"Relpaks": umyalelo wesicelo, iimpendulo. Ezifana neziyobisi

Uqaqanjelwa, nangona ubomi emngciphekweni ukubandezeleka kwabantu, kodwa kwangaxeshanye kunciphisa kakhulu umgangatho wobomi. Ukutyhubela iminyaka, ishishini lamachiza isebenzela ukudala iimveliso ukuba nje ukuphelisa iimpawu buhlungu kwesi sifo, kodwa ukuphembelela iinkqubo ezibangela le migraine. Ngapha koko, ukuba bayeke intlungu nga ntlungu namandla. Kodwa ezinye iimpawu migraine ezifana isicaphucaphu, ubuntununtunu ukukhanya ukubanyamezela nezandi, akukho lula ukuphelisa. Ichiza for migraine "Relpaks" kule nkalo, iingcali zithi omnye kakhulu ngempumelelo. Yintoni na eli chiza? Indlela ukuthatha kwaye yintoni apho oogxa bakhe? Konke oku uyakwazi ukufunda kuyo.

incazelo ekwakhiweni

Eyona engundoqo esebenzayo kweziyobisi "Relpaks" ukulungiselela - ngokohlobo eletriptan hydrobromide iqulethwe emacwecweni mg-20. Kukho kwakhona umthamo-40 mg. Nezincedisi bavame asetyenziswe ishishini lamachiza lactose monohydrate, nemagnesium stearate, isodiyam croscarmellose kunye MCC. Ezi zihlanganisi musa kuchaphazela ukukwazi ichiza ukuya ukwetyisa, kwaye aluchaphazeli umzimba uphela. Amacwecwe migraine "Relpaks" camera inwebu iqokobhe -orenji, oluqulathe titanium dioxide, colorants, monohydrate lactose, hypromellose kunye triacetin.

tablet nganye abunjwe enembonakalo biconvex ngeenxa zonke. Kwelinye icala elinye Sikrolwe «REP 20» okanye «REP 40 '(ngokuxhomekeke kwisixa equlethwe elucwecweni esisebenza) kunye« Pfizer »- kwenye. Kwenye blister ingena 2, 3, 4, 6 okanye 10 tablets, mvisiswano leyo, kwelinye icala, zipakishwe iibhokisi zekhadibhodi 1, 2, 3, 4, 5, 6 okanye 10 ziingceba.

Pharmacokinetics kunye pharmacodynamics

Medicine "Relpaks" ngokukhawuleza kakuhle wendele emva ulawulo ngomlomo, ingakumbi xa zidityaniswe kunye nokutya okunamafutha. Absorption kuna eletriptan malunga 81%, kwaye babizwa ngokuba bioavailability - 50%. Umxholo iphezulu into esebenzayo kwi plasma igazi sele iiyure enye enesiqingatha emva ezithatha ichiza.

Eyona into Amalungiselelo engundoqo esebenzayo "Relpaks" ithe umsebenzi omhle ngokunxulumene iiproteni plasma (malunga nama-85%). nethe Primary eletriptan lwenzeka kwi iiseli esibindini. Ngaloo kwakhiwa metabolite amabini ajikelezayo, omnye (basekwa N-igcwala) akukho msebenzi. Le yesibini (eqalisiweyo N-demethylation) iye kakhulu iimpawu ezifanayo umbandela yokuqala, kodwa eyavela kwi plasma yi% 10-20 kuphela uyondelelwano lwee- eletriptan. Ngenxa metabolite esebenzayo lungenasiphumo appreciable nezinyangayo.

Iipilisi Migraine "Relpaks" iimpendulo ze iingcali ezo uninzi HIV, olusebenzayo nokuba besini lomguli. Kukhuthaza le metabolites ichiza kwenziwa kangangoko enkulu izintso (malunga ne-90%), kunye nge emathunjini.

Izifundo iye yaqinisekisa ukunqongophala ifuthe habituation ukuba eyona nto iphambili ebonakalayo ichiza, ngoko namhlanje akukho miqobo ixesha unyango intlungu migraine ngokusebenzisa iziyobisi "Relpaks".

