"Imovan": imiyalelo ukusetyenziswa. Ukuphonononga malunga analogue neziyobisi nokuthengisa imithetho ezikhemisti

Medicament "imovan" yemiyalezo kuchonga njenge uncedo ubuthongo, ebhekisela tsiklopirrolonov qela. Amalungiselelo anazo anxiolytic, thile, relaxant kwezihlunu, sine iipropati anticonvulsant.

pharmacodynamics

A isiphumo iziyobisi enyangayo "imovan" (umsebenzisi kungqinwa) ezinxulumene ne ukususela agonist ethile receptors omega (esasisaziwa ngokuba benzodiazepine receptor uhlobo yabo yokuqala neyesibini). Amayeza kunciphisa ixesha ukulala nokunciphisa izehlo eke okuqala kunye nobusuku, kwaye andise ixesha nokuphucula umgangatho ubuthongo. data PSG ukubonisa ukuba ichiza "imovan" kwizigulane abaphethwe sokulibala, ukulala kunciphisa kwisigaba sokuqala kwaye lwenze wesibini, iivenkile kwesesithathu nakwesesine (ubuthongo obukhulu) kunye inyathelo ngamazwi (REM) isigaba. Uphando ngokubhalisa polysomnograms ukurhoxiswa zange phendla phi nkobe ukuphuthelwa olubonakalayo emva ukuthatha iyeza iintsuku ezingamashumi amabini anesibhozo. Ezinye iimvavanyo abonisa ukuba xa usebenzisa ichiza ngenxa elinesixhenxe iiveki Ukunyamalala isiphumo thile akukho ulandelwe.

Pharmacokinetics

ipilisi zokulala "imovan" wendele ngokukhawuleza, kungakhathaliseki ukuba ukutya. Xa plasma emva ulawulo yomlomo 3,75 no 7.5 milligrams kwemali ngaphakathi enye enesiqingatha ukuya kwiiyure ezimbini ufikelele xi iphezulu malunga-30 no-60 ng / ml, ngokulandelelana. Ekubeni iiproteni plasma yegazi nabangamakhoboka unsaturated ibuthathaka (malunga nama-45%). Kwinqanaba kwiproteni ngenxa kumngcipheko leendibano kunye nezinye iziyobisi liphantsi kakhulu. iziyobisi "imovan" isasazeka kakhulu ngokukhawuleza ukusuka kwegazi. Guide ingxelo ukuba eyavela ngobisi lwebele ayafana nalawo kuvandlakanywa plasma. Isiqingatha-umphefumlo ichiza kakuhle lo gama uthatha ekucetyiswa imithamo avareji iiyure ezintlanu. Ichiza ibonakala ubukhulu becala ngokohlobo metabolites Umchamo (malunga nama-80%) kunye endleni (16%).

Ubungqina obubonakalayo buxela ukuba

Medicament "imovan" umyalelo ibonisa ukusetyenziswa ekunyangeni lwemeko, zezomzuzwana, efuna yezifo abadala. Ngokukodwa, kusetyenziswa neenzima nokulala ebusuku kunye eke yokuqala.

ifomu Release komsindo

Ichiza ifumaneka ngohlobo amacwecwe ezimhlophe umboniso-isale umgca elimbhoxo kwicala elinye. Enye unit lwendlela luyinto icandelo esebenzayo eziquka - zopiclone - 7.5 milligrams mass. Tablets "imovan" Kwakhona sodium carboxymethylstarch, titanium dioxide, calcium hydrogenphosphate dihydrate, nemagnesium stearate, monohydrate lactose, starch ingqolowa, hypromellose.

A indlela for ukwamkelwa kunye nexesha zonyango

medicament ngomlomo kuboniswe ngoko nangoko ukulala ebusuku ngaphambi yakhe. Ukuba kunokwenzeka, unyango kufuneka sibe sifutshane kwaye mayingagqithi kweeveki ezine, kuquka nexesha yokwehla balawule. Ukuthatha ichiza ixesha elide kunokuba kumiselwe kwiMigaqo, baya kuvunyelwa kuphela emva kokuba uhlolo lobuchwepheshe isigulane. kufuneka sisoloko ukuqala unyango kunye ithamo lisezantsi olusebenzayo, ukwandisa ukuba kuyimfuneko, kodwa ayikwazi ukudlula idosi ubuninzi. Xa ugwayi ezidlulayo (umzekelo, okubangelwa kukutshintsha lwendawo ngexesha hambo) ikhondo unyango ingadluli kwiintsuku ezimbini ukuya ezintlanu. Xa lwemeko ubuthongo, kuba iiveki ezimbini ukuya kwezintathu. Kwimeko ukuphuthelwa ezigulo ezondeleyo kufuna unyango ixesha elide, ubude emiselwe ngugqirha.

