukulungiselela "Protamine sulfate": imiyalelo yokusebenzisa

isisombululo kujongwa kufuneka ilawulwe uvuza IV kade okanye bolus. Ngenxa yoko iqondo lolawulo kufuneka ngaphezu 5 mg ngomzuzu. ukuqaliswa ngokukhawuleza beziyobisi ingenza isigulane basabela anaphylactoid.

Umthamo we medicament kuxhomekeke indlela wolawulo. Ithamo kubalwa kufuneka ichithwe ngo-300-500 ml ka 0.9% isisombululo chloride amandla sodium. Akuvunyelwe ngqo ukungena ngaphezulu kwe-150 mg kweziyobisi imizuzu engama-60.

• Nge Inaliti bolus umthamo protamine sulfate lifinyele kuxhomekeke kwixesha elidluleyo ukusuka kulawulo lweeHedfowuni. Oku kungenxa yokuba i-yokugqibela lusoloko isuswe emzimbeni womntu.
• Ukuba lweeHedfowuni ilawulwa ngedriphu efakwa, kuyimfuneko ukuba uyeke nokuhlanganiswa kwaye usebenzise malunga 20-30 mg protamine sulfate.
• Xa Inaliti ongama of lweeHedfowuni umthamo protamine sulfate 1-1.5 mg 100 IU lweeHedfowuni. Ngoko 25-50 yokuqala mg kufuneka kancinane kulawulwa yegazi, kwaye ubuninzi eseleyo - ngedriphu efakwa iiyure 8-17. Kwakhona ulawulo kunokwenzeka ngakanye, kodwa oko kuya kufuna esweni ngqongqo of APTT.
• Xa ungenelelo olungele kwimeko extracorporeal isisombululo ukujikeleza umthamo ayikhumbule 1.5 mg ukuya 100 ME lweeHedfowuni.

Ubude ubuninzi unyango kweemali iintsuku ezi-3.

Action ngu-lomsebenzi

Ngaba sulfate protamine ukuba baxabane ezingalunganga? Manual ithi ngokubanzi le ichiza ukunyamezeleka ngokwentelekiso kakuhle zizigulane. Noko ke, kwezinye iimeko, oko kodwa inokubangela iziphumo ezibi inxalenye abanamajoni omzimba, sentliziyo esiswini, kwakunye isikhumba:

• bradycardia, ukuncitshiswa wegazi;
• ukugabha nentliziyo;
• ukurhawuzelelwa, irhashalala, uphuhliso yokusabela anaphylactoid;
• uziva ashushu, bevakalelwa mfutshane ngumphefumlo, kunye ukuthoba isikhumba.

Ngaphezulu kunye nentsebenziswano kunye namanye amachiza

sisombululo kujongwa ezilungiselelwe ulawulo efakwa azingqinelani penicillins kunye cephalosporins. Njengoko ukuba yinto ochasene, libya kweemolekyuli heparins ubunzima, iziyobisi esebenzayo kunokwandisa ixesha nobushushu ntshukumo relaxants non-depolarizing kwezihlunu.

An libanda, beziyobisi esinxulunyaniswa ne ukopha. Oku kubangelwa yinto yokuba into mbuzo umsebenzi eliphezulu anticoagulant. Kulo mzekelo, kufuneka ekuqhubeni unyango nomqondiso.

ulwazi oluthile

Oko umele ukwazi phambi kokuba ufake isisombululo efana protamine sulfate? Iingcali zithi ukusetyenziswa kweli chiza kufuneka bagadwe ngeliso elibukhali ngugqirha ekufuneka esweni isigulane igazi ekunqandeni rhoqo.

Phambi kokuba kuqaliswe ichiza kuyimfuneko ukuqinisekisa umthamo wegazi isigulane eyaneleyo ngayo. Oku kungenxa yokuba hypovolemia kakhulu kwandisa umngcipheko kokuwa.

iimeko Ukugcinwa yonikezelo ezikhemisti, ithuba lokugcinwa

Nokuba bathengisa ngokukhululekileyo ezikhemisti iziyobisi "Protamine sulfate '? Iresiphi ngolwimi Latin okanye Russian, qiniseka ukuba ukubonisa ayinikiwe, kungenjalo ichiza akhululwe.

kuthetha ukugcina ingqalelo kuyimfuneko wonke abantwana ekhuselweyo elangeni apho ubushushu umoya phakathi izidanga-4 no-10. Kufuneka kuqatshelwe ukuba isisombululo "sulfate Protamine" efakwa kuyo nayiphi na imeko kufuneka emkhenkceni.

Impilo kweli chiza yiminyaka-4 ukusuka kumhla wokwenziwa. Musa ukuyisebenzisa Awuphesheya kokuphela eli thuba.

analogue Drug kunye nohlaziyo ngayo

Analogue e izixhobo kwengxelo ezininzi kunene. Isisombululo efakwa nga kufakwe iziyobisi ezifana 'Protamine "kunye" Protamine-Verein ".

Ngokuphathelele ncomo kubathengi, phantse bonke bephela ezincomekayo. "Sulfate Protamine" - le yindlela esebenza kakhulu nesebenzayo ezifumanekayo kumntu wonke. Oku lo mbono kwabelwana sisininzi kwizigulane. Bathi ukuba olu nyango ayiniki lweeHedfowuni ukuze kuthintelwe inkqubo igazi ekunqandeni, ukuphucula imeko yomguli ngexesha ukopha enzima.

Njengoko ku nempikiswano eli chiza ziquka ukusebenza ngamandla kwaye ixesha elide. Ngaphezu koko, ukuphumeza isiphumo isiqabu isigulane kufuneka ukuphumeza kunyango ixesha elide. Elona xesha lininzi ukusetyenziswa kweli chiza ziintsuku ezintathu.