"Katalodon": imiyalelo yokusetyenziswa, intengo kunye nokuhlaziywa. Analog "Catadolone"

Uluphi ulungiso "lweCatadolon"? I-analogues, ixabiso kunye nemiyalelo yokusetyenziswa kwesi sidakamizwa iya kuboniswa kwimiba yale nqaku. Ukususela kuyo uya kufumanisa ukuba lithetha ukuthini ukuba, kungakhathaliseki ukuba kukho ukuchasene kunye nemiphumo emibi, kwindlela ekhutshwe ngayo, equlethwe kuyo kunye nokunye.

Ukupakisha, uhlobo lokuvelisa, ukubunjwa

Isilwanyana "Catadolon" sithengiswa kwiifom ezimbini ezahlukeneyo. Inkcazo yabo, ukubunjwa kunye nokupakishwa esiya kujonga kwangoku.

• Amachiza e-"Catadolon Forte" yi-biconvex yellow oval tablet (ngakwelinye icala umgca) oqulethe iziphumo ezahlukeneyo. Ulungiselelo luqukethe isithako esisebenzayo esinjenge-flupirtine maleate, kunye nabanye abancedisayo. Iibhilebhe zifakwa kwiibhalantshi ze-10, 7 kunye ne-14, ezipakishwe kwiipakethi zekhadibhodi.
• Iipsululwazi "I-Catadolon Retard" kwinqabileyo ye-gelatin yombala obomvu. Isiqulatho sesilwanyana singumgubo we-green-yellow yellow hue. I-capsule enye iqukethe i-flupirtine i-maleate, kunye nezinye izinto ezongezelelweyo ngendlela ye-gelatin, i-magnesium stearate, amanzi, i-titanium dioxide, i-E172, i-silicon dioxide, i-lauryl sulfate ye-sodium, i- calcium hydrogen phosphate i-dihydrate kunye ne-copovidone. Isilwanyana sipakishwe kwiipakethi zekhadibhodi ngee-30, 50 okanye i-capsules eziyi-10.

Isenzo se-Pharmacological yesilwanyana

Iyintoni na isicatshulwa esicatshungulwayo kwaye ingaba i-analog? "I-Catadolone" ingeyona i-opioid analgesic enefuthe le-antispastic kwaye ineziganeko ezininzi ezahlukeneyo.

Amachiza awayilo umlutha kwaye unokufumana umphumo ophakathi. Emva kokungena emzimbeni, ichaphazela i-G-protein, ngaloo ndlela itshintsha ukuhluka kwezinto ezikhoyo kwiitriki ze-calcium kunye nokuzinzisa iimbombo ze-neuronal.

Ziziphi iipropati zesilwanyana kunye ne-analog yayo? "I-Catadolone" kufuneka ithathwe kwii-doses ezingadluli kwizinga eliphezulu elivumelekileyo. Kule meko kuphela into esebenzayo ayiyi kuchaphazela i-H- ne-M-holinoretseptory, kunye ne-opioid, i-dopamine, i-serotonin, i-alpha2 kunye ne-alpha1-adrenergic receptor.

Emva kokuthatha iipilisi okanye iipilisi, i-anesthesia ivela ngokuvula izitishi ze-potassium ezikhoyo kwiiseli zamathambo.

Ngokweengcali, eli chiza linempembelelo entle kwi-NMDA receptors. Inqanda ukuhamba kwee-calcium ions ezidlulayo kwiindonga ezingenakunqandeka zeembrane.

Inqobo yesenzo sonyango

I-agent kunye ne-analog yayo isebenza njani emzimbeni womntu? "I-Catadolon" iqukethe i-flupirtine ekubunjweni kwayo. Yiyo le nto engavumelekanga ukukhathazeka kwemizwa ukuba iphendule kwi-nociceptive stimuli. Ngenxa yesiphumo, i-analgesia iyenzeka.

Iyeza alinakuchukumisi, kwaye akavumelanga ukuba zikhule zibe zizifo ezingapheliyo. Ukongeza, iyanciphisa kakuhle intlungu sele ikhona.

Emva kokuthatha amachiza ngaphakathi, kukho i-miorelaxation (ngokuthintela i-neurons ephakathi). Omnye akanakunceda ukuthetha ukuba le nkunkuma iyakwazi ukukhusela i-neurons kwi-toxins. Ngokusebenzisa amashaneli e-calcium, isilwanyana sinciphisa ixabiso le-i-calcium ioni kwiiseli.

