Adjuvant kunye chemotherapy neoadjuvant

izifo Oncological ukulidla enye yeendawo zokuqala kwinani abafayo emhlabeni. Ngelishwa, izehlo lomhlaza ayenziwanga kakhulu, kodwa kunokuba ukwanda. Izazinzulu zizama ukufumana iindlela ukuphatha ezimbi somhlaza eyayiza ukumelana ngokupheleleyo esi sifo. Namhlanje olwenziwe iindlela ezi-3 ukuya kulwa umhlaza: utyando, ichemotherapy kunye nonyango radiation. Bonke bephela zijoliswe kususwe nethumba yaye kuyayinciphisa ingozi ukuphinda. Ukumisa ukukhula iiseli ezingaqhelekanga, yenzelwa adjuvant kunye nechemotherapy neoadjuvant. Ezi ndlela zisetyenziswa nokuba unyango ehlanganisiweyo, yedwa (phantsi ezimbi ezithile oncological).

chemotherapy Adjuvant - kuthetha ntoni?

Chemotherapy - indlela unyango. Ukuze sibe nokumiliselwa zisetyenziswa arhente cytostatic ejoliswe ngokubulala iiseli ithumba. Izigulane badla uzibuze: ichemotherapy adjuvant - ntoni na? Eli gama lithetha ekuqhubeni unyango emva izifundo uqhaqho. Ngokusekelwe kule adjuvant ichemotherapy - njengenyathelo kuyimfuneko ukukhusela uphuhliso ngakumbi zomhlaza. Olu hlobo lonyango lisetyenziswa phantse zonke nangezilonda. Isetyenziswa umhlaza wemiphunga, isifuba, isisu, amathumbu kunye namanye amaziko. Chemotherapy senziwa phambi nasemva kotyando. Kuba ezinye iintlobo zomhlaza (isifo Hodgkin kaThixo, ithumba inxenye obomvu komlomo, isikhumba), nto ke unyango kuphela.

imihlobo chemotherapies

Onke amachiza chemotherapy zingabameli cytotoxic. isenzo sabo sibhekiswe ukutshatyalaliswa kunqandwa iiseli ithumba. Oku kungenziwa ngeendlela ezahlukeneyo. Kwiimeko ezininzi, iziyobisi ziphazamise Yindibanisela DNA yeselula. Ngenxa yoko, ithe amandla layo ahlulelane. Ukophulwa ezwi DNA okanye umsebenzi wenziwe ngokusebenzisa yi iyalungisa bajikeleze ngokwaphula amakhonkco phakathi nucleotides.

Amachiza chemotherapy engenazakhiwo ezahlukeneyo. Ezinye zazo yenzelwe ngenxa yezityalo (medicament "Vincristine"), ngoxa abanye bangamalungu arhente alkylating i (isisombululo okanye "Cyclophosphamide" tablets). Kwakhona, amaqela zee-arhente chemotherapeutic ziquka antibiotics ezithile, anthracyclines kunye neziyobisi platinum. Abameli kula maqela - mayeza 'rubomycin "," Adriamycin ". chemotherapy Adjuvant ikhutshwa phandle ngedriphu efakwa. Ioli azipilisi zithathwa ngaphantsi kakuhle, ngoko wasebenzisa kunqabile. Kwezinye iimeko, amayeza zoshwankathelo zilawulwe intraperitoneally, oko kukuthi, waya kwisisu. Maxa wambi ukufikelela sisetyenziselwa isitofu ase-umfutho.

Yintoni chemotherapy na?

Njengazo zonke ezinye iintlobo zonyango, chemotherapy adjuvant uye okukhomba ethile. Phambi kokuqala unyango kunye arhente cytotoxic, kuyimfuneko ukuba kuqhuba uviwo olupheleleyo malunga nesigulane eso. Emva koko ugqirha ihlalutya umngcipheko isigqibo ichemotherapy. Kukho Yayibubungqina zilandelayo yonyango cytostatics:

1. yamathumba Hematopoietic (leukemias). Nale hlobo lomhlaza chemotherapy yeyona ndlela kuphela ukujongana iiseli ezingaqhelekanga.
2. A Ithumba esiqwini izihlunu - rhabdomyosarcoma.
3. Horionkartsinoma.
4. Wilms thumba kunye Burkitt kaThixo.
5. neoplasm yingozi webele, wesibeleko kunye waso, wokugaya, womchamo, imiphunga, njl Kwezi meko, ichemotherapy adjuvant - .. Ingaba indlela eyongezelelweyo unyango. It lwenziwa emva kususwa nethumba.
6. In umhlaza esingasebenziyo. Kwezinye iimeko, unyango kunye arhente cytotoxic nga ukunciphisa ubungakanani thumba. Kuyimfuneko ukuba enze unyango ngotyando (umzekelo, umhlaza ovarian). Kwakhona, le ndlela nga tirhisiwaka ukwenzela ukunciphisa isikali kotyando (yamathumba amabele). Kule meko, sebenzisa nechemotherapy neoadjuvant.
7. ukunakekela lokudambisa. Xa iintlobo phambili komhlaza chemotherapy isetyenziswa ukwenza lula imeko yesigulane. Amaninzi asisetyenziswa ebantwaneni. Kwakhona ke isetyenziswa unonophelo lokudambisa kulo, umhlaza kwesisu ubuchopho okanye entanyeni.