Xa uthelekisa nezinye "Relpaks" application pharmacodynamic ichiza Umsebenzisi ukhankanya into yokuba impahla yayo engundoqo esebenzayo ngoweqela yegazi serotonin uyakhetha kunye receptors neuronal, usebenzisa iziphumo kwezinye iintlobo kubo. Ngaloo selectivity kubonakala ukuba kakhulu xa kuthelekiswa receptors ibekwe kwemithambo carotid. Protivomengrinoznuyu umsebenzi eletriptan umisela ukukwazi layo nje kuphela licuthe imithambo yegazi ibekwe ngaphakathi cranium, kodwa nempembelelo entle kuhlobo ukudumba neurogenic. Kulo mzekelo, iyeza esebenzayo uye udlubu nafuthe receptors ye femoral kunye nemithambo yenhliziyo.

ubungqina

"Relpaks" imiyalelo kweziyobisi ukusetyenziswa ziyacetyiswa ngayo iifayile ezimbini migraine:

1. Ngenxa aura xa idityaniswe iimpawu intlungu ezibukhali ezifana ezibonwayo, nezihlwabisayo, injini, ukuqgiba kunye nezigulo eziviwayo.
2. Ngaphandle aura, xa ukongeza kwi intloko nomonde ochaphazelekayo isicaphucaphu, ukugabha, uvakalelo ukukhanya kunye nesandi.

Ukuba kukho ezinye iintlobo esi sifo ukusetyenziswa chiza kuphela nemiphumo emihle, kodwa inokubangela iingxaki eziliqela. Ngoko ke, phambi kokuba usebenzise olu amayeza ukuphelisa intloko ebuhlungu, migraine, kufuneka udibane ingcali yaye baye iimviwo eneenkcukacha. Oku kuya kunceda nje ukuba ukumisela unyango ngokwaneleyo, kodwa ecaleni ungcipheko olukhawulezileyo kwimpilo umguli.

Izimo

Qwalasela uluhlu Izimo zokusetyenziswa "Relpaks" iziyobisi. Tablets, njengoko kutshiwo apha ngasentla, i eletriptan egu- iziphumo zenkqubo kwi inyama kunye neempembelelo iinkqubo ezininzi. Kwezinye iimeko, usebenzisa imveliso engamkelekanga okanye engathandekiyo:

• phambi ubuthathaka ephakamileyo umguli zonke izinto eziyinxalenye ichiza;
• enokuphazamisa wesibindi, nezintso, njengoko ukutya kunye kukhuthaza eyona nto ephambili esebenzayo lwenzeka kuzo;
• kunye wegazi eyenzeke;
• kunye nezifo elele okanye esanda ngemini- wentliziyo, kuquka ukuhlaselwa yintliziyo, angina, isifo kwemithambo;
• phambi inklyuzionnyh sisifo iperipheral vascular;
• uma esuswa okanye esele mzuzu of kobuchopho, kwakunye nayiphi na impatho ejikeleza lobuchopho.

Drug "Relpaks" ngokucacile akukhuthazwa ukuba abantu kabani yobudala ingaphantsi kweminyaka eli-18. Ngaphezu koko, eli chiza ayikwazi kusetyenziselwa isiqabu intlungu ezinxulumene yintloko ezifana iintlobo migraine njengoko basilar, lwamehlo kunye hemiplegic.

Sebenzisa ngethuba lokukhulelwa zisanyisa

Ukusetyenziswa ichiza "Relpaks" ngexesha lokukhulelwa sele ngokwaneleyo efunda. Noko ke, uphando laboratory izilwanyana zibonisa isiphumo eletriptan ekukhuleni kosana olungekazalwa. Okokuqala, kukho inani elincinane yemfuza mutated (ngokutsho siseko polyploidy) kubonakele ku mbungu. Okwesibini, enobunzima ngokupheleleyo-gama asezantsi kakhulu kunokuba izilwanyana ukuba akazange afumane ngexesha yokumitha eletriptan. Yiyo loo nto iingcali kulawulo lwakhe yokuqeshwa okukhokelwayo, leyo ukuba inzuzo ezilindelekileyo ukuya unina ngaphezu elizayo kunokwenzeka umngcipheko olungekazalwa. Kufuneka kuqatshelwe ukuba eletriptan, inxalenye beziyobisi ezifumaneka ngobisi yabantu, emva kweentsuku emva kokuba ulwamkelo. Ngoko ke, ukusetyenziswa iyeza ngoonina Lokonga kunokwenzeka kuphela xa ukusilela ukuncancisa ubuncinane ngosuku.

