"Izoket" Chela: umyalelo manual, ncomo, iinkcazelo, analogue, ixabiso

Namhlanje, iingcali ezininzi amisele ukuba izigulane vasodilator ukutshiza "Izoket" prophylactically okanye, ukuba kuyimfuneko, cupping nangemivumbo. Eli chiza uluhlu olubanzi kwakuthethwa ezahlukeneyo. Oku kusetyenziswa ngempumelelo kunyango ezimbi sentliziyo, kuquka ukulwa imeko bukhali.

Pharmacology

arhente Active beziyobisi ukusuka sifuba angina luphawulwa ngeempawu vasodilating kunye vasodilator ngokukhawuleza. Isosorbide dinitrate zivusa ukubunjwa nitrogen oxide kwi eziphilayo kwaye yehlise iimfuno imisipha yenhliziyo oksijini namandla, ngokwenjenjalo kuncitshiswe umthwalo kwi myocardium. Ngokuphumelelayo kunciphisa uxinzelelo kwi kwegazi pulmonary, wehlise igazi kuqukuqela intendelezo ekunene, kunciphisa ezesifuba ventricular udonga kwempixano kunye nokunciphisa uxinzelelo ukuzala nokusebenza iSystolic ekuphuculeni kuzo. Ichiza alunasiphumo kwi nezihlandlo izishunqulelo zentliziyo yaye ubonakalisa neempahla kakuhle lobuchopho. Kwakhona kwandisa imithambo yegazi le Dura mater zobuchopho kwaye ngaloo ndlela ezibangela intlungu entloko. Iindlela yemfundiso malunga nokunikezelwa igazi flow coronary kwindawo apho ukuhamba kwegazi lifinyele. Xa isifo (isifo sentliziyo) kunye angina ngenxa yesenzo beziyobisi izigulane ithuba lokuba ukwandisa umthambo obuvumelekileyo.

Spray "Izoket" wendele ngokukhawuleza phesheya isifo le ndawo emlonyeni, ngoko ke isiphumo sesicelo yayo luqala emva kwemizuzwana engama-30 kwaye sihlala ukuya imizuzu 120. Ngenxa nesantya ivame ezimiselweyo kwizigulana ukuze isiqabu ngokukhawuleza kwezifo ezinzima.

release Form

Ichiza sisisombululo ngokucacileyo, nto leyo ezingenambala kwaye ivumba ezinxilisayo. Ifike iintlobo ezimbini:

1. Spray "Izoket" kunye balawule sublingual. Ngonqakrazo olunye kwi kwisixhobo akhululwayo ngokohlobo amachaphaza amancinane ka omnye umthamo walo ubunjwe 1.25 mg esisebenza - isosorbide dinitrate nezinto abangabancedani: ethanol kunye Macrogol 400 composition zetoti sele a freon, nangona oko kunxulumene kwiziyobisi engenabungozi ngasemva okusingqongileyo. Iveliswe zeebhotile neziselubala ml-15, zibekelelwe ebhokisini kunye kwisixhobo kunye nemiyalelo. Glass ibhotile komkhondo 300 (amathamo), ozakukuvumela ukuba uphathe isixa neziyobisi ukufumana indawo ngendlela efanelekileyo.
2. Umxube Ifom mxube elungiselelwe infusions. 1 ml yale amalungiselelo eziqulethwe 1 mg le element ebonakalayo isosorbide dinitrate kunye nezinto abangabancedani: sodium chloride, isodiyam hayidroksayidi, amanzi. Enye isitsha - 10 ml isisombululo ukumnika. Ifumaneka imiqulu ikhadibhodi lamaqhosha 10 nganye.

Ubungqina obubonakalayo buxela

Spray "Izoket" iingcali abaqeshwe ngokuhlaselwa stenokardicheskie zonke iintlobo kwaye njengenyathelo lokuthintela siyiphephe. Kukwacetyiswa kwakhona ukuba post-iqhosha ithi, iposi engabalulekanga kwinqanaba etsolo, ukwandisa ukunyamezela kunye IMS kunye nonyango lwe Uqhaqho kwimithambo spasm. Kutshizwe "Izoket" kusetyenziswa ichiza ngokusilela ngentliziyo kwelo ventricle lasekhohlo ngempumelelo. Ngokutsho imiyalelo, gxila kuba ukumnika emiselweyo ukuba izigulane ezimbi ezinjalo nemithambo yegazi:

• angina ezingazinzanga ibakho kwimeko preinfarction okanye iposi engabalulekanga yangaphambili;
• angina vasospastic;
• iposi engabalulekanga ngendlela ebukhali, zibangelwa ukungaphumeleli ventricle lasekhohlo intliziyo;
• vasospasm coronary ngexesha ungenelelo zotyando;
• Ukungaphumeleli intliziyo zonke iintlobo;
• ukusilela etsolo intliziyo ventricular ekhohlo;
• nokudumba miphungeni.