umthamo okunikezelwe

Le idosi yemihla ngemihla kubantu abangaphantsi kweminyaka engama-65 ubudala - 7.5 milligrams. izigulane abadala (kweminyaka engama-65), kunye nabo ukuphazamiseka kwesibindi okanye lokubandezeleka yokuphefumla sandla ngokulinganisela, emiselweyo inani ngemihla ka-3,75 milligrams. Thatha amayeza akho ubunzima milligrams ngaphezulu kwe 7.5 ngosuku kuvumelekile kuphela kwiimeko kakhulu. Unyango kwezigulane ukusilela kwezintso, nangona kulo mzekelo akazange atyhile ukuqokelela ichiza kunye metabolites yalo, kuyimfuneko ukuqala nge idosi yemihla ngemihla ka-3,75 milligrams.

imiphumela emibi

Malunga ncomo kulungiselelwa "imovan" lifumaneka kakhulu omhle, oko kudla ukunyamezeleka kakuhle. Kodwa phantse zonke izigulane zithi emva ezithatha ichiza emlonyeni kuhlala kuba krakra. Abanye abantu bethetha ukuvela intloko ebuhlungu, isiyezi kwisiqalo yokusetyenziswa elele iipilisi. Phakathi iingxaki kufuneka kuqatshelwe hypotonia dystrophy, ukozela ntsalela phezu ukuvuka, diplopia, asthenia, ilahleko yobuntu. Kukho umngcipheko esiswini: isicaphucaphu, ukuqunjelwa, umlomo owomileyo. Ngamanye amaxesha kukho ngayo ulusu ezifana irhashalala kunye ukurhawuzelela, kwiimeko ezinqabileyo - reactions anaphylactic, angioedema kukothuka. Ngokuba ezinye izigulane emva kokuthatha iipilisi belele kuvela saka, ukudakumba, amabi, iingxaki uququzelelo lweentshukumo, ukuba ndlongondlongo, ukuba nochuku, imo odandathekileyo, ehamba ephupheni, ukuziphatha engafanelekanga (kunokwenzeka nodibaniso kunesifo). Kwanaxa esetyenziswa emacwecweni ngeedosi ngamayeza nokunyanga "imovan" (manual ulumkisa ngale) ukuze aphuhlise ukuxhomekeka engqondweni nasemzimbeni.

yokuyeka

Abanye abantu emva kumiwe yamayeza unyango iphuhlisa ekubalekeni syndrome. Iimpawu zaso inokuba nomahluko, badla ke kuvela ngohlobo ixhala, ukudideka, ukululama sokulibala, tachycardia, ukuba nochuku, lafa, intloko ebuhlungu, ingqondo, ukwanda ukubila, ubusuku amabi, tachycardia, ukuphazamiseka, nemibono. Kwiimeko ezinqabe kakhulu uxhuzula.

Izimo

Abantu abane hypersensitivity ukuya izithako lithetha "imovan" bayinikele umva ukusetyenziswa kwayo. Kwakhona, ipilisi zokulala abalindelekanga bathunyelwa ukuba izigulane gravis kwi ukusilela kakhulu esibindini ngohlobo kakhulu (kunye ingozi Encephalopathy), kakhulu umoya syndrome, ukusilela kakhulu nokuphefumla, ukulala. Contraindicated neziyobisi phambi kweminyaka elishumi elinesibhozo. Abantu linembali iziyobisi, utywala, nokuba likhoboka neziyobisi, iziyobisi isetyenziswe zizazi, njengokuba kulo mzekelo, kukho nengozi yokuba ukuxhomekeka ukwanda okanye ukuxhatshazwa.

