"Montelukast": ncomo, imiyalelo kunye analogue beziyobisi

"Montelukast" - malunga ncomo zeziyobisi ngokulula zifumaneka kwiiforam online kunye neziza abazinikeleyo kwingxaki sombefu - a ochasene ezaziwa leukotriene D4-receptor. Ichiza Isetyenziswa ngokubanzi kwisiseko ngexesha unyango kunye ukuthintela uhlaselo uphawu esi sifo. ukwakheka Balanced uvumela ukusetyenziswa kweziyobisi ngenxa unyango izigulane phantse naliphi iqela ubudala.

release Form

Izizathu zokuba "montelukast" wafumana ubukhulu becala uhlolo ezintle, lukhulu. Noko ke, into yokuqala ozithandayo iliso lakho - oku, Kakade ke, izixhobo ezahlukeneyo tablets, wathengisa phantsi igama lorhwebo le data.

Okwangoku le nkqubo ilawulwa matrix ezintathu. Oku malunga iipilisi eqhelekileyo kunye kwimvulophu ngefoyile (1 unit iqulethe 10 mg wenkqu esebenzayo) kunye analogue zabo ukuhlafuna (4 mg ne-5 mg ngokulandelelana kwazo reagent). isiseko Base kuzo zombini ezi meko, izenzo montelukast sodium, kodwa ukwakhiwa amacandelo ezininzi abangabancedani ezahlukeneyo - Mannitol kunye aspartame zikhona iisampulu ezilungiselelwe yokufakwa kwangoko ngexesha ukusetyenziswa.

Xa izimvo ngokufuthi pops up umbuzo mbumbulu, leyo ngoku wozibonakalisa ngamatyathanga ekhemesti. Khusela nxamnye ngomgunyathi kuba, ukuba imali ngexesha ingqalelo imbonakalo imveliso imithi.

Ngokukodwa, ukuhlafuna Ipilisi kunye milligrams 4 esisebenza, ine i seqanda kunye namona ezipinki (inkcazo olungqamana iipilisi ne cherry incasa, kunye nokusetyenziswa kwezinye neencasa umahluko yokwakha), ziphinde ziphawulwe amanani "4" kwicala elinye. Analogs apho eyona nto iphambili esebenzayo yi-1 mg ngakumbi - ngeenxa kwaye ezibhalwe "ezintlanu". Iipilisi njenge iqokobhe geometrically ziyindawo uxande; Baya beige yabala Inani "10".

ukubandakanya kwemithi

"Montelukast" (iimbekiselo echaza iimeko apho reagent ezinzima ukumqumbisa allergies zinqabile kakhulu) - oku ngummeli ngokuqhelekileyo iziyobisi iqela antibronhokonstriktornyh. I algorithm uvumela izenzo zakhe ukuthetha nje "nolwalamano olusenyongweni" kunye intermedianty / prostaglandins kunye thromboxanes.

Eyona umsebenzi ichiza - leukotriene "abenzi boluvo" cysteinyl uvimba we isixokelelwano sokuphefumla. Ezi ezenza ukugcina umsebenzi omkhulu kuphuhliso isifuba inyumoniya kwaye kananjalo ukukhuthaza ukuba Yindibanisela netuwa ke leyo oluhlala kwaye nzima ukuba isifo.

inani rhoqo kukhokelela ekuncipheni ebalulekileyo ubungqongqo iimpawu kule yangasemva ukuhla jikelele inani yokuhlaselwa sombefu (njengoko kuqatshelwe zizigulane ezininzi, utshintsho HIV sele kwaphawulwa kwimihla zokuqala unyango).

features metabolic

"Montelukast" (reviews oosokhemisti zibonisa ukuba ukhetho lokwenene stand-ins libe lelona nkqubo amanani labavelisi, oko kukuthi umntu amachiza-izithethantonye, ebhekisela nokubunjwa kwayo molekyuli twatse-yem aba ingxenye ephambili, kukho amaxesha amaninzi ibiza ngaphezu kwaleyo yokulungiselela ochazwe), engena plasma igazi, sibophelela ngokupheleleyo kunye neeproteni yayo. Kwizifundo zonyango, isiphumo zarekhodishwa 99, 37%. Kwangaxeshanye, bioavailability sayo ngokomlinganiselo ngqo kwinkqubo kunikezelo. Umzekelo, izithako amacwecwe-5-mlligrams efanele afunxwa 73%, ngelixa analogue nge nqanawa inwebu apho kukho izinto amaxesha 2 esebenzayo ngakumbi, - kuphela 64%.

