"Metodzhekt": Ukubuyekezwa isifo samathambo, ingakumbi isicelo kunye nokusebenza

isifo samathambo sisifo ukwisigaba ezigulo ezondeleyo. It asinyangeki, kodwa unako isantya ukuqhubela phambili kwesifo kunye nokuthintela kukuvela iingxaki. Kule meko, iphathwa immunosuppressants. Kwabo neziyobisi nje ezinxulumene "Metodzhekt". Nohlolo isifo samathambo qaphela ukuba iyeza inyathelo ngokukhawuleza, kodwa emva kweenyanga 2-6.

"Metodzhekt": ukubunjwa, Composition

Oveliswa kwifomu isisombululo yolawulo injectable medicament "Metodzhekt". Ukuhlaziya isifo samathambo bathi ichiza xa esetyenziswa rhoqo, ngokuthe ngcembe kususa ukudumba namalungu. Kuyanceda ukubuyela ubomi obuqhelekileyo.

Amachiza isekelwe phezu component asebenzayo methotrexate disodium. izithako ezincinane Yek amanzi, kunye sodium chloride kunye hayidroksayidi.

Ichiza iveliswa xa isirinji evaliweyo ilungiselelwe ngenaliti. Le ngesirinji babe 7,5- 25 mg isisombululo injectable. Ibhokisi iqulethe:

• ngesirinji glass;
• umlomo plastic;
• inaliti xa zibekelelwe blister ezizodwa;
• yesikhokelo.

Le isinyibiliko lokugcinwa seminyaka emibini. Iveliswe ku Germany.

iipropati kwemithi

Libhekisela immunosuppressive neyeza antimetabolite "Metodzhekt" (iimpendulo arthritis zibonisa ukuba ichiza emva ifakwe emzimbeni kungabangela isicaphucaphu kunye nesiyezi). Ichiza luphawulwa iipropati anti-ithumba. It is a ochasene folate. Unciphisa dihydrofolate reductase, nto leyo ethatha inxaxheba kuvuselelwa dihydrofolic acid ibe tetrahydrofolic. Le into esebenzayo apha isebenza njengomthuthi amaqhekeza carbon ukuze begazi of nucleotides purine kunye nezakhi zawo.

Ichiza abangaphangeliyo DNA amagama kunye nokulungiswa. Abangaphangeliyo iseli mitosis. Methotrexate kakhulu echaphazela bystroproliferiruyuschie iiseli ezinxulumene lomongo wethambo, izihlunu osandul, nangezilonda okubulalayo mucosal epithelium.

Ngendlela eyiyo psoriatic kunye isifo samathambo. Xa unyango na kwezi zifo kwaye avuleke ichiza i immunosuppressive anti-ukudumba endalweni. Imiphumo emihle nothomalaliso ngenxa boxinzelelo ukwandisa adenosine kwinkqubo kwindawo arhabaxa.

Ubungqina obubonakalayo buxela

Izimvo "Metodzhekte" abonisa ukusebenza beziyobisi. Uphawula ukuba ukunyamezeleka kakuhle kwaye awafane kunokubangela iziphumo ezingalindelekanga.

Sebenzisa iyeza kunye isifo samathambo kunye samathambo, samathambo mthetho ongumntwana sikhatshwa ezondeleyo ezimbaxa kunye ikhula ngenkuthalo.

Ubungqina obubonakalayo buxela ukuba iinaliti isebenza samathambo psoriatic, kunye ukhwekhwe ngokubanzi. Kwimeko yokugqibela, "Metodzhekt" lisetyenziswa xa unyango yemigangatho akuphumelelanga.

Izimo nokusetyenziswa

Uphawula ukuba ngokugqibeleleyo kunceda iziyobisi "Metodzhekt" ukuba isifo samathambo, ncomo. Awukwazi ukusebenzisa iyeza ukuba umsebenzi isibindi okungaqhelekanga, kakubi iziselo ipirithi, ukusilela kwezintso esinzima inqanaba lophuhliso.

