"Velaksin" bucala: angqina nomonde, imiyalelo ukusetyenziswa, analogs

Ingaba ndithenga lakhula ngaphandle kokumiselwa? Uluhlu iimveliso ezifana ayikho enkulu. Oku kungenxa yokuba ukuba idle, kunye nentaphane yeziphumo ebezingalindelekanga. Ngoko ke, ngaphambi kokuba uthathe iindlela ezinjalo, qiniseka ukuba atyelele yincutshe.

ulwazi jikelele

Ukudakumba abaphathwa ziziyobisi. Kodwa ukuphucula ukusebenza kwenkqubo luvo, oogqirha ezininzi ukugunyazisa izigulane zabo yokunciphisa ezahlukeneyo. Enye yazo ichiza "Velaksin". Baqinisekiswa ngale sixhobo kunye neempawu zayo kunye nemiyalelo zokusetyenziswa ziza thaca ngezantsi.

Ukubunjwa ichiza, uhlobo lwaso kwimveliso

Ziziphi ifomu ukuba ivelise yeQela njenge "Velaksin"? Iipilisi kunye njengezingxobo - zezona ntlobo kuphela ichiza.

Tablets "Velaksin" amhlophe, wakrola icala elinye "E741", ngokumila setyhula tyaba kwaye chamfer. isithako lwabo esebenzayo i venlafaxine, nto imelwe ngendlela hydrochloride. Kwakhona ifakiwe kule amayeza ziquka amacandelo abangabancedani ezifana anhydrous colloidal dust, monohydrate lactose, isodiyam wesitatshi glycolate, nemagnesium stearate kunye MCC.

tablets zipakishwe kwiipakethe blister kunye iibhokisana ngokulandelelana.

Drug "Velaksin" - njengezingxobo, imiyalelo zokusetyenziswa leyo afakwe kwi ukupakisha, iphepha, gelatin ijiye. Baye amfusa ikepusi kunye zeendawana enemibala. Icandelo esebenzayo yale fomu kwakhona venlafaxine esimbaxa. Ngaphandle ingoma yakhe le amayeza ziquka izithako ezongezelelweyo.

Njengoko imisebenzi iziyobisi?

"Velaksin" - isizukulwana esitsha anti-nokudakumba. Ngokutsho isakhiwo eekhemikhali nempahla yayo esebenzayo asisiso naluphi na udidi ezaziwayo lakhula (umz, tricyclic, tetracyclic, okanye enye). Iingcali zithi ichiza esebenzayo enantiomer 2 racemate.

Umgaqo amanyathelo kweli chiza kunxulumene namandla wayo potentiate i CNS zothumelo luvo uyibona.

Ngokutsho imiyalelo, venlafaxine kunye metabolite zayo ezinkulu (EFA okanye O-desmetilvenlafaksin) imele inhibitors ezinamandla le reuptake of norepinephrine kunye serotonin kunye inhibitors ezibuthathaka dopamine reuptake. Asikwazi ukuba ezi izinto banako ukunciphisa umsebenzi beta-adrenergic emva kokuba amayeza owodwa kwaye rhoqo. EFA kunye venlafaxine zisebenza ngokufanayo nxamnye reuptake of neurotransmitters.

Yintoni na iziyobisi ephawulekayo "Velaksin"? Guide ingxelo ukuba isithako esebenzayo eli chiza i sendiselane kunye receptors not translate the kunye m-cholinergic, ingqondo α1-adrenoceptors kunye histamine H1-receptor. Ngaphezu koko, abangaphangeliyo sisenzo Mao kwaye akukho ukufana ne fentsiklidinovymi, opioid, benzodiazepine kunye NMDA-receptor.

Le kinetics beziyobisi

ingaba ichiza ako, "Velaksin" (tablets)? Imiyalelo Sebenzisa ithi eli candelo esebenzayo kweli chiza ako kakuhle ukusuka ethunjini. Emva nedosi enye ye-medicament xa kukho umthamo 25-150 mg kokugqalisela yayo ephezulu egazini kuphunyelelwa emva kweeyure 2.4. Ngoko venlafaxine awulungelelananga umzimba ngexesha yokupasa lokuqala esibindini. Ukuba ichiza kuthathwa kunye nokutya, ngelixa incopho ukunyuka yayo yoxinaniso ngemizuzu 27-30 plasma.

Le metabolite ephambili ithathwa njengendlela O-desmetilvenlafaksin. Bawo ubomi kunye nokupheliswa nesiqingatha-ubomi venlafaxine ziiyure 11 no-5, ngokulandelelanayo (output yi izintso ngohlobo ingaguqukanga).

Le kinetics amachiza kwiimeko ezizodwa clinical

Drug "Velaksin" myalelo ukufunda kubantu abane kwesibindi abanezinye iimpawu kinetic ezifunekayo. igazi yoxinaniso beziyobisi ukwanda kwezi zigulane, yaye umlinganiselo walo zinomgutyulo, phezu koko, lincitshiswe.