iziphumo ebezingalindelekanga ezinxulunyaniswa nokusetyenziswa kweziyobisi "Relpaks"

Nokuthwaleka "Relpaks" iingcali ncomo iziyobisi zinika inkcazelo malunga aqine ezibuthathaka ziziphumo ebezingalindelekanga, leyo wedwa kwixesha elifutshane ixesha. Akukhathaliseki ukuba ithamo (20 mg okanye 40) efunyenwe sisigulane. Ezi mpawu zixhaphakileyo wabona xa ezithatha ichiza zezi:

• ukudumba lweHo- ngeempumlo kunye pharynx (pharyngitis, nokuthimliswa);
• zemizwa ezifana esibuhlungu, "amaqhuma goose";
• ukozela;
• isiyezi okanye ebuhlungu;
• myasthenia gravis okanye hypoesthesia;
• hypertonicity ye imicu izihlunu;
• ubuhlungu okanye uzive ngokuqinileyo ngasemva nesifuba;
• arrhythmias kwentliziyo, xa tachycardia ethile;
• izifo dyspeptic ezifana iintlungu okanye ukungaphatheki esiswini, umlomo owomileyo , nentliziyo;
• ukwanda ukubila;
• ukufikelwa okanye Ukugodola nazo.

Thathela ingqalelo ukwakheka eekhemikhali "Relpaks", iingcali musa ngaphandle uphuhliso kukwalisa amacandelo ichiza, ekusenokwenzeka luboniswe inkangeleko yabangxamayo, urhawuzelelwa okanye bomvu. Ukongeza, kwiimeko ezinqabileyo, izigulane akhathalele ngezenzeko ezifana:

• anorexia;
• lymphadenopathy;
• ukudideka, imincili okanye uxinezeleko, efuna lability ngokweemvakalelo;
• photophobia, intlungu lweliso lakho, conjunctivitis, lancitshiswa okanye ukwanda lacrimation;
• kungcamla kwekhono;
• unkenteza ezindlebeni, okanye bomzimba;
• uxinzelelo lwegazi oluphezulu;
• ukuhlaselwa somoya;
• izakutshintsha kwixesha ithoni ilizwi;
• ukudumba em- ngomlomo;
• kwesisu okanye ukurhuda;
• samathambo okanye arthrosis;
• myalgia okanye myopathy;
• polyuria okanye rhoqo ukuchama;
• ukuphazamiseka kokuya;
• besisu kobuchopho.

Thathela ingqalelo iziphumo ebezingalindelekanga-okhankanywe ngentla, ukusetyenziswa njengendlela migraine "Relpaks" Kucetyiswa ukuba enze phantsi kweliso ziingcali, yaye kuphela emva kokuba izifundo eziyimfuneko izifo ekhoyo iza kwenziwa, nto leyo nzima unyango.

intsebenziswano

Cinga intsebenziswano kunye arhente amanye amachiza antimigraine "Relpaks". isikhokelo Amayeza oluqulathe ulwazi olubanzi malunga ukuhambelana yayo kunye nezinye iziyobisi akufuneki ukuba kuthathwe kunye amayeza eziyimfuneko amaqela alandelayo:

• inhibitors isozyme, eziquka "erythromycin", "ketoconazole" "Clarithromycin" yaye "Itraconazole";
• inhibitors protease, kuquka "nelfinavir" yaye "Indinavir".

Iingcali kwakhona uqaphele into yokuba ulwamkelo ngaxeshanye "Relpaks" amayeza iziyobisi "Propanolol" yaye "Verapamil" kungabangela kuphela ukwanda okubonakalayo uxinzelelo lwegazi, kodwa ukuphucula ingozi yokuba ezinye iziphumo ebezingalindelekanga. Ukwanda uxinzelelo lwegazi enokulindelwa kwimeko ukusetyenziswa odibeneyo ichiza ngeziyobisi caffeine. Yiyo loo nto iingcali bacebisa ukuba lokuphumla imihla phakathi namatheko zamachiza ezifana 'Relpaks "(analogue nabo bawe phantsi le nkcazelo) kunye neziyobisi ergotaminopodobnyh.

