Ichiza "Sulpiride": ncomo, izalathisi, analogs

Psychosis ngegalelo ubucaka kunye uluntu ngonaphakade. Ukutyhubela iinkulungwane ezininzi kwakukholelwa ukuba ubephethwe ziidemon kwi umntu ogulayo, yaye ngoko ke "unyango" le ngxaki iye efanelekileyo. Phambi ekudalweni isiqabu amayeza neuroleptic ukuphazamiseka engqondweni livelise unyango leengcambu eliphuhliswe ngokusekelwe Belladonna, henbane, opiates. Kwenziwe njengoko unyango kunye calcium (emthanjeni) kunye ebhaptiza isigulana sisiyobisi yokulala.

I chlorpromazine yokuqala antipsychotic ingabizwa, eyasetyenziswa ngokubonakalayo ngenxa unyango izigulane kunye neengxaki zempilo yengqondo ukususela 1953. Okwangoku, uluhlu amayeza antipsychotic, antipsychotics yandiswa kakhulu. Enye amachiza asetyenziswa kakhulu eli qela yi "Sulpiride". Baqinisekiswa ichaza ngaye antipsychotic Nedlac kakhulu.

pharmacodynamics beziyobisi

ukusebenza Neuroleptic "sulpiride" antidofaminergicheskim enxulumene intshukumo, m. E. In kwiibloko ichiza luvo central ikakhulu nezamkeli dopaminergic. Dopamine alicandelo obalulekileyo "inkqubo umvuzo" yobuchopho - ivuselela kuyabuya ubumnandi, ukwanelisa kune, nayo, ichaphazela iinkqubo zemfundo zenkuthazo. Ngeedosi eliphezulu ngokwaneleyo, ekuveliseni inkqubo nayiphi na amava HIV (kwi ngokoluvo ayinyani lomntu) - ulwamkelo ukutya okumnandi, ukwabelana ngesondo, akukho iminqweno emzimbeni amnandi. Njengoko isixa Ukwanda dopamine kwinkqubo luvo kuphuculwe intuthuzelo ngokwasengqondweni, kunye nokuhla - ukuphuhlisa iimpawu zokudakumba.

Action "sulpiride" kwi idosi kuma-600 mg (yonke imihla amayeza) yi zohlobo antipsychotic. Ukuba iidosi ngaphantsi kwama-600 mg - ivuselela zimandla kunye neziphumo bucala. Kodwa serotonicheskie, histamine, iziyobisi adrenergic receptors ngandlela encinane.

Imithi - analogue

Le medicament "Sulpiride" - neuroleptic Nedlac, ngoweqela of benzamides endaweni - ine inani elikhulu ngokwaneleyo lamayeza ezifanayo kumafa kwaye isiphumo. Kukho iziyobisi ezifana ikhowudi kwinqanaba ATC 4th. Ezi "Betamax", "tiaprid", "Eglonil". Ngaphandle kwezi, kukho imfuno yabathengi ebanzi "Prosulpin", "Eglek" "elithozamisayo '" Vero Sulpiride "," Sulpiride Belupo. " Izimvo onke amayeza abathengi babe zombini kwicala akhabayo kunye navumelanayo. Konke kuxhomekeke ebukhulwini karhulumente yesigulane impilo, uvakalelo lwakhe eyona nto ephambili esebenzayo - sulpiride, kwaye umthamo ichiza eyabelwe ukufumana ugqirha.

Ubungqina obubonakalayo buxela ukuba bafumane amayeza

Sam neuroleptic "Sulpiride", analogs alo sphere ebanzi ifuthe linokukwenziwa ukufumana i kwezifo ngokwaneleyo. Yithathe phambi ngesifo kwi zigaba etsolo, nangemini yento ezingapheliyo. Sulpiridsoderzhaschih kuvunyiwe ukusetyenziswa antipsychotics ngexesha nqanaba nokoyika kuphuhliso waphazamiseka (a ukuphazamiseka engqondweni bendalo, ekhatshwa isiphazamiso osezingqondweni ukusukela nesiyezi kunye isiqaqa). Kaninzi ichiza emiselweyo zezigulo ezahlukeneyo bangonwabi nokudandatheka, kungakhathaliseki imvelaphi yabo.