Xa insufficiency kwezintso kakhulu, ukusilela kwezintso kunye kugqitywe eliphakathi iyonke ye-EFA kunye venlafaxine luyacutheka kunye nokuphelisa nesiqingatha sexesha-ubomi elide.

Kufuneka kuqatshelwe ukuba isini kunye nobudala isigulane aluchaphazeli pharmacokinetics beziyobisi ethathelwa ingqalelo.

Ubungqina obubonakalayo buxela ukuba

Kutheni kufuneka sibe isixhobo ezifana 'Velaksin "? Ukusetyenziswa kweli chiza eboniswe ukuxinezeleka of imvelaphi ezahlukeneyo (kuba unyango kunye prophylaxis).

Uvala ukuqashwa

Kuphantsi kwaziphi iimeko abakwazi ukusebenzisa iziyobisi "Velaksin"? Izimvo ezigulane kunye oogqirha bathi le ichiza contraindicated ukufumana:

• ngexesha kokufumana Mao inhibitor ;
• enokuphazamisa ezinzima kidney;
• ngexesha lokukhulelwa okukrokrelwayo okanye elisekwe;
• enokuphazamisa kakhulu kwesibindi;
• ngexesha lokuncancisa;
• e elivisayo nobuntwana, oko kukuthi, de yobudala emntaneni;
• nge uvakalelo oluphezulu ukuya ichiza.

Ngaphaya koko, eli chiza kufuneka kuthathwe ngenyameko angina ezingazinzanga, iposi engabalulekanga (kubandakanywa elisandul bafudukele), lwegazi, unditsho imbali, tachycardia, ukwehla kobunzima, ukwanda koxinzelelo intraocular, engile-ukuvalwa neglaucoma, ukuthambekela opha yangaphakathi kwaye eluswini, States manic.

Drug "Velaksin" (tablets): imiyalelo yokusetyenziswa

"Velaksin" bucala kufuneka kuthathwe kuphela esidlweni. Loqalo yedosi obacetyiswayo ichiza 75 mg, lahlulwe ngeedosi 2 umahlule (ngamanye amazwi, i-37.5 mg kabini ngemini), yonke imihla.

Ukuba emva kweeveki eziliqela unyango, imeko yomguli akubi ngcono, idosi yemihla ngemihla inyuswe ukuya 150 mg ngosuku, ngeedosi ezimbini wahlukanisa (ngamanye amazwi, 75 mg kabini ngosuku).

Ukuba isigulana sidinga idosi aphezulu i yeQela (umz, disorder enkulu edakumbisayo, okanye ezinye iimeko ezifuna unyango emileyo), ngoko ke yamagcisa na kumisela 150 mg kweziyobisi ngeeyure ezi-2, uze emva koko ngokuthe ngcembe kwandisa ithamo nge-75 mg (iintsuku 2-3 kamva) ukuze kufikelelwe isiphumo ezinqwenelekayo.

Ngokutsho imiyalelo, idosi iphezulu "Velaksina" yi 375 mg ngosuku. Emva ekufezekiseni le ziphumo zinqwenelekayo, oko ngokuthe ithotywe kwinqanaba ubuncinane.

Uthintelo zingabuyi kunye nonyango nokugcinwa

ukunakekela awusekele mali ingathatha ukususela kwiinyanga ezintandathu. Kulo mzekelo, amayeza esithathwe ngeedosi engephi.

Xa insufficiency wobulali sezintso kufuneka ulungiso Umthamo irejimeni. Xa isifo efanayo ithamo eliphakathi ekucetyiswa ngaphantsi nge-25-50%. Kufuneka kuqatshelwe ukuba venlafaxine kufuneka ingasetyenziswa xa insufficiency kakhulu kwezintso, ekubeni kungekho lwazi malunga nokhuseleko unyango olunjalo ukuza kuthi ga ngoku, akukho.

Abantu abo bangekhoyo wehemodialysis, kufuneka afumane i-50% ye idosi yesiqhelo beziyobisi emva eziphelweni kweseshoni.

Ngokuba ubulali hepatic ulungiso insufficiency nomthamo kwirejimeni kwakhona ingafuneki. Xa sifo ithamo zokumodareyitha kufuneka licuthwe ngama-50%. Ngokumalunga ukusilela kakhulu hepatic, kule meko ukusetyenziswa venlafaxine akuvumelekanga.

Xa abadala, ichiza "Velaksin" kufuneka zisetyenziswe ngokuqaphela okukhulu. Oku kungenxa ekugxojweni izintso kunokwenzeka. Izigulane kufuneka amisele ithamo lisezantsi olusebenzayo. Kulo mzekelo, isigulane kufuneka abe phantsi kweliso unyango rhoqo.

Rhoxisa yeQela

Ekugqityweni lokufumana ichiza kufuneka kuqwalaselwa ukuba ukunciphisa ithamo ngokuthe (phakathi evekini). Kulindeleke ukuba bagcine imeko yomguli, ukwenzela ukunciphisa umngcipheko reactions emibi ne ukupheliswa ichiza.