Inkqubo nechemotherapy

Yinto eyaziwayo ukuba ichemotherapy akusoloko lula kunyanyezelwa. Kwiimeko ezininzi, izigulane zifumana phezu inkitha iziganeko ezibi ezivela nolawulo arhente cytotoxic. Ezinye izigulane imithi.

chemotherapy Adjuvant yenziwa izifundo. Ubude unyango iinyanga ezi-3 ukuya kwelesi-6 (ngamanye amaxesha ngaphezulu). Ukukhetha indlela emiselwe ugqirha esekelwe kwi imeko yesigulane. Eyona babeqhuba ngeenyanga ezintandathu malunga 6-7 Imijikelo nechemotherapy. Kukholelwa ukuba kaninzi isigulane ufumana unyango, i ngcono isiphumo. Umzekelo, ichemotherapy unokuthatha iintsuku ezi-3 qho kwiiveki 2-4. Ngexesha unyango kuyimfuneko ukuba esweni ngenyameko imeko yesigulane. Kwakhona, uvavanyo lwegazi kunye ngomlinganiselo ngendlela ikhefu phakathi izifundo.

Izimo ukuba chemotherapy

Nangona ukusebenza konyango kunye arhente cytotoxic, kodwa azisoloko emiselweyo. Wonke ugqirha uyazi ukuba ichemotherapy adjuvant ichaphazela kuphela inkqubo ithumba, kodwa iiseli esempilweni. Ngokukodwa, libhekisela leukocytes. Amanye amachiza anemiphumela eyingozi kwinkqubo sentliziyo kunye nemiphunga. Izimo for chemotherapy zithathwa izifo kakhulu izintso wesibindi. Oku kungenxa yokuba semngciphekweni nokungaphumeleli kwezi imizimba inkulu kakhulu. Kwakhona chemotherapy ayikwazi ingasetyenziswa kwizigulane kunye cholecystitis imbali calculary (enyongweni). Izimo yonyango ngamachiza cytotoxic utshintsho yokuhlola egazini jikelele. Zibekele ezithile iparameters apho unyango akwenzeki. Ezi ziquka: i zegazi count engaphantsi kwe-100 * 10⁹, ukuncipha hematocrit kunye mpilo. Kwakhona akunakwenzeka ukwenza ichemotherapy kwizigulane kunye ezinzima asthenia syndrome. Kucingwa ezamkelekayo unyango lwe ubunzima bomzimba-40 kg okanye ngaphezulu.

Iziphumo ebezingalindelekanga kweziyobisi chemotherapeutic

Ubungqongqo unyango chemotherapeutic ilele neziphumo zalo. Ngaphandle obubonakala yangaphandle iziphumo ezibi iziyobisi, kukho utshintsho kwi zePCR. Isiphumo ephambili kucingelwa ukuba ingcinezelo kwenkqubo hematopoietic. Oku ikakhulu kuchaphazela leukocyte lwegciwane. Ngenxa yoko, iziphumo ezibi kwi iiseli ezimhlophe zegazi, amajoni omzimba ubunzima. Oku kuboniswa ubuthathaka jikelele, ukuzimanya iintlobo zosulelo. Enye effect side - ukuba iziphumo neurotoxic iziyobisi. Ezinye izigulane ziphazamiso ukudakumba, tearfulness, ukulala. Kwakhona, izigulane ingxelo isicaphucaphu, ukugabha kunye norhudo. engemihle arhente cytostatic kuchaphazela imbonakalo izigulane. Ngosuku loviwo, ephawulwe alopecia (ilahleko iinwele), nesikhumba luthuthu.

cancer Isisu: ichemotherapy

iinkqubo Oncological esiswini abonakala rhoqo. Kaninzi ukuphuhlisa ngokusekelwe polyposis okanye isilonda Peptic. Ezibonisa ezingundoqo umhlaza esiswini - ukuba buhlungu kummandla epigastric, Ukwehluleka ukutya inyama, regurgitation. Kumanqanaba okuqala kwinkqubo somhlaza utyando kuyimfuneko. Yeyona resection organ, kunye nokudalwa anastomosis phakathi kuvuleke iminxunya namathumbu. chemotherapy Adjuvant umhlaza esiswini lwenziwa yokungabikho Izimo. It ikuvumela ukuba wandise ixesha kuxolelwe, kwaye ithintela Ukudlulela. Ngelishwa, iziyobisi cytotoxic akusebenzi kakuhle kuzo zonke iintlobo zomhlaza isisu. Yangqineka imiphumela yayo eyakhayo adenocarcinoma. Uye enze kwakhona umlinganiselo yokhathalelo lokudambisa.

