Imiyalelo yokusebenzisa - ampicillin

Impela eyadlulayo, oko kwazeka ukuba indlela engundoqo bhetyebhetye iindidi ezahlukeneyo magciwane elwa i β-lactamase kunye nemveliso yazo. Bayaphumelela kakhulu igalelo ekutshatyalalisweni zokuzikhusela amakhonkco elwa phantse enze nefuthe lazo nezinyangayo. Ukuze yoyiswe le nefuthe elibi, iye yaphuhliswa kwaye zilungiswe ngokoqobo iikhemikali ukuba okunqanda β-lactamase ngokuyintloko clavulanic acid imixube sulbactam kunye tazobactam.

Ezi zinto zibandakanya njengoko imiba ebizwa ngokuba ingibitorozaschischonnyh penicillin - amachiza zidibene, eziquka penicillin olwa nawo. Imizekelo eyaziwa kakhulu kumalungiselelo ezinjalo ampicillin-sulbactam, amoxicillin, ticarcillin kunye nabanye besenza iqela penicillins. ukusebenzisa kwabo kakuhle nabo ngenxa yokuba ukusebenza njengenxalenye ezahlukahlukeneyo edibeneyo le cephalosporin lokwenziwa III, ngoxa ukusebenza esisebenza ehleli kwinqanaba eliphezulu.

Ngexesha imidibaniso eyahlukeneyo, ezisetyenziswa iziyobisi ezininzi namhlanje equka antibiotics ubume kunye inhibitors of β-lactamase, kukho umsebenzi yokuqala ngokutsha penicillins kwaye phantse wachacha ngokupheleleyo ukusebenza kwazo kwezonyango ekulweni uninzi eyaziwa ngokuba anaerobes namhlanje staphylococci kunye Igram iintsholongwane. Ukongeza, xa imixube ezinjalo ekwandiseni ezinye elwa. iziyobisi obunjalo bobabo ampicillin / sulbactam, leyo kuxhomekeke ngumvelisi zisenako aveliswe phantsi amagama okanye unazin Sulatsillin.

Olu nyango lubandakanya ampicillin kunye sulbactam, aba bakhoyo apha umlinganiselo we-2: 1. Njengoko kuboniswe yesikhokelo, ampicillin kunye sulbactam kule ukulungiselela ngaphandle eneneni bavimbe β-lactamases kuba umsebenzi ngokwanelisayo abuthethileyo Neisserial kunye atsinetobakterov.

Ngokuqhelekileyo ukuba iziyobisi lwangaphakathi walunyukiswa abelwa sultamicillin, ubunjwe sulbactam kunye ampicillin. Iipilisi xa walunyukiswa bangene emzimbeni. Ngoko ke indlela haydrolisis kunye nesiphumo zidibene equka i ampicillin neziyobisi kunye sulbactam, nto leyo iphucula bioavailability of ampicillin kwinqanaba eliphezulu ukuba afezekiswa xa isamkela i idosi olulinganayo ampicillin zemveli.

Abaliqela spectrum ezibanzi msebenzi, yaye eli chiza. Ngoko ke, ukusetyenziswa ezininzi iziyobisi kuboniswa usulelo kwegciwane imvelaphi TTP, sinusitis iimilo ezahlukeneyo kunye umyalezo. Iyeza kumiselwe izifo phecana ukungaphefumli: kwemigudu yomoya, inyumoniya.

Ngokutsho imiyalelo ukusetyenziswa, ampicillin enesiqulatho sulbactam iyasebenza unyango iintlobo ezahlukeneyo zamangenelela intraabdominal kunye zangasese, kuquka usulelo ezithambileyo izihlunu, ithambo kunye nosulelo ezimanyeneyo, septicemia.

Amalungiselelo ampicillin kunye sulbactam ngokubonakalayo ngempumelelo ngakumbi xa kuthelekiswa amoxicillin / clavulanate kwi unyango lwezifo ukuba basungule atsinetobakterom.

Le umthamo ichiza limisela imiyalelo ukuze zisetyenziswe. Ampicillin imiselwe ngomlomo, ithamo kuba abadala kwi 0,375-0,75 iigram kungakhathaliseki ukuba ukutya amaxesha amabini ngexesha lasemini, ukuba esi sifo isimilo lula. Kwiintlobo kakhulu ngakumbi na amayeza esetyenziswa 1.5-3.0 grams imini xa obubungqongo banda, idosi angandiswa ku 6.0 grams.

iziyobisi Babies yaphathwa ngeedosi ebalwe malunga 50 micrograms ngosuku ngalunye ikhilogram enye sobunzima umntwana. Ukwamkelwa wenziwa kabini.

ifomu Ukukhululwa umthamo beziyobisi ikuchaza ngokweenkcukacha imiyalelo ukusetyenziswa. Ampicillin nayo athathwe ngaphandle amacwecwe uhlobo powder kusetyenziswa ukulungiselela ukumiswa ekhethekileyo (xa ilawulwa ngomlomo). Kwaye ngaphandle kokuba ukusetyenziswa kweziyobisi ngenaliti, kuba oku evela ifomu powder. Isinyibilikisi enikezwa ne beziyobisi iphakheji enye.