Prokinetics - ntoni na? isizukulwana esitsha prokinetics: uluhlu

Prokinetics - ntoni na? Kumazwe ico, akukho ukuvumelana malunga amayeza zibandakanyiwe kweli qela, ngoko yonke gastroenterologist ngokwakhe simisela ukuba zazise okubhalwe kule kuluhlu, yaye wenza ntoni na. Prokinetics - ntoni na? Nantso into abazama ukufumana phandle.

Inkcazo kunye nenkcazo emfutshane

Prokinetics - ntoni na? Eli qela amachiza ezivuselela le motility tube yokwetyisa kwaye uthintele amaza anastaltic.

izifo emathunjini soloko ilandelwa lutshintsho lwemithetho reflux of chyme ukusuka kwezona ziseza ntsi iindawo wamathumbu kwi overlying, waphula umthetho sicatshulwa bolus okanye ngxi kwi ingxenye emathunjini. Zonke ezi mpawu zinxulunyaniswa promotion kakuhle chyme yi ityhubhu yokwetyisa, ngoko ukususa iimpawu angaba, echaphazela yindibanisela izihlunu agudileyo kweendonga zayo. Nantso into prokinetics. ukusebenza kwabo unyango ngenxa yokuvimba balo matshinana transfer ion (dopamine, receptors-5-HT4, combined) okanye azinampembelelo yokucolwa of acetylcholine. Ukuphumeza effect clinical kungenxa kwenani of acetylcholine emqhokrweni zobuchopho okanye yokukhulisa iimveliso cholinesterase leyo iphucula yokubola keyshia, iimveliso ukuncitshiswa keyshia kwalapho.

imiphumela Physiologically ukusuka iziyobisi kubonakala ukwandisa kwentliziyo ithoni sphincter esophageal, ukufudusa lweziqulatho isisu, uququzelelo phakathi antrum kunye duodenum, elinemveliso emathunjini peristalsis.

Iqela lokuqala iziyobisi

Prokinetics - iziyobisi ngokuthintela dopamine D2-receptors, ngaloo ndlela ekuvuseleleni umsebenzi kwezihlunu nokubonelela imicu emathunjini ukusebenza antiemetic. La mayeza ziquka: "metoclopramide" (abameli isizukulwana wokuqala - "Reglan" yaye "Raglan"), "bromopride", "Domperidone" (isizukulwana yesibini), "Dimetpramid", "Itopride".

iziyobisi Prokinetic, esetyenziswa ukunyanga isifo gastroezofagialnoreflyuksnoy (GERD), YAZHDPK, ukuqunjelwa, umlinganiswa functional, licuthe le kuvuleke iminxunya emva kokonzakala kwaye ngenxa azikhuli, postoperative paresis ngoncedo esiswini, ukuphazamiseka of kuphuma inyongo, flatulence.

Kwakhona prokinetics - iziyobisi isetyenziselwe isicaphucaphu nokugabha ezibangelwa ityhefu okanye waphula kwesidlo imithetho, izifo umyalezo ziintsholongwane, ukukhulelwa kwithuba leenyanga ezintathu yokuqala, insufficiency etsolo coronary, intloko kwentlungu, zomzimba, imitha kunye nechemotherapy. Kuphumelele ukubuyisa imvelaphi vestibular, njengoko ayichaphazeli indlebe oluphakathi kunye Oblongata Medulla.

Antipsychotics ukunceda ukugabha

"Sulpiride" yaye "Levosulpirid", i neuroleptic kunye indlela efanayo amanyathelo, nayo iba nemiphumo emihle anti-emetic, ngoko ingasetyenziswa xa kusenziwa gastroenterological.

"Metoclopramide" (prokinetics): imiyalelo yokusetyenziswa

"Metoclopramide" - a stimulator ngqo zihlunu gingxi kwaye zonke iipropati eziyimfuneko ukuze kuphunyezwe iziphumo ngokwezonyango eqaphelekayo, kodwa ngenxa nemiqobo gematogistologicheskie permeability kufuneka isetyenziswe ngobulumko. ziphumo bezingalindelekanga kunokwenzeka ezifana spasm ye imisipha yobuso, uphawu lwe 'iinyawo crow ngayo ", Buze zesingqisho ulwimi, ukuphazamiseka bulbar, inkantsi ekrtraokulyarnyh izihlunu, torticollis spasmodic, imvakalozwi ngokugqithisileyo izihlunu extensor, Parkinson engqondweni, somnolence, ubuthathaka, ukuduma, intloko ebuhlungu, ixhala, ukudideka.