Iindlela ukusetyenziswa kutshizwe

A ukulungiselela ngokwemo ngokutshizwa kutshizwa kwi kwisisu ngomlomo yomguli, ngenxa yokuba lo ngokukhawuleza ongena egazini. Inaliti nganye inika yokungenisa idosi enye. Imiyalelo yokusebenzisa ibhekisa ngeendlela ezahlukeneyo usebenzisa ichiza, kuxhomekeka iimpawu.

Ukuze cupping ukuhlasela stenokardicheskie phambi noxinezeleko ezayo emzimbeni okanye emphefumlweni ezinokubangela etsolo, zila yokuphefumla, kwaye isigulane wamkela amathamo-1 ukuya ku-3 emva kwesithuba imizuzwana 30 phakathi inaliti. Yandisa esithathwa ngaphandle specialist kweliso akuvumelekanga.

Kwimeko exacerbation orhanelwa sisifo sentliziyo okanye iposi engabalulekanga, etsolo phezu isigulane wamkela amathamo-1 ukuya ku-3 phantsi kolawulo olungqongqo zombini izinga lentliziyo kunye noxinzelelo lwegazi. Ukuba akukho ngcono, ngoko le nkqubo iphindiwe imizuzu emihlanu kamva sisigqibo ugqirha. Kwimizuzu elishumi ezayo, imeko kufuneka izinze. Kungenjalo, unako ukuphinda ukusetyenziswa kwakhona phantsi kweliso gqirha.

Phambi inkqubo unyango cupping spasm coronary (ngokuba catheterization ukuxilongwa okanye iinkqubo zokunyangwa) elawulwa nomntu ogulayo ngenaliti 1-2. Xa kwavela imfuneko idosi kungaba liphindwe, kodwa kuphela xa i parameters ulawulo nokuhamba kwegazi.

iingcebiso ezithile ukusetyenziswa isitshizi

Kwiimeko xa isitshizi esitsha isicelo okokuqala, okanye emva kokuba ithamo yokugqibela sele iiyure ezingaphezu kwama-24, uyacebiswa ukuba ukwalathisa umatshini wokuqala emoyeni, kuba awukwazi ziqulathe idosi efunekayo. Kuba amathamo ngokungqinelana డొమైన్ idomeyini umyalelo gqolo icinezelwe ekupheleni, bandula ke bakhululwa. Ngexesha ukusetyenziswa kwisixhobo kwibhotile yokufefeza kufuneka wobomi kwaye nkqo. Sebenzisa isilumkiso kwaye uphephe angena emehlweni. Ngeli xesha lonke unyango kufuna ulawulo rhoqo uxinzelelo lwegazi (BP) kunye ECG imiwe. Ixabiso uxinzelelo lwegazi kufuneka ibe ngaphantsi kwe-100 mm HG. Art. ukurhoxiswa ngokukhawuleza lo myalelo mthethweni iziyobisi, ngoko ithamo elimisiweyo licuthwa ngokucuthwa. iziselo ezinxilisayo akukhuthazwa ngexesha uthatha zetoti "Izoket".

Iingcali Ukubuyekezwa zibonisa ukuba idosi aphezulu amayeza, ntonje ukutyunjwa okanye ukusetyenziswa ngendlela kunokukhokelela kuphuhliso nokunyamezelana kumguli. Loo msebenzi yaye ukusetyenziswa nezinye iziyobisi iqanjwa nitrate. Kwiimeko ezinjalo, oogqirha Siyaleza ukucima ukusetyenziswa kweziyobisi iintsuku 2-3, yaye emva kwikhondo unyango rhoqo, eyathatha iiveki 3-6, yokuthatha ikhefu iintsuku 3-5, afake okwethutyana namanye amachiza kunye neziphumo ezifanayo. Kwiimeko ezininzi, emva kokuphazamiseka okanye ukupheliswa uvakalelo lomguli ebuyiselweyo kunokuba ngokukhawuleza. kuthetha amacandelo eyenziwe metabolites njengoko ezintsweni phantse ngokupheleleyo.

Idosi isicelo isisombululo

Ngokutsho iimfuno kumalungiselelo umyalelo 'Izoket "(ukuba isisombululo ukumnika) lisetyenziswa yegazi. Esithathwa kwe vrechom kokuphatha ngabanye ezingqanyaniswe hemodynamic kunye parameters kwezonyango isigulane. Therapy kufuneka uqale idosi eliphantsi kunye nokwandisa kancinci uzise mali efunekayo. Imiyalelo Kucetyiswa idosi ichanekile 2-7 mg / hr, ngokulandelelana, idosi umlinganiselo malunga 7.5 mg / hr. Kwiimeko of umthamo yimfuneko kakhulu angandiswa ku-10 mg / hr.