Ixesha elifunekayo ukuze nomhla epheleleyo iyeza, kuxhomekeke idosi, ubude unyango kunye lomntu ngamnye.

imiphumela emibi

Iyini imiphumela engamkelekanga ichiza kungabangela "Velaksin"? Baqinisekiswa bathi uphuhliso abo okanye ezinye iziganeko ezibi kulandela basisebenzise esi sixhobo kuxhomekeke idosi ezifunyenweyo.

Ukusabela kakhulu rhoqo wabonakalisa uhlobo ezimbi ziquka oku kulandelayo:

• lwegazi, sinciphise ukutya, amaphupha okungaqhelekanga, ukuqhina, sokulibala, isicaphucaphu, ukuthoba eluswini, iingcangcazela, ukugabha, amahlaba kwezihlunu, umlomo owomileyo;
• saka, hepatitis, ukwehla kobunzima, tachycardia, hyponatremia, ukungakhathali, hypotension postural, isiyezi, indlela manic, excitability luvo, yawning, paresthesia, syndrome neuroleptic, badengeka, serotonergic syndrome;
• ithoni ukwanda imisipha, ukuxhuzula, dysuria, photosensitivity, ukugcinwa wokuchama, anorgasmia;
• ukopha eluswini, ukuchama okungaqhelekanga, menorrhagia, sinciphise yobuntu, ukubila;
• thrombocytopenia, ukuphazamiseka yokuhlala, erythema multiforme, mydriasis, Stevens - Johnson, ukuphazamiseka ezibonwayo, incasa kakuhle, isongezo ukopha xesha, ubuthathaka, irhashalala eluswini, ukudinwa, ukusabela anaphylactic.

Kufuneka kuqatshelwe ukuba emva ekurhoxisweni ngokukhawuleza wesithuthi kuqwalaselwa okanye ukunciphisa umlinganiselo walo zinokwenzeka ngayo kwicala ezifana luvo nochuku, ukudinwa, urhudo, ukozela, iveze, intloko ebuhlungu, paraesthesias, isicaphucaphu, hypomania, ukugabha, ukubila, ukudla, ugwayi, eyomileyo emlonyeni, ixhala, isiyezi kunye nokudideka. Ngokuqhelekileyo, ezi mpawu abanomoya uye ngaphandle naluphi na unyango.

izincomo

Thengisa ukuba lakhula ngaphandle kokumiselwa? Uluhlu la mayeza ayikho enkulu kakhulu ( "Prozac", "Paxil", "Despres", "Azafen", "Persian", "amitriptyline"), kwaye ichiza "Velaksin" ayifakwanga phakathi kuyo. Thenga oko ezikhemisti, ungakwazi kuphela ngokumiselwa kagqirha.

Ngaphambi kokuba le amayeza phantsi kovavanyo, ingakumbi izigulane nokuphazamiseka edakumbisayo, kufuneka kuqwalaselwe amathuba eliphezulu amalinge ukuzibulala. Kulo mba, ekuqaleni unyango iziyobisi ekucetyiswa ukuba zisetyenziswe idosi iphantsi phantsi kweliso zonyango abasenyongweni.

Abantu kweepesente ezingama ngexesha unyango kunye lakhula inokuphuhlisa karhulumente manic okanye hypomanic.

Izigulane kufuneka uqiniseke ukuba alumkise ngemfuneko ukubona ngoko nangoko nogqirha xa kukho izinto urticaria, irhashalala okanye negazi lakho.

Ezinye izigulane kwinkqubo lokufumana venlafaxine waphawula idosi-oxhomekeke ukunyuka koxinzelelo lwegazi.

izigulane abadala kufuneka walumkisa yaphula siwe kunye nesiyezi nophuhliso kunokwenzeka.

Ngexesha unyango lwe-mali kufuneka uphephe iziselo ezinxilisayo.

"Velaksin" bucala: angqina nomonde, analogue imveliso

Yintoni abantu bathi ngalo eli chiza nomntu ogulayo? abathengi abaninzi baye ingxelo inani elikhulu effects ezithi zenzeke ngexesha uthatha le amayeza. rhoqo eli chiza kubangela ngayo ezingalunganga ezifana ukozela, buthathaka, sokulibala, ukuxhuzula, ukucinga okungaqhelekanga, ukudandatheka kunye nokudideka. Ukongeza, ezinye izigulane zithi ezi ziphumo ahlale emva kokugqiba unyango. Kwakhona, abasebenzisi abaninzi ukhalaze malunga inkangeleko nokuqaleka kunye nokuxhomekeka.

Yintoni indawo bucala ezifana 'Velaksin "? Analogs yale ichiza ukuba kufunyanwa kuzo zonke drugstores. Njengomgaqo, iingcali Ezi ziquka oku kulandelayo: "Venlafaxine Sandoz", "Efevelon", "Alvent", "Nyuvelong", "Velafaks", "Dapfiks", "Voksemel", "Venlaksor", "Vensuert", "venlafaxine".