Kwezinye iimeko, Kuyancomeka ukuthatha prokinetiki? Imiyalelo zokusetyenziswa uthe ukusetyenziswa engathandekiyo kwiimeko hypersensitivity ukuba ichiza, ithumba le neuron adrenal, emathunjini, perforation kwamathumbu babazise nokopha, nangezilonda prolaktinozavisimoy, sokuwa kunye nezigulo extrapyramidal, ukuya kwiiveki 16, umbungu lo mntwana, ngexesha zisanyisa, abantwana abangaphantsi emi-5. Amanyathelo kufuneka umiselwe kwi clearance yehlise creatinine, ukwanda koxinzelelo lwegazi, isifuba, abaneminyaka ukuya kwiminyaka eli-14.

Kuginya iyeza isiqingatha seyure phambi kokuba isidlo, phezu elucwecweni at 9:00, 12:00, 15:00 no 18:00. Ubude unyango - iiveki ezine ukuya kwezintandathu, maxa wambi oko kwandiswa ukuya kwiinyanga ezintandathu.

Ukuba ifom release - ulwelo, oko ilungiselelwayo intramuscularly okanye yegazi. Kuba abadala kunye nabantwana abangaphezu kweminyaka eli-14 - 10 mg. Iphezulu ngalinye ngexesha elinye - 20 mg idosi yemihla ngemihla - 60 mg. Imixholo ampoule ke exutywe saline isotonic okanye isisombululo iswekile-5%.

"Domperidone": imiyalelo yokusebenzisa

"Domperidone" uyamkhetha ngakumbi dopamine receptor blocker, ngaphandle ukungena BBB, ke xa ulwamkelo ayikho kuqulunqwe iziphumo ebezingalindelekanga ezichazwe ngasentla. Nangona kunjalo, ukwandisa secretion of prolactin, oko ekwenza gynecomastia, galactorrhea, kunye nokungabikho menses. Ukongeza, izigulane ingxelo irhashalala, umlomo owomileyo, urhudo kunye yintloko.

Akukhuthazwa ukuba zisetyenziswe ngabantu kukwalisa amacandelo amayeza, ukopha evela iphecana zesisu, emathunjini, prolactinoma, zisanyisa, iminyaka neminyaka emi-5 ubudala okanye ukukhathaza ukuya kilograms-20. Amanyathelo ukuba uyithathe xa ukhulelwe, kwezintso kunye / okanye insufficiency hepatic.

Sela imizuzu engamashumi amabini phambi kwesidlo ngasinye ku-10 mg, ukuba kuyimfuneko, kwaye asele ngaphambi kokuba uye kulala. Ithamo liphezulu ngosuku - 80 mg. Ukuba ikhona kwi kunyango asidi, ukunciphisa secretion yejusi esiswini, kufuneka bahlukile ukusela domperidone, ukwabelana ngokutya ukutya.

"Itopride": imiyalelo yokusebenzisa

"Itopride" idibanisa iimpawu ochasene dopamine receptor kunye blocker of acetylcholinesterase. Ukusebenza inkqubo hypothalamic-yebhinqa-adrenal, ukwanda lamanani somatostatin nokucutha hormone adrenocorticotropic. A nefuthe elibi ichazwa njenge leukopenia, thrombocytopenia, reactions hypersensitivity, hyperprolactinemia, isicaphucaphu, lafa, senyongo. Ngexesha reception, kuyafuneka ukuba esweni imeko igazi peripheral, nokuqinisekisa akukho iziphumo ebezingalindelekanga.

Akukhuthazwa ukuba abantu hypersensitivity sohlobo okanye ilibele, imbali ukopha zesisu, obturating le mithambo isisu okanye ucinezelo yequmrhu amazwe evela ngaphandle, phantsi uneminyaka elishumi elinesithandathu, ukukhulelwa, nokuncancisa.

Ichiza kuthathwa ngomlomo phambi okutya 50 mg kathathu ngemini.

Abamelene "Acetylcholine"

Eli qela libandakanya:

• "Aceclidine" (M-cholinomimetic);
• "Fiziostigmin" "Galantamine" "Tegaserod" "Prucalopride" (ingathityazwa cholinesterase inhibitor)

La machiza bangamalungu kuphela ngokuyinxenye ibandla prokinetics ngenxa yeziphumo zazo ecaleni: iziphumo ngokutshintshiselana ion potassium, yaye ngenxa yoko, kululwa interval QT, nto leyo ekhokelela uqhushululu kwesingqisho intliziyo. Iqela mayeza ukhutshiwe emarikeni amayeza ngenxa yesi sizathu.