Xa vertigo imvelaphi ezahlukeneyo icebisa ukuba ukuthatha "Sulpiride" umyalelo manual. Izimvo kwizigulane kunye nabasebenzi bezonyango luphawulwa kakuhle medicament ekunyangeni neuritis vestibular, xa uhlobo ukusilela vertebrobasilar-basilar kunye namajelo eendaba otitis kunye unxinzelelo cranial, kunye nesifo Meniere kaThixo (yobungakanani ulwelo kwi yangaphakathi indlebe kwisisu, nto leyo ibeka uxinizelelo olukhulu iiseli unoxanduva lokugcina kuvuselele umzimba kunye noqhelwaniso yayo space).

Ngenxa "Sulpiride" yinxalenye kwanonyango ebanzi zingasetyenziswa kwimisebenzi zonyango isifo isilonda Peptic kwaye ocaphuka msinya kwamathumbu syndrome.

Ngubani ekufuneka ukuyeka iziyobisi antipsychotic ngokusekelwe sulpiride?

Neuroleptics "Sulpiride" analogue lwemithi eyona nto ephambili esebenzayo inoluhlu elithile Izimo. Musa ukuba abantu hypersensitivity ukuba sulpiridu nokuhlupheka hyperprolactinemia (eziphakamileyo kakhulu amanqanaba le prolactin hormone egazini). Ngako oko, eli chiza ayikho wabelwa prolactin-oxhomekeke yamathumba (umhlaza webele, prolactinoma posa , njalo njalo).

Ngaphezu koko, "Sulpiride" (zikhombisa ezichazwe ngasentla) uyakuthintela loomyalelo pheochromocytoma (yamathumba hormonally esebenzayo chromaffin iseli), njengemanic kunye ezahlukeneyo ukuphazamiseka ngokwenene kunye yokuziphatha ndlongo sokuwa. Musa ukusebenzisa oku sulpiridsoderzhaschih amayeza sizoku lwisana kunxilwe utywala ludlule, etheni iziyobisi thile amayeza kunye analgesics ezidakumbisayo.

Not ziboniswa ukusetyenziswa neuroleptic "Sulpiride" izigulane abangaphantsi kweminyaka eli-18 kunye namabhinqa ngexesha zisanyisa.

imiphumela emibi kunokwenzeka of

Indlela Ezingalunganga ukuba neuroleptic yena analogue "sulpiride" angqina nomonde kunye neengcali zezempilo okuluphawu enkulu ngokwaneleyo, zisiba kakhulu imeko izigulane. Kukho amathuba hyperprolactinemia ngeendlela ezahlukahlukeneyo (gynecomastia, seTrojan, frigidity, kunciphise amandla, galactorrhea, ukunyuka ubunzima emzimbeni).

nokubonakaliswa okuqhubekayo kangangoko syndrome extrapyramidal, apho kuboniswa ukuphazamiseka zophendlo lwezifo ze ubungakanani kunye nomgangatho yayiqalwe eziveliswa izihlunu skeletal, tshintsha kwi kwezihlunu. Noko ke, ukukhubazeka akukho iliphawu engqina isibakala le extrapyramidal syndrome.

Njengoko reactions icala ku "Sulpiride" analogs neuroleptic, Inokwenzeka lafa, akathisia (ukungakwazi sibe kuphumla), zeDyskinesia, sokulibala, ukozela, ixhala excitability ephakamileyo, ukuba nochuku. Ngazo iimpawu syndrome neuroleptic yingozi, luphawulwa ezingaqhelekanga yawo, lisuke labuna ulusu, komzimba.

ziziphumo ebezingalindelekanga ezivela iphecana zesisu inokuba uza ukoma emlonyeni, uphuhliso heartburn, isicaphucaphu imbonakalo, ubuqhophololo, ukuqhina kwesisu. ukusebenza kunokwenzeka of transaminases hepatic kunye obrak phosphatase.

