Izazinzulu ziye zafumana iziphumo ezintle uvavanyo kwe ichiza elitsha for ileukemia

Izazinzulu ziye ukwazile ukwakha unyango ngenxa wegazi, nto leyo waphinda wazibonakalisa ngempumelelo. Ngokwenene na kwiimvavanyo zeklinikhi lwabonisa ukuba thumba ngo-71% ezigulane kunye terminal leukemia lancipha okanye shwaka ngokupheleleyo.

iqela High-risk

Esi sifundo, ogama iziphumo zapapashwa Journal of Clinical Oncology, lwenziwa inxaxheba izigulane ezingama-24 kunye ezondeleyo leukemia lymphocytic lowo amanye amayeza ziye alusebenzi. Iminyaka izigulane zazisuka engama-40 ukuya 73. Ukongeza, ukuba bathathe inxaxheba kwisifundo ngasinye safumana umlinganiselo iintlobo ezintlanu ezahlukeneyo unyango, kuquka unyango "Ibrutinib" - ichiza esisetyenziswa ngokubanzi lo hlobo lomhlaza. Oku wabeka nxaxheba emngciphekweni omkhulu kunye elingama eliphantsi.

yolingo lwezonyango

Iqela kwiZiko loPhando noFundo Hatchinsona Cancer kusetyenziswa unyango kwangoko ekuthiwa immunotherapy timoralnogo receptor (CAR). Nale hlobo unyango, iiseli T zabo yomguli acatshulwe egazini, waliguqula kwiimeko elebhu. Kulo mzekelo, baye kancinane ukuqaphela CD19 - iantigens kumphezulu weeseli zomhlaza.

Emva koko, ezi seli elungisiweyo zinto lesitofu ubuyiselwe kumguli, ebangela ukuba alwe wegazi, yaye bazingela phinda iiseli umhlaza ukuya iantigens CD19. Abaphandi ingxelo ukuba emva kweenyanga ezintandathu kunye nesiqingatha ngo-17 ka-24 izigulane zasinciphisa ithumba okanye wanyamalala ngokupheleleyo.

"Ngaphambili ke akwaziwa ukuba kunokwenzeka ukuba ukusebenzisa immunotherapy timoralnogo iiseli receptor T yonyango kwezigulane leukemia ezondeleyo lymphocytic, nayo leyo ilungu kwiqela high-risk - Uthe ukufunda eli Umbhali uGqr Cameron uFudo, immunotherapy umphandi kwi Fred hutchinson Centre. - isifundo sethu sibonisa ukuba iiseli CAR T ilunyango ethembisa kakhulu ukuba izigulane CLL abangengabo unyango ifanele "Ibrutinib '."

Yintoni CLL?

Chronic leukemia lymphocytic - sisifo iqala umongo lithambo lomntu (kwi kwizihlunu ezithambileyo ngaphakathi amathambo apho akhiwa iiseli zegazi). Xa izigulane CLL, wamathambo uvelisa lymphocyte ezininzi kakhulu engaqhelekanga (uhlobo okungaqhelekanga iiseli ezimhlophe zegazi).

Njengokuba isifo siqhubeka, ezi iiseli ezingaqhelekanga iziinxalenye kunye sikhulise nkovu iindawo, udakada nesibindi. Ubungakanani "yamathumba lymphoid" ezinjalo lingaba nokulinganiswa kusetyenziswa iintlobo ezahlukeneyo ukuskena.

iiseli usempilweni - kukuba iiseli zokhuselo lomzimba ukuba ukunceda ekulweni nezifo, kodwa izigulane CLL, azisebenzi kakuhle kwaye babange isiyaluyalu. Ngokutsho American Cancer Society, leukemia lymphocytic engapheliyo ngo-2017 luya kuba imbangela yokufa 4660. Kwakhona kulindeleke ukuba iimeko ezintsha malunga 20.110 kwesi sifo.

imiphumela emibi

unyango olutsha luye iziphumo ebezingalindelekanga ebalulekileyo, nangona uninzi lwazo ingathityazwa. Kuphononongo malunga 83% ezigulane ezivavanyiweyo cytokine release syndrome, i ingxaki eliqhelekileyo emva konyango T-iiseli kunye neempawu ezifana fever, isicaphucaphu, kuthibaza, kunye noxinzelelo lwegazi ephantsi engaqhelekanga. Ngelishwa, ezimbini izigulane zaye esibhedlele, omnye wafa ngexesha unyango.

iiveki ezine emva konyango, abaphengululi yahlalutya iisampuli lomongo wethambo izigulane 12, owathi ngenxa unyango baba kuxolelwe, ukuze abone ukuba waqhubeka imeko emva kokugqiba unyango. Kwezi, asixhenxe kwakungekho iiseli umhlaza wolusu.

Uphononongo isekhona isaqala, kodwa sele amahle kakhulu. ziphumo bezingalindelekanga ngokuqinisekileyo ingxaki, kodwa iinzuzo ezinokubakho ngaphezulu kakhulu zabo.