Kanye imeko kwisiqingatha-ebomini reagent: yeziXhobo ukuhlafuna iipilisi, ngokuva ukutya, eshiya umzimba emva kweeyure-2 emva yokwamkela, kodwa izinto usemthethweni amacwecwe eqhelekileyo - emva kwemizuzu 180-200. Kule ukucoca plasma uyahluka 43-45 ml / minute. Kwaye, Okubangel 'umdla kukuba, 0.2% kuphela iidosi ohamba imijelo womchamo. Emathunjini, xa kuthelekiswa, - ngaphezu kwe-85%.

Ukususela amagqabaza abasemagunyeni ohloniphekileyo, kulandela ukuba inkqubo pharmacokinetic ngokufanayo kakuhle kwizigulane amadoda namabhinqa, yaye enza uhlengahlengiso kakhulu ngenxa yobudala kunye ngezifo sezintso xa kubalwa servings yonke imihla iyeza iyafuneka. Kodwa ukusilela kwesibindi, ingakumbi xa kufikwa sisifo kakhulu, kufuna ingqalelo ekhethekileyo kumalungiselelo weshedyuli zonyango.

Ubungqina obubonakalayo buxela ukuba

Xa sigwetyelwe ukusetyenziswa "montelukast" Uphengululo drug (it abantwana namayeza akhuthazwayo ngokohlobo gum, iipilisi, camera inwebu iqokobhe, uyacebiswa ukuba amisele abantu abadala kuphela kunye abafikisayo), ekhohlo kwi kwiiforam, Kakade ke, kusinceda siqonde. Noko ke, ekhokelwa kuphela izimvo zabanye abantu - yinto impazamo enkulu, ngenxa yokuba kungekho kokubonisana gqirha, "ukuchonga" uhlobo sombefu, kwaye okona kubalulekileyo - ukufumanisa izizathu livela nzima.

Ngokumalunga ingxelo esemthethweni, isangqa apho iimpawu, ukugula kunye neminye imiqathango ecaciswe ngolu hlobo lulandelayo:

• aqaqambayo inyumoniya kubangelwa umthwalo ngokugqithiseleyo ngokomzimba;
• Zonyaka / nokuthimliswa ezingapheliyo, uhlobo ezikumila kunje of imvelaphi;
• somoya;
• imfuno amanyathelo othintelo.

Oyidlayo lusebenze

"Montelukast" (feedback kakubi kunzima kakhulu ukufumana, kuba eyona nto esebenzayo kudala isetyenziswe ngempumelelo njengecandelo ongundoqo iziyobisi ezininzi) ilawulwa ngomlomo, kanye ngosuku, ngaphandle azibophelele ishedyuli "sakusasa - sasemini -. Isidlo"

Kuba amacwecwe chewable, 4 mg kunye 5 mg kukho iidosi ezinjalo imithetho:

• abantwana abaneminyaka ephakathi kweminyaka emi-2 nelesi-5: 1 iyunithi yemveliso (4 mg) ngosuku, ngexesha lokulala, kude ekufezekiseni ulawulo iimpawu kunye isongezo kwekhosi enyanzelekileyo kwiiveki 2-4 ukulungisa isiphumo isiphumo;
• izigulane kweminyaka 6 ukuya kwi-14 ubudala: indlela efanayo, kodwa kwixesha elinye-izinga - mg-5.

Nangeepilisi nge ngumsongi ngefoyile ye efanelekileyo ezilandelayo:

• abadala kunye nabantwana iminyaka engaphezu kwe-15 ubudala, ukubandezeleka asthma inyumoniya okanye nokuthimliswa ezigulo ezondeleyo: Unit 1 (10 mg of material) / imihla ngokuhlwa;
• ukuthintela amahlaba: idosi enye ngexesha ubude isithuba seentsuku 14-28.

effect side

"Montelukast" umyalelo (reviews lubonisa ukuba nkqu ukuthobela ngokupheleleyo kunye nenkokheli ngokusesikweni reactions Nedlac yobukho izithako ekupheleni ayikwazi ngaphandle) ukuba kubekwe ichiza ezinokuba ekhuselekileyo, kodwa lo mbandela wokuba non-ezithile "impendulo" kwi yinxalenye yomzimba kwiimeko ngabanye kusengenzeka.

simo Avumele:

• GI: utyatyazo, umlomo owomileyo, intlungu syndrome isisu, isicaphucaphu;
• intliziyo negazi imigca: ukwanda okubonakalayo kakhulu izinga ukubetha;
• irhashalala eluswini, urticaria, hematoma lendawo;
• isixokelelwano sokuphefumla: iimpumlo ezivuzayo nokukhohlela;
• CNS: isiyezi, ukudinwa, isimo ukudandatheka beman kunye ngokugqithiseleyo lengqondo kukuphazamiseka;
• musculoskeletal: myalgia kunye arthralgia (kubandakanywa unditsho.).
• Okunye: Iimpawu uphawu izifo ezihlasela zosulele ngokuphefumla kunye neAvian.

