Methotrexate. Imiyalelo yokusebenzisa

Medicine "Methotrexate" i-arhente antitumor. Le medicament ifakiwe iqela antimetabolites - bachasene acid folic. Product umsebenzi "Methotrexate" imiboniso nxamnye iiseli likhula ngokukhawuleza. Ukongeza, ichiza uyakwazi ekuphembeleleni eminye imiphumo immunosuppressive.

"Methotrexate". Imiyalelo yokusebenzisa. Iimpawu.

Ichiza ezimiselweyo wegazi etsolo emithanjeni, Ewing kaThixo nee-, myagkokletochnoy kunye osteosarcoma, retinoblastoma, iseli intsholongwane nangezilonda ze isizalo kunye iba lityhalarha, isifo trophoblastic, medulloblastoma. "Methotrexate" Imiyalelo kwi isicelo icebisa ukusetyenziswa kunye umhlaza womntu obhinqileyo kunye wesizalo, ulusu, kuvuleke iminxunya, ureter kunye isinqe kwezintso, ibele, umphunga, izintso, isibindi, intloko penile carcinomas nentamo, kwakunye ne chlamydia. Ichiza iboniswe ukuba isifo samathambo, ukhwekhwe neentlobo kakhulu ezifika kwi engekho asebenza japan enyangayo therapy eyaneleyo.

"Methotrexate". Imiyalelo yokusebenzisa.

Le medicament yenzelwe efakwa, ngomlomo, intralyumbalnogo kunye nokusetyenziswa intramuscular. Ibhetshi unomonde ngabanye. Ugqirha ithatha ingqalelo esi sifo ethile, imeko kwenkqubo hematopoietic, unyango antitumor wesekethe.

Ukusetyenziswa kweziyobisi Ingabangela ukudla, stomatitis (sikabhobhosi), gingivitis, isicaphucaphu, pharyngitis. Kwiimeko ezinqabe kakhulu, kukho enteritis, urhudo, pancreatitis, melena. ngenzuzo elide nsuku kwezinye iimeko ezibangela kwesibindi, necrosis kwesibindi, okunamafutha yoma, abanesigulo kwesibindi periportal.

reactions Ezingalunganga nokusetyenziswa ichiza "Methotrexate" yemiyalezo ngokucalula nokwahlula anaemia, leukopenia, isiyezi, ukudinwa, thrombocytopenia, aphasia, unditsho, intloko ebuhlungu, somnolence.

Kwezinye iimeko, sigulo ukuba sexesheni Inokwenzeka, ukuphazamiseka spermatogenesis, oligospermia, namandla, yehle yobuntu.

Ezinye izigulane kufuneka Ngokuzimela, hematuria, umsebenzi ukuphazamiseka sezintso lomlinganiswa, yehle ukumelana usuleleko, ifiva, urticaria, epidermal necrolysis ityhefu, photosensitivity, irhashalala, abrasions, amaqhakuva, telangiectasia.

Contraindicated "Methotrexate" kunye leukopenia, ukukhulelwa, ukuphazamiseka wesibindi, nezintso libizwe. Akunconywa isixhobo kunye immunodeficiency. Xa kufuneka uthathe amayeza ngexesha zisanyisa, isondlo kufuneka kupheliswa. Ngenxa yoko, amanye amaphononongo ziseke iziphumo yaManzi naMahlathi kunye embryotoxic.

Namakhosikazi aselekhulile yokuzala kufuneka ukuyisebenzisa ethembekileyo xa kusetyenziswa "methotrexate".

iziyobisi ezicetyiswayo isilonda Peptic kwi duodenum kunye nesisu, effusion pleural, ascites, isifo sezintso, sifo, nokudumba (sikabhobhosi).

Izigulane irhashalala igqithiselwe ngoku okanye kutshanje, i-herpes (i-herpes) kunye nezinye izifo ezosulelayo etsolo "Methotrexate" ongaphathiswanga.

Phambi kokuba unyango lisetyenziswa kwi imvelaphi unyango eziyimfuneko ukulawula umfanekiso igazi (peripheral), umsebenzi nezintso, nomhlehlo wesibindi.

Xa isicelo of "Methotrexate 'ukuba isifo samathambo okanye ukhwekhwe luyafuneka ukwenza uvavanyo igazi eqhelekileyo (ezineenkcukacha) ubuncinane kanye ngenyanga, iimvavanyo kwilebhu umsebenzi kwesibindi, zezintso - ubuncinane kanye ngenyanga okanye iinyanga ezimbini.

Phambi kokuba ukutyunjwa isigulane kufuneka bazazi zonke izinto ezichaseneyo okusolwayo. "Methotrexate" i amayeza kakhulu. Ukwenzela ukuphepha iingxaki ezingafunekiyo ukusetyenziswa iyeza kufuneka esweni ngugqirha.