Ithumba marker HE4: ukucazulula Isalathisi rate

Oncology - ngxaki yingozi. Qho ngonyaka ngenxa yesi sifo sibulala abantu abaninzi. unobangela yaziwa yesine wokufa umhlaza zamaqanda. Ngaphezu koko, izinga lokusweleka lelona liphezulu kwimimandla phambili. Umhlaza sinokunyangwa xa ezichongiweyo kusekwangoko yophuhliso lwayo. Oku kuya kunceda ithumba isiphawuli HE4 umhlaza epithelial ovarian. Yintoni izinga le isalathisi kuchazwe ngezantsi.

Ukusebenzisa le hlobo lomhlaza

Iimpawu badla bayaqonda kunzima, ukusukela ukuba inxulumene ngqo ithumba uluhlu waso yaye ke awukacaci. Ngokwenkcazelo yi-Arhente International Lophando Umhlaza, lo nyaka emihlanu elingama izigulane ezinomhlaza ovarian kwi zigaba yokugqibela malunga nowama-46%. Kodwa xa ubona esi sifo usaqala, izinga ukusinda lanyuka ukuya 94%. Uphando lwakutshanje ubanike abantu ithuba ukulwa esi sifo. Ukubona ekuqaleni yobubi xa nisaqala yabamakishi ithumba kwesi sifundo. Ngenxa yokwanda inqanaba babo oogqirha isandi alarm. Kweli nqaku siza kuqwalasela le HE4 ithumba isiphawuli.

Guquka ithumba elimakishayo

Emzimbeni womntu kukho izinto zibe ngumqulu encinane, ezo zibizwa ngokuba bamakishi ithumba. Bona inxaxheba kumaqumrhu ohlukeneyo nokomzimba kwaye kwemichiza yaye kuyingozi ubungakanani yesiqhelo. Yonke into iza kuba ezahlukeneyo, xa umthamo yabo iya kunyuka. Oku kubonisa ukuba amathuba yobubi. Umzekelo, ukuba ukuchonga umhlaza ovarian, yeyona ndlela isetyenziswa ngokuqhelekileyo CA-125 ithumba isiphawuli. Kodwa kamva afika ukuba isiphawuli thumba HE4 ichaza ngokuchane ngakumbi Oncology.

Le protein serous oluthintela protease enzyme, eliguqulelwe lithetha "iproteni yabantu -. Ezine khala" Imali efunekayo esincinci kunjalo umsebenzi iba lityhalarha kunye amadlozi ekwakhiweni. Kwakhona ke isakhiwo le nokuphefumla, tube Imibhobho, kwaye ngenwebu yangaphakathi. Kodwa esebenza kakuhle ngayo nendlela luchaphazela pepsin ngamnye, oko ayide icace.

Ubungqina obubonakalayo buxela ukuba uhlalutyo ngenjongo

A imali encinci ithumba isiphawuli HE4 inokuba yiyo nayiphi umfazi. ukunyuka umthamo wayo izifo ezifana:

- umhlaza Ovarian.

- Oncology endometrium.

- umhlaza wamabele.

- Lung umhlaza.

Benefits HE4

Ngoko oncomarker HE4 kuthetha inkqubo esele amabi. It asinako ukuqinisekiswa kwenkqubo ingozi, okanye ukudumba zamaqanda. Oku kubonisa indlela esisebenza HE4.

kuneyokuqala, nethumba isiphawuli CA-125, kwakhona kukuqaphela umhlaza, kodwa sele ngokuchanekileyo kwindawo encinane. Oko kukuthi, i-mali ka-CA-125 uba mkhulu kwi zigaba yokugqibela uphethwe elichanekileyo. Umqulu HE4 izakwenyuka nge malunga neminyaka emithathu ngaphambi kokuba inkcazelo ngqo esi sifo.