Kwiimeko ezininzi, abantu ukusilela intliziyo ifuna ngeedosi eziphezulu ichiza. Ukuqaliswa ichiza kufuneka baye kufumana unyango izigulane phantsi kweliso zeengcali kunye nokusetyenziswa kweenkqubo oluzenzekelayo ukumnika. Inkqubo yonke lukhatshwa izikhombisi ulawulo ukujikeleza (uxinzelelo lwegazi kunye nezinga kwentliziyo).

A Isisombululo nolawulo efakwa yayilungiswe kwiimeko walaliswa ngokukhawuleza phambi kokuba inkqubo. Ichiza awugcinwanga ngaphezu kweeyure ezingama-24. iindlela ukulungiselela:

• ukuba iqela 0,01% (100 micrograms / ml) - ml-50 ka-0.1% iziyobisi ukuze 500 ml ilungele yolawulo ukulungiselela;
• ukuba iqela 0,02% (micrograms 200 / ml) - 100 ml ka 0.1% isisombululo beziyobisi unako ukuvelisa 500 ml medicament ilungele yolawulo.

Izimo kunye izinyathelo

Ichiza akayibonisanga ukuba izigulane hypersensitive ukuba iikhompawundi nitrate, kwakunye neminye imiba kutshizwe "Izoket". Isicelo kwakhona akuvumelekanga ukuba isigulane izifo ezifana:

• hypotonia, apho uxinzelelo iSystolic singaphantsi 90 mm HG.;
• insufficiency semithambo kwinqanaba etsolo, umz, ngexesha ukothuka okanye inciphise nemithambo;
• pericarditis kunye tamponade pericardial;
• uthuke cardiogenic kwiimeko apho kungekho kungenzeka ukuba balungise abanye uxinzelelo ndlela ventricle lasekhohlo intliziyo;
• cardiomyopathy hypertrophic;
• ukuvalwa glaucoma.

Ukongeza, ichiza akayibonisanga abantu abangaphantsi kweminyaka elishumi elinesibhozo ubudala. Imiyalelo yokusebenzisa icebisa ukuba ukusetyenziswa kweziyobisi ngononophelo ezigqithisileyo phantsi kweliso lomgadi kwiimeko ezinjalo:

• iposi engabalulekanga ne kwemali etsolo xa isigulane kuye a xi kwanciphisa ngasekhohlo ukuzaliswa intliziyo ventricle;
• noxinzelelo intracranial;
• mitral kunye / okanye stenosis aortic;
• uzingela ukwenzeka okuba na ukuphazamiseka intolerance nomonde ummiselo kwegazi negazi;
• kwezintso okanye isibindi ukusilela.

Ukukhulelwa ne zisanyisa

Izazinzulu kuphuhliso lezifundo zezilwanyana iziyobisi ziye zaqhutywa. Ukucikideka ovavanyo kwabonisa ukuba umphumo umonakalo ekukhuleni kosana olungekazalwa sele zenziwe. Nangona kunjalo, ngexesha lokukhulelwa kunye lokwaphusa ixesha ukuqeshwa inkonxa kucetyiswa kuphela kwezo kwiimeko apho iinzuzo yenzelwe abafazi baya kuba kakhulu ngaphezu ingozi kwimveku okanye lwebele-usana. Unyango ngala matyala kufuneka ibe phantsi kolawulo olungqongqo titshala, parameters ulawulo ukujikeleza (uxinzelelo lwegazi kunye izinga yabetha intliziyo), kwakunye nemeko jikelele yesigulana.

Intsebenziswano kunye namanye amachiza

Akuvunyelwe ukwabelana vasodilators kunye "Izoket" ukulungiselela (spray). ukusebenzisa kwabo kudityaniswa kubangele ukwanda ukusebenza iqinile. Nomphumela ofanayo kuthetha ukwamkelwa ngaxeshanye "Izoket" kwaye loo amayeza kutshizwe: antihypertensives, blocker calcium channel, "Quinidine" okanye "novokainamid" neuroleptics, 5-phosphodiesterase inhibitors.

Ukuqinisa ukusebenza antianginal xa ukusetyenziswa kudibaniso nge iziyobisi ezifana "Amiodarone", "propranolol", "Nifedipine", "Verapamil, 'kunye namanye blocker le calcium channel kade.