Pharmacokinetics yonyango

Xa iipilisi kunye neepsulules "I-Catadolon Retard" zingena kwindlela yokugaya, izinto ezisetyenziswayo zonyango zifakwe ngokupheleleyo (malunga nama-90%). Ngesinye isikhathi i-75% yesandi esamkelweyo isetyenziswe kwisibindi.

Isiqingatha-zobomi beziyobisi ezivela emzimbeni ngamahora angama-7 ukuya ku-15. Ukufika kuma-70% emachiza atyhulwa yizintso, kunye nezinye eziswini.

Abantu asebekhulile, kunye nezigulane ezinobungozi obunobungozi kunye nomsebenzi wezintso, ukukhutshwa komyinge wesigamu-ubomi kuya kwanda.

Ukulungiswa kweCatadolon: izibonakaliso zokusetyenziswa

Izibonakaliso zokusetyenziswa kwezi zidakamizwa ziintlungu ezivela kwimvelaphi eyahlukeneyo (emnene neyomodareyitha), ezibangelwa yimisipha yomzimba.

Ngoko ke kukuphi ukuphambuka kweziyobisi kunye nomfanekiso wabo owenziwe? "I-Catadolon" isoloko isetyenziselwa ukuhamba emva kweentsholongwane kunye nentloko, intlungu emva nangentamo, iimvumi ezimbi kunye nezicubu, njl njl.

Ukungqinelana nokusetyenziswa kweyeza

Iyeza "iCatadolon" alixhaswanga kakhulu ngenxa yezifo zengqondo kunye nesibindi, i-hypoalbuminemia, i-allergies kwisithako esisebenzayo okanye izinto ezincedisayo, ukukhalaza ezindlebeni, kunye nokunyanga kwabantu asebekhulile, abantwana kunye nezidakwa.

Indlela yokulawulwa kwemveliso yeyeza

Ndingayifumana njani iyeza "iCatadolon"? Iipsulsi akukho nhlobo ayikwazi ukuhlaziywa. Umlinganiselo weso siza ukhethwa kuphela kumntu ngamnye.

Iirejimeni zonyango zilandelayo zifakiwe kwimigaqo ehamba neyeza:

• Abantu abadala abangaphantsi kweminyaka engama-65 ubudala banqunywe i-100 mg yesilwanyana kane ngeentsuku (i-1, i-capsule 1). Kubalulekile ukunamathela kwixesha elifanayo lexesha phakathi kwamanani eyeza. Ngeentlungwini ezinzima, ungathatha iipsululwazi ezimbini kathathu ngosuku. Kufuneka ikhunjulwe ingqalelo ukuba i-dosage yamanqanaba onke kufuneka ibe ngama-600 mg (oko kukuthi i-capsules 6).
• Abadala (emva kweminyaka engama-65), isilwanyana "Catadolone" kufuneka sithathwe kwi-100 mg kabini ngosuku. Ngokuxhomekeke kwinqanaba lentlungu, le dosi inganyuswa ibe yi-300 mg ngosuku.
• Abagulayo abanesifo sokungaphumeleli kweengso okanye i-hypoalbuminemia ngokuqhelekileyo banqunywe ngaphezu kwe-300 mg yesilwanyana ngemini.
• Xa kunesifo sokukhubazeka kwesibindi, amayeza ayinakuthathwa kwiqondo elingaphaya kwama-200 mg ngosuku. Ubungakanani bonyango olunjalo luyahluka. Nangona kunjalo, unyango lwangexesha elide ludinga ukulawula umsebenzi we-enzyme yesibindi.

Iingxoxo zokulungiselela "i-Catadolon" ziqukethe into efanayo esebenzayo njengento yokuqala. Nangona kunjalo, xa ukhetha njengenxalenye, kufuneka uhlale udibana nogqirha uze ukhethe umlinganiselo ophezulu.

Ukugqithisa kweziyobisi

Kukho iingxelo ezizimeleyo zamatyala okugqithisa ngokwezilwanyana "Catadolon" ngeenjongo zokuzibulala. Kule meko, ezi zilandelayo zibonakaliswa: i-nausea, i-tachycardia, ukudideka, ukulila, ukunyuka kwe-mucosa yomlomo, ukungaboniyo.

Njengoko unyango lweempawu ezinjalo lusebenzisa i-diuresis ephoqelekileyo. Ukongezelela, isigulane sinikezelwa ngekhabhoni kunye ne-electrolytes. Ekugcinweni kwawo onke amanyathelo adwelisiweyo isimo sempilo yesigulane siphucula emva kokuphela kweeyure ezingama-6 ukuya ku-12.

