Medicine kunye abanxibe impahla. androstenedione ephakeme

Androstenedione ibhekisa hormone sex eyindoda. Le androgen yi testosterone siphu-. Ngabantu, ogama imveliso kwenzeka kakhulu amatyhalarha. Kwabasetyhini, 60% ye androstenedione kubangelwa utshintsho peripheral, 40% evela kwi adrenal kunye zamaqanda. Xa bubuhle izinga ngesondo wesiseko kunye secretion kwale hormone iphezulu kunase testosterone, kwaye kakhulu elide ivakalise extraadrenal ukuguquka kwalo testosterone.

kwinqanaba androstenedione uzimisele ngendlela entsonkothileyo DHEA-S kunye DHEA. Oku kuyimfuneko ukulungiselela iinjongo zokuxilonga kunye nokuvavanya ifuthe kwezonyango kwiimeko hyperandrogenic.

androstenedione ephakamileyo ekuhlalutyeni igazi uphawu izigulane adrenal uthinte hyperplasia nature naso. Ngaphezu koko, xa izinga eliphezulu uchonge syndrome Cushing, hyperplasia okanye neoplasm stroma wamatyhalarha kwi isizalo, kwakunye ethunjini ACTH secretion.

androstenedione iphakamileyo sibonakala izigulane hirsutism kunye zamaqanda polycystic.

Xa yezonyango, ke lamanani serum hormone isetyenziswa ngokubanzi esweni impumelelo ungenelelo zonyango kunye nokusetyenziswa glucocorticoids e hyperplasia azalwa adrenal, njengoko uthathwa umlinganiselo ichanekileyo kunezinye androgens.

Akukho androstenedione wande, and vice versa, ukunciphisa isiqulatho yawo lubonisa ubukho irhengqa-cell anemia. Pathology kuphuhliswa sizoku lwisana insufficiency ovarian kunye adrenal.

Androstenedione. Ahlolwa?

Izinto ezibonisa ukuba isifundo zezi:

- unyango esweni isifo imiqathango hyperandrogenic;

- nokuphazamiseka ekuzaleni kwi imvelaphi hormone ukungaphumeleli;

- unyango kunye glucocorticoids.

ingqalelo ekhethekileyo ihlawulwa androstenedione abantu ababandakanyekayo abanxibe impahla umsebenzi. Kukholelwa ukuba amalungiselelo hormone, kunye nemixholo yawo ukukhuthaza ukukhula kwezihlunu. Nangona kunjalo, oku akusoloko kunjalo.

Androstenedione i hormone engundoqo adrenal kwaye inokujikwa okanye testosterone okanye estrogen. Kwimeko yokuqala ngayo iyavuseleleka ukuguquka transcriptase ethile. Kufuneka kuqatshelwe ukuba umqokozo nenguqulelo yezinto androstenedione steroid ukuya testosterone lisondele kwe DHEA. Oku kukhokelela amandla enkulu yayo ukuguqula. Ngaloo ndlela, ukuguquka isiphumo of androstenedione ukuya yangasemva testosterone phantsi kwempembelelo omnye enzyme ukuze baye dihydrotestosterone. Oku, igalelo kuphuhliso lweziqhamo ezininzi ezingemnandi. kudaleke Dihydrotestosterone kunye nentloko balding, yaye wawandisa yesinye, kwakunye nokukhula iinwele kakhulu kwi umzimba nobuso. Ukongezelela, iimpawu steroid nto ayinayo, ke alunasiphumo kwi mass kwezihlunu. Ngoko, xa androstenedione ukwanda, kukho ithuba ukwanda lamanani dihydrotestosterone.

Ukongeza kwezi ziphumo, kukho enye ingxaki - gynecomastia. Kukhuthaza ukukhula ukuguqulwa ebeleni testosterone ukuya estradiol (aromatization).

Nangona ziqinisekiso ezentengiso ukuba linyuke androstenedione ukusebenza elihle ngokukhula kwezihlunu xa isetyenziswe ngokuchanekileyo, hormone "ukuxhaphaza" basoloko inkqubo engalindelekanga kwaye kunzima. Kwakhona ingqalelo into yokuba ukunyuka kwamazinga testosterone usebenzisa iziyobisi hormone, Kakade ke, ichaphazela nkqubo olawula imveliso steroid ngesondo.

Namhlanje, androstenedione kunye nefuthe layo phezu kwabantu kakuhle. Ngaphezu koko, xa efumana ezo okanye amanye amalungiselelo hormone kufuneka athathe ingqalelo iimpawu eziphilayo nganye. Ngokomzekelo, kwezinye ukwanda xi legalelo androstenedione luncedo ngokukhula kwezihlunu, ngoxa abanye kunokubangela iingxaki ezinzulu.