Ukwanda uxinzelelo intracranial xa isigulane kwenzeke ngexesha unyango kunye atropine kunye nezinye m-holinoblokatorami.

ukuhla kakhulu kuxinzelelo wegazi, okukhokelela perfusion coronary, ivela phantsi kwempembelelo alpha-blocker kunye sympathomimetic.

side effects kanye nohlaziyo

Imiyalelo echazwe a lot of side effects ukuze kunokubangelwa iziyobisi "Izoket" (spray). Izimvo ezinye abanyangwa eli chiza, bonisa ukubonakala yintloko, nto leyo amayeza ubizwa ngokuba "nitrate". Njengomgaqo, emva kweentsuku 2-3 ingxaki liyalahleka ngokwayo yaye akafuni kufuna ukulungiswa. Kunokuba kunqabile medicament kunokubangela izenzakalo ezifana isicaphucaphu, anozizi eluswini, ukugabha, kunye umlomo owomileyo. Ezinye izigulane abafumene amayeza okokuqala, ekhala ubuthathaka jikelele, isiyezi, kunciphisa uxinzelelo lwegazi kunye nokuziva silale. Oku kubangelwa ukuphazamiseka ezincinane ekusebenzeni kwenkqubo sentliziyo. Baya kuvela xa usebenzisa lokuqala okanye kwagqithiswa idosi ekhuthazwayo.

Noko ke, ngokutsho ncomo, izigulane isaziso kunye nokusebenza. Kwaye xa benikwa ngokungqinelana neemfuno zoqeqesho yeziphumo ebezingalindelekanga azenzeki njalo njalo. Le Okungumahluko yintloko kwiintsuku zokuqala ukusetyenziswa, okuhambisana uninzi amatyala, kodwa ngokuqhelekileyo idlula kwiintsuku ezimbalwa.

Egqithayo ngokomthamo

An libanda, beziyobisi kunokubangela eziliqela ezinxaxhileyo ezinzulu: syncope, ukuwa, uxinzelelo oluphezulu intracranial, nokushisa, ukuxhuzula, ukuphazamiseka umsebenzi ezibonwayo, ukubila okwandileyo, methemoglobinemia, bradycardia, uphelelwa ngamandla, okanye ukuba khokhoma. Kungenxa yoko le nto kubalulekile ukuba self-intliziyo, uthabathe ichiza uyifaka neemfuno yincutshe!

Ukuba ezi mpawu zixelwe kufuna ukususwa ichiza beqhuba unyango ejoliswe uzinzo imeko yesigulane.

analogs

Medicament "Kardiket» (CHWARZ Pharma, Germany) - enye amachiza afana nalawo ixhaphakileyo (analogs) beziyobisi "Izoket" (spray). Ixabiso le indawo kuxhomekeke xi ukwimo esebenzayo kunye nenani iipilisi kwi iphakheji.

Umzekelo, i-arhente emacwecweni 20 mg "Kardiket kunamandla" (20 iiPC. On iphakheji) uvela engange 62 ukuya ku-72, lo gama amalungiselelo efanayo, kuphela xa kukho umthamo amacwecwe mg 40 kwaye ubungakanani amaqhosha 50, kukho ixabiso 210-220 engange.

Iqela amayeza "Nitrosorbid" iveliswayo iinkampani ezininzi Russian, yaye iindlela ezahlukeneyo woyekelelo, kakhulu, sisiyobisi endaweni "Izoket". Analogue eli qela kufuneka igama "Nitrosorbide-Rusfar", "Nitrosorbide", "Nitrosorbide NS", "Nitrosorbide-UWI."

iindleko

Ezikhemisti Russian kuya kufuneka ukuba uhlawule ukusuka engange 365 ukuya 470 nganye ekuqulunqeni idosi "Izoket" (spray). Ixabiso kwakheka ngokuxhomekeke indawo lo walivala ithende ngemiyinge emincinci kunye nobume bayo. Kwiiwebhusayithi ezithengisa amayeza zinokuthengwa ngexabiso eliphantsi kunokuba ekhemesti aqhelekileyo kufutshane nekhaya lakho. Kodwa xa wayala phezu Internet kuya kufuneka ukuba uhlawule imali engange-200 ukwenzela ukuhanjiswa okanye ufumana arhente simahla ex lomhlathi, nto leyo akusoloko lula kuyiphi indawo.

Kwakhona, nangaliphi na ekhemesti unako ukuthenga impahla (10 ezineengqayi) kanzulu isisombululo ukumnika "Izoket". ixabiso layo kuyahluka 906-980 engange.

Overview

Ichiza yenziwa yinkampani isiJamani "YUSB Pharma GmbH". Aphezulu ubomi iminyaka emihlanu. Imigaqo intengiso - kukho amayeza kagqirha. Emva ixesha elide ukusetyenziswa kucetyiswa ukuba ukujonga ukusebenza kwale sisitshizi. Ileyibhile le kutshizwe itsalwa utolo ezantsi. Xa ulwelo efika kwinqanaba kufuneka ibe ukufumana ichiza elitsha, kuba ukusetyenziswa kwe-ibhotile ekhoyo kuphela kunokwenzeka kancinane axis, apho ityhubhu owanyayo egxile engamanzi.