Iimpendulo ezimbi emva kokuthatha iziyobisi

Kwezinye izigulane, emva kokuthatha amacwecwe okanye iifomsile ze "Catadolone", kunokubakho iziphumo ezinjenge:

• Utywaba, ubuthathaka jikelele kunye nokukhathala;
• I-flatulence, i-nausea kunye nentlungu yesisu;
• Ukugubha, ukunyanzelisa;
• Intloko kunye nexhala;
• Ukuphendulwa kwemizwa;
• I-hepatitis yobisi;
• Ukugqithiswa kombono.

Imiphumo emibi ingenzeka ngokungalindelekanga kwaye iphantseke ngokukhawuleza ngexesha lokunyanga.

Ukusebenzisana kwezidakamizwa

Ngaphandle kokufumana ukulungiselela "uCatadolone" ngeendlela ezifana ne "Warfarin" kunye ne "Diazepam", umphumo wokuqala ungomelezwa. Oku kubangelwa ukuba izidakamizwa ezibalwe zidibaniswa lula kunye nama-proteins, eziququzelela ukuxothwa kwe-flupirtine kwiiseli.

Ukuzihlaziya, ukuphucula imisipha kunye ne-ethanol kuphucula iziphumo zabo phantsi kwefuthe leziyobisi.

Akukhuthazwa ukudibanisa iyeza kunye neParacetamol, iCarbamazepine kunye neFlupirtin.

Kufuneka kwakhona kuqatshelwe ukuba kunye nokusetyenziswa kweso siza kunye ne "Kumarin" kuyimfuneko ukubeka iliso kwi-index yeprothrombin.

Imiyalelo ekhethekileyo

Ngaphambi kokusebenzisa imithi ye "Catadolon", kufuneka ufunde imiyalelo. Ithi:

• Esi sidakamizwa sifanele sisetyenziswe kuphela xa unyango kunye nezinye i-analgesics lichazwe.
• Ngexesha lokusetyenziswa kwamachiza kubantu abanomsebenzi wokunciphisa umzimba, kuyimfuneko ukubeka ingqalelo kwi-concentration ye-creatinine egazini.
• Kubantu abangaphezu kweminyaka engama-65, kunye nezigulane ezine-hypoalbuminemia kunye nokungakwazi ukuguqulwa kwamanqatha, kufuneka kwenziwe utshintsho lomthamo.
• Izigulane kufuneka zilumkiso ukuba ngexesha lotyando, ingqalelo ekhethekileyo kufuneka ihlawulwe kwiimpawu zengozi yesibindi. Xa le miqondiso ibonakalisiwe, kufuneka ukuba uyeke ukuthabatha unyango kwaye udibane nodokotela.
• Ngexesha lotyando kunye nesilwanyana "uCatadolone", iimpendulo ezingamanga zolu vavanyo lwe-urobilinogen, i-bilirubin kunye neprotheni kumchamo zinokwenzeka.
• Xa usebenzisa izilwanyana eziphakanyisiweyo zezilwanyana, isigulane sinokuthi i-urine stained green. Oku akusiyo impawu zekliniki kwanoma yiphina intsholongwane.
• Ngethuba lokunyanga, kuyimfuneko ukushiya ukulawulwa kwamatshini kunye nokuqhuba izithuthi, njengoko izigulana zingakhula isisu kunye nokulala.

Ukulungiswa kwe "Catadolon": ukufana, ukuhlaziywa, intengo

Ukufaniswa kwesi siluleko yilungiselelo "Flugesic". Ngokumalunga neempawu, amayeza alandelayo athi kubo: "Akupan", "i-Nefopam", "iMilistan" kunye ne "Sinmeton".

Ixabiso leziyobisi embuzweni liphezulu kakhulu. Njengomthetho, uhluka phakathi kwama-ruble ayi-900 no-1200 (kuxhomekeke kwifom kunye nenani lamathebhulethi, iifomsile).

Ngokutsho kweengxelo zezigulane, iyeza "iCatadolon" liphumelele kwaye likhawuleza liphelise nayiphi na intlungu ye-syndromes. Naphezu kwenani elikhulu leempendulo ezingathandekiyo, izidakamizwa zixhaphaza ngokuqhelekileyo zisebenzisa le ndlela yokulungisa i-anesthesia ngokuziyeka.

Ngokubhekisele kwizigulane eziqhelekileyo, ezinye zazo zikhalaza ukuba ukuthatha le mayeza kaninzi kubangelwa utywala kunye nobuthakathaka jikelele.

Ngokutsho koogqirha, isilwanyana "uCatadolone" sisoloko sisetyenziselwa ukuhlinzwa. Yisisombululo esinamandla, ngoko, akufanele kuthathwe ngaphandle kokumisela ugqirha.