Ngako oko, ngokuhlola ngumhlaza kungabonwa kusekwangoko, akakafiki kuphuhliswa mpawu. Ngaphandle koku, okotshiweyo of ithumba isiphawuli HE4 ayisetyenziselwa ezikhoyo uphando kwingingqi zamaqanda. Akanako ukubona intsholongwane neentlobo mucoid zomhlaza.

HE4 isetyenziselwa esweni unyango kwabafazi sele iqalile. Ngako oko, ukuba uhlalutyo unyango kuphinda uya kwenza, emva koko kusetyenziswa unyango idlula.

Ngokutsho inani elimakishayo ithumba uyakwazi ukubona ukuyilwa nakujoliso olutsha zasesekondari iiseli ithumba ngenxa neeyantlukwano ukuqhambuka original zomzimba ezikufutshane okanye ukuvuselelwa.

zePCR Uphelile HE4

Kubanga ukufa ngakumbi ngenxa yomhlaza kukuchonga esi sifo kwi zigaba yokugqibela yophuhliso lwayo. Ngoncedo HE4 kuhlalutyo nga Ukukhangela kusekwangoko somhlaza, oku kunciphisa amathuba okuba ukufa. abamakishi Ithumba kungabonwa egazini losana emthanjeni. Ukunikezelwa olufanelekileyo yokuhlaziya kufuneka:

• Nikela igazi esokuba ungatyanga okanye emva kweeyure ezine ukuya kwezintlanu emva kwesidlo. Unga ukusela amanzi, kodwa kucetyiswa ukuba yekofu okanye isiselo.
• Ukuba kunokwenzeka, kwiintsuku ezimbalwa a (iintsuku ezi-3-4) phambi kokuba unikezelo yokuhlaziya akazange athathe nawaphi na amayeza.
• Ngaphambi kokuba nayiphi na Uhlalutyo angadli okanye umsi.
• Ukuqala unyango umfazi isandla phezu uhlalutyo kanye qho kwiinyanga ezintathu. Kwixesha elizayo, ngokwaneleyo omnye - amabini amaxesha ukuze ingqinwe.

Kwezinye iimeko, uphando elawulwa abantwana. Kufuneka sisele amanzi abilayo kangangesiqingatha seyure phambi kokuba unikezelo zohlalutyo. Umthamo umndilili ndasela amanzi kufuneka 150-200 ml.

Abasetyhini kufuneka uhlolelwe xa bekukho iintlungu kwindawo zangasese, waphazamisa sexesheni, kunciphise onombilini.

Xa isifundo kubalulekile ukuba kumgangatho ophezulu ithumba elimakishayo.

Ithumba marker HE4: yombhalo

ISithethe kuxhomekeke ngesondo, ubudala isigulane. Emva kokuba uvavanyo lwegazi abulawe, kufuneka ukuba ulinde. Umphumo iya kuba sesilungile iintsuku ezimbalwa.

Umqulu HE4 ukuqaphela ukufunda ekhethekileyo chemiluminescent.

Undoqo yile: kukho indlela enombhalo iikhompawundi olifunayo neprothini 4-th. Ngoko kukho utshintsho iimpawu zazo okusegazini. Lo iza ekwenyukeni indlela chweba. Ngoku ngoncedo iindlela negalelo okubona nokubala inqanaba ithumba elimakishayo.

Norms amadoda kunye namakhosikazi

A Imali eqhelekileyo protein-4 abasetyhini ngexesha pre-exesheni umkhulu 70 pmol / l, yaye emva exesheni - ngaphantsi kancinane kune okanye ilingana 140 pmol / L. Okukhona ezi zibonisa, kokukhona amathuba somhlaza isifo ovarian.

Kodwa kufuneka wazi ngokuqinisekileyo ukuba kukho izithethe ubudala, oko kukuthi, idatha batshintshwa ngokuxhomekeke kubudala. Ngoko ke kungcono ukufumana yonke ingcaciso evela kugqirha wakho. Le nto ibonisa HE4 ithumba isiphawuli.

