Lipid-yandisa iziyobisi "Rosuvastatin": imiyalelo yokusebenzisa

Medicine "Rosuvastatin" yemiyalezo ichaza neziyobisi hypolipidemic of statins. Ukusebenza kwale ndlela sikhethe inhibition ukhuphiswano lwe HMG-onx reductase. Ukusetyenziswa kwe kulungiselelwa "Rosuvastatin" (imiyalelo zokusetyenziswa it qinisekisa) izihlandlo eziliqela inyuke LDL catabolism, isantya nokunyuka kwamaxabiso receptors LDL hepatic kunye nesixa VLDL lifinyele. Ngokubhekisele iimpawu pharmacokinetic iziyobisi lipid-yandisa, ukuba ngaba isiphumo konwaywa yokwamkela yayo waphawula iintsuku ezisixhenxe emva kokuqalisa unyango, ufikelela japan yayo kakhulu kwiiveki ezine.

Athathe ipilisi "Rosuvastatin" umenzi icebise ukuba abantu abanengxaki ifomu olungumxube hypercholesterolemia (uchwetheze IIb) hypercholesterolaemia okanye IIA (kubandakanywa heterozygous) njenge njengesongezelelo yokudla.

Ngaloo nokusebenza ephezulu ichiza hypolipidemic esebenzayo na kwimeko xa ezinye iindlela zonyango (umthambo, ukuncitshiswa ubunzima bomzimba) musa kukhokelela ekuphunyezweni yoko efanelekileyo nezinyangayo. Ngaphezu koko, sebenzisa uyakhetha arhente "Rosuvastatin" yemiyalezo icebisa njengoko ichiza abangabancedani ngexesha unyango homozygous uhlobo hypercholesterolemia usapho.

Yabela la macwecwe engaqondanga ngokungqongqo xa kukho ogulayo kwezifo ezinzima zesibindi, myopathy okanye ukuphazamiseka ezivakaliswe kule kwizintso. Ngexa lokukhulelwa, naye kufuneka uthathe iziyobisi lipid-lisibekele "Rosuvastatin." Iyeza le contraindicated kwithuba zisanyisa. Ngaphezu koko, ayikhuthazwa ukuba kwezi tablets ngaxeshanye cyclosporine okanye hypersensitivity amacandelo zabo. Abantu lowo uneminyaka elishumi elinesibhozo, kwaye akukho mfuneko ukumisela arhente uyakhetha "Rosuvastatin." Imiyalelo yokusebenzisa ukuba akukhuthazwa ukuba ulithathe ngalo kwimeko ukuxhomekeka etywaleni esekwe kwezintso ukusilela okanye isibindi izifo.

Ngononophelo olukhulu ukusebenzisa amachiza lipid-yandisa babe ngabantu ukuhlupheka electrolyte, yonyango kunye pathways ukuphazamiseka, hypothyroidism okanye hypotension. Xa nokudumba, sokuwa ongalawulekiyo, proteinuria, umothuko omkhulu kunye nongenelelo zotyando kufuneka Musa ezithatha ichiza, "Rosuvastatin." Ukongeza, ezi Izimo isihlobo izifo zofuzo kwimisipha ubudala nangaphezulu kweminyaka engamashumi amathandathu anesihlanu.

Xa ndiqukumbela, kufuneka athi malunga reactions ezingalunganga kunokwenzeka, kukuvela ezo kuxhokonxwa ulwamkelo lithetha "Rosuvastatin." Ngokomzekelo, izigulane ezininzi ezikhala iintlungu esiswini, ukuqhina, isiyezi kunye isicaphucaphu. Ukongeza, kukho ingozi encinci myopathy, proteinuria, asthenia , kunye myalgia.