గుర్తులు ibhaloni anhydrase inhibitors: indlela inyathelo wamehlo ukuba ukunyanga iglaucoma agalelwa

గుర్తులు ibhaloni anhydrase inhibitor womchamo, ezo ezingafanelekanga kusetyenziswa womchamo okanye mochegonki. Inkomba la machiza yi glaucoma. Makhe sihlolisise ngokweenkcukacha abo athandwa kakhulu.

Acetazolamide (Acetazolamide)

Kuye iipropati umchamo. Kumisa anhydrase గుర్తులు ibhaloni tubules sezintso proximal kunciphisa reabsorption ye K, Na kunye namanzi (diuresis ebangela ukwanda), oko kukhokelela ekuncipheni kwe BCC kunye lactic metabolic. anhydrase గుర్తులు ibhaloni depresses umzimba ciliary kwaye kukhokelela ukuthoba yengcinezelo intraocular, kwaye kucutha secretion uburharha zolwelo ebuchotsheni kubangela umsebenzi antiepileptic. It has ukufakwa elungileyo evela iphecana zesisu, Cmax egazini ngeeyure ezimbini. Isiphumo unokuthatha ukuya kwiiyure ezili-12. 40-60% kwandisa IOP kwaye kunciphisa imveliso ulwelo intraocular.

Iimpawu & Izikali

Eyona engundoqo ezibonisa: lwegazi ocular, glaucoma. Xa glaucoma, ngaphakathi bathathe 0.125-0.25 g amaxesha 1-3 ngemini, imihla iintsuku ezi-5, emva koko kufuneka ikhefu iintsuku ezimbini.

iziphumo ezingalindelekanga: isicaphucaphu, ukungabi namdla, urhudo, aleji, ingqiqo kakuhle wetatshi, paraesthesia, ukuduma, ukozela. Konke oku kubangela గుర్తులు ibhaloni anhydrase inhibitors. Amalungiselelo nabo Izimo. Le uvakalelo kakhulu (ukuya sulfonamides kubandakanywa), isifo Addison kaThixo, nomkhwa asidi, isifo sisibindi kunye nesifo sezintso, ukukhulelwa, iswekile sinwenwa, uremia.

izithintelo Ukusetyenziswa: Embolism yemiphunga, emphysema yemiphunga (ukwanda asidi).

Ichiza: Ipilisi ze eziveliswa e Poland Polpharma "Diakarb" ku 0.5 g

Dorzolamide (dorzolamide)

Abangaphangeliyo anhydrase గుర్తులు ibhaloni isoenzyme II Umsebenzi (Uqala ingathityazwa ukuxovwa indlela carbon dioxide kunye asidi emzimbeni) umzimba iliso ciliary. Secretion ukufuma intraocular yehliswa ngama-50%, ukucola phantsi ukuyilwa ion yesoda, yaye ngokuyinxenye kunciphisa ukuthuthwa kwamanzi kunye sodium. Kungancitshiswa ngama- 38% yemveliso kolwelo intraocular ukuba aluchaphazeli ukuphuma. Utyhutyha kulo lweliso lakho becala ngenxa kwesebe, inwebu okanye sclera. Inxalenye bafakwa esililini systemic nemithambo ye mucosal Eye (ukuba kwenzeke umchamo kunye nezinye iziphumo sulfonamides eziphambili). Emva kokuba impahla iye bangena igazi, ungena ngokukhawuleza kwi iiseli ezibomvu, eziquka izixa ezikhulu anhydrase గుర్తులు ibhaloni II. Dorzolamide 33% yento kwiiproteni plasma. Isiphumo esiphezulu iqinile abonisa emva instillation nge iyure 2 noovimba angu-12. Xa backfilling ku-2 phinda phinda ngo-9-21% ngosuku liyancipha xi intraocular xa wabethelela amaxesha 3 ngosuku - ukuya 14-24%. Ukuncitshiswa xi intraocular ngokusebenzisa isisombululo 2% ungenza ubukhulu 4,5-6,1 mm HG. A isisombululo ka-3% iya kuba nempumelelo kangako kuba ngokukhawuleza uya wahlamba ngaphandle kwisisu conjunctival njengoko ibangela ukukrazula olomeleleyo. Ngokubambisana ne timolol nokuqeshwa onesiphumo eyongezelelweyo ngokukhawuleza ukusuka kwi-13 ukuya kwi-21%. mpembelelo incinane uxinzelelo lwegazi kunye izinga senhliziyo kuye గుర్తులు ibhaloni anhydrase inhibitors. Womchamo eli qela ayisetyenziselwa injongo eyenzelwe yona kuphela. Kule kamva.

Iimpawu & Izikali

Iimpawu: eziziiprayimari neziziisekondari open-angle neglaucoma, hypertension ocular. Ichiza kuboniswa 1 yokuyeka izihlandlo 2-3 ngosuku.

iziphumo ezingalindelekanga: paresthesia, ukwehla kobunzima, ukudakumba, irhashalala, aplasticheskayaanemiya, agranulocytosis, ukudinwa, intloko ebuhlungu, ityhefu epidermal necrolysis, incasa ekrakra emlonyeni, isicaphucaphu, ukunyuka Ebubanzini inwebu, iridocyclitis, blepharitis, keratitis, conjunctivitis, photophobia, ukungaboni, ayarhawuzela yaye ukuntlontlozela imvakalelo emehlweni, ukungakhululeki, Stevens - Johnson syndrome, ukutsha, amehlo alilayo.

