Ichiza "Daraprim": imiyalelo ukusetyenziswa, inxalenye yokwenene, analogue kunye nohlolo

Malaria liqela kwezifo kumda wesangqa-ebemzele esosulelayo, ezo idluliselwe ukuba abantu xa iingcongconi ze sodidi bohlobo liluma. Kuba imeko zophendlo lwezifo ezifana luphawulwa ifiva, kuthibaza, splenomegaly, hepatomegaly kunye nezinye.

Ngexesha unyango ngesiquphe yaye akufanelekanga lwemalariya ukufa kwenzeka (kwiimeko ezininzi).

Eyona ngokuqhelekileyo ukuba unyango lwezifo ezifana usebenzisa iziyobisi "Daraprim". Imiyalelo yokusebenzisa, ncomo, amaxabiso kunye analogue iyeza iya thaca ngezantsi.

Ukubunjwa, imilo, ezingxobeni inkcazo kwaleyo yokulungiselela

Ichiza "Daraprim" ukuqeqesha uqulathwe kwibhokisi eyenziwe yekhadibhodi, kuthengiswa azipilisi umbala omhlophe ngaphaya kwawo. Le into esebenzayo kugqalwa kuthetha pyrimethamine.

Thenga eli chiza inokuba iiseli nentaba ukuba zingafakwa kwiibhokisi kwikhadibhodi.

Iimpawu beziyobisi

Yintoni unyango "Daraprim"? Imiyalelo yokusebenzisa zibonisa ukuba lo msebenzi ngokuchasene ichiza. Kuye antitoksoplazmoidnoe kwaye seengcongconi neziphumo, yaye kunegalelo yokuvimba folatreduktazy inguqu folic acid folinic.

Olu nyango kukuthi isebenze ukulwa i-Plasmodium gciwane kunye ne- toxoplasmosis. Kwakhona unalo shizontotsidnoe senzo.

Xa abantu, beziyobisi umbuzo aluchaphazeli ngohlobo (ngokwesondo) Plasmodium falciparum, njengoko ndayihluthwa umsebenzi gamontotsidnoy. Noko ke, oku kuthetha unako ukuze kuthintelwe inkqubo izichumiso gamont carrier nomzimba (ngamanye amazwi, iye gamontostaticheskoe action).

Ubungqina obubonakalayo buxela ukuba ukungena lekrstva

Drug "Daraprim", apho umyalelo uya thaca ngezantsi, kujongwe ukuba unyango kunye nothintelo seengcongconi. Kwakhona, oko omiselwe toxoplasmosis (iziphene kwaye ezifunyenwe) kunye uveitis (toxoplasmosis okanye imvelaphi ayaziwa).

Izimo iipilisi

Kuphantsi kwaziphi iimeko apho kufuneka ingamiselwa iyeza "Daraprim"? Guide uthi ithetha contraindicated kunye hypersensitivity kunye megaloblastic B12-imibala anaemia, bunxulunyaniswa yokunqongophala folic acid.

C balumke ngeyona zicingeleka iziyobisi ezimiselwe ukufundwa iimeko folate-nokuqhwalela yaye ukusilela hepatic okanye kwezintso.

Medicament "Daraprim": imiyalelo yokusebenzisa

Analogue iyeza iya zidweliswe ngezantsi.

Thatha iipilisi kufuneka ibe ngaphakathi kuphela. umthamo wabo kuxhomekeka kubungqina.

Kuthintelo amayeza seengcongconi emiselweyo 1 tablet kanye ngemini. Abantwana abaminyaka yobudala eyi-5-10 Kucetyiswa ukuba ukuthatha amayeza e ithamo isiqingatha.

Prophylaxis kufuneka uqale nje ngaphambili okanye ngoko nangoko emva kokuba efikile kummandla apho kukho amathuba eliphezulu yokosulelwa seengcongconi ngayo. Kulo mzekelo, ithamo amayeza kule ithamo kufuneka kuqhubeke kule nyanga izayo.