"Aceclidine": imiyalelo yokusebenzisa

Prokinetics - yintoni na, njani yaye nini yokuzisebenzisa? Enoba kwenzeka ntoni na, qiniseka ukuba adibane nogqirha kunye nokufunda ingqalelo le imiyalelo ukusetyenziswa.

"Aceclidine" lisetyenziswa ukunqanda ulhleko lwe ithoni wokugaya kwaye isinye emva kotyando, kunciphisa ingcinezelo intraocular, ke ngoko inokusetyenziswa zamehlo. Product Ifomu - ngenaliti, zenyuse kwesikhumba nge 2.1 ml kwesisombululo 0.2%. Max ngexesha - 0.004 g, ngaphezu akukho imihla kwe 0.012, iziphumo ebezingalindelekanga - ptyalism, ukubila, kunye norhudo.

Izimo ukuba ukusetyenziswa zezi isifo sentliziyo, iHDL ophakamileyo, isifuba inyumoniya, kunye nezinye parkinsonism hyperkinesias, ukukhulelwa, ukopha kwisisu.

"Fiziostigmin" lisetyenziswa kwi practice lwamehlo, kodwa maxa wambi sebenzisa kwi Gastroenterology kwi kule paresis emathunjini. Ichiza zifakwa phantsi eluswini 0.5 - 1 ml kwesisombululo 0.1%. Le mali iphezulu ichiza ngosuku mayingagqithi 0.001 g

ziphumo bezingalindelekanga someleza izinkcwe, bronchospasm, spasm wamathumbu kwemisipha, isantya entliziyweni, yombono.

Contra-ukwalatha: angina, sokuwa, isifuba, isithintelo ngoomatshini isisu, peritonitis, nokudumba, ukukhulelwa.

"Galantamine": imiyalelo yokusebenzisa

"Galantamine" kwiimeko ezithile isetyenziswa njengento ochasene for relaxants kwezihlunu kwixesha postoperative kunye ukuncipha kwezihlunu kwamathumbu kunye isinye. Izimo ukuba ukusetyenziswa zezi hypersensitivity, sokuwa, isifuba, uxinzelelo lwegazi ngasentla 139/99 mmHg, COPD, occlusion mechanical we bile isisu, sezintso umsebenzi ongaboniyo, iminyaka engama-9. Limited ukuba injongo ukukhulelwa kwiimeko apho tywaleni ezinokubakho ukudlula iinzuzo. Ngexesha zisanyisa, unako idluliselwe umntwana ngokusebenzisa ubisi.

iziphumo ezingalindelekanga: ukuncitshiswa izinga lentliziyo, TTP, AV yaye kuvalwe, arrythmia, isicaphucaphu, ukugabha, urhudo, ukuqunjelwa, aqaqambayo, ngumchamo wokuchama, haematuria, lafa.

Isenokuba ufakwe kwesikhumba, intramuscularly, butofelwe, transdermally, ngomlomo. Iidosi ayilungiswanga ngamnye, ngokusekelwe imbali sifo, yaye kufuneka lilungiswe gqirha khona. I-avareji idosi yemihla ngemihla abadala - 10 ukuya kuma-40 mg, yahlulwe yaba amathamo ezimbini ukuya kwezine.

Isizukulwana esitsha prokinetics

Ngenxa yokuba namhlanje Itopride kuvelisa iziyobisi ezifana "Ganaton", "Itomed", "Pramer". Enye i entsha nesebenza abo isizukulwana prokinetiki esitsha njenge "koordinaks" kunye "Prepulsid". Nangona kunokubangela iziphumo ebezingalindelekanga ezimandundu entliziyweni.

Ethandwa kakhulu phakathi gastroenterologists kuhlala "Motilium" (esebenzayo nto - domperidone), okuhlanganisa umgangatho metoclopramide, kodwa abe neziphumo zayo ezimbi.

Zeziphi pprokinetiki kakhulu ngempumelelo? Uluhlu iimveliso ngoku:

1. "Itopride" (esisebenza) - "Ganaton", "Itomed", "primer" (igama zorhwebo).
2. "Metoclopramide" - "Raglan" "Reglan".
3. "Cisapride" - "koordinaks", "Prepulsid".
4. "Domperidone" - "Motilium", "Motilak", "Motinorm", "Passazhiks".

Ngoku siyazi ukuba prokinetic enjalo. Dwelisa njengoko ubona, inkulu kunene. Kodwa khumbula, phambi kokuba ukusebenzisa naliphi na iyeza kufuneka udibane nogqirha wakho! Hlala uphilile!