isicelo yegazi "sulpiride" angasabela ukunyuka koxinzelelo lwegazi (kunqabile - ukuhla uxinzelelo lwegazi, isiyezi), ukwanda izinga intliziyo, ukwanda QT-lekhefu. kunqabile kakhulu, kodwa unako ukuva ukuba i "Sulpiride" impendulo kweziyobisi kumagqirha zibonisa uhlobo torsadedepointes zophuhliso arrhythmia.

kubonakaliswa komzimba ezifana irhashalala eluswini, pruritus, izilonda eczematous. Ngamanye amaxesha uyakwazi ukuva malunga nokuhluthwa acuity olubonakalayo.

umthamo kunye circuit isicelo mode

Ngokutsho imiyalelo ukusetyenziswa medicament, izigulane ngokuqhelekileyo abadala ngokuxhomekeke yezifo yedosi emiselweyo ka 100-300 mg ngosuku (yahlulwe 2-3 amathamo). isisombululo ngomlomo yaphathwa idosi ezahlukeneyo: 100-800 mg ngosuku yolawulo intramuscular (phambi kokuba ukusetyenziswa ndinganyikimisi ngokuyimfuneko). Ubuninzi yedosi ngoyaba ngenxa omdala 1.6 g

Ukuba kuthe kwanyanzeleka ukuba abele "sulpiride" ukuze abantwana abangaphantsi kweminyaka eli-18 ubudala, idosi kufuneka ubalwe ngokuthathela ingqalelo ubunzima ngenxa ka-5 mg kwekilogram ubunzima bomzimba ngalinye.

Ukuba isigulana kukho imeko psychosis kwi oyingozi okanye engapheliyo eqongeni, unyango siqala nolawulo intramuscular (400-800 mg ngemihla). Kwiimeko ezininzi, ixesha lonyango ziiveki ezingama-2. Kamsinya nje impilo umguli, ngenaliti intramuscular kugqithiselwa ulwamkelo "sulpiride 'ngaphakathi ipilisi. Neuroleptic "Sulpiride" ncomo isigulane ichaza nje amayeza olusebenzayo. Lokuqhubeka kwekhosi unyango nga iyakumiselwa kwaye kuphela ngugqirha khona.

ngeedosi kakhulu

Naziphi na Iimpawu ezithile ezibonisa ubunyani yokudlula ngokwemithamo eliphezulu ngokuvunywe ngasentla, hayi. Ngokuqhelekileyo kwezi meko, kukho uxinzelelo lwegazi okwandileyo, ukungaboni. Mhlawumbi uphuhliso umthomalalisi (kwezithandani osezingqondweni ondiqumbise ziziyobisi, eliphantsi ukusebenza, lo gama amathamo aphezulu - thile). Kwiimeko ezininzi, imiphumo ichiza "Sulpiride" angqina isigulane lubonisa ukubonakala isicaphucaphu, umlomo owomileyo, ukwanda ukubila, ukugabha. Kwiimeko ezinqabe nezimpawu extrapyramidal, gynecomastia kungenziwa izigulane abangamadoda (ukukhula lwebele). Kakhulu awafane athethe parkinsonism ngokukhawuleza, ukufa isiqaqa.

Njengoko iyeza ukukhetha for "sulpiride" ngaphandle kweintanethi, unyango kwangumqondiso kucetyiswa, kuxhomekeke kwimeko yomguli. Kwezinye iimeko, izicelo inyathelo holinoblokatory engundoqo.

Yintoni ukunikela ingqalelo?

Ngokupheleleyo zonke iimveliso iqela antipsychotic (kuquka sulpiridsoderzhatsie "Betamax", "Vero Sulpiride", "Prosulpin", "Sulperid Belupo", "Eglonil", "Sulpiride") buyekezwa iingcali kunye nemiyalelo yokusebenzisa kwaye lithintela imvelaphi beziselo zotywala. Izigulana sokuwa Kucetyiswa ukuba baqhube izifundo zeklinikhi electrophysiological ziye sulpiride oko lihlisa zokuthethelela umsebenzi nokuhlutha izinto. Ukuba ichiza isetyenziswa concomitantly kunye iziyobisi kwandisa umngcipheko arrhythmias ventricular, izigulane ezinjalo kufuna esweni rhoqo electrocardiogram. Ukwanda QT-lokuphumla kuxhomekeke idosi.