Ke ukuba unyango seengcongconi ukuba ichiza "Daraprim"? Guide ingxelo ukuba unyango yesifo onjalo wenziwa ngokubanzi. Amayeza kudityaniswe "sulfadoxine" okanye "sulfalena". It ibhalwa isixa-mali ka-1 ukuya ku-3 amacwecwe ulwamkelo. Abantwana abaminyaka yobudala eyi-9-14 ndikunike amacwecwe pirimetrina 2 kunye neminyaka 4-8 - nye.

Kuba unyango toxoplasmosis abantwana abadala ngaphezu kweminyaka emi-6 yaye abadala kucetyiswa ukuba athathe 2 "Daraprima" iipilisi ngosuku, kunye nabantwana iminyaka 2-6 - nye.

Ubude unyango le arhente ziiveki 3-6. Ukuba kuyimfuneko, le khosi yayiphindwa.

imiphumela emibi

Ukufumana iziyobisi seengcongconi kunokubangela reactions ezahlukeneyo ezichaseneyo ebekwe. Wakhathazeka kakhulu ebonakalisiwe:

• amahlaba esiswini, intloko ebuhlungu, umqala ezomileyo okanye emlonyeni, ubuthathaka, isicaphucaphu;
• isiyezi, ukugabha, dermatitis, urhudo (ekuqaleni konyango), irhashalala, ukudandatheka;
• kutshintsha nombala ulusu, ifiva, ianemia, leukopenia;
• ukuwa yegazi, thrombocytopenia, embhedeni emlonyeni, fenilalaninemi, ugwayi.

imithi

"Warfarin" yaye "quinidine" ukwandisa ubungozi kunye nokusebenza beziyobisi.

Enetyhefu umngcipheko isibindi wokwenzakala linokunyuswa kakhulu nge zombini "Daraprima" ne "lorazepam". Kwakhona ngcono myelosuppression, nto leyo ibangwa iziyobisi cytotoxic (kuquka "methotrexate").

Abasafunda ukuhamba wegazi kunye CNS emva nolawulo "pyrimethamine" yaye "methotrexate" kwandisa amathuba ukuxhuzula.

Xa abantu abanezifo wegazi etsolo myeloid, sisamkela "cytosine arabinoside," "Aunorubitsina" kunye pyrimethamine kunokubangela lomongo wethambo aplasia.

iingcebiso ezithile ngokufumana see-

amayeza kujongwa emiselweyo isilumkiso abantu kwezintso okanye ukusilela isibindi, kwaye ukunqongophala azalwa ngayo folic acid okanye ngenxa ukungondleki.

Xa ukunyanga toxoplasmosis ukwenzela ukunciphisa ingozi lomongo wethambo ingcinezelo, nto leyo endinga indlela reception calcium folinate okanye folic acid.

Ngeli xesha lonke unyango kufuneka wenziwe veki nganye yegazi yesigulane.

Analogs neendleko

arhente Price ingxelo malunga 7-8 amawaka engange. nucleoside noshowo oku ukulungiselela no. Noko ke, ezinye iingcali athi iimpawu ezifanayo amayeza afana "Milife", "Zener" (umgubo), "Plaquenil" yaye "Lariam".

reviews

Ngoku uyazi iimpawu amayeza beziyobisi "Daraprim". Guide ixabiso le sixhobo sele thaca kweli nqaku.

Fumana ncomo yabathengi yale amachiza seengcongconi kunzima. Ngapha koko, njengoko nisazi, malunga 85-90% amatyala osulelo nesi sifo kwenzeka iindawo eAfrika. Njengomgaqo, bosulela abantwana abangaphantsi kweminyaka emihlanu.

Iingcali ingxelo ukuba izinga lokusweleka ngenxa seengcongconi liye lehla ngokuphawulekayo emva ukusebenzisa iziyobisi. Noko ke, asingabo bonke abantu ithuba lokuba asebenzise eli ziko ngethuba usulelo.