Kufuneka ubeke ichiza kunye lomongo wethambo hypoplasia, igazi kakhulu, leukopenia, kunye thrombocytopenia. Akwenzeki ukuba bafake kwi ezimbi esosulelayo benxibe ezingapheliyo kunye yondele. Engamiswanga kweziyobisi ngenxa amanxeba sisilonda le kwisisu ngomlomo phecana zesisu.

Musa ukusebenzisa iziyobisi izigulane imibala kakhulu omzimba, abakhulelweyo kunye nabafazi phindeke. unyango ngamachiza singàphunyezwa ngaxeshanye kunye nophuhliso zokugonya eziphilayo. Izimo ekusebenziseni kusetyenziswa izinto abasemthethweni hypersensitivity ukuya medicament.

Sebenzisa iyeza ngononophelo kufuneka abantu bathwaxwa ascites, zesisu iphecana isithintelo, emzimbeni. Phantsi kweliso gqirha, kufuneka ube nomonde effusion pleural okanye peritoneal, ngokunjalo abantu kwezintso. Nge arhente care lisetyenziswa kwizifo ezosulelayo, amagciwane, iintsholongwane kunye olwaye lwamfimfitha. Kufakwe abantu abanengxaki alula herpes zoster, imasisi, izigulane chicken pox, izigulane strongiloidozidom kunye amebiasis.

izigulane abadala ubudala nabantwana, unyango amayeza kufuneka asebenzise kukhulelwa oluthembekileyo. Mazikhuselwe emva kokuphela unyango iinyanga ezintandathu. Ukuba umfazi akhulelwa ngexesha unyango, kubalulekile ukuqwalasela umlinganiselo wenkcaneko lweziphumo elibi ichiza ekukhuleni kosana olungekazalwa.

Methotrexate ludlulele ubisi lwebele kwaye ezinokudala umngcipheko umntwana. Xa unyango "Metodzhektom" kufuneka ayeke webele ukondla usana lwakho ngexesha unyango.

umthamo

Alawulwa ngurhulumente kwesikhumba, butofelwe kunye neziyobisi intramuscularly "Metodzhekt". Imiyalelo yokusebenzisa kunye nengxelo Kucetyiswa ukuba ukusebenzisa ichiza kanye ngeveki, ngexesha elifanayo. Ubude unyango lulawula ugqirha.

Abantu abadala kunye namayeza isifo samathambo emiselweyo ku 7.5 g kanye ngeveki. Indlela zolawulo inokuba na. Kufuneka kuqale idosi liphantsi. Ukuba ukunyamezeleka kakuhle sisigulane, idosi ebegqwese ukwanda nge-2.5 mg ngeveki. ubuninzi rate veki ilingana no-25 mg.

Isiphumo kubonwa emva kweeveki 4-8 yokwaluka unyango. Xa ukwazile ukuba ukususa iimpawu zesi sifo, iidosi kancane kancane kuze ubuncinane. Ikhosi therapeutic elinokuthatha ukuya kuma kwiminyaka elishumi okanye ngaphezulu.

Xa unyango lwe psoriatic samathambo kunye ukhwekhwe kwiveki phambi lokwaluka unyango kucetyiswa ukuba kungafundiswa uvavanyo ithamo 5.10 isisombululo mg ngenxa efumanise yeziphumo ebezingalindelekanga.

Ukuba akukho imiyalelo akukho omnye ugqirha, kufuneka uqale mg 7.5 kanye ngeveki. Idosi ichanekile kancane. Kufuneka abasayi kwenziwa-25 mg isisombululo ngeveki. ithamo ngeveki Owona mbane of mg 30 ukhwekhwe. Isiphumo kubonwa emva kweeveki 2-6. Emva ekufezekiseni le ziphumo zinqwenelekayo, idosi lifinyele.