Ngokwezonyango, icikidwa ukuba indlela migraine ekuthethwa ngayo kweli nqaku modem kunye izinto ezinxulumene beta-blocker, estrogensoderjath hormone okanye zokucwangcisa ngomlomo, kodwa ukuba yokunciphisa tricyclic.

libanda

Ukuba ngaphezulu ugqirha imali abawacebisayo iziyobisi "Relpaks" yemiyalezo ulumkisa libanda, oko kubangele ukwanda ziqhubeke uxinzelelo lwegazi kunye nezinye ukuphazamiseka kwenkqubo sentliziyo. Xa kuvela kunye nonyango kwangumqondiso kucetyiswa ukuba lavage kuyimfuneko esiswini.

umthamo

"Relpaks" iingcali Drug Sicebisa uthathe ekuqaleni yokuhlaselwa migraine. Ukuba ebuhlungu kunye nezinye izigulo udibaniso kukuphatha sesigulane iiyure eziliqela, njengoko ichiza igcina ukusebenza kwayo. Kufuneka kuqatshelwe ukuba ulwamkelo kweziyobisi njenge arhente othintelo ukuba migraine na inexpedient, kuba kwakungqina ukuba kule meko ayinayo yifuna. Ngelo xesha xa besondela aura (izigulane, abanale migraine ixesha elide kunokuba ukuchonga le meko) ezithatha ichiza nje kuphela intlungu elandela aura, kodwa kuyakunceda ukuba neempawu ezifana isicaphucaphu, ukozela kunye photosensitivity. Oku kwenzeka akukho kanye, kodwa ke kuphela emva kokuba uhlaselo yintloko. Ngoko ke, abanale migraine kufuneka bangabangxameli ukusela ipilisi ixesha ngalinye a izifo.

Ithamo yokuqala kweziyobisi kwizigulana iminyaka 18-65 ubudala yi-40 mg. Emva kokuba ukukhululeka intlungu migraine akwazi ukuqwebela. Kulo mzekelo, esi sikhokelo incomela ukuba ukuthatha kwakhona ichiza kwi idosi enye, kodwa iiyure hayi ngokukhawuleza kwe-2 emva kokuba ulwamkelo lokuqala. Kwimeko yokusilela ichiza xa ebuhlungu nokomelela ngexesha iiyure ezi-2 emva kokuba ulawulo zeziyobisi, kwakhona ukuthatha ayikhuthazwa ithamo. Iingcali zibonisa ukuba uhlaselo elandelayo migraine kwi isigulane inye fakwa idosi yokuqala "Relpaks" iziyobisi. izigxeko Consumer kwesi sihlandlo ziqulathe ulwazi efanayo.

Ithamo ubuninzi medicament efunyenweyo phakathi kosuku olunye mayingagqithi mg 160. Ukusela tablet kufuneka lonke, ngaphandle ukuhlafuna, ukusela intabalala iziselo.

oyi

Ukusetyenziswa "ukulungiselela Relpaks 'kunokwenzeka kuphela emva kokuqinisekisa lokufunyaniswa" migraine ". Oku kungenxa yokuba xa yintloko Nedlac, leyo nayo zingabangelwa ngesibetho, kwemithambo komsipha kunye nezinye izifo ezinzulu, ukuqeshwa kwakhe kungabangela iingxaki ezahlukeneyo. Ngaphezu koko, oko ayinqweneleki ukusebenzisa eli chiza ukuba uza kuziphelisa zonke iintlungu kakhulu kwi migraine phakathi izifo sentliziyo ukugula le wezintso kwaye isibindi, njengoko oku kungabangela uxinzelelo oluphezulu lwegazi ukuya kwinqanaba ezibalulekileyo. Kunjalo izigulane lowo ingozi yokuba nesifo sentliziyo iphezulu. Kungenxa yoko le nto phambi emisela "Relpaks" ichiza isigulane kufuneka bangenele uviwo olupheleleyo. Izigulane ngexesha ukusetyenziswa kwiminyaka 65 ichiza kufuneka abe phantsi kweliso ziingcali, ekubeni ukuba qho waphawula ukunyuka koxinzelelo lwegazi.