Unyango Adjuvant umhlaza webele

chemotherapy Adjuvant ngayo umhlaza webele iyafuneka naziphi na iintlobo histological yenkqubo somhlaza. It lwenziwa emva kotyando, nokuba umthamo utyando (mastectomy okanye resection kwamacandelo zamabele). Oku kuyimfuneko ukuba siphephe ukuba Ukudlulela iiseli ezingaqhelekanga kwiindawo nkovu kunye namaziko ezikude. Kwiimeko ezinqabe kakhulu, ichemotherapy ayikho unyango inyanzelekile ukuba umhlaza webele. Umzekelo, ukuba ubukhulu Ithumba ngaphantsi kwe-1 cm kwaye zasasazwa kwiindawo nkovu. Kwakhona ngononophelo kufuneka ingasetyenziswa kwizigulane abaselula. Xa unyango premenopausal ngeziyobisi cytotoxic oluqhutywa zonke izigulane ngaphandle abo Izimo.

Ngaba adjuvant wayenyangwa iBorder cystadenoma?

abafazi abaninzi baqhelene nale lokufunyaniswa a cyst (cystadenoma) ye isizalo. Kwiimeko ezininzi, ukuyilwa ebubonisayo, yaye kunqabile ukuba aye inkqubo somhlaza. Nakuba kunjalo, kukho ezinye iintlobo cystadenoma, nenokuthi maxa wambi ichaphazeleke inguqu amabi. Ezi ziquka yamathumba serous asemdeni kunye papillary. Iimpawu ngokuseka abe iintlungu esiswini, ukuphazamiseka exesheni. Bona ezifunyanwa ultrasound zangasese. ukuxilongwa zingenziwa kuphela cystadenoma biopsy. Xa ukubunjwa unyango umda lwentsebenziswano efunekayo, imali leyo kuxhomekeke kubudala yesigulane. chemotherapy Adjuvant lwenziwa kwiimeko ezinqabileyo apho ingozi ithumba Ukudlulela eliphezulu. Kwakhona kokuba kuboniswe inkqubo umhlaza iphinde kwelinye yamaqanda.

Umhlaza wemiphunga

Mhlaza iqhelekileyo umhlaza wemiphunga. Uthabatha izigidi zabantu ehlabathini lonke. chemotherapy Adjuvant e umhlaza wemiphunga phantse lonke kubonisiwe. Kuyimfuneko kuphela emva kotyando, kodwa indlela ozimeleyo yamathumba kwentamo cell encinane. Wasebenzisa ezahlukahlukeneyo iziyobisi. Phakathi kwabo, "Tsisplastin" amayeza "Vinorelbine", "gemcitabine" kunye nabanye. Uphawu esingundoqo ichemotherapy na umhlaza wemiphunga neuropathy central kunye nokubandakanyeka lweendawo nkovu thoracic. Yonyango ngamachiza cytotoxic singàphunyezwa kuphela xa kuthe ukungaphumeleli isigulane, ubukho kwezifo decompensated, ebudaleni kunye kwinqanaba 4 inkqubo somhlaza.

Chemotherapy edityaniswe kuphuhliso metastases

Enye yeenjongo ezingundoqo unyango - ukususa metastases kunye ichemotherapy adjuvant. Kukholelwa ukuba ngalo isenzo kweziyobisi cytotoxic yehla kakhulu umngcipheko ithumba ukuphinda. Ngenxa chemotherapy kwixesha postoperative kwi umhlaza webele, wemiphunga, wesibeleko kwaye ezithweni kukho nokususwa ngokupheleleyo metastases kwiindawo nkovu yengingqi. Kwakhona lunciphisa ubungozi ukuvela kwazo amalungu ezikude. Ngako oko, unyango of Cancer somhlaza kunceda yinkqubo ecothayo kwezinye iimeko - lunyango ngokupheleleyo.

iingcali Izimvo kunye nezigulane malunga ichemotherapy adjuvant

Ngokutsho oncologists, ichemotherapy yeyona ndlela ngxwaba sesichengeni. It ofihla kuphela amajoni omzimba yomguli, kodwa kakuhle zivunwe izigulane. Noko ke, namhlanje ukuphathwa kweziyobisi cytotoxic iye positives ngaphezu minuses. Kuyaphawuleka ukuba indlela ezidityanisiweyo ekulweni ngumhlaza amathuba yongeniselo basinde.