Abantu abane wezintso kwaye ukusilela wesibindi, kwakunye ichiza abadala kufuneka isetyenziswe ngobulumko.

Abantwana abangaphantsi kweminyaka elishumi elinesithandathu banesifo samathambo abangabantwana kufuneka uthathe amayeza ngomlinganiselo 10-15 mg / m ² komhlaba yomzimba. Ithamo kufuneka kwandiswa ukuya kutsho kwi-standard-20 mg / m ^2. Abantwana bayakhuthazwa iziyobisi alawulwa intramuscularly.

Ukuthintela iziphumo ebezingalindelekanga, oogqirha amisele ngosuku olulandelayo emva kokuba ukuxhaswa folic acid nokufakelelwa, kwiintsuku ezintlanu ezilandelayo. Phambi kokuba isitofu, kwaye ngomhla ekumisweni ivithamin B9 Aninako ukusela ichiza.

Iziyobisi kunye nomphumela ofanayo

Ukuba 'Metodzhekt "akazange eze ngenxa unyango, ugqirha angafaka endaweni ichiza omnye, efanayo kumafa kunye nesenzo yayo. Xa analogs abaqhelekileyo "Metodzhekta" ziquka:

• "Vero Methotrexate."
• "Zeksat".
• "Metortrit".
• "Methotrexate".
• "Methotrexate-Teva".
• "Treksan".
• "Triksilem".
• "Evetreks".

Ezi kunye nezinye analogs ngokulula endaweni ichiza, kodwa kufuneka zikhethwe ngugqirha khona.

iindleko

Nikelani ingqalelo iindleko eziphezulu "Metodzhekt" ncomo iziyobisi. Xa isifo samathambo (ixabiso eli yeza malunga 600-750 engange nganye 0.75-1 ml, ngokuba 800-1400 engange, unako ukuthenga i 1.5 ukuya 2.5 ml yokulungiselela) abangekho ukuba ukhethe. Isifo ifuna labagula kakhulu. Ntoleyo, ngelishwa, lubiza kakhulu.

Ilumkisa ngelithi, into ebangela ukuba ufake indlela ngeveki "Metodzhekt" umyalelo manual. Uphengululo (ixabiso ngasentla izinto zisenokwahluka ngokuxhomekeke kwindawo Pharmacy) abonisa ukuba iindleko isiyobisi kakhulu eziphakamileyo, kodwa nangona oku, ichiza unika nemiphumo emihle.

Ukusebenza ichiza

Qaphela ukuba enze ubomi benene ekulweni "Metodzhekt" ncomo samathambo samathambo iziyobisi. Ukuphumelela kuthetha kwaba abantu abaninzi.

Injecting iziyobisi ivumela ichiza wendele ngqo kwi egazini, ngokudlulisela isisu kwakunye namathumbu. Le ndlela yokusebenzisa unika ngobuchule ngaphezu amayeza ngomlomo.

"Metodzhekt" ngokusekelwe methotrexate ubhekisela arhente ezingundoqo nokuguqula antirheumatic. It has iipropati enamandla anti-ukudumba. Kokuba okwenziwa kwizigaba ezahlukeneyo isifo samathambo. Itshintsha khosi yesi sifo. Isetyenziswa ziintlungu, ukuqina kunye ukudumba kwamalunga.

Ichiza linceda abantu abaninzi ukuba baphile ubomi obuqhelekileyo, ndiyasebenza. Azikhuli ukuqhubela phambili inkqubo izifo umonakalo intlala articular kunye kwithishyu. Ifuthe lolawulo ichiza waphawula emva kweenyanga ezintandathu.

Izimvo oogqirha

Amaxesha amaninzi, ukuze ukunyanga isifo samathambo, ugqirha emiselweyo "Metodzhekt". Izimvo oogqirha bathi leyo ndawo ibanga iziphumo ebezingalindelekanga kwaye zivunwe kakuhle zizigulane. Kucingwa enye immunosuppressant ilungileyo. Ingasetyenziswa ukugcina impilo lonke ixesha, iminyaka eliqela.