Ukulinganiselwa Izimo

"Montelukast" (imiyalelo zokusetyenziswa yeyona ncomo kakhulu ezintle, kunye nolwazi oluqulethwe kuyo, ngokwemiqathango ukungabi naxanasi, imibuzo evela kumalungu foram phantse ukuba akukho) ayiyi kusebenza ukuba:

• Kubonakele ubuthathaka landile ukuya ukwakhiwa amayeza (kuyinyaniso kuzo zonke iintlobo tablets);
• kwafunyaniswa ukuba izifo ilifa ezinqabileyo, kuquka nabo apho ephilayo akuthethi zivalele galactose okanye abafumana amadlala yelactose ngxaki (esi sithintelo asisebenzi ukuhlafuna iipilisi);
• isigulane ubunzima phenylketonuria;
• isigulane alikhange ijikwa kwiminyaka emibini (tablet camera "kweminyaka" - engama-15).

Libanda: Iimpawu and Treatment

Uhlolisiso lubonisa, "Montelukast" 4 mg (iimbekiselo ngale fom woqoqosho reagent, enyanisweni, twatse amagqabaza ekufuneka zifundisiwe ukuhlafuna analogs equlathe 5 mg wenkqu esebenzayo) ezingaphezu ngemihla izinga ukusetyenziswa okukuchaphazela isiphumo esifanayo amacwecwe mg 10 . Iimpawu ezininzi libizwa of libanda, kunokubonwa izigulane kwiqela omncinane. Abadala, nokuba xa uthatha 200 mg / ngosuku iinyanga ezi-5, abanye abasabela okungaqhelekanga mbaleko.

Ugqaliselo uphawu olunye landa lamanani ichiza zezi:

• Ndandilunxanelwe;
• ukozela;
• isisu ubuhlungu ndawo;
• ukuphalaza;

Unyango kuliwa, esekelwe kumfanekiso lwezonyango saphawula. Ulwazi malunga nokusebenza ihaemodialysis abangekhoyo.

imithi, kwaye analogue kakhulu ethandwa

"Montelukast" 5 mg (reviews of ukuhlafuna iisampulu kwesokunxele oogqirha babantwana, bilisa phantsi ingcamango yokuba ichiza, ngaphandle kwamathandabuzo, ufanelwe imfutshane bonke abazali abatsha), kwakunye nezinye iintlobo leukotriene receptor ochasene, xa esetyenziswa ngokunxuseneyo ne-arhente ezifanelekileyo ekukhawuleziseni okuhambisa ezintle : iimpawu yesifuba iba ngaphantsi kakhulu, inani uhlaselo lancipha. Noko ke, ukurhoxiswa ngokukhawuleza unyango olwenziwe ngokusekelwe corticosteroids ukurhogele ayikhuthazwa.

yazo ebalulekileyo kwiinkqubo pharmacokinetic ezibandakanya theophylline kunye prednizola elibhaqiweyo. Kodwa ukufakwa kwi "ngokumanyene" kunye phenobarbital lehla ngama-40%.

Wezenzi ukuba zinqanda Yindibanisela CYP3A4 isoenzyme, kufuneka isetyenziswe kuphela phantsi kweliso zonyango.

analogs zezakhiwo ukuba amaninzi afumaneka kwi ezithengiswayo:

• "Monkasta".
• "Singlon".
• "Singulair".
• "Ektalust".
• "Singuleks".

"Singulair" okanye "montelukast": ncomo oogqirha kunye noosokhemesti

Ngokutsho pharmacologists ingcali, ingxoxo-mpikiswano malunga nokuba ngabaphi na amachiza kuba ikhuseleke kwaye isebenza kakuhle, ngamampunge, ekubeni "Singulair" yaye "montelukast" banye noseko efanayo amayeza. wegqitha nje ubhaliso lomenzi igama kurhwebo lokuqala, kwaye eyesibini ngamazwe. Amagqirha ngabanye kunye nezigulane, Noko ke, ithatha imbono eyahlukileyo uze ucinge amayeza asasazwa phantsi apho balalisa khona, isigqibo kuphela echanekileyo.