Thina mhaka umdla ilandelayo. Xa wenziwe HE4 yombhalo, ufumana le datha ilandelayo: sesithathu kwisiqingatha lemvu Isibalo amazinga ithumba elimakishayo, kodwa CA-125 ngokuqhelekileyo uhlala eqhelekileyo obuvumelekileyo.

Yintoni izinga loo zabantu? Kuyinto kwinqanaba 4 ng / ml kunye ngezantsi. Kufuneka uqaphele kwimeko ukuba bafumane umsebenzi onamandla kunene. Oku uyakwazi ukuthetha kuphuhliso somhlaza emzimbeni yesifo eyingozi.

Kukho utshintsho nemigangatho ubudala. Emva kweminyaka engamashumi amane amadoda kwesantya 2-2.5 ng / ml, emva kweminyaka engamashumi amathandathu - 4.5-6.5 ng / ml.

Iinkcukacha-manani zibonisa ukuba ngakumbi abantu bazo zonke izigaba zexesha ukuba ufune uncedo lonyango. Baza baphakamisa markers ithumba egazini kwaye ngezifo le ingaba wendlala.

analysis imposiso

Kufuneka Mayisoloko ikhunjulwa into yokuba uhlalutyo self zabamakishi Ithumba akukho sizathu ukuqinisekisa okanye ukuphikisa Oncology. Ngokuchanekileyo kodwa usebenzise HE4 kunye nezinye cazululo. Kungcono ukuba bacande kulo kunye ne-CA-125. Kwaye nokukwenza iintlobo ezahlukeneyo uxilongo, ezinjengelebhu zomculo.

Ngamanye amaxesha Ixabiso eliphezulu thumba abamakishi HE4 ayikho ngenxa yobubi. Siya ukuhlalutya isiphumo okungamanga ukuba:

• phambi kwezifo systemic ilifa, echaza utshintsho transmembrane Regulator zofuzo;
• ubukho bezinye inflammations enzala isakhiwo;
• ukusilela kwezintso ezingapheliyo;
• cyst ovarian;
• myoma.

Indlela ukuba azazi iimpawu zosulelo lwe somhlaza?

Xa iziphazamiso incinane umzimba kuyimfuneko ukuba udibane nogqirha. Iya kulimisela uhlalutyo kwi epithelial ithumba isiphawuli HE4 umhlaza ovarian. Ummiselo okanye ukutenxa iya kutyhila ngokukhawuleza. Ekuqaleni iimpawu kungangabikho ngokupheleleyo. Kodwa nayiphi na imeko, uhlalutyo kufuneka achithe kwi:

• ukuhlukunyezwa zamaqanda kunye neengxaki sexesheni kwi nabafazi;
• ahlekise kule ndawo zangasese;
• Ukonakala kwenye impilo jikelele kunye umdla ukuncipha;
• ezinzima ngqiqweni komzimba;
• bengenamdla.

Phezu isiqinisekiso uxilongo akukho mfuneko yokuba aphakuzele, kuba umhlaza iphathwa ngempumelelo namhlanje. Kakade ke, olu luvavanyo, kodwa zingaphunyezwa baze baphume yomlo owoyisileyo.

Self-iyeza akwamkelekanga ukuthembela emi yedwa phezu iingcebiso leengcali.

Kuya kuthatha nomonde kunye namandla, ngenxa yokuba amayeza - ngumsebenzi onzima, apho inophawu elide kunye ezingemnandi.

isiphelo

Umphumo okungalungile kunokuba, ukuba ithumba ngaba ukudala HE4 okanye iyafumaneka kunyuswa ayanelanga ukuba ubone.

Ngaphandle kwento yokuba uhlalutyo iza kubonisa, akukho mfuneko ukuba buhlungu ngaphambi kwexesha bayimisa wena ukuba isifo. ziingcali zonyango uyakwazi ukuchonga isifo kwaye ukumisela unyango, kodwa ke kuphela emva kokuba zoviwo ezipheleleyo.