Isilumkiso! Ngokuphathelele yokwamkela ichiza "Relpaks" yemiyalezo iqulethe iimbekiselo yeziphumo ebezingalindelekanga ezifana nesiyezi kunye ukozela, ngoko ufanele ulumke gqitha xa uqhuba izithuthi kunye ekulawuleni nobuchwepheshe entsonkothileyo.

Analogs "Relpaks" ixabiso iziyobisi

Uninzi amachiza enziwe kwakhona ziinkampani zamachiza kwi-West, kukho kunoogxa zasekhaya. Sinako sithethe nxamnye Pfizer - umvelisi "Relpaks" iziyobisi. Noko ke, ekubeni yayiyimini yabhaliswa kutshanje nje, ukuza kuthi ga ngoku akukho iziyobisi eyayiza kuba iimpawu ezifanayo njengoko ichiza "Relpaks". Analogs main eletriptan esisebenza nayo yayaziwa, ukusuka apho kunokwenziwa isigqibo sokuba kulungiselelwa yahlukile. indleko yalo eRashiya uvela engange-380 ukuya 1200. Ixabiso ethile ixhomekeke kwinani amacwecwe kwiphakheji yaye yintoni umthamo wabo.

Ngu indlela lwempembelelo iimpahla ebuchotsheni emacwecweni "Relpaks" kukho isasetyenziswa eziliqela, nto leyo musa kwahluka nje lukhulu kuye ngeendleko, kodwa kumathuba amaninzi imali eninzi kakhulu. Umzekelo, eyanceda migraine "Zomig" zinokuthengwa ngexabiso ngomyinge 400 engange nangeepilisi ezintathu. Iziyobisi "Imigran" yaye "Sumatriptan" Kwakhona efanayo "Relpaksom" liye ifuthe nexabiso. Kuphela iziyobisi, zibiza ngaphantsi kakhulu "Relpaks" icwecwe - i "Kofetamin". ixabiso labo ayidluli 75 engange pack nganye.

Izimvo kulungiselelwa

Ngoko ke, ukuba lo mbuzo ubalulekileyo. Yintoni bacinga ngale mveliso amayeza "Relpaks" Abaxhasi kunye noogqirha zabo? Ziziphi iingenelo neengozi ukuba eli chiza? Into yokuqala bangathini-80% abaphenduli - lo nokusebenza aphezulu iipilisi "Relpaks" nkqu kuhlaselwa kakhulu migraine. Ingxelo evela kwizigulane, emva ukuthatha ipilisi nje enye intlungu uya kude emva kwemizuzu 30-40. Malunga ne-8% abaxumi uphando lubonise ukuba emva ukusetyenziswa kwe-dose yokuqala ka-40 mg zisandula iimpawu ezifana nongcangcazelo na imilenze ze ukuntlontlozela ebusweni kunye nezandla. Nangona kunjalo, ezi ziganeko emibi kwenzeka iiyure ezimbini ngaphandle okwenzayo.

Ngaphantsi kwe-1% ezigulane abaye yabelwe ichiza "Relpaks", ulwamkelo lokuqala akukho awayevakalelwa ngayo yonke ukusebenza kwayo. Isinye kwisithathu xa kwakhona ubulungeleyo beziyobisi iye nempembelelo yayo, kunye nabanye kwanyanzeleka ukuba ukufumana indawo.

Iingcali uqaphele phakathi iingenelo yokulungiselela yegalelo etsho imithambo yegazi yentloko. Kodwa ke, qaphela ukuba imbonakalo nkqu iziphumo ebezingalindelekanga ezininzi minor isigulane kufuneka alale nje. Le nto iya kuba yanele zonke nesenzeko ezingentle elidlulileyo. Iingcali kwakhona uqaphele oku kulandelayo: ngokwahlukileyo kumayeza ezifanayo, ezo kungekhona inxalenye "Relpaks" abantu eletriptan iziyobisi lula kakhulu zivunwe migraine.