Ukuba ngexesha unyango, "sulpiride" kwakukho iimpawu komzimba (nto leyo ibonisa ukuba uphuhliso neuroleptic yingozi syndrome), ngokuthi kusetyenziswa ichiza kufuneka kupheliswa.

kumiwe ngesiquphe unyango "sulpiride" kungabangela iimpawu ukurhoxiswa. Maltitol ekhoyo kweli chiza yenza kube nzima ukuba usebenzise ngabantu abanengxaki fructose ukunganyamezelani.

Ngeli xesha lonke unyango kufuneka uqaphele kwezithuthi kunye nokuphunyezwa kwe imisebenzi yophatho efuna impendulo lengqondo ngokukhawuleza ingqondo eliphezulu.

amayeza Sulpiridsoderzhaschie nokukhulelwa

Abafazi ngexesha lokukhulelwa "ncomo Sulpiride 'lwesandla ngendlela ezininzi ezintle. ithamo aphezulu avumelekile ukuba abasetyhini abakhulelweyo yi 200 mg ngosuku zange ukubacaphukisa iziphumo yaManzi naMahlathi (kuka uphuhliso osandul). Ngokwemithamo elikhulu ichiza kwabasetyhini abakhulelweyo Akukho lwazi olukhoyo. Kwakhona, akukho data kwi impembelelo enokubakho lwamachiza-antipsychotics kuphuhliso ingqondo wosana.

Ngokubanzi, abasebenzi bezempilo bakhetha ukuba usebenzise "Sulpiride" kuba unyango lwe abafazi abakhulelweyo, ngaphandle kwakwiimeko apho nemiphumo emihle kwabasetyhini ufakwa ingozi olungekazalwa. Kwiimeko ezinjalo, "Sulpiride" umyalelo (paramedics reviews kuqinisekiswa) ikhuthaza ilawulwa ngokwemithamo asezantsi kunokwenzeka yaye ukuba kunokwenzeka ukunciphisa ixesha lonyango.

Xa abantwana abazelwe abasetyhini abathatha ngexesha lokukhulelwa amayeza sulpiridsoderzhaschie wambi waphawula iimpawu emathunjini (ukuqunjelwa, njalo njalo. N.) Ezinxulumene atropinopodobnye nempembelelo neuroleptics. Ngamanye amaxesha uyakwazi ukuva extrapyramidal syndrome. Ngethuba lokuncancisa wamkelekile "sulpiride" contraindicated.

Mbiko lwezigulane "sulpiride"

Ubuninzi izigulane kwi "Sulpiride" ncomo beziyobisi ishiya ingculaza. Neuroleptic ngokwaneleyo ezisebenzayo ithethelele iimpawu ezibhengeziweyo. Abantu abathatha "Sulpiride" okanye analogue zalo iimpawu sengqondo ngexa isilonda esiswini okanye isilonda duodenal, ingxelo ukuhla ubunzulu iintlungu esiswini kunye nokuphucuka kwi imeko ngokubanzi.

imiqulu elincinane medicament (mg-50 ukuya 300 ngosuku) badla emiselweyo ukuba izigulane ayayamkela izikhalazo nesiyezi rhoqo ezivela ngenxa yezizathu ezahlukeneyo. Ubuninzi kwezi zigulane wayanelisekile kunye neziphumo zonyango.

ngeedosi ezinkulu "sulpiride" (ngaphezu kwama-600 mg ngosuku), ngokokubona abasebenzi bezonyango ukunika isiphumo olusebenzayo antipsychotic kwizigulane. Imithamo ngaphantsi kwama-600 mg, kwaye ngokoluvo kumagqirha kunye nezigulane, ithwalelwe nezikhuthazayo kunye nefuthe bucala.

Kukho iqela lezigulane bayishiya "sulpiride" ngendlela embi. Ngaba abantu ukuphuhlisa isicaphucaphu, uvuyo, isiyezi. Iimpawu Negative yaphela emva ukupheliswa i "sulpiride".