Ichiza yityhefu, yaye ngoko ke, xa isetyenziswa, oogqirha ukucebisa nigcine kwisekethe zolawulo kunye umthamo. Ukwandisa okanye ukunciphisa izinga ngcembe yaye kuphela phantsi kweliso zonyango. Oku kuya kuthintela iingxaki kunokwenzeka. Bonke abafazi sele ekunyango with "Metodzhekt", oogqirha bacebisa ukusetyenziswa zokucwangcisa ethembekileyo njengendlela ezinokuchaphazela kakubi olungekazalwa.

Nohlolo ukusetyenziswa ebantwaneni

kuphela imithi kufuneka kusetyenziswe "Metodzhekt". Nohlolo samathambo samathambo ebantwaneni ukuthetha iziphumo ezidibanisayo, enika iyeza. Kubantwana, nto ibhalwa ml-2 kanye ngeveki. Abanye abafana abaye ngaphambili ababenengxaki amalungu emva iinaliti aqale ukubaleka, ukuze babe ngakumbi. Zakwazi ukufikelela ixesha elide uxolelo sifo wehlise.

Kids abaye baphathwa "Metodzhektom" akukho kwahluka noontanga babo. Badlala kakhulu, kunye neentlungu amalungu ayeke ukuphazamisa kubo. Baye imilenze ngaphantsi idumbile, emaqatheni. Improvement ayenzeki kwangoko, yaye emva inaliti 3-4.
Abanye oomama zithi ukuba wenza izitofu phambi nokutya, nibe isicaphucaphu kunye nesiyezi. Amayeza emva kudla zivunwe ngcono abantwana. Nangona ukusebenza ichiza, akunamsebenzi ukunika 100 recovery%.

Medicine "Metodzhekt": nokubuyekeza ku isifo samathambo

Imibono ngale ukulungiselela ubunjwe kakhulu entle. Izigulane bathi umthengisi ithintela uphuhliso esi sifo, kodwa, ukuba uyasetyenziswa kufuneka kugcinwe phantsi kweliso elibukhali likagqirha.

Medicine khipha ukudumba, nokuphelisa iintlungu, kodwa hayi zonke iintlungu kuhamba ngokupheleleyo. Abanye banyanzelwa ukuba athathe analgesics ezongezelelweyo. Ichiza uyasebenza iveki, yaye ukuba ixesha ayenzi ukwenza shot, iimpawu zesi sifo kungenzeka kwakhona. Izigulane va isiqabu emva inaliti 5.

Kukho abantu abaye unciphiso idosi kunye nokupheliswa ichiza yabangela nefuthe elibi. Bona wabonakaliswa uhlobo lwesifo, iintlungu, isiyezi kunye isicaphucaphu. Aba bantu ziye zaphawula ukuba idosi kufuneka licuthwa ngokucuthwa yaye kuphela emva kokuba kufikelelwe kuxolelwa ngokupheleleyo.

izigulane ezingaphezulu ezikhala yokuba ichiza kunzima ukufumana ezikhemisti kwaye kufuneka ngokukodwa odolwe. Ezininzi abanelisekanga ngexabiso eliphezulu ichiza. Bakuphawula abanikaziyo ukuba izigulane ngamayeza isifo samathambo kufuneka sikhutshwe ngaphandle kwentlawulo, njengoko asinguye wonk 'Andinamali yaneleyo ukuyithenga uyikhulule ngentlawulelo.

Ngokubanzi, ngokuba unyango kwezifo ezinzima namalungu omnye amachiza zinamandla kwaye mihla "Metodzhekt". Uphengululo (kunye nesifo samathambo abantwana kunye nabantu abadala, oku kubalulekile ngokukodwa) baveza ukuthi ithintela uphuhliso sifo kwaye kuyanceda ukufumana uxolelo ixesha elide.