Le anhydrase inhibitor గుర్తులు ibhaloni (wamehlo) ine Izimo zilandelayo: uvakalelo ngokugqithiseleyo (ukuba sulfonamides kubandakanywa), ebuntwaneni, isifo sisibindi kunye nesifo sezintso, ukukhulelwa kunye nokuncancisa.

Ukulungiselela: eyedrops "Trusopt" equlathe 1 ml 20 mg solution dorzolamide hydrochloride. yentsha - 5 ml. Oku kwaveza eNetherlands yi-Merck Sharp & Dohme.

inhibitors anhydrase గుర్తులు ibhaloni: Brinzolamide (brinzolamide)

blocker ezintsha anhydrase గుర్తులు ibhaloni kokuba ikhono xa isicelo ngokwemixholo ekunciphiseni ezibalulekileyo IOP yolawulo. Brinzolamide anazo selectivity ophezulu anhydrase గుర్తులు ibhaloni II, kunye neempawu ifanelekileyo emzimbeni ukuba angene ngempumelelo kwi esweni. Xa kuthelekiswa ne dorzolamide kwaye atsetozolamidom ziphuma ukuba brinzolamide - iqela kweziyobisi yeyona elinamandla గుర్తులు ibhaloni anhydrase inhibitors. Kukho ubungqina bokuba ulawulo esematheni okanye efakwa of brinzolamide kukhokelela kuphuculo disk optic. Kwaye kunciphisa yi-avareji ye-20% IOP. Ayikasebenzi zonke గుర్తులు ibhaloni anhydrase inhibitors. Indlela yokusebenza ekhethekileyo evela brinzolamide.

Iimpawu and esithathwa

Iimpawu: lwegazi ocular, vula-engile glaucoma. Sebenzisa amaxesha 2 ngosuku yolahlo.

iziphumo ezingalindelekanga: incasa enxamnye, imvakalelo umzimba amazwe, ukungaboni phezu instillation (ixesha) kwaye a ukuzwa otshisayo. Zidluliselwe ekuhlaleni ngaphezu dorzolamide.

Izimo: ubuntununtunu kakhulu ukuba ichiza (ukuba sulfonamides kuquka), abantwana ubudala, ukukhulelwa kunye nokuncancisa.

Ukulungiselela: eyedrops "Azopt" equlathe 1 ml a ukumiswa 10 brinzolamide mg. Umthamo nengqayi of ml-5. Iveliswe kwi USA ngu Alcon.

Yintoni enye ezi గుర్తులు ibhaloni anhydrase inhibitors?

yezabelo prostaglandin

Latanoprost (latanoprost) - receptor prostaglandin agonist uyakhetha. Kwandisa ephuma amanzi intraocular ngokusebenzisa uvea, nto leyo ekhokelela ukuba ngokunciphisa xi intraocular. Impembelelo ekuvelisweni uburharha zolwelo akuyi kunceda. Ungatshintsha ubungakanani umfundi, kodwa kancinane kuphela. Xa backfilling ungena ngohlobo isopropyl kaEtere ngokusebenzisa inwebu apho hydrolyzed kwi imeko ethile eziphila kuzo esebenzayo acid, leyo zichazwe iiyure zokuqala 4 fluid intraocular kwaye plasma kwiyure yokuqala. 0,16l / kg - umthamo zokusasaza. iiyure ezimbini emva koko iphumelele ukufumaneka liphezulu uburharha zolwelo, emva kokuba isasazwa ukuya ekuqaleni isiqwempu ngaphambili, ngamanye iinkophe kunye conjunctiva, uze Asikokungena kwicandelo ngomva (ngezixa ezincinane). Le fom inxaxheba nezihlunu iliso Oku hayi umzimba, ingakumbi kwi biotransformation esibindini. Advantageously, metabolites kwazona kwi yokuchama. Makhe sijonge ezinye గుర్తులు ibhaloni anhydrase inhibitors.

Unoprostone (unoprostone)

unoprostone Isopropyl i yemvelaphi a docosanoid nokunciphisa ngokukhawuleza uxinzelelo intraocular (IOP) usebenzisa indlela pharmacologic yakutshanje. Ngaphandle kokutshintsha imveliso ngexesha kulwelo intraocular, kube lula ukuphuma kwayo. Uhlolisiso lubonisa ukuba, xa kuthelekiswa ne-0.5% timolol maleate, unoprostone isopropyl Umsebenzi efanayo okanye ngakumbi ukunciphisa IOP. Ichiza alichaphazeli yokuhlala kwaye akafuni abangele ukuncitshiswa kwegazi emzimbeni ocular, miosis okanye mydriasis; kwenwebu ngokutsha ukulibaziseka nazo andibhaqwa. Emva mlonyeni unoprostone lingatshintshanga isotropy zange labonwa plasma.

inhibitors anhydrase గుర్తులు ibhaloni ukuze ukunyanga iglaucoma agalelwa kufuneka imiselwe kuphela ngugqirha, self-iyeza ayivumelekanga.