Sebenzisa ngethuba lokukhulelwa zisanyisa

Thatha iipilisi "imovan" abasetyhini abakhulelweyo kunye phindeke belele ayikhuthazwa. Xa ichiza ilawulwa ngexesha senyanga yesithathu usana lisenokuba iziphumo ezingalunganga ezifana hypotension, ukudandatheka yokuphefumla, emzimbeni. Abafazi uceba okanye ukukhulelwa ekucingelwa kufuneka ayeke ezithatha ichiza.

libanda

Ngokuqhelekileyo libanda, iimpawu wabonisa CNS ukudandatheka ezingafani ukusuka somnolence elula isiqaqa (kuxhomekeka idosi). Kwiimeko inobulali, kukho ukungakhathali, ukozela, ukudideka, ngaphezu kakhulu - silale, ukudandatheka yokuphefumla, Ataxia, hypotonia, ukufa isiqaqa. Kuyinto kunqabile kakhulu block atrioventricular. Ezisongela ubomi libanda, akakho, ukuba ulwamkelo ipilisi zokulala nto idityaniswe ulwamkelo namanye amachiza leyo zisidimaze luvo central, okanye utywala. Kwakhona iimpawu libanda, ukuba mandundu xa imeko jikelele yomguli iye buthathaka okanye comorbidities. Kwiimeko ezinjalo, oko ungaze ekufeni (ezinqabileyo). Phambi ichiza ngeedosi ngokugqithisileyo eboniswe unyango kwangumqondiso kwaye inkxaso esibhedlele. I ingqalelo kakhulu kufuneka ihlawulwe imisebenzi sentliziyo zokuphefumla. Amanyathelo ezifana carbon isebenza kwaye nokuwahlamba nesisu efficacious kuphela xa kwenziwa ngokukhawuleza emva kokuba ukusetyenziswa medicament "imovan".

analogs

Banikwa amachiza thile generic ezifana "Somnol", "Thorson", "Relakson", "Piklodorm" kunye nabanye. Ngenxa umthetho, ukuba zitshiphu ngaphezu yakuqala, kodwa kwangaxeshanye ziyasebenza kangako.

oyi

Njengoko kuchaziwe ngaphambili, ngokuthatha nadlamkisayo, kuquka iziyobisi "imovan", kunokubangela uphuhliso ukuxhomekeka engqondweni nasemzimbeni. Umngcipheko kwandisa kunyango ixesha elide kwaye uthatha iipilisi belele ngeedosi eziphezulu, kunye nokusetyenziswa kakubi kotywala, izinto psychotropic, kwakunye phambi ixhala. Ukuba ukubonakala umzimba umngena ukuyeka unyango ngamachiza ukuze aphuhlise i syndrome ukurhoxiswa, oko kuchazwe ngasentla. Ukuze uphephe oku, kufuneka ukunciphisa ithamo kweziyobisi ngokuthe ngcembe. Zingawuthintela njani na umngcipheko iziphumo ebezingalindelekanga ezifana kunesifo anterograde, oko kuyanceda ukuba uyigcine imithetho ezimbini: Kufuneka ukusela ipilisi nje kokuba balale (ukuphepha isixa esikhulu bexesha phakathi ukusetyenziswa kweziyobisi ukulala) kunye ulale iiyure ezintandathu (akuyiphazamisi ubuthongo ngaphambi iiyure ezintandathu emva kokuba ndilale). Iyeza na eboniswe yonyango uxinezeleko yaye nokuba ukuwafihla iimpawu zayo.

imithi

unyango ngaxeshanye yokulala iipilisi 'imovan "kunye utywala kukhokelela ekwandeni umthomalalisi. Ukongeza, awukwazi ukuthatha amayeza kunye namachiza onyango, ezicinezelayo inkqubo luvo: barbiturates, lakhula nge sine okudambisa, antipsychotics, arhente antitussive, iintlungu, analgesics ezidakumbisayo, iziyobisi antiepileptic amanyathelo engundoqo. Kwimeko ukusetyenziswa kunye nempembelelo nokudakumba kwinkqubo luvo kwengeniso. Kwakhona, musa ukusela kunye "imovan" iipilisi kunye neziyobisi trimipramine, ngokuba xi plasma ngabaya kunye nefuthe layo iya kuncitshiswa. Joint reception buprenorphine soporific kwandisa umngcipheko zokudakumba nokuphefumla (isiphumo zinokude ibulale).

Apho ukuthenga "imovan"

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